Dr Benjamin Pickard

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

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Personal statement

Ben Pickard obtained a BSc in Biochemistry from Imperial College London (1992), and a PhD from the University of Edinburgh (1996). Before coming to the University of Strathclyde, he worked at the Babraham Institute, Cambridge on factors regulating DNA methylation, and at the Molecular Medicine Centre, Edinburgh, identifying genetic risk factors for common psychiatric illnesses such as schizophrenia, bipolar disorder and major depression.

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Publications

Genes associated with amyloid-beta-induced inflammasome-mediated neuronal death identified using functional gene trap mutagenesis approach
Yap Jeremy Kean Yi, Pickard Benjamin Simon, Gan Sook Yee, Chan Elaine Wan Ling
International Journal of Biochemistry and Cell Biology Vol 136 (2021)
https://doi.org/10.1016/j.biocel.2021.106014
The role of neuronal NLRP1 inflammasome in Alzheimer's disease : bringing neurons into the neuroinflammation game
Yap Jeremy Kean Yi, Pickard Benjamin Simon, Chan Elaine Wan Ling, Gan Sook Yee
Molecular Neurobiology Vol 56, pp. 7741-7753 (2019)
https://doi.org/10.1007/s12035-019-1638-7
PEGylation of polypropylenimine dendrimers : effects on cytotoxicity, DNA condensation, gene delivery and expression in cancer cells
Somani Sukrut, Laskar Partha, Altwaijry Najla, Kewcharoenvong Paphitchaya, Irving Craig, Robb Gillian, Pickard Benjamin S, Dufès Christine
Scientific Reports Vol 8 (2018)
https://doi.org/10.1038/s41598-018-27400-6
Specialised information processing deficits and distinct metabolomic profiles following TM-domain disruption of Nrg1
O'Tuathaigh Colm M P, Mathur Naina, O'Callaghan Matthew J, MacIntyre Lynsey, Harvey Richard, Lai Donna, Waddington John L, Pickard Benjamin S, Watson David G, Moran Paula M
Schizophrenia Bulletin Vol 43, pp. 1100–1113 (2017)
https://doi.org/10.1093/schbul/sbw189
Genomics of lithium action and response
Pickard Benjamin S
Neurotherapeutics Vol 14, pp. 582-587 (2017)
https://doi.org/10.1007/s13311-017-0554-7
Brain changing tubers : gene expression changes following mediaeval tuber consumption
Woods N, Gebril A, Simpson Ann, Iannetta Ppm, Kenicer G, Tate R J, Pickard B, Gray A I, Ferro V A
Planta Medica Vol 81, pp. S1-S381 (2016)
https://doi.org/10.1055/s-0036-1596241

More publications

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Teaching

  • Teaching across Biomedical Sciences classes: BM110, 108, 109, 210, 214, 321, 326, 327, 422, 423, 430, 432; Pharmacy: MP422; Postgraduate: BM934, 937, 951, 942, 952, 953, 959.
  • Coordinator of Biomedical Sciences classes BM321, BM423; Postgraduate: BM934, 937, 952.
  • Personal Development Advisor
  • Internal/external examiner PhD theses
  • External examiner MSc Neuroscience, UCL, (2013-2015)

Certificates of Recognition in University of Strathclyde Student Union Teaching Excellence Awards: 2012, 2013, 2014. Winner: Most Supportive Teacher 2017.

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Research Interests

  1. The use of gene traps in human cell lines to create mutational libraries that can be screened to reveal biological pathways: e.g., lithium mood stabiliser action, the formation of the perineuronal net, beta-amyloid toxicity in Alzheimers, human defence mechanisms against bacterial infection.
  2. The formation of the special type of extracellular matrix called the Perineuronal Net (PNN) which surrounds certain brain neurons and, when defective, may be a causative factor in psychiatric disorders.
  3. Two new rules we have discovered that link the amino acid composition of a protein to its expression level.

Projects

DTP 2224 University of Strathclyde | Campbell, Iona
Chamberlain, Luke (Principal Investigator) Pickard, Ben (Co-investigator) Campbell, Iona (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Development of a long-lifetime dye for gated-STED microscopy
Edkins, Robert (Principal Investigator) Pickard, Ben (Co-investigator)
01-Jan-2020 - 31-Jan-2021
Biomedical Vacation Scholarships
Coats, Paul (Principal Investigator) Jiang, Hui-Rong (Principal Investigator) Lawrence, Catherine (Principal Investigator) McDonald, James (Principal Investigator) Pickard, Ben (Principal Investigator)
09-Jan-2018 - 31-Jan-2018
Biomedical Vacation Scholarships / R180191-5
Pickard, Ben (Principal Investigator)
02-Jan-2018 - 17-Jan-2018
Pharmacells contribution to IAA Secondment
Carswell, Hilary (Principal Investigator) Pickard, Ben (Co-investigator) McKittrick, Craig (Research Co-investigator)
25-Jan-2016 - 31-Jan-2017
Development of novel gene delivery systems for brain targeting by intravenous administration
Dufès, Christine (Principal Investigator) Pickard, Ben (Co-investigator)
01-Jan-2016 - 30-Jan-2019

More projects

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Contact

Dr Benjamin Pickard
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: benjamin.pickard@strath.ac.uk
Tel: 548 4572

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