Professor Judith Pratt

Emeritus Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Contact

Personal statement

Research Professor (2013-), Professor of Systems Neuroscience (2003), PhD (Institute of Psychiatry 1982).  Co-Director of Psychiatric Research Institute of Neuroscience in Glasgow (PsyRING; psyring.co.uk) a collaboration between the Universities of Strathclyde and Glasgow and NHS Greater Glasgow & Clyde.  Since 1997, PsyRING has engaged in major collaborations with Pharmaceutical companies to provide translational solutions for drug discovery and development in Psychiatric disease. 

Research Interests are focussed on understanding the molecular and neural systems that underpin behaviour in mental health and disease. We are a multidisciplinary, friendly team with expertise spanning genetics, molecular biology, brain imaging and behaviour.

Schizophrenia: PsyRING has provided new insight into the glutamate hypothesis of schizophrenia.  We have demonstrated that PCP produces schizophrenia-like changes in brain imaging, GABAergic interneurone markers and cognition. Novel therapeutic targets have been identified (e.g. serominic) and validated.   We have determined the functional brain networks subserving PCP-induced disruption of cognition and their restoration by the pro-cognitive drug modafinil.  Current work is focussed on understanding the neurobiological mechanisms of genetic risk factors for schizophrenia. We have identified a novel risk gene for schizophrenia MAP2K7 and shown that it produces schizophrenia-like working memory deficits. In a recent multicentre translational medicine grant with Pfizer we have identified key neural substrates underpinning behavioural deficits in DISC1 mouse models and demonstrated that the thalamic reticular nucleus is a key region affected in the models.

Cannabinoids: We are investigating the mechanisms of interaction between the constituents of cannabis (e.g. THC and cannabidiol) and with THC and other psychoactive drugs.  Recent work is focussed on environment-environment interactions determining the impact of prenatal infection and adolescence THC exposure on brain systems and behaviour in adulthood.

CeNsUS (Centre for Neuroscience at the University of Strathclyde): Through multidisciplinary collaborations within CeNsUS we are 1) applying novel algorithms from network science to understanding brain systems underpinning drug actions in disease and  2) developing medical devices for deep brain stimulation 3) Investigating the role of the reticular thalamic nucleus in the corticothalamic system using optogenetics

Public engagement.  Engaged in activities at the Glasgow Science Festival, Glasgow Science Centre, Schools, Restaurants, British Association for the Advancement of Science 

Back to staff profile

Publications

Site‐specific inhibition of the thalamic reticular nucleus induces distinct modulations in sleep architecture
Visocky Vladimir, Morris Brian J, Dunlop John, Brandon Nick, Sakata Shuzo, Pratt Judith A
European Journal of Neuroscience Vol 59, pp. 554-569 (2024)
https://doi.org/10.1111/ejn.15908
16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability
Openshaw Rebecca L, Thomson David M, Bristow Greg C, Mitchell Emma J, Pratt Judith A, Morris Brian J, Dawson Neil
Communications Biology Vol 6 (2023)
https://doi.org/10.1038/s42003-023-04891-2
Building the evidence base for community pharmacy depression services
Weir Natalie, Kernaghan David, Watson Margaret, Akram Gazala, Maxwell Margaret, Pratt Judith
Mental Health Care Futures (2023)
Improving the validity and translation of preclinical research
Pratt Judith A, Robinson Emma S J, Fernandes Cathy, Heal David, Stanford S Clare
Journal of Psychopharmacology Vol 36, pp. 779-780 (2022)
https://doi.org/10.1177/02698811221104064
Glycan degradation promotes macroautophagy
Baudot Alice D, Wang Victoria M-Y, Leach Josh D, O’Prey Jim, Long Jaclyn S, Paulus-Hock Viola, Lilla Sergio, Thomson David M, Greenhorn John, Ghaffar Farah, Nixon Colin, Helfrich Miep H, Strathdee Douglas, Pratt Judith, Marchesi Francesco, Zanivan Sara, Ryan Kevin M
Proceedings of the National Academy of Sciences Vol 119 (2022)
https://doi.org/10.1073/pnas.2111506119
Enzymatic degradation of cortical perineuronal nets reverses GABAergic interneuron maturation
Willis Ashleigh, Pratt Judith A, Morris Brian J
Molecular Neurobiology Vol 59, pp. 2874-2893 (2022)
https://doi.org/10.1007/s12035-022-02772-z

More publications

Back to staff profile

Professional Activities

Building the evidence base for community pharmacy depression services: a systematic review and multi-stakeholder consensus exercise
Speaker
7/10/2023
REF- Sub-panel 4 (External organisation)
Advisor
1/5/2021
New insight into genetic schizophrenia risk
Recipient
21/4/2020
The importance of the thalamic reticular nucleus in disrupted thalamocortical connectivity in rodent models of schizophrenia risk factors
Speaker
7/10/2018
Translational rodent models of social behaviours and social cognition: challenges, insights and prospects for new treatments
Speaker
22/7/2018
A key role for the TRN in NMDA Receptor and DISC1 Models of Schizophrenia-Related Thalamo-Prefrontal Cortex Dysconnectivity
Speaker
7/12/2016

More professional activities

Projects

Building the Evidence Base for Community Pharmacy Depression Services: a Systematic Review and Multi-stakeholder Consensus Exercise (CMHP-PRUK CP Mental Health Services)
Weir, Natalie Mcfadyen (Principal Investigator) Akram, Gazala (Co-investigator) Pratt, Judith (Co-investigator) Watson, Margaret (Co-investigator)
16-Jan-2023 - 31-Jan-2024
IMPC:Cognitive and ethological characterisation of mice lacking melatonin MT2 receptors
Pratt, Judith (Principal Investigator)
01-Jan-2017 - 31-Jan-2018
Characterising mice syntenic for human 16p11.2 in relation to schizophrenia and autism
Pratt, Judith (Principal Investigator)
01-Jan-2016 - 14-Jan-2018
PsyRING project with Servier Phase 1
Pratt, Judith (Principal Investigator)
01-Jan-2014 - 31-Jan-2019
Interrogating the cortico striatal thalamo cortical CSTC circuitry implications for neuropsychiatric drug discovery | Visockis, Vladimir
Pratt, Judith (Principal Investigator) Sakata, Shuzo (Co-investigator) Visockis, Vladimir (Research Co-investigator)
01-Jan-2013 - 10-Jan-2019
Interrogating the cortico striatal thalamo cortical CSTC circuitry implications for neuropsychiatric drug discovery
Pratt, Judith (Principal Investigator) Sakata, Shuzo (Co-investigator)
01-Jan-2013 - 30-Jan-2017

More projects

Back to staff profile

Contact

Professor Judith Pratt
Emeritus Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: j.a.pratt@strath.ac.uk
Tel: 548 2856