Professor Judith Pratt

Research Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Research Professor (2013-), Professor of Systems Neuroscience (2003), PhD (Institute of Psychiatry 1982).  Co-Director of Psychiatric Research Institute of Neuroscience in Glasgow (PsyRING; psyring.co.uk) a collaboration between the Universities of Strathclyde and Glasgow and NHS Greater Glasgow & Clyde.  Since 1997, PsyRING has engaged in major collaborations with Pharmaceutical companies to provide translational solutions for drug discovery and development in Psychiatric disease. 

Research Interests are focussed on understanding the molecular and neural systems that underpin behaviour in mental health and disease. We are a multidisciplinary, friendly team with expertise spanning genetics, molecular biology, brain imaging and behaviour.

Schizophrenia: PsyRING has provided new insight into the glutamate hypothesis of schizophrenia.  We have demonstrated that PCP produces schizophrenia-like changes in brain imaging, GABAergic interneurone markers and cognition. Novel therapeutic targets have been identified (e.g. serominic) and validated.   We have determined the functional brain networks subserving PCP-induced disruption of cognition and their restoration by the pro-cognitive drug modafinil.  Current work is focussed on understanding the neurobiological mechanisms of genetic risk factors for schizophrenia. We have identified a novel risk gene for schizophrenia MAP2K7 and shown that it produces schizophrenia-like working memory deficits. In a recent multicentre translational medicine grant with Pfizer we have identified key neural substrates underpinning behavioural deficits in DISC1 mouse models and demonstrated that the thalamic reticular nucleus is a key region affected in the models.

Cannabinoids: We are investigating the mechanisms of interaction between the constituents of cannabis (e.g. THC and cannabidiol) and with THC and other psychoactive drugs.  Recent work is focussed on environment-environment interactions determining the impact of prenatal infection and adolescence THC exposure on brain systems and behaviour in adulthood.

CeNsUS (Centre for Neuroscience at the University of Strathclyde): Through multidisciplinary collaborations within CeNsUS we are 1) applying novel algorithms from network science to understanding brain systems underpinning drug actions in disease and  2) developing medical devices for deep brain stimulation 3) Investigating the role of the reticular thalamic nucleus in the corticothalamic system using optogenetics

Public engagement.  Engaged in activities at the Glasgow Science Festival, Glasgow Science Centre, Schools, Restaurants, British Association for the Advancement of Science 

Publications

Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model : a central role for gene environment interactions
Mitchell Emma J, Thomson David M, Openshaw Rebecca L, Bristow Greg C, Dawson Neil, Pratt Judith A, Morris Brian J
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-69130-8
16p11 duplication disrupts hippocampal-orbitofrontal-amygdala connectivity, revealing a neural circuit endophenotype for schizophrenia
Bristow Greg C, Thomson David M, Openshaw Rebecca L, Mitchell Emma J, Pratt Judith A, Dawson Neil, Morris Brian J
Cell Reports Vol 31 (2020)
https://doi.org/10.1016/j.celrep.2020.107536
Temporal dissociation of phencyclidine-induced locomotor and social alterations in rats using an automated homecage monitoring system : implications for the 3Rs and preclinical drug discovery
Mitchell Emma J, Brett Ros R, Armstrong J Douglas, Sillito Rowland R, Pratt Judith A
Journal of Psychopharmacology (2020)
Map2k7 haploinsufficiency induces brain imaging endophenotypes and behavioral phenotypes relevant to schizophrenia
Openshaw Rebecca L, Thomson David M, Thompson Rhiannon, Penninger Josef M, Pratt Judith A, Morris Brian J, Dawson Neil
Schizophrenia Bulletin Vol 46, pp. 211-223 (2020)
https://doi.org/10.1093/schbul/sbz044
JNK signalling mediates aspects of maternal immune activation : importance of maternal genotype in relation to schizophrenia risk
Openshaw Rebecca L, Kwon Jaedeok, McColl Alison, Penninger Josef M, Cavanagh Jonathan, Pratt Judith A, Morris Brian J
Journal of Neuroinflammation Vol 16 (2019)
https://doi.org/10.1186/s12974-019-1408-5
Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse
Kouskou Marianna, Thomson David M, Brett Ros R, Wheeler Lee, Tate Rothwelle J, Pratt Judith A, Chamberlain Luke H
Experimental Neurology Vol 308, pp. 35-46 (2018)
https://doi.org/10.1016/j.expneurol.2018.06.014

More publications

Professional activities

New insight into genetic schizophrenia risk
Recipient
21/4/2020
The importance of the thalamic reticular nucleus in disrupted thalamocortical connectivity in rodent models of schizophrenia risk factors
Speaker
7/10/2018
Translational rodent models of social behaviours and social cognition: challenges, insights and prospects for new treatments
Speaker
22/7/2018
A key role for the TRN in NMDA Receptor and DISC1 Models of Schizophrenia-Related Thalamo-Prefrontal Cortex Dysconnectivity
Speaker
7/12/2016
Canadian College of Neuropsychopharmacology, Canada
Keynote/plenary speaker
1/2008
Life Science , UK
Keynote/plenary speaker
1/2008

More professional activities

Projects

IMPC:Cognitive and ethological characterisation of mice lacking melatonin MT2 receptors
Pratt, Judith (Principal Investigator)
01-Jan-2017 - 31-Jan-2018
Characterising mice syntenic for human 16p11.2 in relation to schizophrenia and autism
Pratt, Judith (Principal Investigator)
01-Jan-2016 - 14-Jan-2018
PsyRING project with Servier Phase 1
Pratt, Judith (Principal Investigator)
01-Jan-2014 - 31-Jan-2019
Interrogating the cortico striatal thalamo cortical CSTC circuitry implications for neuropsychiatric drug discovery | Visockis, Vladimir
Pratt, Judith (Principal Investigator) Sakata, Shuzo (Co-investigator) Visockis, Vladimir (Research Co-investigator)
01-Jan-2013 - 10-Jan-2019
Interrogating the cortico striatal thalamo cortical CSTC circuitry implications for neuropsychiatric drug discovery
Pratt, Judith (Principal Investigator) Sakata, Shuzo (Co-investigator)
01-Jan-2013 - 30-Jan-2017
MUSE: Models of University and Schools Engagement
Bedford, Tim (Principal Investigator) Angus, Michael (Academic) Biggs, James (Academic) Clark, Andrew (Academic) Gibson, Ann-Marie (Academic) Haw, Mark (Academic) Jamieson, Jonathan (Academic) Leckie, Joy Susan (Academic) Marlow, Marion (Academic) McIvor, Arthur (Academic) McMichan, Lauren (Academic) McMichan, Lauren (Academic) Murdoch, Graham (Academic) Newlands, Emma (Academic) Pratt, Judith (Academic) Ross, Kirsty (Academic) Rowe, David (Academic) Santoro, Ninetta (Academic) Suau, Cristian (Academic) Thomson, David (Academic) Marshall, Stephen (Co-investigator) Mulholland, Anthony (Co-investigator) Nash, David (Co-investigator) Wilson, Alastair (Co-investigator)
This project aims to explore how substance misuse affects the brain and how this leads to changes in mood and behaviour. It will synergise with and enhance the Health and Wellbeing curriculum area of the Curriculum for Excellence.
In the first year of this project, a multidisciplinary team of Strathclyde researchers led by Professor Judith Pratt have established a link with a secondary school and its associated feeder school. It is envisaged that this vertically integrated approach will contribute to supporting the transition between primary and secondary school and enable the secondary pupils to become mentors for the primary pupils.
In discussion with teachers the specific drugs for the project have been established based upon their impact on society and legal status; alcohol, tobacco and cannabis. Senior pupils (S3) have been selected based upon the criteria that they would benefit most from being introduced to the value of research as a knowledge building tool.
To date the team of an early career researcher and established researchers have led on an interactive workshop with the primary (P7) and S3 pupils to discuss how drugs affect brain function, mood and behaviour. Pupils have also been introduced to the concept of how drugs may highjack the brain reward system which may lead to addiction. Armed with this information, pupils have been provided with research weblinks by Strathclyde researchers. Pupils will work in teams to further research a particular drug and produce a poster of their findings with guidance from Strathclyde researchers and teachers. Additionally S3 pupil will visit the Strathclyde Fabrication lab to produce models of the brain. Pupils will present their findings to parents and the wider school community at Strathclyde campus events.
01-Jan-2013 - 31-Jan-2016

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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