Professor Chris John Price

Chair In Industrial Crystallisation

Chemical and Process Engineering

Personal statement

I am passionate about particles, especially how we can influence their formation by controlling crystallization to deliver particles with physical attributes designed to deliver optimal performance in formulated products. I have recently moved from managing particle science related innovation and product development in the pharmaceutical industry to pursue fundamental research in crystallization focussing on enhancing the purification of organic molecules by active intervention during the crystal growth process.

Publications

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Publications

Digital process design to define and deliver pharmaceutical particle attributes

Urwin Stephanie J, Chong Magdalene WS, Li Wei, McGinty John, Mehta Bhavik, Ottoboni Sara, Pathan Momina, Prasad Elke, Robertson Murray, McGowan Mark, al-Attili Mais, Gramadnikova Ekaterina, Siddique Mariam, Houson Ian, Feilden Helen, Benyahia Brahim, Brown Cameron J, Halbert Gavin W, Johnston Blair, Nordon Alison, Price Chris J, Reilly Chris D, Sefcik Jan, Florence Alastair J

Chemical Engineering Research and Design Vol 196, pp. 726-749 (2023)

https://doi.org/10.1016/j.cherd.2023.07.003

Properties of packed bed structures formed during filtration : a two and three-dimensional model

Eales William, Price Chris J, Hicks William, Mulheran Paul A

Organic Process Research and Development (2023)

https://doi.org/10.1021/acs.oprd.3c00147

Development of a spatially offset Raman spectroscopy probe for monitoring pharmaceutical drying

Al-Attili Mais, Ferreira Carla, Price Chris, Faulds Karen, Chen Yi-Chieh

Chemical Engineering Research and Design Vol 192, pp. 510-520 (2023)

https://doi.org/10.1016/j.cherd.2023.02.041

Modelling solution speciation to predict pH and supersaturation for design of batch and continuous organic salt crystallisation processes

McGinty John, Wheatcroft Helen, Price Chris J, Sefcik Jan

Fluid Phase Equilibria Vol 565 (2023)

https://doi.org/10.1016/j.fluid.2022.113676

Crystal structure of a copper-mefenamate complex solvated with diglyme and water

Chong Magdalene W S, Ottoboni Sara, Martin Alan R G, Bowering Deborah, Price Chris J, Nordon Alison, Oswald Iain D H, Ward Martin R

Acta Crystallographica Section E: Structure Reports Vol 78 (2022)

https://doi.org/10.1107/S2056989022010647

Digital design of filtration and washing of active pharmaceutical ingredients via mechanistic modelling

Ottoboni Sara, Brown Cameron J, Mehta Bhavik, Jimeno Guillermo, Mitchell Niall A, Sefcik Jan, Price Chris J

Organic Process Research and Development Vol 26, pp. 3236-3253 (2022)

https://doi.org/10.1021/acs.oprd.2c00165

More publications

Research

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Professional Activities

Development of a Spatially Resolved Spectroscopy probe for In-line Monitoring of Pharmaceutical Drying

Contributor

21/3/2023

Spatially Offset Raman Spectroscopy for the Monitoring of Solvent Content During Pharmaceutical Drying

Contributor

12/4/2022

CPACT Webinar Series

Contributor

24/2/2022

Development of Spatially Resolved Spectroscopy for In-line Monitoring of Pharmaceutical Drying

Contributor

2022

Spatially and Angularly Resolved Diffuse Reflectance NIR Spectroscopy for In-line Monitoring of Solvent Content During Pharmaceutical Drying

Contributor

20/10/2021

Integrated Filtration and Washing Modelling to Predict Continuous Isolation Performance.

Contributor

2020

More professional activities

Projects

Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation

Price, Chris John (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Sefcik, Jan (Co-investigator)

11-Jan-2022 - 10-Jan-2025

Visualization of fluid and impurity transport during filtration, washing and drying

Ottoboni, Sara (Principal Investigator) Price, Chris John (Principal Investigator) Kathyola, Thokozile (Principal Investigator) Das, Gunjan (Principal Investigator) Schroeder, Sven L.M. (Principal Investigator)

Isolating active pharmaceutical ingredients (APIs) of specified purity and particle size
distribution is an economically important industrial process. Problems with product
composition and performance can arise from uncontrolled processes that occur
during filtration, washing and drying. Physical transformations during these stages are
very poorly understood. We will use both in situ 2D imaging and ex situ 3D
tomography to elucidate the effects of API morphology, particle size/distribution, and
wash solvent miscibility and concentration. The results will inform best practice in
process design and operation to minimise out of specification product via mechanistic
understanding of the dissolution/precipitation/redistribution of impurities and
agglomeration. We hope to pinpoint microstructural variations in the porous bed and
the location of impurities and residual mother liquor inclusions.

01-Jan-2021 - 31-Jan-2022

Industrial Case Account - University of Strathclyde 2019 / S190404-113

Price, Chris John (Principal Investigator)

01-Jan-2019 - 30-Jan-2024

Industrial Case Account - University of Strathclyde 2019 | Eales, William

Price, Chris John (Principal Investigator) Mulheran, Paul (Co-investigator) Eales, William (Research Co-investigator)

01-Jan-2019 - 01-Jan-2023

Master Development Manufacturing Services Agreement CMAC National Facility NF179

Florence, Alastair (Principal Investigator) Price, Chris John (Co-investigator)

01-Jan-2019 - 30-Jan-2019

AZ compounds for evaluation in Continuous Filtration Device

Price, Chris John (Principal Investigator)