Personal statement

I am passionate about particles, especially how we can influence their formation by controlling crystallization to deliver particles with physical attributes designed to deliver optimal performance in formulated products. I have recently moved from managing particle science related innovation and product development in the pharmaceutical industry to pursue fundamental research in crystallization focussing on enhancing the purification of organic molecules by active intervention during the crystal growth process.

Publications

Modelling solution speciation to predict pH and supersaturation for design of batch and continuous organic salt crystallisation processes: McGinty John, Wheatcroft Helen, Price Chris J, Sefcik Jan; Fluid Phase Equilibria Vol 565 (2023); https://doi.org/10.1016/j.fluid.2022.113676
Development of a spatially offset Raman spectroscopy probe for monitoring pharmaceutical drying: Al-Attili Mais, Ferreira Carla, Price Chris, Faulds Karen, Chen Yi-Chieh; Chemical Engineering Research and Design Vol 192, pp. 510-520 (2023); https://doi.org/10.1016/j.cherd.2023.02.041
Crystal structure of a copper-mefenamate complex solvated with diglyme and water: Chong Magdalene W S, Ottoboni Sara, Martin Alan R G, Bowering Deborah, Price Chris J, Nordon Alison, Oswald Iain D H, Ward Martin R; Acta Crystallographica Section E: Structure Reports Vol 78 (2022); https://doi.org/10.1107/S2056989022010647
Digital design of filtration and washing of active pharmaceutical ingredients via mechanistic modelling: Ottoboni Sara, Brown Cameron J, Mehta Bhavik, Jimeno Guillermo, Mitchell Niall A, Sefcik Jan, Price Chris J; Organic Process Research and Development, pp. 1-18 (2022); https://doi.org/10.1021/acs.oprd.2c00165
Axial dispersion in curved channels in the presence of pulsating flow: Valitov Gleb, Rossi Damiano, Price Chris, Gavriilidis Asterios, Mazzei Luca; Chemical Engineering and Processing - Process Intensification Vol 180 (2022); https://doi.org/10.1016/j.cep.2021.108629
Fluid and impurity transport during online isolation experiments conducted with X-ray tomography: Ottoboni Sara, Shahid Muhid, Martin Alan, Kathyola Thokozile, Das Gunjan, Schroeder Sven, Marathe Shashidhara, Rau Christopher, Wanelik Kaz, Price Chris John; 13th World Filtration Congress (2022)

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Professional activities

Spatially Offset Raman Spectroscopy for the Monitoring of Solvent Content During Pharmaceutical Drying: Contributor; 12/4/2022
CPACT Webinar Series: Contributor; 24/2/2022
Development of Spatially Resolved Spectroscopy for In-line Monitoring of Pharmaceutical Drying: Contributor; 2022
Spatially and Angularly Resolved Diffuse Reflectance NIR Spectroscopy for In-line Monitoring of Solvent Content During Pharmaceutical Drying: Contributor; 20/10/2021
Integrated Filtration and Washing Modelling to Predict Continuous Isolation Performance.: Contributor; 2020
Investigating the isolation performance of a novel continuous filtration unit for pharmaceutical process development and manufacturing: A case study using paracetamol and related impurities.: Contributor; 2019

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Projects

Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation: Price, Chris John (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Sefcik, Jan (Co-investigator); 11-Jan-2022 - 10-Jan-2025
Visualization of fluid and impurity transport during filtration, washing and drying: Ottoboni, Sara (Principal Investigator) Price, Chris John (Principal Investigator) Kathyola, Thokozile (Principal Investigator) Das, Gunjan (Principal Investigator) Schroeder, Sven L.M. (Principal Investigator); Isolating active pharmaceutical ingredients (APIs) of specified purity and particle size
distribution is an economically important industrial process. Problems with product
composition and performance can arise from uncontrolled processes that occur
during filtration, washing and drying. Physical transformations during these stages are
very poorly understood. We will use both in situ 2D imaging and ex situ 3D
tomography to elucidate the effects of API morphology, particle size/distribution, and
wash solvent miscibility and concentration. The results will inform best practice in
process design and operation to minimise out of specification product via mechanistic
understanding of the dissolution/precipitation/redistribution of impurities and
agglomeration. We hope to pinpoint microstructural variations in the porous bed and
the location of impurities and residual mother liquor inclusions.; 01-Jan-2021 - 31-Jan-2022
Industrial Case Account - University of Strathclyde 2019 | Eales, William: Price, Chris John (Principal Investigator) Mulheran, Paul (Co-investigator) Eales, William (Research Co-investigator); 01-Jan-2019 - 01-Jan-2023
Industrial Case Account - University of Strathclyde 2019 / S190404-113: Price, Chris John (Principal Investigator); 01-Jan-2019 - 30-Jan-2024
Master Development Manufacturing Services Agreement CMAC National Facility NF179: Florence, Alastair (Principal Investigator) Price, Chris John (Co-investigator); 01-Jan-2019 - 30-Jan-2019
AZ compounds for evaluation in Continuous Filtration Device: Price, Chris John (Principal Investigator); 05-Jan-2017 - 07-Jan-2018

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Address

Chemical and Process Engineering
James Weir

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Professor Chris John Price

Chair In Industrial Crystallisation

Chemical and Process Engineering