
Professor Chris John Price
Chair In Industrial Crystallisation
Chemical and Process Engineering
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Digital process design to define and deliver pharmaceutical particle attributes Urwin Stephanie J, Chong Magdalene WS, Li Wei, McGinty John, Mehta Bhavik, Ottoboni Sara, Pathan Momina, Prasad Elke, Robertson Murray, McGowan Mark, al-Attili Mais, Gramadnikova Ekaterina, Siddique Mariam, Houson Ian, Feilden Helen, Benyahia Brahim, Brown Cameron J, Halbert Gavin W, Johnston Blair, Nordon Alison, Price Chris J, Reilly Chris D, Sefcik Jan, Florence Alastair J Chemical Engineering Research and Design Vol 196, pp. 726-749 (2023) https://doi.org/10.1016/j.cherd.2023.07.003 Properties of packed bed structures formed during filtration : a two and three-dimensional model Eales William, Price Chris J, Hicks William, Mulheran Paul A Organic Process Research and Development (2023) https://doi.org/10.1021/acs.oprd.3c00147 Development of a spatially offset Raman spectroscopy probe for monitoring pharmaceutical drying Al-Attili Mais, Ferreira Carla, Price Chris, Faulds Karen, Chen Yi-Chieh Chemical Engineering Research and Design Vol 192, pp. 510-520 (2023) https://doi.org/10.1016/j.cherd.2023.02.041 Modelling solution speciation to predict pH and supersaturation for design of batch and continuous organic salt crystallisation processes McGinty John, Wheatcroft Helen, Price Chris J, Sefcik Jan Fluid Phase Equilibria Vol 565 (2023) https://doi.org/10.1016/j.fluid.2022.113676 Crystal structure of a copper-mefenamate complex solvated with diglyme and water Chong Magdalene W S, Ottoboni Sara, Martin Alan R G, Bowering Deborah, Price Chris J, Nordon Alison, Oswald Iain D H, Ward Martin R Acta Crystallographica Section E: Structure Reports Vol 78 (2022) https://doi.org/10.1107/S2056989022010647 Digital design of filtration and washing of active pharmaceutical ingredients via mechanistic modelling Ottoboni Sara, Brown Cameron J, Mehta Bhavik, Jimeno Guillermo, Mitchell Niall A, Sefcik Jan, Price Chris J Organic Process Research and Development Vol 26, pp. 3236-3253 (2022) https://doi.org/10.1021/acs.oprd.2c00165
Publications
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Development of a Spatially Resolved Spectroscopy probe for In-line Monitoring of Pharmaceutical Drying Contributor 21/3/2023 Spatially Offset Raman Spectroscopy for the Monitoring of Solvent Content During Pharmaceutical Drying Contributor 12/4/2022 CPACT Webinar Series Contributor 24/2/2022 Development of Spatially Resolved Spectroscopy for In-line Monitoring of Pharmaceutical Drying Contributor 2022 Spatially and Angularly Resolved Diffuse Reflectance NIR Spectroscopy for In-line Monitoring of Solvent Content During Pharmaceutical Drying Contributor 20/10/2021 Integrated Filtration and Washing Modelling to Predict Continuous Isolation Performance. Contributor 2020
Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation Price, Chris John (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Sefcik, Jan (Co-investigator) 11-Jan-2022 - 10-Jan-2025 Visualization of fluid and impurity transport during filtration, washing and drying Ottoboni, Sara (Principal Investigator) Price, Chris John (Principal Investigator) Kathyola, Thokozile (Principal Investigator) Das, Gunjan (Principal Investigator) Schroeder, Sven L.M. (Principal Investigator) Isolating active pharmaceutical ingredients (APIs) of specified purity and particle size
distribution is an economically important industrial process. Problems with product
composition and performance can arise from uncontrolled processes that occur
during filtration, washing and drying. Physical transformations during these stages are
very poorly understood. We will use both in situ 2D imaging and ex situ 3D
tomography to elucidate the effects of API morphology, particle size/distribution, and
wash solvent miscibility and concentration. The results will inform best practice in
process design and operation to minimise out of specification product via mechanistic
understanding of the dissolution/precipitation/redistribution of impurities and
agglomeration. We hope to pinpoint microstructural variations in the porous bed and
the location of impurities and residual mother liquor inclusions. 01-Jan-2021 - 31-Jan-2022 Industrial Case Account - University of Strathclyde 2019 / S190404-113 Price, Chris John (Principal Investigator) 01-Jan-2019 - 30-Jan-2024 Industrial Case Account - University of Strathclyde 2019 | Eales, William Price, Chris John (Principal Investigator) Mulheran, Paul (Co-investigator) Eales, William (Research Co-investigator) 01-Jan-2019 - 01-Jan-2023 Master Development Manufacturing Services Agreement CMAC National Facility NF179 Florence, Alastair (Principal Investigator) Price, Chris John (Co-investigator) 01-Jan-2019 - 30-Jan-2019 AZ compounds for evaluation in Continuous Filtration Device Price, Chris John (Principal Investigator) 05-Jan-2017 - 07-Jan-2018
Professional Activities
Projects
distribution is an economically important industrial process. Problems with product
composition and performance can arise from uncontrolled processes that occur
during filtration, washing and drying. Physical transformations during these stages are
very poorly understood. We will use both in situ 2D imaging and ex situ 3D
tomography to elucidate the effects of API morphology, particle size/distribution, and
wash solvent miscibility and concentration. The results will inform best practice in
process design and operation to minimise out of specification product via mechanistic
understanding of the dissolution/precipitation/redistribution of impurities and
agglomeration. We hope to pinpoint microstructural variations in the porous bed and
the location of impurities and residual mother liquor inclusions.
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Contact
Professor
Chris John
Price
Chair In Industrial Crystallisation
Chemical and Process Engineering
Email: chris.price@strath.ac.uk
Tel: 574 5303