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Dr D Rotondo

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Publications

Regulation of lipid metabolism by microRNAs
Tate Rothwelle, Rotondo Dino, Davidson Jillian
Current Opinion in Lipidology Vol 26, pp. 243-244, (2015)
http://dx.doi.org/10.1097/MOL.0000000000000186
Blood immunoglobulins, complement and TNF receptor following minimally invasive surgery in patients undergoing pulmonary lobectomy
Leaver H. Anne, Craig Stewart R., Rotondo Dino, Walker William S.
Current Metabolomics Vol 2, pp. 196-203, (2015)
http://dx.doi.org/10.2174/2213235X03666150106232345
Genetics and molecular biology : the role of retinoic acid receptor genes in acute promyelocytic leukemia
Davidson Jillian, Tate Rothwelle, Rotondo Dino
Current Opinion in Lipidology Vol 24, pp. 364-365, (2013)
http://dx.doi.org/10.1097/MOL.0b013e328363b199
Eicosapentaenoic acid suppression of systemic inflammatory responses and inverse up-regulation of 15-deoxy Δ12,14 Prostaglandin J2 production
Davidson Jillian, Higgs Warren, Rotondo D
British Journal of Pharmacology Vol 169, pp. 1130-1139, (2013)
http://dx.doi.org/10.1111/bph.12209
Characterisation of the prostaglandin E2-ethanolamide suppression of tumour necrosis factor-α production in human monocytic cells
Brown Kirsten L., Davidson Jillian, Rotondo D
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Vol 1831, pp. 1098–1107, (2013)
http://dx.doi.org/10.1016/j.bbalip.2013.03.006
Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators
Brown Iain, Cascio Maria G., Rotondo D, Pertwee Roger G., Heys Steven D., Wahle Klaus W.J.
Progress in Lipid Research Vol 52, pp. 80-109, (2013)
http://dx.doi.org/10.1016/j.plipres.2012.10.001

more publications

Research interests

research interests have centred on the pivotal role that monocytes play in coordinating immune responses by releasing cytokines, prostaglandins and fatty acids. The cytokines released from monocytes, particularly interleukin-1 and tumour necrosis factor-alpha, can also amplify the antigen-induced activation of T-cells whereas prostaglandins such as PGE2 and fatty acids are potent inhibitors of activation. Recent data indicates that IL-1-stimulated fatty acid release can result in the biosynthesis of fatty acid ethanolamides including arachidonyl ethanolamide (anandamide) in addition to eicosanoids. Arachidonyl ethanolamide, regarded as an endogenous ligand for cannabinoid receptors, has been shown in our studies to modulate the activity of many monocyte and lymphocyte functions. Several major areas are being studied, including modulation of human monocyte and T-lymphocyte activities by PGE2, fatty acids and fatty acid ethanolamides.  Current work has been directed toward an attempt to understand the mechanisms by which PGE2 and fatty acids regulate: cytokine production, phagocytosis of E. coli O157 in human monocytes and the downregulation of human CD4+ lymphocyte function, especially  via the generation of intracellular cyclic AMP and cyclic GMP. The role of novel steroids, acting via PGs, on the modulation of immune cell activities is also being investigated as these provide another important potential therapeutic target

 

Negative feedback reguation of Immune responses by PGE2

Professional activities

Member of the Editorial Commentary Team- \Current Opinion in Lipidology\""
Editorial board member
1/2008

more professional activities

Projects

BBSRC Doctoral Training Grant (DTG) | Lumb, Felicity Elspeth
Harnett, William (Principal Investigator) Rotondo, D (Co-investigator) Lumb, Felicity Elspeth (Research Co-investigator)
Period 01-Oct-2011 - 23-Feb-2016
Immunoglobulin E production in vivo
Rotondo, D (Principal Investigator)
Period 01-Dec-2013 - 31-Dec-2014

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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