Dr Dino Rotondo

Senior Teaching Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Publications

Iminosugar idoBR1 isolated from Cucumber Cucumis sativus reduces inflammatory activity
Nash Robert J, Bartholomoew Barbara, Penkova Yana B, Rotondo Dino, Yamasaka Fernanda, Stafford Graham P, Jenkinson Sarah F, Fleet George WJ
ACS Omega Vol 5, pp. 16263-16271 (2020)
https://doi.org/10.1021/acsomega.0c02092
Predictive binding affinity of plant-derived natural products towards the protein kinase G enzyme of Mycobacterium tuberculosis (MtPknG)
M. Qasaymeh Rana, Rotondo Dino, Oosthuizen Carel B, Lall Namrita, Seidel Veronique
Plants Vol 8 (2019)
https://doi.org/10.3390/plants8110477
Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion
Brown Iain, Lee Jisun, Sneddon Alan A, Cascio Maria G, Pertwee Roger G, Wahle Klaus WJ, Rotondo Dino, Heys Steven D
Prostaglandins, Leukotrienes and Essential Fatty Acids, pp. 1-10 (2019)
https://doi.org/10.1016/j.plefa.2019.102024
The prostaglandin EP4 receptor is a master regulator of the expression of PGE2 receptors following inflammatory activation in human monocytic cells
Kashmiry Alaa, Tate Rothwelle, Rotondo Giuliana, Davidson Jillian, Rotondo Dino
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Vol 1863, pp. 1297-1304 (2018)
https://doi.org/10.1016/j.bbalip.2018.07.003
Regulation of lipid metabolism by microRNAs
Tate Rothwelle, Rotondo Dino, Davidson Jillian
Current Opinion in Lipidology Vol 26, pp. 243-244 (2015)
https://doi.org/10.1097/MOL.0000000000000186
Blood immunoglobulins, complement and TNF receptor following minimally invasive surgery in patients undergoing pulmonary lobectomy
Leaver H Anne, Craig Stewart R, Rotondo Dino, Walker William S
Current Metabolomics Vol 2, pp. 196-203 (2015)
https://doi.org/10.2174/2213235X03666150106232345

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Research interests

research interests have centred on the pivotal role that monocytes play in coordinating immune responses by releasing cytokines, prostaglandins and fatty acids. The cytokines released from monocytes, particularly interleukin-1 and tumour necrosis factor-alpha, can also amplify the antigen-induced activation of T-cells whereas prostaglandins such as PGE2 and fatty acids are potent inhibitors of activation. Recent data indicates that IL-1-stimulated fatty acid release can result in the biosynthesis of fatty acid ethanolamides including arachidonyl ethanolamide (anandamide) in addition to eicosanoids. Arachidonyl ethanolamide, regarded as an endogenous ligand for cannabinoid receptors, has been shown in our studies to modulate the activity of many monocyte and lymphocyte functions. Several major areas are being studied, including modulation of human monocyte and T-lymphocyte activities by PGE2, fatty acids and fatty acid ethanolamides.  Current work has been directed toward an attempt to understand the mechanisms by which PGE2 and fatty acids regulate: cytokine production, phagocytosis of E. coli O157 in human monocytes and the downregulation of human CD4+ lymphocyte function, especially  via the generation of intracellular cyclic AMP and cyclic GMP. The role of novel steroids, acting via PGs, on the modulation of immune cell activities is also being investigated as these provide another important potential therapeutic target

 

Negative feedback reguation of Immune responses by PGE2

Professional activities

Member of the Editorial Commentary Team- \Current Opinion in Lipidology\""
Editorial board member
1/2008

More professional activities

Projects

Immunoglobulin E production in vivo
Rotondo, Dino (Principal Investigator)
01-Jan-2013 - 31-Jan-2014
BBSRC Doctoral Training Grant (DTG) | Lumb, Felicity Elspeth
Harnett, William (Principal Investigator) Rotondo, Dino (Co-investigator) Lumb, Felicity Elspeth (Research Co-investigator)
01-Jan-2011 - 23-Jan-2016

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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