Dr Dino Rotondo

Senior Teaching Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences


Garcinia mangostana, anti-acne and anti-inflammatory potential : an in silico study
Blicharska N, Rotondo D, Jackson S, Seidel V
Planta Medica Vol 88, pp. 1546 (2022)
Phytochemical study and immunomodulatory activity of Fraxinus excelsior L.
Qasaymeh Rana Mohammad, Rotondo Dino, Seidel Veronique
Journal of Pharmacy and Pharmacology (2022)
Garcinia mangostana, anti-acne and anti-inflammatory potential : an in silico study
Blicharska Natalia, Rotondo Dino, Jackson Simon, Seidel Veronique
70th International Congress and Annual Meeting of the Society for Medicinal Plant & Natural Product Research (GA) (2022)
Cholesterol 25-hydroxylase expression following immune activation in response to SARS-CoV-2 infection
Davidson Jillian, Rotondo Dino
Current Opinion in Lipidology Vol 32, pp. 266-267 (2021)
Iminosugar idoBR1 isolated from Cucumber Cucumis sativus reduces inflammatory activity
Nash Robert J, Bartholomoew Barbara, Penkova Yana B, Rotondo Dino, Yamasaka Fernanda, Stafford Graham P, Jenkinson Sarah F, Fleet George WJ
ACS Omega Vol 5, pp. 16263-16271 (2020)
Predictive binding affinity of plant-derived natural products towards the protein kinase G enzyme of Mycobacterium tuberculosis (MtPknG)
M. Qasaymeh Rana, Rotondo Dino, Oosthuizen Carel B, Lall Namrita, Seidel Veronique
Plants Vol 8 (2019)

More publications

Research interests

research interests have centred on the pivotal role that monocytes play in coordinating immune responses by releasing cytokines, prostaglandins and fatty acids. The cytokines released from monocytes, particularly interleukin-1 and tumour necrosis factor-alpha, can also amplify the antigen-induced activation of T-cells whereas prostaglandins such as PGE2 and fatty acids are potent inhibitors of activation. Recent data indicates that IL-1-stimulated fatty acid release can result in the biosynthesis of fatty acid ethanolamides including arachidonyl ethanolamide (anandamide) in addition to eicosanoids. Arachidonyl ethanolamide, regarded as an endogenous ligand for cannabinoid receptors, has been shown in our studies to modulate the activity of many monocyte and lymphocyte functions. Several major areas are being studied, including modulation of human monocyte and T-lymphocyte activities by PGE2, fatty acids and fatty acid ethanolamides.  Current work has been directed toward an attempt to understand the mechanisms by which PGE2 and fatty acids regulate: cytokine production, phagocytosis of E. coli O157 in human monocytes and the downregulation of human CD4+ lymphocyte function, especially  via the generation of intracellular cyclic AMP and cyclic GMP. The role of novel steroids, acting via PGs, on the modulation of immune cell activities is also being investigated as these provide another important potential therapeutic target


Negative feedback reguation of Immune responses by PGE2

Professional activities

Member of the Editorial Commentary Team- \Current Opinion in Lipidology\""
Editorial board member

More professional activities


Industrial PhD studentship with ILC LTD- Doctorate@work. The Development of Treatment for Atopic Dermatitis Through the use of Interferons
Mullen, Alexander (Principal Investigator) Rotondo, Dino (Principal Investigator) Mullen, Alexander (Co-investigator)
01-Jan-2021 - 31-Jan-2024
Immunoglobulin E production in vivo
Rotondo, Dino (Principal Investigator)
01-Jan-2013 - 31-Jan-2014

More projects


Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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