Dr Dino Rotondo

Senior Teaching Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

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Publications

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Publications

In silico studies on the anti-acne potential of Garcinia mangostana xanthones and benzophenones: Blicharska Natalia, Ben Ahmed Ziyad, Jackson Simon, Rotondo Dino, Seidel Veronique; Zeitschrift fur Naturforschung C (2024); https://doi.org/10.1515/znc-2023-0118
Phytochemical study and immunomodulatory activity of Fraxinus excelsior L.: Qasaymeh Rana Mohammad, Rotondo Dino, Seidel Veronique; Journal of Pharmacy and Pharmacology Vol 75, pp. 117-128 (2023); https://doi.org/10.1093/jpp/rgac076
Garcinia mangostana, anti-acne and anti-inflammatory potential : an in silico study: Blicharska N, Rotondo D, Jackson S, Seidel V; Planta Medica Vol 88, pp. 1546 (2022); https://doi.org/10.1055/s-0042-1759275
Garcinia mangostana, anti-acne and anti-inflammatory potential : an in silico study: Blicharska Natalia, Rotondo Dino, Jackson Simon, Seidel Veronique; 70th International Congress and Annual Meeting of the Society for Medicinal Plant & Natural Product Research (GA) (2022)
Cholesterol 25-hydroxylase expression following immune activation in response to SARS-CoV-2 infection: Davidson Jillian, Rotondo Dino; Current Opinion in Lipidology Vol 32, pp. 266-267 (2021); https://doi.org/10.1097/MOL.0000000000000765
Iminosugar idoBR1 isolated from Cucumber Cucumis sativus reduces inflammatory activity: Nash Robert J, Bartholomoew Barbara, Penkova Yana B, Rotondo Dino, Yamasaka Fernanda, Stafford Graham P, Jenkinson Sarah F, Fleet George WJ; ACS Omega Vol 5, pp. 16263-16271 (2020); https://doi.org/10.1021/acsomega.0c02092

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Research

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Research Interests

research interests have centred on the pivotal role that monocytes play in coordinating immune responses by releasing cytokines, prostaglandins and fatty acids. The cytokines released from monocytes, particularly interleukin-1 and tumour necrosis factor-alpha, can also amplify the antigen-induced activation of T-cells whereas prostaglandins such as PGE2 and fatty acids are potent inhibitors of activation. Recent data indicates that IL-1-stimulated fatty acid release can result in the biosynthesis of fatty acid ethanolamides including arachidonyl ethanolamide (anandamide) in addition to eicosanoids. Arachidonyl ethanolamide, regarded as an endogenous ligand for cannabinoid receptors, has been shown in our studies to modulate the activity of many monocyte and lymphocyte functions. Several major areas are being studied, including modulation of human monocyte and T-lymphocyte activities by PGE2, fatty acids and fatty acid ethanolamides. Current work has been directed toward an attempt to understand the mechanisms by which PGE2 and fatty acids regulate: cytokine production, phagocytosis of E. coli O157 in human monocytes and the downregulation of human CD4+ lymphocyte function, especially via the generation of intracellular cyclic AMP and cyclic GMP. The role of novel steroids, acting via PGs, on the modulation of immune cell activities is also being investigated as these provide another important potential therapeutic target

Negative feedback reguation of Immune responses by PGE2