Personal statement
Mission
The goal of our research team is to understand (1) how brain state is organized at the level of neural circuits, (2) how brain state affects brain functions, (3) how brain state is regulated, and (4) whether and how manipulation of brain state can modify disease pathology.
Strategy
Out strategies are (1) to study normal information processing, (2) to study abnormal information processing, and (3) to develop tools to modulate brain functions. Our main techniques are in vivo ensemble recording, Ca2+ imaging, optogenetics, and behavioural approaches.
Research interests
Research Projects
1. State-dependent auditory processing and perception
When we are paying attention to sound, we can vividly perceive it. When sleep, however, our perception is siginificantly diminished. But what is happening in the brain? Because our brain activity ('brain state') continuously changes, it is extremely important to address the following three questions: 1) how is each brain state organized at the level of neural circuit? 2) how do brain states affect sensory processing and perceptual decision? and 3) how are brain states regulated? We are addressing these questions by taking multidisciplinary approaches, with a focus on dynamic interplays between the auditory system and neuromodulatory systems.
2. The circuit mechanism of abnormal hearing
Brain circuits often generate auditory perception even in the absence of auditory inputs, such as auditory hallucinations. But how? We are particularly focusing on phantom auditory perception, so-called tinnitus. Tinnitus is a symptom, which is often associated with hearing loss. Considering aging society and age-related hearing loss, a better understanding of the neural basis of tinnitus is extremly urgent. We are aiming to identify neural correlates of tinnitus at the level of neuronal circuits. By using a massively parallel extracellular recording technique and a behavioural approach, we are determining relationships between tinnitus and abnormal neural population activity in the auditory thalamocortical circuit. This research program will provide further insight into the development of new treatment for tinnitus sufferers.
3. Technology development to improve and restore hearing
Once we understand both normal and abnormal states, a next step is to explore strategies to restore abnormal states into the normal one. In addition, we can also think of how we can boost our normal brain functions. To achieve these goals, we are developing new approaches and technologies. We are particularly interested in the improvement and restoration of sensory abilities by controlling neural activity. Combining advanced technologies in rodents as a model, we are developing novel strategies to improve and restore hearing.
***Our research team is currently accepting applications from prospective PhD students and postdocs. In particular, persons who have strong background in physics, mathematics, or engineering are strongly encouraged to apply. ***
Professional activities
- Fiber photometry-based investigation of brain function and dysfunction
- Speaker
- 25/10/2022
- Frontiers in Systems Neuroscience (Journal)
- Peer reviewer
- 2022
- Optical interrogation of Alzheimer's disease pathology
- Speaker
- 13/5/2021
- Frontiers in Neuroscience (Journal)
- Peer reviewer
- 2021
- Frontiers in Neuroscience (Journal)
- Peer reviewer
- 2021
- Symposium on neuromodulatory systems
- Speaker
- 11/7/2020
More professional activities
Projects
- DTP 2224 University of Strathclyde | Abbot, James
- Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Abbot, James (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2025
- Depression-like behaviour in a mouse model of Alzheimer’s disease: a reverse translational study.
- Bushell, Trevor (Principal Investigator) Sakata, Shuzo (Co-investigator)
- 01-Jan-2022 - 30-Jan-2025
- Lysozyme encapsulated gold nanoclusters – a new therapeutic agent for Alzheimer’s disease
- Jiang, Hui-Rong (Principal Investigator) Chen, Yu (Co-investigator) Sakata, Shuzo (Co-investigator)
- 01-Jan-2022 - 30-Jan-2025
- Deep brain technologies to understand the cellular origin of diseases DEEPER | Abbot, James
- Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Abbot, James (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2025
- Does immunomodulation promote resilience to Alzheimer’s pathology?
- Bushell, Trevor (Principal Investigator) Sakata, Shuzo (Co-investigator)
- 01-Jan-2022 - 28-Jan-2023
- Sleep regulation by neuron-astrocyte interactions
- Sakata, Shuzo (Principal Investigator)
- 01-Jan-2021 - 30-Jan-2024
More projects
Address
Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing
Hamnett Wing
Location Map
View
University of Strathclyde
in a larger map