Dr Shuzo Sakata

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Mission
The goal of our research team is (1) to understand how sensory information is processed by brain circuits, and (2) to develop better strategies for the improvement and restoration of sensory abilities, with emphasis on hearing.

Strategy
Out strategies are (1) to study normal information processing, (2) to study abnormal information processing, and (3) to develop tools to modulate brain functions. Our main techniques are in vivo ensemble recording, optogenetics, and behavioural approaches. 

 

Publications

Distinct temporal coordination of spontaneous population activity between basal forebrain and auditory cortex
Yague Josue G., Tsunematsu Tomomi, Sakata Shuzo
Frontiers in Neural Circuits, pp. 1-26, (2017)
http://dx.doi.org/10.3389/fncir.2017.00064
Depth-specific optogenetic control in vivo with a scalable, high density µLED neural probe
Scharf Robert, Tsunematsu Tomomi, McAlinden Niall, Dawson Martin D., Sakata Shuzo, Mathieson Keith
Scientific Reports Vol 6, (2016)
http://dx.doi.org/10.1038/srep28381
State-dependent and cell type-specific temporal processing in auditory thalamocortical circuit
Sakata Shuzo
Scientific Reports Vol 6, (2016)
http://dx.doi.org/10.1038/srep18873
Optogenetic activation of neocortical neurons in vivo with a sapphire-based micro-scale LED probe
McAlinden Niall, Gu Erdan, Dawson Martin D, Sakata Shuzo, Mathieson Keith
Frontiers in Neural Circuits Vol 9, (2015)
http://dx.doi.org/10.3389/fncir.2015.00025
Rhythmic auditory cortex activity at multiple timescales shapes stimulus–response gain and background firing
Kayser Christoph, Wilson Caroline, Safaai Houman, Sakata Shuzo, Panzeri Stefano
Journal of Neuroscience Vol 35, pp. 7750-7762, (2015)
http://dx.doi.org/10.1523/JNEUROSCI.0268-15.2015
Stochastic transitions into silence cause noise correlations in cortical circuits
Mochol Gabriela, Hermoso-Mendizabal Ainhoa, Sakata Shuzo, Harris Kenneth D., de la Rocha Jaime
Proceedings of the National Academy of Sciences Vol 112, pp. 3529–3534, (2015)
http://dx.doi.org/10.1073/pnas.1410509112

more publications

Research interests

Research Projects
1. State-dependent auditory processing and perception
When we are paying attention to sound, we can vividly perceive it. When sleep, however, our perception is siginificantly diminished. But what is happening in the brain? Because our brain activity ('brain state') continuously changes, it is extremely important to address the following three questions: 1) how is each brain state organized at the level of neural circuit? 2) how do brain states affect sensory processing and perceptual decision? and 3) how are brain states regulated? We are addressing these questions by taking multidisciplinary approaches, with a focus on dynamic interplays between the auditory system and neuromodulatory systems.

2. The circuit mechanism of abnormal hearing
Brain circuits often generate auditory perception even in the absence of auditory inputs, such as auditory hallucinations. But how? We are particularly focusing on phantom auditory perception, so-called tinnitus. Tinnitus is a symptom, which is often associated with hearing loss. Considering aging society and age-related hearing loss, a better understanding of the neural basis of tinnitus is extremly urgent. We are aiming to identify neural correlates of tinnitus at the level of neuronal circuits. By using a massively parallel extracellular recording technique and a behavioural approach, we are determining relationships between tinnitus and abnormal neural population activity in the auditory thalamocortical circuit. This research program will provide further insight into the development of new treatment for tinnitus sufferers.

3. Technology development to improve and restore hearing
Once we understand both normal and abnormal states, a next step is to explore strategies to restore abnormal states into the normal one. In addition, we can also think of how we can boost our normal brain functions. To achieve these goals, we are developing new approaches and technologies. We are particularly interested in the improvement and restoration of sensory abilities by controlling neural activity. Combining advanced technologies in rodents as a model, we are developing novel strategies to improve and restore hearing.

***Our research team is currently accepting applications from prospective PhD students and postdocs. In particular, persons who have strong background in physics, mathematics, or engineering are strongly encouraged to apply. ***

 

Professional activities

FENS 2016
Organiser
3/7/2016
International Symposium on Optogenetics 2015
Organiser
4/12/2015
Society for Neuroscience
Participant
12/11/2011
Autumn School in Cognitive Neuroscience
Invited speaker
28/9/2011

more professional activities

Projects

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Webster, Jack Fraser
Wozny, Christian (Principal Investigator) Sakata, Shuzo (Co-investigator) Webster, Jack Fraser (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2019
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Winstanley, Ruaridh Francis
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Winstanley, Ruaridh Francis (Research Co-investigator)
Period 01-Oct-2015 - 01-Oct-2019
Towards a better understanding of developing and ageing auditory system
Sakata, Shuzo (Principal Investigator)
Period 18-Feb-2017 - 17-Mar-2017
Medical Devices Doctoral Training Centre Renewal | Varkonyi, Gabor
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Varkonyi, Gabor (Research Co-investigator)
Period 01-Oct-2013 - 01-Oct-2017
Interrogating the cortico striatal thalamo cortical CSTC circuitry implications for neuropsychiatric drug discovery | Visockis, Vladimir
Pratt, Judith (Principal Investigator) Sakata, Shuzo (Co-investigator) Visockis, Vladimir (Research Co-investigator)
Period 01-Oct-2013 - 01-Oct-2017
The function of sub-second brain waves in REM sleep
Sakata, Shuzo (Principal Investigator)
Period 01-Apr-2016 - 31-Mar-2019

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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