Dr Shuzo Sakata

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Mission
The goal of our research team is (1) to understand how sensory information is processed by brain circuits, and (2) to develop better strategies for the improvement and restoration of sensory abilities, with emphasis on hearing.

Strategy
Out strategies are (1) to study normal information processing, (2) to study abnormal information processing, and (3) to develop tools to modulate brain functions. Our main techniques are in vivo ensemble recording, optogenetics, and behavioural approaches. 

 

Publications

Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula
Webster Jack F, Vroman Rozan, Balueva Kira, Wulff Peer, Sakata Shuzo, Wozny Christian
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-65349-7
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
Bradley Sophie J, Molloy Colin, Valuskova Paulina, Dwomoh Louis, Scarpa Miriam, Rossi Mario, Finlayson Lisa, Svensson Kjell A, Chernet Eyassu, Barth Vanessa N, Gherbi Karolina, Sykes David A, Wilson Caroline A, Mistry Raj, Sexton Patrick M, Christopoulos Arthur, Mogg Adrian J, Rosenthorne Elizabeth M, Sakata Shuzo, Challiss R A John, Broad Lisa M, Tobin Andrew B
Nature Chemical Biology Vol 16, pp. 240-249 (2020)
https://doi.org/10.1038/s41589-019-0453-9
Simultaneous electrophysiology and fiber photometry in freely behaving mice
Patel Amisha A, McAlinden Niall, Mathieson Keith, Sakata Shuzo
Frontiers in Neuroscience Vol 14 (2020)
https://doi.org/10.3389/fnins.2020.00148
State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states
Tsunematsu Tomomi, Patel Amisha A, Onken Arno, Sakata Shuzo
Elife Vol 9 (2020)
https://doi.org/10.7554/eLife.52244
Pathway-dependent regulation of sleep dynamics in a network model of the sleep-wake cycle
Héricé Charlotte, Sakata Shuzo
Frontiers in Neuroscience Vol 13 (2019)
https://doi.org/10.3389/fnins.2019.01380
Theta oscillations alternate with high amplitude neocortical population within synchronized states
Munro Krull Erin, Sakata Shuzo, Toyoizumi Taro
Frontiers in Neuroscience Vol 13 (2019)
https://doi.org/10.3389/fnins.2019.00316

more publications

Research interests

Research Projects
1. State-dependent auditory processing and perception
When we are paying attention to sound, we can vividly perceive it. When sleep, however, our perception is siginificantly diminished. But what is happening in the brain? Because our brain activity ('brain state') continuously changes, it is extremely important to address the following three questions: 1) how is each brain state organized at the level of neural circuit? 2) how do brain states affect sensory processing and perceptual decision? and 3) how are brain states regulated? We are addressing these questions by taking multidisciplinary approaches, with a focus on dynamic interplays between the auditory system and neuromodulatory systems.

2. The circuit mechanism of abnormal hearing
Brain circuits often generate auditory perception even in the absence of auditory inputs, such as auditory hallucinations. But how? We are particularly focusing on phantom auditory perception, so-called tinnitus. Tinnitus is a symptom, which is often associated with hearing loss. Considering aging society and age-related hearing loss, a better understanding of the neural basis of tinnitus is extremly urgent. We are aiming to identify neural correlates of tinnitus at the level of neuronal circuits. By using a massively parallel extracellular recording technique and a behavioural approach, we are determining relationships between tinnitus and abnormal neural population activity in the auditory thalamocortical circuit. This research program will provide further insight into the development of new treatment for tinnitus sufferers.

3. Technology development to improve and restore hearing
Once we understand both normal and abnormal states, a next step is to explore strategies to restore abnormal states into the normal one. In addition, we can also think of how we can boost our normal brain functions. To achieve these goals, we are developing new approaches and technologies. We are particularly interested in the improvement and restoration of sensory abilities by controlling neural activity. Combining advanced technologies in rodents as a model, we are developing novel strategies to improve and restore hearing.

***Our research team is currently accepting applications from prospective PhD students and postdocs. In particular, persons who have strong background in physics, mathematics, or engineering are strongly encouraged to apply. ***

 

Professional activities

External examiner
Examiner
11/2/2019
Optical approaches to interrogate state-dependent and cell-type-specific activity in the brain
Speaker
5/12/2018
State-dependent information processing in the brain
Speaker
22/8/2018
Circuit-based interrogation of Alzheimer's disease
Speaker
21/8/2018
Annual Meeting of the Japan Neuroscience Society
Organiser
26/7/2018
Annual Meeting of the Japan Neuroscience Society
Participant
26/7/2018

more professional activities

Projects

Photometry-based in vivo calcium imaging for circuit-based interrogation of Alzheimers pathology
Sakata, Shuzo (Principal Investigator)
01-Jan-2019 - 01-Jan-2020
Neural interfacing using visible light communication
Sakata, Shuzo (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Macdonald, Alexander
Macdonald, Alexander (Research Co-investigator) Corrigan, Damion (Principal Investigator) Sakata, Shuzo (Co-investigator) Mathieson, Keith (Co-investigator)
01-Jan-2018 - 01-Jan-2022
EPSRC Centre for Doctoral Training in Future Power Networks and Smart Grids | Macdonald, Alexander
Corrigan, Damion (Principal Investigator) McCormick, Christopher (Co-investigator) Sakata, Shuzo (Co-investigator) Macdonald, Alexander (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Mapping the neuronal networks in neurodegeneration.
Tobin, Andrew (Principal Investigator) Sakata, Shuzo (Co-investigator)
01-Jan-2018 - 30-Jan-2019
Global reduction in Alzheimer's pathology by basal forebrain activation
Sakata, Shuzo (Principal Investigator)
01-Jan-2017 - 30-Jan-2018

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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