Dr Shuzo Sakata

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Mission
The goal of our research team is to understand (1) how brain state is organized at the level of neural circuits, (2) how brain state affects brain functions, (3) how brain state is regulated, and (4) whether and how manipulation of brain state can modify disease pathology.

Strategy
Out strategies are (1) to study normal information processing, (2) to study abnormal information processing, and (3) to develop tools to modulate brain functions. Our main techniques are in vivo ensemble recording, Ca2+ imaging, optogenetics, and behavioural approaches. 

 

Publications

Mutual interactions between brain states and Alzheimer’s disease pathology : a focus on gamma and slow oscillations
Byron Nicole, Semenova Anna, Sakata Shuzo
Biology Vol 10 (2021)
https://doi.org/10.3390/biology10080707
NDNF is selectively expressed by neocortical, but not habenular neurogliaform cells
Webster Jack F, Vroman Rozan, Beerens Sanne, Sakata Shuzo, Wozny Christian
European Journal of Neuroscience Vol 53, pp. 3561-3575 (2021)
https://doi.org/10.1111/ejn.15237
Region-specific and state-dependent astrocyte Ca2+ dynamics during the sleep-wake cycle in mice
Tsunematsu Tomomi, Sakata Shuzo, Sanagi Tomomi, Tanaka Kenji F, Matsui Ko
Journal of Neuroscience Vol 41, pp. 5440-5462 (2021)
https://doi.org/10.1523/JNEUROSCI.2912-20.2021
Pre-prints : a more affordable and quicker way to share research results
de Castro Pablo, Sakata Shuzo
(2021)
Effects of optogenetic stimulation of basal forebrain parvalbumin neurons on Alzheimer's disease pathology
Wilson Caroline A, Fouda Sarah, Sakata Shuzo
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-72421-9
Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula
Webster Jack F, Vroman Rozan, Balueva Kira, Wulff Peer, Sakata Shuzo, Wozny Christian
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-65349-7

More publications

Research interests

Research Projects
1. State-dependent auditory processing and perception
When we are paying attention to sound, we can vividly perceive it. When sleep, however, our perception is siginificantly diminished. But what is happening in the brain? Because our brain activity ('brain state') continuously changes, it is extremely important to address the following three questions: 1) how is each brain state organized at the level of neural circuit? 2) how do brain states affect sensory processing and perceptual decision? and 3) how are brain states regulated? We are addressing these questions by taking multidisciplinary approaches, with a focus on dynamic interplays between the auditory system and neuromodulatory systems.

2. The circuit mechanism of abnormal hearing
Brain circuits often generate auditory perception even in the absence of auditory inputs, such as auditory hallucinations. But how? We are particularly focusing on phantom auditory perception, so-called tinnitus. Tinnitus is a symptom, which is often associated with hearing loss. Considering aging society and age-related hearing loss, a better understanding of the neural basis of tinnitus is extremly urgent. We are aiming to identify neural correlates of tinnitus at the level of neuronal circuits. By using a massively parallel extracellular recording technique and a behavioural approach, we are determining relationships between tinnitus and abnormal neural population activity in the auditory thalamocortical circuit. This research program will provide further insight into the development of new treatment for tinnitus sufferers.

3. Technology development to improve and restore hearing
Once we understand both normal and abnormal states, a next step is to explore strategies to restore abnormal states into the normal one. In addition, we can also think of how we can boost our normal brain functions. To achieve these goals, we are developing new approaches and technologies. We are particularly interested in the improvement and restoration of sensory abilities by controlling neural activity. Combining advanced technologies in rodents as a model, we are developing novel strategies to improve and restore hearing.

***Our research team is currently accepting applications from prospective PhD students and postdocs. In particular, persons who have strong background in physics, mathematics, or engineering are strongly encouraged to apply. ***

 

Professional activities

FENS Forum of Neuroscience 2020
Organiser
2020
Frontiers in Neuroanatomy (Journal)
Editorial board member
2020
External examiner at University of Reading
Examiner
29/11/2019
External examiner at University of St Andrews
Examiner
11/2/2019
Optical approaches to interrogate state-dependent and cell-type-specific activity in the brain
Speaker
5/12/2018
State-dependent neural ensemble dynamics in brainstem
Invited speaker
9/2018

More professional activities

Projects

Sleep regulation by neuron-astrocyte interactions
Sakata, Shuzo (Principal Investigator)
01-Jan-2021 - 30-Jan-2024
Deep brain technologies to understand the cellular origin of diseases DEEPER
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Wozny, Christian (Co-investigator) McAlinden, Niall (Research Co-investigator)
01-Jan-2021 - 30-Jan-2025
Developing therapies for Alzheimer's disease
Jiang, Hui-Rong (Principal Investigator) Sakata, Shuzo (Co-investigator)
01-Jan-2020 - 31-Jan-2022
Understanding the action mechanisms of gamma oscillation for AD disease
Jiang, Hui-Rong (Principal Investigator) Sakata, Shuzo (Principal Investigator)
01-Jan-2020 - 30-Jan-2021
Immunomechanisms of gamma oscillation treatment for Alzheimer's disease
Jiang, Hui-Rong (Principal Investigator) Sakata, Shuzo (Co-investigator) Harte, Tanith (Post Grad Student)
The study aims to identify the specific immune cells and molecules which mediate the action of induced gamma oscillation, a potential novel treatment for AD patients.
01-Jan-2019 - 30-Jan-2022
Photometry-based in vivo calcium imaging for circuit-based interrogation of Alzheimers pathology
Sakata, Shuzo (Principal Investigator)
01-Jan-2019 - 01-Jan-2020

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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