Dr Shuzo Sakata

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

The goal of our research team is (1) to understand how sensory information is processed by brain circuits, and (2) to develop better strategies for the improvement and restoration of sensory abilities, with emphasis on hearing.

Out strategies are (1) to study normal information processing, (2) to study abnormal information processing, and (3) to develop tools to modulate brain functions. Our main techniques are in vivo ensemble recording, optogenetics, and behavioural approaches. 



Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula
Webster Jack F, Vroman Rozan, Balueva Kira, Wulff Peer, Sakata Shuzo, Wozny Christian
Scientific Reports Vol 10 (2020)
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
Bradley Sophie J, Molloy Colin, Valuskova Paulina, Dwomoh Louis, Scarpa Miriam, Rossi Mario, Finlayson Lisa, Svensson Kjell A, Chernet Eyassu, Barth Vanessa N, Gherbi Karolina, Sykes David A, Wilson Caroline A, Mistry Raj, Sexton Patrick M, Christopoulos Arthur, Mogg Adrian J, Rosenthorne Elizabeth M, Sakata Shuzo, Challiss R A John, Broad Lisa M, Tobin Andrew B
Nature Chemical Biology Vol 16, pp. 240-249 (2020)
Simultaneous electrophysiology and fiber photometry in freely behaving mice
Patel Amisha A, McAlinden Niall, Mathieson Keith, Sakata Shuzo
Frontiers in Neuroscience Vol 14 (2020)
State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states
Tsunematsu Tomomi, Patel Amisha A, Onken Arno, Sakata Shuzo
eLife Vol 9 (2020)
Pathway-dependent regulation of sleep dynamics in a network model of the sleep-wake cycle
Héricé Charlotte, Sakata Shuzo
Frontiers in Neuroscience Vol 13 (2019)
Theta oscillations alternate with high amplitude neocortical population within synchronized states
Munro Krull Erin, Sakata Shuzo, Toyoizumi Taro
Frontiers in Neuroscience Vol 13 (2019)

More publications

Research interests

Research Projects
1. State-dependent auditory processing and perception
When we are paying attention to sound, we can vividly perceive it. When sleep, however, our perception is siginificantly diminished. But what is happening in the brain? Because our brain activity ('brain state') continuously changes, it is extremely important to address the following three questions: 1) how is each brain state organized at the level of neural circuit? 2) how do brain states affect sensory processing and perceptual decision? and 3) how are brain states regulated? We are addressing these questions by taking multidisciplinary approaches, with a focus on dynamic interplays between the auditory system and neuromodulatory systems.

2. The circuit mechanism of abnormal hearing
Brain circuits often generate auditory perception even in the absence of auditory inputs, such as auditory hallucinations. But how? We are particularly focusing on phantom auditory perception, so-called tinnitus. Tinnitus is a symptom, which is often associated with hearing loss. Considering aging society and age-related hearing loss, a better understanding of the neural basis of tinnitus is extremly urgent. We are aiming to identify neural correlates of tinnitus at the level of neuronal circuits. By using a massively parallel extracellular recording technique and a behavioural approach, we are determining relationships between tinnitus and abnormal neural population activity in the auditory thalamocortical circuit. This research program will provide further insight into the development of new treatment for tinnitus sufferers.

3. Technology development to improve and restore hearing
Once we understand both normal and abnormal states, a next step is to explore strategies to restore abnormal states into the normal one. In addition, we can also think of how we can boost our normal brain functions. To achieve these goals, we are developing new approaches and technologies. We are particularly interested in the improvement and restoration of sensory abilities by controlling neural activity. Combining advanced technologies in rodents as a model, we are developing novel strategies to improve and restore hearing.

***Our research team is currently accepting applications from prospective PhD students and postdocs. In particular, persons who have strong background in physics, mathematics, or engineering are strongly encouraged to apply. ***


Professional activities

External examiner
Optical approaches to interrogate state-dependent and cell-type-specific activity in the brain
State-dependent information processing in the brain
Circuit-based interrogation of Alzheimer's disease
Annual Meeting of the Japan Neuroscience Society
Annual Meeting of the Japan Neuroscience Society

More professional activities


Developing therapies for Alzheimer's disease
Jiang, Hui-Rong (Principal Investigator) Sakata, Shuzo (Co-investigator)
01-Jan-2020 - 31-Jan-2021
Understanding the action mechanisms of gamma oscillation for AD disease
Jiang, Hui-Rong (Principal Investigator) Sakata, Shuzo (Principal Investigator)
01-Jan-2020 - 30-Jan-2021
Immunomechanisms of gamma oscillation treatment for Alzheimer's disease
Jiang, Hui-Rong (Principal Investigator) Sakata, Shuzo (Co-investigator) Harte, Tanith (Post Grad Student)
The study aims to identify the specific immune cells and molecules which mediate the action of induced gamma oscillation, a potential novel treatment for AD patients.
01-Jan-2019 - 30-Jan-2022
Photometry-based in vivo calcium imaging for circuit-based interrogation of Alzheimers pathology
Sakata, Shuzo (Principal Investigator)
01-Jan-2019 - 01-Jan-2020
Neural interfacing using visible light communication
Sakata, Shuzo (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Macdonald, Alexander
Macdonald, Alexander (Research Co-investigator) Corrigan, Damion (Principal Investigator) Sakata, Shuzo (Co-investigator) Mathieson, Keith (Co-investigator)
01-Jan-2018 - 01-Jan-2022

More projects


Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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