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Dr Philipp Seib

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

RESEARCH OVERVIEW

Our research mission is to assess the biological performance of drug delivery systems by developing cell culture systems that mimic the three-dimensional and cellular makeup of a tissue or tumour. Our experience in the field of pharmaceutical sciences—working at the interface of biomaterials, tissue engineering and stem and cancer cell biology—provides the expertise needed to achieve this mission. We are currently exploring the following research themes: 

 

Advanced drug delivery systems: the cellular response

We study the cellular response of drug delivery systems, including nanomedicines. Nanomedicines are specifically engineered, multiple-component, nanosized drugs and drug delivery systems whose use is emerging as a promising approach for treating many diseases, including cancer. The drug payloads of nanomedicines can differ widely, but the effectiveness of any nanomedicine relies on its ability to reach the tumour microenvironment. In addition, the nanomedicine often must deliver its drug payload to a specific internal cell compartment in order to yield the desired therapeutic effect. One of the bottlenecks for the translation of nanomedicines into clinical practice is the lack of suitable model systems for monitoring the cellular fate of nanomedicines, both in vitro and in vivo. Our laboratory focuses on the development of a repertoire of technologies for studying the cellular responses of nanomedicines. Our interests span the range from intracellular trafficking to application-oriented biocompatibility testing.

 

Engineering cellular microenvironments for stem and cancer cells

Our in vitro research focuses on overcoming the issues that arise when stem cells are studied in a highly artificial context that ignores their native microenvironment. The typical in vitro cell culture environment strips cells of most of the contextual signals and physical cues that arise from accessory cells and the extracellular matrix (ECM) found in intact tissues (e.g. tumours). The standard culture substrate for cells is treated polystyrene, which not only fails to mimic the complexity of the actual cell microenvironment, but also generates an artificial two-dimensional cell layer. We are developing a number of culture systems that better reflect the cellular microenvironments that occur in healthy and diseased tissues, including the three-dimensional space that stem cells normally occupy in a tissue.

We have recently extended the concept of an engineered stem cell microenvironment to three-dimensional scaffolds that are implanted in vivo and can serve as “traps” for circulating tumour cells. An emerging paradigm is that the stem cell niche can be hijacked by circulating tumour cells during the process of cancer metastasis. We are exploiting this feature to engineer artificial in vivo stem cell niches that selectively lure and trap cancer cells within the scaffold. The outcome of these studies will be unique new strategies for cancer therapy.

 

Silk-based drug delivery systems

We have a particular interest in exploring the use of silk for drug and cell delivery applications. Silk is an approved biopolymer for use in humans and has remarkable physical properties (e.g. it is tougher than any manmade fibre). Silk, a common suture material, has long been recognised for its biocompatibility and biodegradability. We are using it as a scaffold for tissue engineering and as a biopolymer for drug and cell delivery. Silk can be processed under mild aqueous conditions to generate several biomedically useful formats, including self-assembling silk hydrogels, nanoparticles, films and scaffolds.

 

Personal lab webpage is at:

www.SeibLab.com 

Publications

Reverse-engineered silk hydrogels for cell and drug delivery
Seib F Philipp
Therapeutic Delivery Vol 9, pp. 469-487, (2018)
http://dx.doi.org/10.4155/tde-2018-0016
Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery
Newland B., Taplan C., Pette D., Friedrichs J., Steinhart M., Wang W., Voit B., Seib F.P., Werner C.
Nanoscale Vol 10, pp. 8413-8421, (2018)
http://dx.doi.org/10.1039/C8NR00603B
Self-assembling hydrogels from reverse-engineered silk
Seib Philipp
Self-assembling BiomaterialsSelf-assembling Biomaterials, (2018)
Degradation behavior of silk nanoparticles – enzyme responsiveness
Wongpinyochit Thidarat, Johnston Blair F., Seib F. Philipp
ACS Biomaterials Science & Engineering Vol 4, pp. 942-951, (2018)
http://dx.doi.org/10.1021/acsbiomaterials.7b01021
Biocompatibility assessment of silk nanoparticles : hemocompatibility and internalization by human blood cells
Maitz Manfred F., Sperling Claudia, Wongpinyochit Thidarat, Herklotz Manuela, Werner Carsten, Seib F. Philipp
Nanomedicine: Nanotechnology, Biology and Medicine Vol 13, pp. 2633-2642, (2017)
http://dx.doi.org/10.1016/j.nano.2017.07.012
Silk nanoparticles : proof of lysosomotropic anticancer drug delivery at single cell resolution
Totten John D., Wongpinyochit Thidarat, Seib F. Philipp
Journal of Drug Targeting, pp. 1-8, (2017)
http://dx.doi.org/10.1080/1061186X.2017.1363212

more publications

Professional activities

Materials Science and Engineering: C (Journal)
Peer reviewer
14/6/2018
Seminar Speaker University of Reading
Speaker
24/5/2018
Biomaterials (Journal)
Peer reviewer
12/4/2018
Advanced Therapeutics (Journal)
Peer reviewer
10/4/2018
Materials Science and Engineering: C (Journal)
Peer reviewer
30/3/2018
Grant review The Royal Society
Examiner
20/3/2018

more professional activities

Projects

Tracing the fate of nanomedicines in the tumour microenvironment (MC Career Integration) | Totten, John
Seib, Philipp (Principal Investigator) Johnston, Blair (Co-investigator) Totten, John (Research Co-investigator)
Period 01-Oct-2015 - 01-Apr-2019
EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Brownlee, William John
Seib, Philipp (Principal Investigator) Wilson, Clive (Co-investigator) Brownlee, William John (Research Co-investigator)
Period 01-Feb-2015 - 01-Feb-2018
Engineered culture surfaces for the isolation and expansion of bone fide mesenchymal stem cells (MSCs)
Seib, Philipp (Principal Investigator)
Period 01-Mar-2017 - 28-Feb-2018
EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Huff Guelbert, Samuel
Seib, Philipp (Principal Investigator) Wilson, Clive (Co-investigator)
Period 01-Oct-2013 - 17-Mar-2017
Engineering self-assembling silk hydrogels for the delivery of stem cells
Seib, Philipp (Principal Investigator)
Period 13-Oct-2016 - 12-Oct-2018
Endocytic uptake of nanomedicines
Seib, Philipp (Principal Investigator)
Period 01-Nov-2014 - 31-Oct-2015

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
John Arbuthnott Building Robertson Wing

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