Save this page
Save this page

My Saved Pages

  • Saved page.

My Saved Courses

  • Saved page.
Reset

Recently visited

  • Saved page.

Dr Philipp Seib

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

RESEARCH OVERVIEW

Our research mission is to assess the biological performance of drug delivery systems by developing cell culture systems that mimic the three-dimensional and cellular makeup of a tissue or tumour. Our experience in the field of pharmaceutical sciences—working at the interface of biomaterials, tissue engineering and stem and cancer cell biology—provides the expertise needed to achieve this mission. We are currently exploring the following research themes: 

 

Advanced drug delivery systems: the cellular response

We study the cellular response of drug delivery systems, including nanomedicines. Nanomedicines are specifically engineered, multiple-component, nanosized drugs and drug delivery systems whose use is emerging as a promising approach for treating many diseases, including cancer. The drug payloads of nanomedicines can differ widely, but the effectiveness of any nanomedicine relies on its ability to reach the tumour microenvironment. In addition, the nanomedicine often must deliver its drug payload to a specific internal cell compartment in order to yield the desired therapeutic effect. One of the bottlenecks for the translation of nanomedicines into clinical practice is the lack of suitable model systems for monitoring the cellular fate of nanomedicines, both in vitro and in vivo. Our laboratory focuses on the development of a repertoire of technologies for studying the cellular responses of nanomedicines. Our interests span the range from intracellular trafficking to application-oriented biocompatibility testing.

 

Engineering cellular microenvironments for stem and cancer cells

Our in vitro research focuses on overcoming the issues that arise when stem cells are studied in a highly artificial context that ignores their native microenvironment. The typical in vitro cell culture environment strips cells of most of the contextual signals and physical cues that arise from accessory cells and the extracellular matrix (ECM) found in intact tissues (e.g. tumours). The standard culture substrate for cells is treated polystyrene, which not only fails to mimic the complexity of the actual cell microenvironment, but also generates an artificial two-dimensional cell layer. We are developing a number of culture systems that better reflect the cellular microenvironments that occur in healthy and diseased tissues, including the three-dimensional space that stem cells normally occupy in a tissue.

We have recently extended the concept of an engineered stem cell microenvironment to three-dimensional scaffolds that are implanted in vivo and can serve as “traps” for circulating tumour cells. An emerging paradigm is that the stem cell niche can be hijacked by circulating tumour cells during the process of cancer metastasis. We are exploiting this feature to engineer artificial in vivo stem cell niches that selectively lure and trap cancer cells within the scaffold. The outcome of these studies will be unique new strategies for cancer therapy.

 

Silk-based drug delivery systems

We have a particular interest in exploring the use of silk for drug and cell delivery applications. Silk is an approved biopolymer for use in humans and has remarkable physical properties (e.g. it is tougher than any manmade fibre). Silk, a common suture material, has long been recognised for its biocompatibility and biodegradability. We are using it as a scaffold for tissue engineering and as a biopolymer for drug and cell delivery. Silk can be processed under mild aqueous conditions to generate several biomedically useful formats, including self-assembling silk hydrogels, nanoparticles, films and scaffolds.

 

Personal lab webpage is at:

www.SeibLab.com 

Publications

Biocompatibility assessment of silk nanoparticles : hemocompatibility and internalization by human blood cells
Maitz Manfred F., Sperling Claudia, Wongpinyochit Thidarat, Herklotz Manuela, Werner Carsten, Seib F. Philipp
Nanomedicine: Nanotechnology, Biology and Medicine Vol 13, pp. 2633-2642, (2017)
http://dx.doi.org/10.1016/j.nano.2017.07.012
Silk nanoparticles : proof of lysosomotropic anticancer drug delivery at single cell resolution
Totten John D., Wongpinyochit Thidarat, Seib F. Philipp
Journal of Drug Targeting, pp. 1-8, (2017)
http://dx.doi.org/10.1080/1061186X.2017.1363212
Silk hydrogels for drug and cell delivery
Seib F. Philipp
HydrogelsHydrogels, (2017)
Metabolic reprogramming of macrophages exposed to silk, poly(lactic-co-glycolic acid) and silica nanoparticles
Saborano Raquel, Wongpinyochit Thidarat, Totten John D., Johnston Blair F., Seib Philipp, Duarte Iola F.
Advanced Healthcare Materials, (2017)
http://dx.doi.org/10.1002/adhm.201601240
Silk nanoparticles - an emerging anticancer nanomedicine
Seib F. Philipp
AIMS Bioengineering Vol 42, pp. 239-258, (2017)
http://dx.doi.org/10.3934/bioeng.2017.2.239
Heparin modified polyethylene glycol microparticle aggregates for focal cancer chemotherapy
Seib F. Philipp, Tsurkan Mikhail, Freudenberg Uwe, Kaplan David L., Werner Carsten
ACS Biomaterials Science & Engineering Vol 2, pp. 2287-2293, (2016)
http://dx.doi.org/10.1021/acsbiomaterials.6b00495

more publications

Professional activities

Acta Biomaterialia (Journal)
Peer reviewer
5/12/2017
Advanced Materials (Journal)
Peer reviewer
2/12/2017
Journal of Drug Targeting (Journal)
Peer reviewer
23/11/2017
Biomaterials Science (Journal)
Peer reviewer
20/11/2017
PhD examination at Queen's University Belfast
Examiner
10/11/2017
Molecular Pharmaceutics (Journal)
Peer reviewer
9/11/2017

more professional activities

Projects

Tracing the fate of nanomedicines in the tumour microenvironment (MC Career Integration) | Totten, John
Seib, Philipp (Principal Investigator) Johnston, Blair (Co-investigator) Totten, John (Research Co-investigator)
Period 01-Oct-2015 - 01-Apr-2019
EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Brownlee, William John
Seib, Philipp (Principal Investigator) Wilson, Clive (Co-investigator) Brownlee, William John (Research Co-investigator)
Period 01-Feb-2015 - 01-Feb-2018
Engineered culture surfaces for the isolation and expansion of bone fide mesenchymal stem cells (MSCs)
Seib, Philipp (Principal Investigator)
Period 01-Mar-2017 - 28-Feb-2018
EPSRC Doctoral Training Grant - DTA, University of Strathclyde | Huff Guelbert, Samuel
Seib, Philipp (Principal Investigator) Wilson, Clive (Co-investigator) Huff Guelbert, Samuel (Research Co-investigator)
Period 01-Oct-2013 - 17-Mar-2017
Engineering self-assembling silk hydrogels for the delivery of stem cells
Seib, Philipp (Principal Investigator)
Period 13-Oct-2016 - 12-Oct-2018
Endocytic uptake of nanomedicines
Seib, Philipp (Principal Investigator)
Period 01-Nov-2014 - 31-Oct-2015

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
John Arbuthnott Building Robertson Wing

Location Map

View University of Strathclyde in a larger map