Professor Joop Ter Horst

Visiting Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners.

Publications

Machine learning derived correlations for scale-up and technology transfer of primary nucleation kinetics: Yerdelen Stephanie, Yang Yihui, Quon Justin L, Papageorgiou Charles D, Mitchell Chris, Houson Ian, Sefcik Jan, ter Horst Joop H, Florence Alastair J, Brown Cameron J; Crystal Growth and Design (2023); https://doi.org/10.1021/acs.cgd.2c00192
Multicomponent chiral quantification with UV circular dichroism spectroscopy : ternary and quaternary phase diagrams of Levetiracetam: Charpentier Maxime D, Venkatramanan Raghunath, Rougeot Céline, Leyssens Tom, Johnston Karen, ter Horst Joop H; Molecular Pharmaceutics, pp. 1-14 (2022); https://doi.org/10.1021/acs.molpharmaceut.2c00825
Solubility analysis of 18 active pharmaceutical ingredients and intermediates in the non-polar solvents dioxane, toluene and cyclopentyl methyl ether: Moreno-Leon Carlos, Mack Corin, Roy Sudipta, ter Horst Joop H; Journal of Molecular Liquids Vol 367 (2022); https://doi.org/10.1016/j.molliq.2022.120365
Comparing and quantifying the efficiency of cocrystal screening methods for Praziquantel: Charpentier Maxime D, Devogelaer Jan-Joris, Tijink Arnoud, Meekes Hugo, Tinnemans Paul, Vlieg Elias, de Gelder René, Johnston Karen, ter Horst Joop H; Crystal Growth and Design Vol 22, pp. 5511-5525 (2022); https://doi.org/10.1021/acs.cgd.2c00615
Manufacture of tablets with structurally-controlled drug release using rapid tooling injection moulding: Walsh Erin, Maclean Natalie, Turner Alice, Alsuleman Moulham, Prasad Elke, Halbert Gavin, ter Horst Joop H, Markl Daniel; International Journal of Pharmaceutics Vol 624 (2022); https://doi.org/10.1016/j.ijpharm.2022.121956
Phase diagram determination and process development for continuous antisolvent crystallizations: Mack Corin, Hoffmann Johannes, Sefcik Jan, ter Horst Joop H; Crystals Vol 12 (2022); https://doi.org/10.3390/cryst12081102

More publications

Professional activities

Crystallization in Complex Multicomponent Systems: Speaker; 5/6/2019
University of Rouen: Visiting researcher; 3/6/2019
CORE Workshop: Participant; 20/5/2019
Amecrys network meeting & review meeting: Participant; 7/5/2019
External Examiner for the PhD student Marcelo Henriques da Silva in the group of Marcel Ottens at the TU Delft: Examiner; 15/4/2019
Crystallization in Complex Multicomponent Systems: Speaker; 11/4/2019

More professional activities

Projects

Doctoral Training Partnership 2020-2021 University of Strathclyde | Chambers, Greg: Perrie, Yvonne (Principal Investigator) Ter Horst, Joop (Principal Investigator) Oswald, Iain (Co-investigator) Chambers, Greg (Research Co-investigator); 01-Jan-2020 - 01-Jan-2024
to develop a workflow for the rapid measurement of phase diagrams for multicomponent systems student placement Olayinka Olalere: Ter Horst, Joop (Principal Investigator); 01-Jan-2018 - 31-Jan-2019
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin: Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator); 01-Jan-2018 - 02-Jan-2021
CMAC Core project: Impurity Rejection: Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator); 01-Jan-2017 - 30-Jan-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub): Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator); 01-Jan-2017 - 31-Jan-2023
Scale-Up and Continuos Viedma Ripening: Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator); Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.; 07-Jan-2016 - 12-Jan-2017

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences

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