Professor Joop Ter Horst
Visiting Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Personal statement
Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners.
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Publications
- A workflow for the development of template-assisted membrane crystallization downstream processing for monoclonal antibody purification
- Rajoub Nazer, Gerard Charline J J, Pantuso Elvira, Fontananova Enrica, Caliandro Rocco, Belviso Benny D, Curcio Efrem, Nicoletta Fiore P, Pullen James, Chen Wenqian, Heng Jerry Y Y, Ruane Sean, Liddell John, Alvey Natalie, ter Horst Joop H, Di Profio Gianluca
- Nature Protocols Vol 18, pp. 2998-3049 (2023)
- https://doi.org/10.1038/s41596-023-00869-w
- Machine learning derived correlations for scale-up and technology transfer of primary nucleation kinetics
- Yerdelen Stephanie, Yang Yihui, Quon Justin L, Papageorgiou Charles D, Mitchell Chris, Houson Ian, Sefcik Jan, ter Horst Joop H, Florence Alastair J, Brown Cameron J
- Crystal Growth and Design Vol 23, pp. 681-693 (2023)
- https://doi.org/10.1021/acs.cgd.2c00192
- Multicomponent chiral quantification with Ultraviolet circular dichroism spectroscopy : ternary and quaternary phase diagrams of Levetiracetam
- Charpentier Maxime D, Venkatramanan Raghunath, Rougeot Céline, Leyssens Tom, Johnston Karen, ter Horst Joop H
- Molecular Pharmaceutics Vol 20, pp. 616-629 (2022)
- https://doi.org/10.1021/acs.molpharmaceut.2c00825
- Solubility analysis of 18 active pharmaceutical ingredients and intermediates in the non-polar solvents dioxane, toluene and cyclopentyl methyl ether
- Moreno-Leon Carlos, Mack Corin, Roy Sudipta, ter Horst Joop H
- Journal of Molecular Liquids Vol 367 (2022)
- https://doi.org/10.1016/j.molliq.2022.120365
- Comparing and quantifying the efficiency of cocrystal screening methods for Praziquantel
- Charpentier Maxime D, Devogelaer Jan-Joris, Tijink Arnoud, Meekes Hugo, Tinnemans Paul, Vlieg Elias, de Gelder René, Johnston Karen, ter Horst Joop H
- Crystal Growth and Design Vol 22, pp. 5511-5525 (2022)
- https://doi.org/10.1021/acs.cgd.2c00615
- Manufacture of tablets with structurally-controlled drug release using rapid tooling injection moulding
- Walsh Erin, Maclean Natalie, Turner Alice, Alsuleman Moulham, Prasad Elke, Halbert Gavin, ter Horst Joop H, Markl Daniel
- International Journal of Pharmaceutics Vol 624 (2022)
- https://doi.org/10.1016/j.ijpharm.2022.121956
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Professional Activities
- Crystallization in Complex Multicomponent Systems
- Speaker
- 5/6/2019
- University of Rouen
- Visiting researcher
- 3/6/2019
- CORE Workshop
- Participant
- 20/5/2019
- Amecrys network meeting & review meeting
- Participant
- 7/5/2019
- External Examiner for the PhD student Marcelo Henriques da Silva in the group of Marcel Ottens at the TU Delft
- Examiner
- 15/4/2019
- Crystallization in Complex Multicomponent Systems
- Speaker
- 11/4/2019
Projects
- Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin
- Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator)
- 01-Jul-2018 - 02-Dec-2021
- CMAC Core project: Impurity Rejection
- Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
- 01-Oct-2017 - 30-Sep-2019
- Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
- Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
- 01-Jan-2017 - 30-Sep-2024
- Scale-Up and Continuos Viedma Ripening
- Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator)
- Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.
- 07-Nov-2016 - 12-May-2017
- Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Moreno Leon, Carlos
- Ter Horst, Joop (Principal Investigator) Roy, Sudipta (Co-investigator) Moreno Leon, Carlos (Research Co-investigator)
- 01-Nov-2016 - 21-Jan-2021
- AMECRYS - Continuous Template-Assisted Membrane Crystallisation H2020 FET OPEN
- Ter Horst, Joop (Principal Investigator) Lamprou, Dimitrios (Co-investigator)
- Template-Assisted Membrane Crystallization for Continuous Downstream Biopharma Processing (CRYSPHARMA)
- 01-Oct-2016 - 30-Sep-2020
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Contact
Professor
Joop
Ter Horst
Visiting Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: joop.terhorst@strath.ac.uk
Tel: Unlisted