Professor Joop Ter Horst

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners. 

Publications

A structured approach to cope with impurities during industrial crystallization development
Urwin Stephanie J, Levilain Guillaume, Marziano Ivan, Merritt Jeremy M, Houson Ian, Ter Horst Joop H
Organic Process Research and Development (2020)
https://doi.org/10.1021/acs.oprd.0c00166
On the aggregation and nucleation mechanism of the monoclonal antibody anti-CD20 near liquid-liquid phase separation (LLPS)
Pantuso Elvira, Mastropietro Teresa F, Briuglia Maria L, Gerard Charline J J, Curcio Efrem, ter Horst Joop H, Nicoletta Fiore P, Di Profio Gianluca
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-65776-6
Assessing crystallisation kinetics of Zr metal–organic frameworks through turbidity measurements to inform rapid microwave-assisted synthesis
Griffin Sarah L, Briuglia Maria L, ter Horst Joop H, Forgan Ross S
Chemistry - A European Journal Vol 26, pp. 6910-6918 (2020)
https://doi.org/10.1002/chem.202000993
Nucleation control in continuous crystallization
Sefcik Jan, Ter Horst Joop, McGinty John, Price Chris John
The Handbook of Continuous Crystallization (2020) (2020)
On the effect of secondary nucleation on deracemization through temperature cycles
Cameli Fabio, ter Horst Joop H, Steendam René R E, Xiouras Christos, Stefanidis Georgios D
Chemistry - A European Journal Vol 26, pp. 1344-1354 (2020)
https://doi.org/10.1002/chem.201904239
Enabling direct preferential crystallization in a stable racemic compound system
Harfouche Lina C, Brandel Clément, Cartigny Yohann, Ter Horst Joop H, Coquerel Gérard, Petit Samuel
Molecular Pharmaceutics Vol 16, pp. 4670-4676 (2019)
https://doi.org/10.1021/acs.molpharmaceut.9b00805

More publications

Professional activities

Crystallization in Complex Multicomponent Systems
Speaker
5/6/2019
University of Rouen
Visiting researcher
3/6/2019
CORE Workshop
Participant
20/5/2019
Amecrys network meeting & review meeting
Participant
7/5/2019
External Examiner for the PhD student Marcelo Henriques da Silva in the group of Marcel Ottens at the TU Delft
Examiner
15/4/2019
Crystallization in Complex Multicomponent Systems
Speaker
11/4/2019

More professional activities

Projects

to develop a workflow for the rapid measurement of phase diagrams for multicomponent systems student placement Olayinka Olalere
Ter Horst, Joop (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin
Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 30-Jan-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 31-Jan-2023
Scale-Up and Continuos Viedma Ripening
Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator)
Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.
07-Jan-2016 - 12-Jan-2017
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Moreno Leon, Carlos
Ter Horst, Joop (Principal Investigator) Roy, Sudipta (Co-investigator) Moreno Leon, Carlos (Research Co-investigator)
01-Jan-2016 - 01-Jan-2020

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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