Professor Joop Ter Horst

Visiting Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners. 


Template-assisted crystallization behavior in stirred solutions of the monoclonal antibody Anti-CD20 : probability distributions of induction times
Gerard Charline J J, Briuglia Maria L, Rajoub Nazer, Mastropietro Teresa F, Chen Wenqian, Heng Jerry Y Y, Di Profio Gianluca, ter Horst Joop H
Crystal Growth and Design Vol 22, pp. 3637–3645 (2022)
Co-crystal phase diagram determination by the solution addition method
Svoboda Vaclav, Venkatramanan Raghunath, Jaap Mairi, Lue Leo, ter Horst Joop H, Sefcik Jan
Crystal Growth and Design Vol 22, pp. 3376-3384 (2022)
Impact of impurities on crystallization and product quality : a case study with paracetamol
Urwin Stephanie J, Yerdelen Stephanie, Houson Ian, ter Horst Joop H
Crystals Vol 11 (2021)
Co-crystals of non-steroidal anti-inflammatory drugs (NSAIDs) : insight toward formation, methods, and drug enhancement
Nascimento André LCS, Fernandes Richard P, Charpentier Maxime D, ter Horst Joop H, Caires Flávio J, Chorilli Marlus
Particuology Vol 58, pp. 227-241 (2021)
Simultaneous chiral resolution of two racemic compounds by preferential cocrystallization
Zhou Fuli, Shemchuk Oleksii, Charpentier Maxime D, Matheys Chloé, Collard Laurent, ter Horst Joop H, Leyssens Tom
Angewandte Chemie - International Edition Vol 60, pp. 20264-20268 (2021)
Process modeling and optimization of continuous chiral resolution by integration of membrane and crystallization technologies
Capdevila-Echeverria Jose, Wang Jiayuan, Lakerveld Richard, ter Horst Joop H
Journal of Membrane Science Vol 632 (2021)

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Professional activities

Crystallization in Complex Multicomponent Systems
University of Rouen
Visiting researcher
CORE Workshop
Amecrys network meeting & review meeting
External Examiner for the PhD student Marcelo Henriques da Silva in the group of Marcel Ottens at the TU Delft
Crystallization in Complex Multicomponent Systems

More professional activities


Doctoral Training Partnership 2020-2021 University of Strathclyde | Chambers, Greg
Perrie, Yvonne (Principal Investigator) Ter Horst, Joop (Principal Investigator) Oswald, Iain (Co-investigator) Chambers, Greg (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
to develop a workflow for the rapid measurement of phase diagrams for multicomponent systems student placement Olayinka Olalere
Ter Horst, Joop (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin
Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator)
01-Jan-2018 - 02-Jan-2021
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 30-Jan-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 31-Jan-2023
Scale-Up and Continuos Viedma Ripening
Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator)
Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.
07-Jan-2016 - 12-Jan-2017

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Strathclyde Institute of Pharmacy and Biomedical Sciences

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