Professor Joop Ter Horst

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners. 

Publications

Nucleation Control in Continuous Crystallization
Sefcik Jan, Ter Horst Joop, McGinty John, Price Chris John
The Handbook of Continuous Crystallization (2020) (2020)
Towards continuous deracemization via racemic crystal transformation monitored by in-situ Raman spectroscopy
Xiouras Christos, Belletti Giuseppe, Venkatramanan Raghunath, Nordon Alison, Meekes Hugo, Vlieg Elias, Stefanidis Georgios D, Ter Horst Joop H
Crystal Growth and Design Vol 19, pp. 5858-5868 (2019)
https://doi.org/10.1021/acs.cgd.9b00867
Resolution control in a continuous preferential crystallization process
Dunn Andrew S, Svoboda Vaclav, Sefcik Jan, ter Horst Joop H
Organic Process Research and Development Vol 23, pp. 2031-2041 (2019)
https://doi.org/10.1021/acs.oprd.9b00275
Paracetamol habit modification by impurities
Urwin Stephanie, Martin Alan, Ter Horst Joop
50th Annual Conference of the British Association of Crystal Growth (2019)
Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring
Forbes Neil, Hussain Maryam T, Briuglia Maria L, Edwards Darren P, ter Horst Joop H, Szita Nicolas, Perrie Yvonne
International Journal of Pharmaceutics Vol 556, pp. 68-81 (2019)
https://doi.org/10.1016/j.ijpharm.2018.11.060
Measuring secondary nucleation through single crystal seeding
Briuglia Maria L, Sefcik Jan, Horst Joop H ter
Crystal Growth and Design Vol 19, pp. 421-429 (2019)
https://doi.org/10.1021/acs.cgd.8b01515

more publications

Professional activities

Crystallization in Complex Multicomponent Systems
Speaker
5/6/2019
University of Rouen
Visiting researcher
3/6/2019
CORE Workshop
Participant
20/5/2019
Amecrys network meeting & review meeting
Participant
7/5/2019
External Examiner for the PhD student Marcelo Henriques da Silva in the group of Marcel Ottens at the TU Delft
Examiner
15/4/2019
Crystallization in Complex Multicomponent Systems
Speaker
11/4/2019

more professional activities

Projects

to develop a workflow for the rapid measurement of phase diagrams for multicomponent systems student placement Olayinka Olalere
Ter Horst, Joop (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin
Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 30-Jan-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 31-Jan-2023
Scale-Up and Continuos Viedma Ripening
Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator)
Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.
07-Jan-2016 - 12-Jan-2017
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Moreno Leon, Carlos
Ter Horst, Joop (Principal Investigator) Roy, Sudipta (Co-investigator) Moreno Leon, Carlos (Research Co-investigator)
01-Jan-2016 - 01-Jan-2020

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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