Professor Joop Ter Horst

Visiting Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners. 

Publications

Development of 3D printed rapid tooling for micro-injection moulding
Walsh Erin, ter Horst Joop H, Markl Daniel
Chemical Engineering Science Vol 235 (2021)
https://doi.org/10.1016/j.ces.2021.116498
Combining incompatible processes for deracemization of Praziquantel derivative under flow conditions
Valenti Giulio, Tinnemans Paul, Baglai Iaroslav, Noorduin Willem L, Kaptein Bernard, Leeman Michel, ter Horst Joop H, Kellogg Richard M
Angewandte Chemie - International Edition Vol 60, pp. 5279-5282 (2021)
https://doi.org/10.1002/anie.202013502
Fungicide precursor racemization kinetics for deracemization in complex systems
Guillot Michael, de Meester Josephine, ter Horst Joop H, Riant Olivier, Leyssens Tom
European Journal of Organic Chemistry Vol 2021, pp. 473-482 (2021)
https://doi.org/10.1002/ejoc.202001402
Screening approach for identifying cocrystal types and resolution opportunities in complex chiral multicomponent systems
Li Weiwei, de Groen Mariette, Kramer Herman JM, de Gelder René, Tinnemans Paul, Meekes Hugo, ter Horst Joop H
Crystal Growth and Design, pp. 112-124 (2020)
https://doi.org/10.1021/acs.cgd.0c00890
Enabling mechanical separation of enantiomers through controlled batchwise concomitant crystallization : digital design and experimental validation
Dunn Andrew S, Szilagyi Botond, ter Horst Joop H, Nagy Zoltan K
Crystal Growth and Design Vol 20, pp. 7726-7741 (2020)
https://doi.org/10.1021/acs.cgd.0c00974
Manipulating cocrystal size and morphology using a combination of temperature cycling and additives
Civati Francesco, Svoboda Vaclav, Urwin Stephanie Jane, McArdle Patrick, Erxleben Andrea, Croker D, Ter Horst Joop
Crystal Growth and Design (2020)
https://doi.org/10.1021/acs.cgd.0c01195

More publications

Professional activities

Crystallization in Complex Multicomponent Systems
Speaker
5/6/2019
University of Rouen
Visiting researcher
3/6/2019
CORE Workshop
Participant
20/5/2019
Amecrys network meeting & review meeting
Participant
7/5/2019
External Examiner for the PhD student Marcelo Henriques da Silva in the group of Marcel Ottens at the TU Delft
Examiner
15/4/2019
Crystallization in Complex Multicomponent Systems
Speaker
11/4/2019

More professional activities

Projects

Doctoral Training Partnership 2020-2021 University of Strathclyde | Chambers, Greg
Ter Horst, Joop (Principal Investigator) Perrie, Yvonne (Co-investigator) Chambers, Greg (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
to develop a workflow for the rapid measurement of phase diagrams for multicomponent systems student placement Olayinka Olalere
Ter Horst, Joop (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin
Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 30-Jan-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 31-Jan-2023
Scale-Up and Continuos Viedma Ripening
Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator)
Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.
07-Jan-2016 - 12-Jan-2017

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences

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