Professor Joop Ter Horst

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners. 

Publications

Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring
Forbes Neil, Hussain Maryam T, Briuglia Maria L, Edwards Darren P, ter Horst Joop H, Szita Nicolas, Perrie Yvonne
International Journal of Pharmaceutics Vol 556, pp. 68-81 (2019)
https://doi.org/10.1016/j.ijpharm.2018.11.060
Measuring secondary nucleation through single crystal seeding
Briuglia Maria L, Sefcik Jan, Horst Joop H ter
Crystal Growth and Design Vol 19, pp. 421-429 (2019)
https://doi.org/10.1021/acs.cgd.8b01515
Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisation
Brown Cameron J, McGlone Thomas, Yerdelen Stephanie, Srirambhatla Vijay, Mabbott Fraser, Gurung Rajesh, Briuglia Maria L, Ahmed Bilal, Polyzois Hector, McGinty John, Perciballi Francesca, Fysikopoulos Dimitris, Macfhionnghaile Pól, Siddique Humera, Raval Vishal, Harrington Tomás S, Vassileiou Antony, Robertson Murray, Prasad Elke, Johnston Andrea, Johnston Blair, Nordon Alison, Srai Jagjit, Halbert Gavin, Ter Horst Joop H, Price Chris J, Rielly Chris D, Sefcik Jan, Florence Alastair J
Molecular Systems Design & Engineering Vol 2018, pp. 518-549 (2018)
https://doi.org/10.1039/C7ME00096K
Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisations
Brown Cameron J, McGlone Thomas, Yerdelen Stephanie, Srirambhatla Vijay, Mabbott Fraser, Gurung Rajesh, Briuglia Maria L, Ahmed Bilal, Polyzois Hector, Mcginty John, Perciballi Francesca, Fysikopoulos Dimitris, Macfhionnghaile Pól, Siddique Humera, Raval Vishal, Harrington Tomás S, Vassileiou Antony D, Robertson Murray, Prasad Elke, Johnston Andrea, Johnston Blair, Nordon Alison, Srai Jagjit S, Halbert Gavin, ter Horst Joop H, Price Chris J, Rielly Chris D, Sefcik Jan, Florence Alastair J
Molecular Systems Design and Engineering Vol 3, pp. 518-549 (2018)
https://doi.org/10.1039/c7me00096k
Scaling up temperature cycling-induced deracemization by suppressing nonstereoselective processes
Steendam René R E, ter Horst Joop H
Crystal Growth and Design Vol 18, pp. 3008-3015 (2018)
https://doi.org/10.1021/acs.cgd.8b00121
Particle breakage kinetics and mechanisms in attrition-enhanced deracemization
Xiouras Christos, Fytopoulos Antonios A, Ter Horst Joop H, Boudouvis Andreas G, Van Gerven Tom, Stefanidis Georgios D
Crystal Growth and Design Vol 18, pp. 3051-3061 (2018)
https://doi.org/10.1021/acs.cgd.8b00201

more publications

Professional activities

Crystal Nucleation in Complex Multicomponent Solutions
Speaker
12/9/2017
Tutorial Industrial Crystallization Fundamentals
Speaker
3/9/2017
biwic 2017
Participant
29/8/2017
External Examiner for the PhD student Sharlinda Salim Sachithananthan in the Group of Prof. Sven Schroeder, Leeds University
Examiner
23/8/2017
Giulio Valenti
Host
21/8/2017
Lina Harfouche
Host
21/8/2017

more professional activities

Projects

to develop a workflow for the rapid measurement of phase diagrams for multicomponent systems student placement Olayinka Olalere
Ter Horst, Joop (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin
Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 30-Jan-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 31-Jan-2023
Scale-Up and Continuos Viedma Ripening
Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator)
Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.
07-Jan-2016 - 12-Jan-2017
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Moreno Leon, Carlos
Ter Horst, Joop (Principal Investigator) Roy, Sudipta (Co-investigator) Moreno Leon, Carlos (Research Co-investigator)
01-Jan-2016 - 01-Jan-2020

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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