Professor Joop Ter Horst

Visiting Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Joop ter Horst leads an application driven fundamental research group that will facilitate the paradigm shift to continuous manufacturing in the pharmaceutical industry. The group will identify routes to exploit the fundamental principles relating molecule, crystal structure and crystallization process phenomena to the crystal product quality to come to hybrid separation technologies to be incorporated in the continuous pharmaceutical manufacturing chain. He adopts a view from the molecular level and up for gaining fundamental understanding to use in control and prediction of new industrial crystallization processes. He cooperates with many university groups inside and outside the UK and his research benefits many industrial partners. 


Machine learning derived correlations for scale-up and technology transfer of primary nucleation kinetics
Yerdelen Stephanie, Yang Yihui, Quon Justin L, Papageorgiou Charles D, Mitchell Chris, Houson Ian, Sefcik Jan, ter Horst Joop H, Florence Alastair J, Brown Cameron J
Crystal Growth and Design (2023)
Multicomponent chiral quantification with UV circular dichroism spectroscopy : ternary and quaternary phase diagrams of Levetiracetam
Charpentier Maxime D, Venkatramanan Raghunath, Rougeot Céline, Leyssens Tom, Johnston Karen, ter Horst Joop H
Molecular Pharmaceutics, pp. 1-14 (2022)
Solubility analysis of 18 active pharmaceutical ingredients and intermediates in the non-polar solvents dioxane, toluene and cyclopentyl methyl ether
Moreno-Leon Carlos, Mack Corin, Roy Sudipta, ter Horst Joop H
Journal of Molecular Liquids Vol 367 (2022)
Comparing and quantifying the efficiency of cocrystal screening methods for Praziquantel
Charpentier Maxime D, Devogelaer Jan-Joris, Tijink Arnoud, Meekes Hugo, Tinnemans Paul, Vlieg Elias, de Gelder René, Johnston Karen, ter Horst Joop H
Crystal Growth and Design Vol 22, pp. 5511-5525 (2022)
Manufacture of tablets with structurally-controlled drug release using rapid tooling injection moulding
Walsh Erin, Maclean Natalie, Turner Alice, Alsuleman Moulham, Prasad Elke, Halbert Gavin, ter Horst Joop H, Markl Daniel
International Journal of Pharmaceutics Vol 624 (2022)
Phase diagram determination and process development for continuous antisolvent crystallizations
Mack Corin, Hoffmann Johannes, Sefcik Jan, ter Horst Joop H
Crystals Vol 12 (2022)

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Professional activities

Crystallization in Complex Multicomponent Systems
University of Rouen
Visiting researcher
CORE Workshop
Amecrys network meeting & review meeting
External Examiner for the PhD student Marcelo Henriques da Silva in the group of Marcel Ottens at the TU Delft
Crystallization in Complex Multicomponent Systems

More professional activities


Doctoral Training Partnership 2020-2021 University of Strathclyde | Chambers, Greg
Perrie, Yvonne (Principal Investigator) Ter Horst, Joop (Principal Investigator) Oswald, Iain (Co-investigator) Chambers, Greg (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
to develop a workflow for the rapid measurement of phase diagrams for multicomponent systems student placement Olayinka Olalere
Ter Horst, Joop (Principal Investigator)
01-Jan-2018 - 31-Jan-2019
Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Walsh, Erin
Markl, Daniel (Principal Investigator) Ter Horst, Joop (Co-investigator) Walsh, Erin (Research Co-investigator)
01-Jan-2018 - 02-Jan-2021
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 30-Jan-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
01-Jan-2017 - 31-Jan-2023
Scale-Up and Continuos Viedma Ripening
Steendam, Rienk (Co-investigator) ter Keurst, Marc (Research Co-investigator) Ter Horst, Joop (Principal Investigator)
Viedma ripening involves the transformation of a racemic mixture of chiral crystals into one chiral form. Attempts were made to scale-up this process but failed. In this project the reason for the failed scale-up attempts will be investigated. Scale-up and continuous Viedma ripening will be attempted in a different manner using different setups, compounds and different crystal size distributions.
07-Jan-2016 - 12-Jan-2017

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Strathclyde Institute of Pharmacy and Biomedical Sciences

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