Dr Lian Tian

Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Lian obtained his PhD in Mechanical Engineering from the University of Colorado at Boulder in 2010. He then took his first postdoctoral training in Biomedical Engineering at the University of Wisconsin-Madison in USA and his second postdoctoral training in biology at Queen's University in Canada. He Joined SIPBS in 2020. His research interest is cardiovascular physiology, biomechanics and biology, particularly in pulmonary hypertension. His group has recently focused on right ventricular fibrosis and function in pulmonary hypertension.

Prizes and awards

Outstanding Oral Presentation at Canadian Hypertension Congress
Recipient
2019
Canadian Vascular Network trainee Travel Award for the Young Investigator Forum at Canadian Hypertension Congress
Recipient
2019
Queen’s University Post-Doctoral Travel Award
Recipient
2018
ATS the Assembly on Pulmonary Circulation (PC) Abstract Scholarship
Recipient
2018
Queen’s University Post-Doctoral Travel Award
Recipient
2016
AHA 3CPR Junior Investigator Travel Stipend
Recipient
2016

More prizes and awards

Publications

PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension
Dasgupta Asish, Chen Kuang-Hueih, Lima Patricia DA, Mewburn Jeffrey, Wu Danchen, Al-Qazazi Ruaa, Jones Oliver, Tian Lian, Potus Francois, Bonnet Sebastien, Archer Stephen L
FASEB Journal Vol 35 (2021)
https://doi.org/10.1096/fj.202100361R
Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer
Wu Danchen, Dasgupta Asish, Read Austin D, Bentley Rachel ET, Motamed Mehras, Chen Kuang-Hueih, Al-Qazazi Ruaa, Mewburn Jeffrey D, Dunham-Snary Kimberly J, Alizadeh Elahe, Tian Lian, Archer Stephen L
Free Radical Biology and Medicine Vol 170, pp. 150-178 (2021)
https://doi.org/10.1016/j.freeradbiomed.2020.12.452
Excess protein O-GlcNAcylation links metabolic derangements to right ventricular dysfunction in pulmonary arterial hypertension
Prisco Sasha Z, Rose Lauren, Potus Francois, Tian Lian, Wu Danchen, Hartweck Lynn, Al-Qazazi Ruaa, Neuber-Hess Monica, Eklund Megan, Hsu Steven, Thenappan Thenappan, Archer Stephen L, Prins Kurt W
International Journal of Molecular Sciences Vol 21 (2020)
https://doi.org/10.3390/ijms21197278
Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion
Tian Lian, Xiong Ping Yu, Alizadeh Elahe, Lima Patricia D A, Potus François, Mewburn Jeffrey, Martin Ashley, Chen Kuang-Hueih, Archer Stephen L
Acta Physiologica Vol 229 (2020)
https://doi.org/10.1111/apha.13483
Novel mutations and decreased expression of the epigenetic regulator TET2 in pulmonary arterial hypertension
Potus François, Pauciulo Michael W, Cook Elina K, Zhu Na, Hsieh Alexander, Welch Carrie L, Shen Yufeng, Tian Lian, Lima Patricia, Mewburn Jeffrey, D’Arsigny Christine L, Lutz Katie A, Coleman Anna W, Damico Rachel, Snetsinger Brooke, Martin Ashley Y, Hassoun Paul M, Nichols William C, Chung Wendy K, Rauh Michael J, Archer Stephen L
Circulation Vol 141, pp. 1986-2000 (2020)
https://doi.org/10.1161/CIRCULATIONAHA.119.044320
Epigenetic metabolic reprogramming of right ventricular fibroblasts in pulmonary arterial hypertension : a pyruvate dehydrogenase kinase-dependent shift in mitochondrial metabolism promotes right ventricular fibrosis
Tian Lian, Wu Danchen, Dasgupta Asish, Chen Kuang-Hueih, Mewburn Jeffrey, Potus Francois, Lima Patricia DA, Hong Zhigang, Zhao Yuan-Yuan, Hindmarch Charles CT, Kutty Shelby, Provencher Steeve, Bonnet Sebastien, Sutendra Gopinath, Archer Stephen L
Circulation Research Vol 126, pp. 1723-1745 (2020)
https://doi.org/10.1161/CIRCRESAHA.120.316443

More publications

Research interests

Cardiovascular physiology, biomechanics, biology and modeling in pulmonary hypertension

Professional activities

Frontiers in Cell and Developmental Biology (Journal)
Guest editor
8/7/2021
Targeting right ventricular ischemia, fibrosis and diastolic dysfunction in pulmonary arterial hypertension
Speaker
11/2/2021
Frontiers Research Topic (Journal)
Guest editor
20/4/2020
Scottish Cardiovascular Forum 2020
Speaker
1/2/2020
American Heart Association (AHA) Scientific Sessions
Speaker
16/11/2019
Canadian Hypertension Congress
Speaker
25/9/2019

More professional activities

Projects

Sex-dependent mitochondrial function in right ventricle in pulmonary arterial hypertension
Tian, Lian (Principal Investigator)
01-Jan-2021 - 31-Jan-2021
GEF ISP Lian Tan TU Graz Feb21
Tian, Lian (Principal Investigator)
24-Jan-2021 - 23-Jan-2022
Doctoral Training Partnership 2020-2021 University of Strathclyde | Coyle, Chelbi
Bushell, Trevor (Principal Investigator) Plevin, Robin (Principal Investigator) Tian, Lian (Principal Investigator) MacLean, Mandy (Co-investigator) Coyle, Chelbi (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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