
Dr Martin Wiese
John Anderson Research Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Area of Expertise
- signal transduction
- protein kinases
- Leishmania cell biology
- recombinant protein production
- protein biochemistry
Publications
Research Interests
My research focuses on Leishmania protein kinases as potential drug targets and as important regulators for flagellum maintenance. Leishmania is a protozoan parasite that can cause death in infected humans and animals. Protein kinases have been shown to be essential for survival of this parasite in the infected host. Hence, specific inhibitors for parasite protein kinases have the potential to be ideal drugs to treat leishmaniasis. On the other hand Leishmania has a single flagellum containing structures conserved in all organisms forming cilia or flagella including humans. Understanding how flagellum formation and maintenance is regulated in Leishmania will help to understand and cure human disorders affecting the function of cilia and flagella. I am using phosphoproteomics, molecular parasitology and protein biochemistry to identify relevant protein kinases, their activators and substrates. This will allow me to develop enzyme assays to screen for inhibitors of the target protein kinases, which can be developed into useful medicines.
Professional Activities
Projects
Contact
Dr
Martin
Wiese
John Anderson Research Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: martin.wiese@strath.ac.uk
Tel: 548 2678