Dr Martin Wiese

John Anderson Research Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

I joined the University in 2007 and I’m currently a John Anderson Research Senior Lecturer in Molecular Parasitology and Biochemistry. I mainly teach Biochemistry to undergraduate and postgraduate students. I am involving students in current research projects to provide them with state-of-the-art methods and technologies. This allows them to make an informed decision on their future careers and provides them with appropriate background knowledge to aid them in their personal development. In my research I am investigating Leishmania protein kinases as potential drug targets to cure leishmaniasis and as crucial regulators in flagellum formation and maintenance.
As the Group Leader of the Infection, Immunity and Microbiology Research Group from 2011-2014 I was involved in the general organisation of SIPBS.

Expertise

Has expertise in:

    • signal transduction
    • protein kinases
    • Leishmania cell biology
    • recombinant protein production
    • protein biochemistry

Publications

An arginine deprivation response pathway is induced in Leishmania during macrophage invasion
Goldman-Pinkovich Adele, Balno Caitlin, Strasser Rona, Zeituni-Molad Michal, Bendelak Keren, Rentsch Doris, Ephros Moshe, Wiese Martin, Jardim Armando, Myler Peter J, Zilberstein Dan
PLOS Pathogens Vol 12, (2016)
http://dx.doi.org/10.1371/journal.ppat.1005494
Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability
Cayla Mathieu, Rachidi Najma, Leclercq Olivier, Schmidt-Arras Dirk, Rosenqvist Heidi, Wiese Martin, Späth Gerald F
PLOS Pathogens Vol 10, (2014)
http://dx.doi.org/10.1371/journal.ppat.1004347
The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status
Yau Wai-Lok, Pescher Pascale, MacDonald Andrea, Hem Sonia, Zander Dorothea, Retzlaff Silke, Blisnick Thierry, Rotureau Brice, Rosenqvist Heidi, Wiese Martin, Bastin Philippe, Clos Joachim, Späth Gerald
Molecular Microbiology Vol 93, pp. 80–97, (2014)
http://dx.doi.org/10.1111/mmi.12639
Modulation of Leishmania major aquaglyceroporin activity by a mitogen-activated protein kinase
Mandal Goutam, Sharma Mansi, Kruse Martin, Sander-Juelch Claudia, Munro Laura A, Wang Yong, Vilg Jenny Veide, Tamás Markus J, Bhattacharjee Hiranmoy, Wiese Martin, Mukhopadhyay Rita
Molecular Microbiology Vol 85, pp. 1204–1218, (2012)
http://dx.doi.org/10.1111/j.1365-2958.2012.08169.x
The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection
Alsaadi Manal, Italia Jagdishbhai Laxmanbhai, Mullen Alexander, Kumar M.N.V Ravi, Candlish A.A., Williams Roderick, Shaw C.D., Al-Gawhari Fatima, Coombs Graham, Wiese Martin, Thomson Alison, Puig-Sellart M., Wallace J., Sharp A, Wheeler Lee, Warn Peter, Carter Katharine
Journal of Controlled Release Vol 160, pp. 685-691, (2012)
http://dx.doi.org/10.1016/j.jconrel.2012.04.004
LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5
von Freyend Simona John, Rosenqvist Heidi, Fink Annette, Melzer Inga Maria, Clos Joachim, Jensen Ole Nørregaard, Wiese Martin
International Journal for Parasitology Vol 40, pp. 969-978, (2010)
http://dx.doi.org/10.1016/j.ijpara.2010.02.004

more publications

Research interests

My research focuses on Leishmania protein kinases as potential drug targets and as important regulators for flagellum maintenance. Leishmania is a protozoan parasite that can cause death in infected humans and animals. Protein kinases have been shown to be essential for survival of this parasite in the infected host. Hence, specific inhibitors for parasite protein kinases have the potential to be ideal drugs to treat leishmaniasis. On the other hand Leishmania has a single flagellum containing structures conserved in all organisms forming cilia or flagella including humans. Understanding how flagellum formation and maintenance is regulated in Leishmania will help to understand and cure human disorders affecting the function of cilia and flagella. I am using phosphoproteomics, molecular parasitology and protein biochemistry to identify relevant protein kinases, their activators and substrates. This will allow me to develop enzyme assays to screen for inhibitors of the target protein kinases, which can be developed into useful medicines.

Professional activities

4th conference on protein kinases of parasitic protozoa: targeting signaling pathways in parasites
Invited speaker
22/3/2015
Kinetoplastid Molecular Cell Biology Meeting III, April 2009, Woods Hole, MA, USA
Speaker
4/2009

more professional activities

Projects

BB/J013854/1 BBSRC DPT Studentships (with Glasgow University) | Hargrave, Kerrie
Roberts, Craig (Principal Investigator) Wiese, Martin (Co-investigator) Hargrave, Kerrie (Research Co-investigator)
Period 01-Oct-2014 - 01-Oct-2018
Transfer of Martin Wiese' grants
Wiese, Martin (Principal Investigator)
Period 01-Aug-2007 - 30-Jun-2011

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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