Postgraduate research & PhD opportunities

Pure & Applied Chemistry

Take a look at our postgraduate research and PhD opportunities we have on offer at the University of Strathclyde.

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Accelerating the clinical introduction of novel antibiotic combinations effective against Gram-negative pathogens


Opens:6 January 2020

You will work under the supervision of Dr Fraser J. Scott to investigate Strathclyde Minor Groove Binders in combination with existing antibiotics. Experimental work will involve in vitro susceptibility testing, toxicity testing, and mechanism of action studies on clinical isolates.

Fee status

Subject

Chemistry, Pharmacy and biomedical sciences

Mode of Study

Full Time, Part Time

Funding

Determination and behaviour of microplastics in terrestrial systems


Opens:2 March 2020

This PhD involves the development of analytical methods and their application to investigate the behaviour of microplastic pollutants in the environment. Laboratory and field studies will be used to assess the ability of microplastics to transport potentially toxic elements in terrestrial systems.

Fee status

Home (Scottish), EU, Rest of UK, International, The Channels Islands and Isle of Man

Subject

Chemistry

Mode of Study

Full Time

Funding

Second generation nano-carriers for pancreatic cancer therapy


Deadline:31 March 2021 Opens:31 March 2020

In this project we would like to use established chemistry from our proof of concept studies in order to form a range of second generation particles exploiting combined therapies of laser released anticancer drugs for pancreatic cancer treatment.

Fee status

Home (Scottish), EU, Rest of UK, International, The Channels Islands and Isle of Man

Subject

Chemistry, Pharmacy and biomedical sciences

Mode of Study

Full Time

Funding

Understanding How Cancer Cells Respond to Treatment Using Raman Spectroscopy


Opens:1 April 2020

This project will investigate Raman scattering and its variations (surface enhanced (SERS) and stimulated (SRS)) to assess cancer cells and tissue prior to and following treatment with conventional anticancer drugs and particularly new alternative drugs that have shown promise as anticancer agents.

Fee status

Home (Scottish), EU, Rest of UK, International, The Channels Islands and Isle of Man

Subject

Chemistry

Mode of Study

Full Time

Funding

Biocatalytic Atom Transfer Radical Polymerizations


Opens:7 April 2020

Some enzymes catalyze atom transfer radical polymerizations (ATRP). They represent an environmentally friendly and non-toxic alternative to conventional catalysts. To unlock the potential of bioATRP, advanced polymerization techniques such as electrochemically mediated ATRP and flow chemistry will be investigated.

Fee status

Home (Scottish), EU, Rest of UK, International, The Channels Islands and Isle of Man

Subject

Chemistry

Mode of Study

Full Time

Funding

Raman probes to determine cellular redox potential


Opens:7 April 2020

The discovery of new medicines to treat disease requires the identification, understanding and validation of biological pathways and targets. This project resides in the Healthcare technologies theme, aligning with the growth area of Chemical Biology and the areas of Analytical Science and Synthetic Organic Chemistry.

Fee status

Home (Scottish), EU, Rest of UK, International, The Channels Islands and Isle of Man

Subject

Chemistry, Pharmacy and biomedical sciences

Mode of Study

Full Time

Funding

Equipment costs, Travel costs

Developing an ultrawide dynamic range analytical platform for biomarker panel analysis


Opens:1 June 2020

The aim of this project is to address the challenge of directly detecting disease biomarker panels in serum featuring target species whose relative concentrations span many orders of magnitude.

Fee status

Home (Scottish), EU, Rest of UK, International, The Channels Islands and Isle of Man

Subject

Biomedical engineering, Chemistry, Pharmacy and biomedical sciences

Mode of Study

Full Time

Funding

Postgraduate research opportunities

Second generation nano-carriers for pancreatic cancer therapy

In this project we would like to use established chemistry from our proof of concept studies in order to form a range of second generation particles exploiting combined therapies of laser released anticancer drugs for pancreatic cancer treatment.

Number of places

5

Opens

30 March 2020

Deadline

30 March 2021

Duration

3 years

Eligibility

Must have an undergraduate degree in relevant discipline and satisfy the University's minimal entry requirements for PhD study.

Project Details

Hybrid iron oxide-gold nanoparticles have been shown to have great potential as theranostic agents for cancer therapy [1,2]. The iron oxide core can be used for diagnostic imaging using MRI whilst the gold surface possesses unique optimal properties. When gold nanoparticles or nano-shells are exposed to laser irradiation, they both refract and absorb the light energy and rapidly convert it into heat. This can be exploited as a trigger for drug release.

Our group have shown that hybrid iron oxide-gold nanoparticles can be surface modified with drug molecules through thermally labile mechanisms [1,2]. In our previous work we shown that drug attachment can be reversed at elevated temperatures in order to release. Hence, this system can act as a controlled delivery system by activation (and heat stimulation) using a laser.

In this project we would like to use this established chemistry in order to form a range of second generation particles exploiting combined therapies of anticancer drugs for pancreatic cancer treatment.

 

Techniques used:

Chemical synthesis, HPLC, FTIR, ICP, photon correlation spectroscopy, transmission electron microscopy, biological testing in cancer models

 

References:

[1] Oluwasanmi A, Al-Shakarchi W, Manzur A, Aldebasi MH, Elsini RS, Albusair MK, Haxton KJ, Curtis ADM, Hoskins C. 2017. Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. J Control Release, vol. 266, 355-364. 

[2] Malekigorji M, Alfahad M, Kong Thoo Lin P, Jones S, Curtis A, Hoskins C. 2017. Thermally triggered theranostics for pancreatic cancer therapy. Nanoscale, vol. 9(34), 12735-12745.

How to apply

Please email Dr Clare Hoskins if you would like to apply for this opportunity.