Ion mobility mass spectrometry will be used to characterise an intrinsically disordered protein that is involved in cancer. Screening methods will be developed to identify small molecules that affect the behaviour of the protein, to be used as chemical probes for its validation as a suitable drug target.

You will work under the supervision of Dr Fraser J. Scott to investigate an aspect of Science Education Research. This will likely be on a topic involving the overlap of Science and Mathematics education, but the specific topic is open for discussion.

You will work under the supervision of Dr Fraser J. Scott to investigate Strathclyde Minor Groove Binders in combination with existing antibiotics. Experimental work will involve in vitro susceptibility testing, toxicity testing, and mechanism of action studies on clinical isolates.

You will work under the supervision of Dr Fraser J. Scott to develop Strathclyde Minor Groove Binders as anti-infective agents. Experimental work will include organic chemistry, but also biochemical (enzyme assays), biophysical (UV-vis, NMR) and biology (in vitro activity) aspects.

This PhD involves the development of analytical methods and their application to investigate the behaviour of microplastic pollutants in the environment. Laboratory and field studies will be used to assess the ability of microplastics to transport potentially toxic elements in terrestrial systems.

The student will investigate and quantify structure/reactivity relationships in nickel catalysis using a range of techniques including organic/organometallic synthesis, physical organic chemistry, and density functional theory, as appropriate.

Developing novel methodologies for portable detection of a variety of illicit substances including but not limited to drugs of abuse, explosives, gunshot residue and / or screening of bodily fluids at crime scenes.

Developing novel methodologies for portable, rapid, point-of-care detection of a variety of biomedically relevant markers for use in biomedical diagnostics

This project will investigate Raman scattering and its variations (surface enhanced (SERS) and stimulated (SRS)) to assess cancer cells and tissue prior to and following treatment with conventional anticancer drugs and particularly new alternative drugs that have shown promise as anticancer agents.

Some enzymes catalyze atom transfer radical polymerizations (ATRP). They represent an environmentally friendly and non-toxic alternative to conventional catalysts. To unlock the potential of bioATRP, advanced polymerization techniques such as electrochemically mediated ATRP and flow chemistry will be investigated.

The discovery of new medicines to treat disease requires the identification, understanding and validation of biological pathways and targets. This project resides in the Healthcare technologies theme, aligning with the growth area of Chemical Biology and the areas of Analytical Science and Synthetic Organic Chemistry.

The aim of this project is to address the challenge of directly detecting disease biomarker panels in serum featuring target species whose relative concentrations span many orders of magnitude.

The design, synthesis and evaluation of small molecules to understand the function and disease states of lysosomes.

Cancer nanomedicine is dominating modern healthcare. This project is an opportunity to contribute to the development of intelligent nanomedicines for targeted triggered release of pharmaceuticals in pancreatic cancer.

Design and application of new conjugated polymer photocatalysts for light-driven conversion of carbon dioxide into useful chemical intermediates.

You will work under the supervision of Dr Fraser J. Scott to develop Strathclyde Minor Groove Binders as novel anti-infective agents. Experimental work may include organic chemistry, biochemistry (enzyme assays), biophysisl (UV-vis, NMR) and microbiology (in vitro activity).

The prospective student will work with Dr Fraser Scott to develop new treatments for leishmaniasis using the novel class of anti-infective agents, Strathclyde Minor Groove Binders. This will involve a combination of synthetic chemistry, biophysical measurements and biological evaluation.

This project will explore the area of protein degradation through the application of proteolysis targeting chimeras (PROTACs) for central nervous system (CNS) and lung targeted therapies. Structural and physicochemical properties of potential PROTAC molecules will be assessed through synthesis and computational design.

This PhD project will investigate the chemical interactions between microplastics, soil/sediment, and potentially toxic elements (PTE) through laboratory and field experiments. It will involve aspects of analytical, physical and environmental chemistry.