Professor Glenn Burley

Pure and Applied Chemistry

Personal statement

Glenn A. Burley (GAB) is Professor of Chemical Biology at the University of Strathclyde. The main focus of GAB’s research programme is the development of molecular probes to further our understanding of processes involved in gene expression. GAB was awarded a Bachelor of Medicinal Chemistry (Hon. I) and a PhD in Organic Chemistry from the University of Wollongong, Australia. GAB was a post-doctoral fellow in the Fullerene Science Centre at the University of Sussex (2001-2003) and an Alexander von Humboldt Fellow at the University of Munich (2004-2006). GAB began his independent career as an EPSRC Advanced Fellow in 2007 at the University of Leicester, before moving to Strathclyde in 2011.

Publications

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Publications

The great escape : defining the molecular basis of cellular uptake and endosomal escape of ADCs: Graham Harriet, McWhinnie Fergus, Burley Glenn, Rattray Zahra; RSC Protein and Peptide Science Group (PPSG) 2025 Early Stage Researcher Meeting (2025)
Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers: Armstrong Georgina B, Graham Harriet, Cheung Anthony, Montaseri Hanieh, Burley Glenn A, Karagiannis Sophia N, Rattray Zahra; Advanced Drug Delivery Reviews (2025); https://doi.org/10.1016/j.addr.2025.115648
Chemoselective difluoromethylation of nucleosides: Linden Otto, Axer Alexander, Taladriz-Sender Andrea, Burley Glenn A; Organic Letters Vol 27, pp. 6906-6910 (2025); https://doi.org/10.1021/acs.orglett.5c02204
Preparation of nucleoside analogues : opportunities for innovation at the interface of synthetic chemistry and biocatalysis: Salihovic Admir, Taladriz-Sender Andrea, Burley Glenn A; Chemical Science Vol 16, pp. 11700-11710 (2025); https://doi.org/10.1039/D5SC03026A
Expanding the reaction toolbox for nanoscale direct-to-biology PROTAC synthesis and biological evaluation: Stevens Rebecca, Shrives Harry J, Cryan Jenni, Klimaszewska Diana, Stacey Peter, Burley Glenn A, Harling John D, Battersby David J, Miah Afjal H; RSC Medicinal Chemistry Vol 16, pp. 1141-1150 (2025); https://doi.org/10.1039/D4MD00760C
Quantifying antibody binding : techniques and therapeutic implications: Lodge James, Kajtar Lewis, Duxbury Rachel, Hall David, Burley Glenn A, Cordy Joanna, Yates James WT, Rattray Zahra; mAbs Vol 17 (2025); https://doi.org/10.1080/19420862.2025.2459795

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Research

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Research Interests

The Burley group (www.burleylabs.co.uk) applies a problem-based ethos that utilizes synthetic organic chemistry, biocatalysisand physical organic chemistry to explore regulatory mechanisms of transcription and RNA processing. A second research area of interest is the development of bio-orthogonal chemistries to prepare bioconjugates for cell selective drug delivery.