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Dr Hilary Carswell

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

I am a Senior Research Lecturer in in vivo Biology with particular interests in brain damage and repair. I registered as a Pharmacist in 1992 and obtained my PhD in 1996 at University of Glasgow during which I developed a deep interest in brain damage. I pursued my academic career in stroke research as a postdoctoral researcher and latterly a research fellow at the Wellcome Surgical Institute, University of Glasgow before joining SIPBS in 2007.

My research focuses on understanding mechanisms of brain damage and repair using two strategies namely inflammation and stem cells. I have particular interest in in vivo models of brain damage and current research programmes include understanding how to promote success of stem cells in vivo and the roles of inflammatory cells such as mast cells in stroke. We maintain strong national and international collaborative links with stroke clinicians and researchers, immunologists and Biotech and Pharmaceutical Industry.  

I aim to generate student engagement and research aspirations in Pharmacy and Biomedical Science students and to promote opportunities in science in interdisciplinary areas. 

Publications

In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain application
Osama I., Gorenkova N., McKittrick C.M., Wongpinyochit T., Goudie A., Seib F.P., Carswell H.V.O.
Scientific Reports Vol 8, (2018)
http://dx.doi.org/10.1038/s41598-018-31905-5
Detrimental effects of 2-arachidonoylglycerol on whole blood platelet aggregation and on cerebral blood flow after a focal ischemic insult in rats
Shearer Jennifer A., Coker Susan J., Carswell Hilary V. O.
American Journal of Physiology - Heart and Circulatory Physiology Vol 314, pp. 967-977, (2018)
http://dx.doi.org/10.1152/ajpheart.00299.2017
Placenta-derived cells for acute brain injury
Pischiutta Francesca , Sammali Eliana , Parolini Ornella , Carswell Hilary V. O., Zanier Elisa R.
Cell Transplantation Vol 27, pp. 151-167, (2018)
http://dx.doi.org/10.1177/0963689717732992
The IMPROVE guidelines (ischaemia models: procedural refinements of in vivo experiments)
Percie du Sert Nathalie, Alfieri Alessio, Allan Stuart M, Carswell Hilary VO, Deuchar Graeme A, Farr Tracy D , Flecknell Paul, Gallagher Lindsay, Gibson Claire L, Haley Michael J , Macleod Malcolm R , McColl Barry W , McCabe Christopher , Morancho Anna , Moon Lawrence DF, O’Neill Michael J , Pérez de Puig Isabel , Planas Anna , Ragan C Ian , Rosell Anna , Roy Lisa A , Ryder Kathryn O , Simats Alba , Sena Emily S , Sutherland Brad A , Tricklebank Mark D , Trueman Rebecca C , Whitfield Lucy , Wong Raymond , Macrae I Mhairi
Journal of Cerebral Blood Flow and Metabolism, pp. 1-30, (2017)
http://dx.doi.org/10.1177/0271678X17709185
Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia
McKittrick Craig M., Lawrence Catherine E., Carswell Hilary V.O.
Journal of Cerebral Blood Flow and Metabolism Vol 35, pp. 638-647, (2015)
http://dx.doi.org/10.1038/jcbfm.2014.239
Watermaze performance after middle cerebral artery occlusion in the rat : the role of sensorimotor versus memory impairments
Bingham Deborah, Martin Stephen J, Macrae I Mhairi, Carswell Hilary V O
Journal of Cerebral Blood Flow and Metabolism Vol 32, pp. 989-999, (2012)
http://dx.doi.org/10.1038/jcbfm.2012.16

more publications

Projects

Impact Acceleration Account - University Of Strathclyde 2012 / R120526-231
Carswell, Hilary (Principal Investigator)
Period 01-Oct-2012 - 31-Mar-2017
BB/J013854/1 BBSRC DPT Studentships (with Glasgow University) | White, Samantha
Carswell, Hilary (Principal Investigator) Plevin, Robin (Co-investigator) White, Samantha (Research Co-investigator)
Period 01-Oct-2013 - 20-Apr-2018
Pharmacells contribution to IAA Secondment
Carswell, Hilary (Principal Investigator) Pickard, Benjamin (Co-investigator)
Period 25-Jun-2016 - 31-Mar-2017
BBSRC Doctoral Training Grant (DTG) | White, Samantha
Carswell, Hilary (Principal Investigator) Plevin, Robin (Co-investigator) White, Samantha (Research Co-investigator)
Period 01-Oct-2013 - 20-Apr-2018
Development of starting materials for cell-based treatments (project plan for SMART grant)
Carswell, Hilary (Principal Investigator) Carter, Katharine (Co-investigator) Currie, Susan (Co-investigator) Pickard, Benjamin (Co-investigator)
Period 01-Apr-2015 - 31-Mar-2016
KTA - Visualising stell cell migration in the brain in vivo
Carswell, Hilary (Principal Investigator)
Stem cell therapy holds great promise for improving and speeding up recovery after stroke. A UK Biotechnology Company is currently performing a ground-breaking first-in-man clinical trial to evaluate genetically engineered neural stem cells in stroke patients namely the PISCES study (Pilot Investigation of Stem Cells in Stroke). Following success so far in the phase 1 trial on safety, additional pre-clinical work is needed for the clinical development strategy with a view to commencing a Phase II efficacy study in 2013. The success of these stem cells in improving stroke outcome will have a massive impact on society and economy not just in the UK but world-wide.
Period 01-Apr-2012 - 14-Sep-2012

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing John Arbuthnott Building

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