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Dr Susan Chalmers

Strathclyde Chancellor'S Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

I am a Chancellors Research Fellow, examining the role of mitochondria in neurodegeneration and age-associated decline of the cerebrovasculature.

 

Publications

Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle : Smooth muscle mitochondrial shape and motility changes with age
Chalmers Susan, Saunter Christopher, Girkin John M., McCarron John G.
Journal of Physiology Vol 594, pp. 4283–4295, (2016)
http://dx.doi.org/10.1113/JP271942
Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle
McCarron John G., Chalmers Susan, Wilson Calum, Sandison Mairi E.
Vascular Ion Channels in Physiology and DiseaseVascular Ion Channels in Physiology and Disease, (2016)
http://dx.doi.org/10.1007/978-3-319-29635-7_11
Synthesis of an azido-tagged low affinity ratiometric calcium sensor
Caldwell Stuart T., Cairns Andrew G., Olson Marnie, Chalmers Susan, Sandison Mairi, Mullen William, McCarron John G., Hartley Richard C.
Tetrahedron Vol 71, pp. 9571–9578, (2015)
http://dx.doi.org/10.1016/j.tet.2015.10.052
Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension
Chalmers Susan, Saunter Christopher D., Girkin John M., McCarron John G.
Scientific Reports Vol 5, (2015)
http://dx.doi.org/10.1038/srep16875
Direct visualisation of smooth muscle cell phenotypic plasticity and migration by long-term imaging
Sandison Mairi, Chalmers Susan, Dempster John, McCarron John
FASEB Journal Vol 28, (2014)
From structure to function : mitochondrial morphology, motion and shaping in vascular smooth muscle
McCarron J.G., Wilson C., Sandison M.E., Olson M.L., Girkin J.M., Saunter C., Chalmers S.
Journal of Vascular Research Vol 50, pp. 357-371, (2013)
http://dx.doi.org/10.1159/000353883

more publications

Teaching

PhD opportunities: currently no funded openings for PhD projects, however I am very happy to discuss potential projects and funding routes with interested students.

Research interests

My primary research interest is in mitochondria, with a particular focus on the involvement of these small organelles with calcium signalling processes and the changes associated with age and diseases. I use high-speed and timelapse fluorescence imaging to visualise and modulate mitochondria and calcium signals within live cells and tissue. I have shown that mitochondrial dynamics are uncommon in non-proliferating smooth muscle cells or intact cerebral arteries but are extensive and necessary for vascular smooth muscle proliferation, presenting a novel therapeutic opportunity for vascular disease.

Projects

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Kim, So Jeong
Chalmers, Susan (Principal Investigator) Sandison, Mairi (Co-investigator) Kim, So Jeong (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2019
Targeting mitochondria to protect the brain: visualising the influence of diet and exercise in brain slice models of neurodegeneration
Chalmers, Susan (Principal Investigator)
Period 01-Jun-2016 - 31-May-2017
The influence of exercise on age-associated alterations in neuronal, astrocytic and cerebrovascular calcium signalling and mitochondrial physiology
Chalmers, Susan (Principal Investigator)
Period 01-Oct-2015 - 30-Sep-2016
A neuroprotective diet? Imaging diet-induced mitochondrial and cellular perturbations in brain slice neurovascular junctions
Chalmers, Susan (Principal Investigator)
Period 04-Jan-2016 - 03-Jan-2017
Imaging changes in mitochondrial architecture and mobility in vascular disease
McCarron, John (Principal Investigator) Chalmers, Susan (Co-investigator) Coats, Paul (Co-investigator)
Period 06-Feb-2012 - 30-Jul-2015

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
John Arbuthnott Building Robertson Wing

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