The burden of central nervous system (CNS) disorders, especially with an increasingly aged population, is one of the key global health challenges of our time. To address these challenges, advances in our understanding of disease aetiology and treatment development requires multidisciplinary strategies.
Our research within Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) and across the University utilises such strategies to gain new insights into how the brain and its cells operate in health, and how they become dysfunctional in disease.
Our programmes of work incorporate research from the fundamental neuroscience of cellular function and signalling through to systems neuroscience and disease models. We actively collaborate with researchers within SIPBS and across other faculties (e.g. Engineering) as well as the NHS and the pharmaceutical industry with the ultimate aim of developing new therapeutic targets and strategies for diseases including:
- Alzheimer’s disease
- cognitive and hearing disorders
- multiple sclerosis
More detail regarding our research can be found below and we're happy to hear from those who are interested in potential PhD and post-doctoral research opportunities with us. Please contact the individual group member directly.
Research group members
Dr Trevor Bushell
Reader in Neuropharmacology
Our research focusses on the link between neuroinflammation and CNS function in disorders including Alzheimer’s disease and depression, using a variety of behavioural, electrophysiological and imaging techniques.
Dr Hilary Carswell
Reader in Regenerative Neurobiology
Our research focuses on improving technology for brain repair using several strategies which include stem cells, biomaterials, tissue engineering, immunomodulation, genetic engineering and neurorehabilitation. Current projects include optimising mechanical properties of biomaterials (stiffness and nanostructure) for intracerebral injection after stroke and cross-disciplinary projects using lab-on-a-chip technologies to improve immunomodulation for brain repair with relevance to Alzheimer’s disease and stroke. Recent advances include modulation of microglia to regenerative phenotypes by conditioned media from mesenchymal stem cells.
Professor Luke Chamberlain
Our research is investigating the mechanisms and functional outcomes of protein S-acylation (aka palmitoylation) and how disruption of this post-translational modification contributes to intellectual disability, neurodegeneration and epilepsy.
Senior Research Fellow
My research previously focused on understanding the neural mechanisms involved in the rewarding properties of nicotine. Areas of interest are developing into the role of sleep in neurological disorders.
Dr Natividad Gomez-Roman
Our work aims to understand the tumour biology of brain and ovarian cancers, to help us identify novel treatments to improve patient outcomes. We pursue this by developing experimental models of disease that recapitulate the clinical environment, including three-dimensional cell culture systems using scaffolds, organoids and ex-vivo models, as well as in vivo models of disease.
Dr Sabrina Anne Jacob
My research interests are pharmacy education, mental health, pharmaceutical care, adherence, patients’ attitudes and beliefs, and healthcare access of persons with disabilities.
Dr Hui-Rong Jiang
Reader in Neuroimmunology
Our research focuses on the close communication between the immune system and the central nervous system mediated by immune molecules and cells during the development of neurological disorders, with a particular interest in multiple sclerosis and Alzheimer’s disease.
Professor Judith Pratt
Research Professor of Neuroscience
Our research focuses on how genetic and environmental risk factors for neurodevelopmental disorders such as schizophrenia and autism impact on brain networks and cognition and the development of translational imaging and behavioural models to inform drug discovery.
Professor Phil Winn
Emeritus Professor of Neuroscience
My research moved from psychology into neuroscience, exploring brain-behaviour relationships with a particular interest in structures deep in brain.
Dr Shuzo Sakata
Dr Shuzo Sakata is a systems neuroscientist. His research group is studying state-dependent and cell-type-specific neural information processing by combining in vivo electrophysiological, optogenetic, imaging, and behavioural approaches with machine learning and network modelling.