Dr Peter Childs

Strathclyde Chancellor's Fellow

Biomedical Engineering

Personal statement

I am a Chancellors Fellow within the Department of Biomedical Engineering. My research interests center on mechnicsms to control cell function/fate using mechanical stimulation and biomaterials. The goal of these investigations largely relate to regenerative medicine and tissue repair through the development of new implantable cellular and acellular biomaterials.

Since 2012 I have been involved with a multidisciplinary collaboration using nano-amplitude vibration to stimulate bone formation from adult stem cells in a process dubbed 'nanokicking'. This technology is now being translated towards clinic to produce an osteogenic cell therapy for orthopaedic repair. I have also been involved in the pre-clinical translation of implantable bioactive polymers for growth factor delivery ('HealiOst'). Previously, I was awarded a Royal Society of Edinburgh Enterprise Fellowship and have a keen interest in the clinical/commercial translation of cell engineering technologies.

Publications

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells: Hodgkinson Thomas, Monica Tsimbouri P, Llopis-Hernandez Virginia, Campsie Paul, Scurr David, Childs Peter G, Phillips David, Donnelly Sam, Wells Julia, Salmerón-Sánchez Manuel, Burgess Karl E V, Alexander Morgan, Vassalli Massimo, Oreffo Richard, Reid Stuart, France David J, Dalby Matthew J; Science Advances Vol 7 (2021); https://doi.org/10.1126/sciadv.abb7921
Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products: Childs Peter G, Reid Stuart, Salmeron-Sanchez Manuel, Dalby Matthew J; The Biochemical journal Vol 477, pp. 3349-3366 (2020); https://doi.org/10.1042/BCJ20190382
Plasma polymerised nanoscale coatings of controlled thickness for efficient solid-phase presentation of growth factors: Alba-Perez Andres, Jayawarna Vineetha, Childs Peter G, Dalby Matthew J, Salmeron-Sanchez Manuel; Materials Science and Engineering C Vol 113 (2020); https://doi.org/10.1016/j.msec.2020.110966
Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for three-dimensional bone tissue engineering: Orapiriyakul Wich, Tsimbouri Monica P, Childs Peter, Campsie Paul, Wells Julia, Fernandez-Yague Marc A, Burgess Karl, Tanner K Elizabeth, Tassieri Manlio, Meek Dominic, Vassalli Massimo, Biggs Manus J P, Salmerón-Sánchez Manuel, Oreffo Richard O C, Reid Stuart, Dalby Matthew J; ACS Nano Vol 14, pp. 10027-10044 (2020); https://doi.org/10.1021/acsnano.0c03130
Reduction of pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration: Robertson Shaun N, Childs Peter G, Akinbobola Ayorinde, Henriquez Fiona L, Ramage Gordon, Reid Stuart, Mackay William G, Williams Craig; Journal of Bioscience and Bioengineering Vol 129, pp. 379-386 (2020); https://doi.org/10.1016/j.jbiosc.2019.09.003
Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis: Campsie Paul, Childs Peter G, Robertson Shaun N, Cameron Kenny, Hough James, Salmeron-Sanchez Manuel, Tsimbouri Penelope M, Vichare Parag, Dalby Matthew J, Reid Stuart; Scientific Reports Vol 9 (2019); https://doi.org/10.1038/s41598-019-49422-4

More publications

Professional activities

Therapeutic refinement of tissue engineered cellular implants for non-union fracture repair: Speaker; 11/12/2020

More professional activities

Projects

Healikick - A Combined Atmp Strategy To Supplement Critical Sized Bone Fracture Healing: Reid, Stuart (Principal Investigator) Childs, Peter (Co-investigator); 01-Jan-2020 - 30-Jan-2025

Address

Biomedical Engineering
Graham Hills Building

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