
Dr Susan Currie
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Prize And Awards
- Fellow of the Royal Society of Biology
- Recipient
- 2024
- Fellow of the Royal Society of Biology
- Recipient
- 2024
- Teaching Excellence Award
- Recipient
- 2023
- Elected to Committee of British Society for Cardiovascular Research
- Recipient
- 2020
- Fellow of Physiology
- Recipient
- 2017
- Ambassador for British Society of Cardiovascular Research
- Recipient
- 2017
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Publications
- Cobalt increases oxidation of CaMKII in left ventricular tissue and reduces fibroblast viability and proliferation in female hearts
- Cameron Ruiz Miren, Callan Rachel, Sran Arshdeep, MacQuaide Niall, Pickard Ben, Currie Susan
- Heart Vol 111, pp. A6 (2025)
- https://doi.org/10.1136/heartjnl-2025-SCF.14
- Developing an integrated in vivo model of HFpEF in female rats: metabolic stress, cardiac dysfunction and altered excitation-contraction coupling
- Olatunji Zainab Omotola, MacKenzie Graeme, Currie Susan, MacQuaide Niall
- Heart Vol 111, pp. A6 (2025)
- https://doi.org/10.1136/heartjnl-2025-SCF.15
- From freeze to function : optimised cryopreservation and mitochondrial analysis workflow for skeletal muscle biopsies
- Wahid Maheen, Mackenzie Graeme, Rooney Liam M, Greig Justin C, McConnell Gail, Combet Emilie, Gray Stuart, Murray James T, Currie Susan, Gould Gwyn W, Cunningham Margaret R
- BMC Methods Vol 1 (2024)
- https://doi.org/10.1186/s44330-024-00017-0
- A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium
- Geiser Angéline, Currie Susan, Al-Hasani Hadi, Chadt Alexandra, McConnell Gail, Gould Gwyn W
- Journal of Cell Science Vol 137 (2024)
- https://doi.org/10.1242/jcs.262146
- Altered regulation of Ca2+ handling proteins in an in vivo rat model of Angiotensin II-induced hypertension
- Olatunji Zainab, BOSAKHAR Zainab Y H A H A, MacKenzie Graeme, Cunningham Margaret Rose, MacQuaide Niall, Currie Susan
- Medical Science Forum Vol 27 (2024)
- https://doi.org/10.3390/msf2024027003
- CaMKII augments ROS and Ca2+ entry processes in female cardiac fibroblasts in hyperglycaemic and hypertensive conditions
- Olatunji Zainab, Currie Susan, MacQuaide Niall
- Joint BAS/BSCR meeting at annual BCS conference 2024 (2024)
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Professional Activities
- 48th meeting of EWGCCE
- Participant
- 1/7/2024
- Joint BAS/BSCR meeting at annual BCS conference 2024
- Chair
- 3/6/2024
- Joint BAS/BSCR meeting at annual BCS conference 2024
- Organiser
- 3/6/2024
- Understanding mitochondrial changes in chemotherapy-induced cardiac damage
- Examiner
- 4/2024
- Preclinical cardiac safety screening: exploring and developing work-loop models to identify drug-induced changes in contractility
- Examiner
- 29/2/2024
- 27th annual meeting of the Scottish Cardiovascular Forum
- Participant
- 3/2/2024
Projects
- Investigating the cardiotoxic effects of cobalt on adult human female cardiac fibroblasts
- Currie, Susan (Principal Investigator)
- Cardiotoxicity is a leading cause of drug and device withdrawal from the market and is a major area of focus for safety screening in the pharmaceutical industry as well as in the clinic. Improved technologies for assessing cardiotoxicity using human cells that mimic the heart microenvironment are therefore needed. Within our laboratory we are investigating the impact that circulating cobalt ions (released from metal-on-metal implants in patients with hip replacements) may have on cardiac function. Previous work in our laboratory has examined the impact of cobalt in vivo in an animal model and has shown evidence for cardiac remodelling and diastolic dysfunction. The underlying cardiotoxic mechanism of action of cobalt at a cellular level remains unknown.
This Vacation project will focus on characterisation and physiological responses of human ventricular cardiac fibroblasts (CFs) to cobalt. The project will examine the effects of cobalt on CF phenotype, collagen production and proliferation in both male and female cells derived from healthy human subjects. Key aims will include investigating whether cobalt may cause (i) phenotypic switching of CFs towards a muscle-like phenotype and (ii) evidence of fibrotic, apoptotic or inflammatory signalling. The project will encompass a range of techniques including primary cell culture, imaging, immunocytochemistry and immunoblotting. Should time permit, we may also monitor changes in intracellular calcium responses following cobalt application. Awarded £2,646 - 06-Jan-2025 - 16-Jan-2025
- Investigating cobalt cardiotoxicity in contractile and non-contractile cells of the heart
- Currie, Susan (Principal Investigator) MacQuaide, Niall (Research Co-investigator)
- 08-Jan-2024 - 07-Jan-2027
- Investigating Cobalt Cardio toxicity in Contractile and non contractile cells of the heart
- Currie, Susan (Principal Investigator)
- 08-Jan-2024 - 07-Jan-2027
- Heart Damage Caused by Cancer and Anti-cancer Drugs (Vacation Scholarship)
- Cunningham, Margaret Rose (Principal Investigator) Bauer, Ralf (Co-investigator) Currie, Susan (Co-investigator)
- 27-Jan-2022 - 19-Jan-2022
- Remodelling of E-C coupling in heart failure with preserved ejection fraction (HFpEF)
- Currie, Susan (Co-investigator)
- 01-Jan-2021 - 30-Jan-2024
- Cross-examining interplay between High Mobility Group Box 1 (HMGB1) and coagulation: Defining a role for G protein-coupled receptors (GPCRs) in this complex Coag-Inflammatory nexus
- BOSAKHAR, Zainab Y H A H A (Post Grad Student) Currie, Susan (Co-investigator) Plevin, Robin (Academic) Cunningham, Margaret Rose (Principal Investigator)
- 01-Jan-2020 - 30-Jan-2023
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Contact
Dr
Susan
Currie
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: susan.currie@strath.ac.uk
Tel: 548 2405