Dr Susan Currie

Reader

Strathclyde Institute of Pharmacy and Biomedical Sciences

Contact

Personal statement

Susan Currie obtained her PhD in Biochemistry (cellular signalling and molecular pharmacology) from the University of Glasgow in 1992 then spent two years at Lilly Research Laboratories, USA, where she studied the role of phospholipase A² in mast cell activation. She returned to the University of Glasgow in 1994 to join the then newly formed Clinical Research Initiative in heart disease and became a founder member of the school of cardiovascular studies in Glasgow. During this time she progressed from postdoctoral researcher to Principal Investigator examining the role of Calcium/calmodulin protein kinase ll (CaMKll) in cardiac hypertrophy and heart failure. She moved to the University of Strathclyde in 2005 as a Lecturer in Physiology & Pharmacology and established an independent cardiovascular signalling research group with principal interests in CaMKll modulation of cardiac calcium handling and cardiac inflammation. Dr Currie is currently a Reader/Associate Professor within Strathclyde Institute of Pharmacy & Biomedical Sciences and CaMKll as a therapeutic target in cardiac disease remains a key focus of research. More recent research interests include cardiotoxicity in the context of safety pharmacology and devices as well as altered cardiovascular function in ageing.

Dr Currie is currently research group leader for the Cellular Basis of Disease research group within Strathclyde Institute of Pharmacy & Biomedical Sciences. Externally she is chair of the Scottish Cardiovascular Forum (since 2011), is on the committee for the British Society of Cardiovascular Research and is a Fellow of the Physiological Society. Fellowship was awarded in 2017 in recognition of her contribution to cardiovascular research and the discipline of Physiology. She sits on the editorial boards for a range of scientific journals and regularly reviews research funding applications for a number of research councils and charities. She currently teaches on a wide range of classes across both the MPharm and Biomedical Sciences programmes at the University of Strathclyde and coordinates classes on the MPharm programme. She was awarded Fellowship of the Higher Education Academy in 2008.

Dr Currie previously directed the collaborative MPharm programme between the University of Strathclyde and the International Medical University (IMU) in Kuala Lumpur (2012-2017), acting as MPharm representative on the internationalisation committee and was Deputy Director of the MPharm programme at the University of Strathclyde (2012-2018). She is currently Director of Equality, Diversity and Inclusion within Strathclyde Institute of Pharmacy & Biomedical Sciences.

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Publications

HMGB1 release in the cardiac niche : interplay between HMGB1 and thrombin
Bosakhar Zainab, MacKenzie Graeme, Gu Hui, Currie Susan, Cunningham Margaret
British Journal of Pharmacology Vol 180, pp. 140 (2023)
https://doi.org/10.1111/bph.16105
Effects of acute and chronic cobalt treatment on adult rat cardiomyocyte calcium handling
Olatunji Zainab O, MacMillan Sandy, Cameron-Ruiz Miren, Bosakhar Zainab Y, MacKenzie Graeme, Grant Mary H, Tate Rothwelle, MacQuaide Niall, Currie Susan
Heart Vol 109 (2023)
https://doi.org/10.1136/heartjnl-SCF-2023.18
Cardiac function is compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants
Jenkinson Mark, Meek Dominic, MacMillan Sandy, Tate Rothwelle, Grant Mary, Currie Susan
Heart Vol 109 (2023)
https://doi.org/10.1136/heartjnl-SCF-2023.11
Anti-Cancer Drug-Induced Cardiotoxicity
Currie Susan, Cunningham Margaret Rose, Cross Michael, Maddock Helen Louise
(2022)
https://doi.org/10.3389/978-2-83250-210-5
Cobalt-mediated contractile dysfunction in adult hearts and consequent effects on cardiomyocyte calcium transients
MacMillan S, Olatunji Z O, Bosakhar Z Y, MacKenzie G, Grant M H, Tate R, Macquaide N, Currie S
Acta Physiologica Vol 236, pp. 922 (2022)
https://doi.org/10.1111/apha.13877
Concentration- and time-dependent effects of cobalt in rat and human ventricular cardiac fibroblasts
MacMillan S, Olatunji Z O, Bosakhar Z Y, MacKenzie G, Grant M H, Tate R, Macquaide N, Currie S
Acta Physiologica Vol 236, pp. 614 (2022)
https://doi.org/10.1111/apha.13876

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Professional Activities

British Society for Cardiovascular research Autumn meeting 2023
Participant
2023
Research Inclusivity Event
Participant
2023
Safe Talk Suicide Awareness training
Participant
2023
Inclusive assessment training
Participant
23/11/2022
Artery conference 2022
Participant
2022
Europhysiology 2022
Participant
2022

More professional activities

Projects

Heart Damage Caused by Cancer and Anti-cancer Drugs (Vacation Scholarship)
Cunningham, Margaret Rose (Principal Investigator) Bauer, Ralf (Co-investigator) Currie, Susan (Co-investigator)
27-Jan-2022 - 19-Jan-2022
Remodelling of E-C coupling in heart failure with preserved ejection fraction (HFpEF)
Currie, Susan (Co-investigator)
01-Jan-2021 - 30-Jan-2024
Cross-examining interplay between High Mobility Group Box 1 (HMGB1) and coagulation: Defining a role for G protein-coupled receptors (GPCRs) in this complex Coag-Inflammatory nexus
BOSAKHAR, Zainab Y H A H A (Post Grad Student) Currie, Susan (Co-investigator) Plevin, Robin (Academic) Cunningham, Margaret Rose (Principal Investigator)
01-Jan-2020 - 30-Jan-2023
Doctoral Training Partnership 2020-2021 University of Strathclyde | Geiser, Angeline
Gould, Gwyn (Principal Investigator) Currie, Susan (Co-investigator) Geiser, Angeline (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Investigating connexin 43 expression in adult cardiac fibroblasts
Currie, Susan (Principal Investigator)
31-Jan-2019 - 30-Jan-2019
Investigating the biomolecular complexity of drug-induced cardiotoxicity by fingerprinting single cell and cardiac spheroid mass spectral information using Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS)
Cunningham, Margaret Rose (Principal Investigator) Veerman, Ben (Post Grad Student) Johnston, Blair (Co-investigator) Currie, Susan (Co-investigator)
The aim of this project is to significantly advance upon ongoing efforts in understanding drug-induced cardiotoxicity not only at the single cell level but in a multicellular model that may better reflect the cellular microenvironment of the heart. Extending studies to assess the metabolite changes in the multicellular environment in response to cancer therapeutics may reveal events integral to toxicity which may lead to new knowledge to develop ways to minimise or prevent cellular toxicity in the cardiac niche.
01-Jan-2019 - 28-Jan-2022

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Contact

Dr Susan Currie
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: susan.currie@strath.ac.uk
Tel: 548 2405