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Dr Robert Drummond

Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Publications

Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation
Henry Alasdair D., MacQuaide N., Burton F.L., Rankin A.C., Rowan E.G., Drummond R.M.
Cell Calcium Vol 76, pp. 36-47, (2018)
http://dx.doi.org/10.1016/j.ceca.2018.09.001
The inhibitory effect of Haloxylon salicornicum on contraction of the mouse uterus
Saleem Nabila H., Ferro Valerie A., Simpson Ann M., Igoli John, Gray Alexander I., Drummond Robert M.
Evidence-Based Complementary and Alternative Medicine Vol 2013, (2013)
http://dx.doi.org/10.1155/2013/714075
Spontaneous and electrically evoked Ca2+ transients in cardiomyocytes of the rat pulmonary vein
Logantha Sunil Jit R.J., Cruickshank Stuart F., Rowan Edward G., Drummond R.M.
Cell Calcium Vol 48, pp. 150-160, (2010)
http://dx.doi.org/10.1016/j.ceca.2010.08.002
Regulation of store-operated Ca2+ entry in pulmonary artery smooth muscle cells
McElroy S.P., Drummond R.M., Gurney A.M.
Cell Calcium Vol 46, pp. 99-106, (2009)
http://dx.doi.org/10.1016/j.ceca.2009.05.006
Pharmacological profile of store-operated Ca2+ entry in intrapulmonary artery smooth muscle cells
McElroy S.P., Gurney A.M., Drummond R.M.
European Journal of Pharmacology Vol 584, pp. 10-20, (2008)
http://dx.doi.org/10.1016/j.ejphar.2008.01.018
Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase ß in human endothelial cells
Ritchie E., Saka M., MacKenzie C., Drummond R.M., Wheeler-Jones C., Kanke T., Plevin R.J.
British Journal of Pharmacology Vol 150, pp. 1044-1054, (2007)
http://dx.doi.org/10.1038/sj.bjp.0707150

more publications

Research interests

Atrial fibrillation is the most common cardiac arrhythmia that is encountered clinically and it is associated with significant morbidity and mortality. A significant breakthrough in the understanding of atrial fibrallation occurred in the late 1990s when it was known that ectopic electrical activity that originates within the pulmonary veins is an important trigger for this type of arrhythmia. The pulmonary veins in most species are surrounded by an external sleeve of cardiomyocytes that extends from the left atrium towards the lungs. It is these cells that are considered to be responsible for generating the abnormal electrical activity that triggers atrial fibrillation, although the underlying mechanisms are unknown.

My current focus is on understanding the mechanisms whereby pulmonary vein cardiomyocytes generate spontaeneous electrical activity, and in particular the role that intracellular Ca²+ plays in this process. I am also interested in determining how electrical activity is propagated along the pulmonary vein to the atria, where it can then trigger atrial fibrillation. Since current drug treatments for atrial fibrallation are of limited efficacy, identification of potential novel therapeutic targets for future drug development is extremely important.

Professional activities

Pharmacology Research & Perspectives (Journal)
Editor
2013

more professional activities

Projects

The role of intracellular calcium in the arrhythmogenic activity of pulmonary vein cardiomyocytes
Drummond, Robert (Principal Investigator) Rowan, Edward (Co-investigator)
Period 03-Oct-2011 - 30-Sep-2014

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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