Publications

Characterisation of P2Y receptor subtypes mediating vasodilation and vasoconstriction of rat pulmonary artery using selective antagonists

Dales Markie O, Mitchell Callum, Gurney Alison M, Drummond Robert M, Kennedy Charles

Purinergic Signalling (2022)

https://doi.org/10.1007/s11302-022-09895-x

Characterisation of P2Y₂ receptors in human vascular endothelial cells using AR-C118925XX, a competitive and selective P2Y₂ antagonist

Muoboghare Markie O, Drummond Robert M, Kennedy Charles

British Journal of Pharmacology Vol 176, pp. 2894-2904 (2019)

https://doi.org/10.1111/bph.14715

Hibiscus acid from hibiscus sabdariffa (malvaceae) has a vasorelaxant effect on the rat aorta

Zheoat Ahmed M, Gray Alexander I, Igoli John O, Ferro Valerie A, Drummond Robert M

Fitoterapia Vol 134, pp. 5-13 (2019)

https://doi.org/10.1016/j.fitote.2019.01.012

Spontaneous Ca²⁺ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation

Henry Alasdair D, MacQuaide N, Burton FL, Rankin AC, Rowan EG, Drummond RM

Cell Calcium Vol 76, pp. 36-47 (2018)

https://doi.org/10.1016/j.ceca.2018.09.001

The inhibitory effect of Haloxylon salicornicum on contraction of the mouse uterus

Saleem Nabila H, Ferro Valerie A, Simpson Ann M, Igoli John, Gray Alexander I, Drummond Robert M

Evidence-Based Complementary and Alternative Medicine Vol 2013 (2013)

https://doi.org/10.1155/2013/714075

Spontaneous and electrically evoked Ca2+ transients in cardiomyocytes of the rat pulmonary vein

Logantha Sunil Jit RJ, Cruickshank Stuart F, Rowan Edward G, Drummond RM

Cell Calcium Vol 48, pp. 150-160 (2010)

https://doi.org/10.1016/j.ceca.2010.08.002

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Research interests

Atrial fibrillation is the most common cardiac arrhythmia that is encountered clinically and it is associated with significant morbidity and mortality. A significant breakthrough in the understanding of atrial fibrallation occurred in the late 1990s when it was known that ectopic electrical activity that originates within the pulmonary veins is an important trigger for this type of arrhythmia. The pulmonary veins in most species are surrounded by an external sleeve of cardiomyocytes that extends from the left atrium towards the lungs. It is these cells that are considered to be responsible for generating the abnormal electrical activity that triggers atrial fibrillation, although the underlying mechanisms are unknown.

My current focus is on understanding the mechanisms whereby pulmonary vein cardiomyocytes generate spontaeneous electrical activity, and in particular the role that intracellular Ca²+ plays in this process. I am also interested in determining how electrical activity is propagated along the pulmonary vein to the atria, where it can then trigger atrial fibrillation. Since current drug treatments for atrial fibrallation are of limited efficacy, identification of potential novel therapeutic targets for future drug development is extremely important.

Professional activities

Pharmacology Research & Perspectives (Journal)

Editor

2013

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Projects

The role of intracellular calcium in the arrhythmogenic activity of pulmonary vein cardiomyocytes

Drummond, Robert (Principal Investigator) Rowan, Edward (Co-investigator)

03-Jan-2011 - 30-Jan-2014

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

Robertson Wing

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