Dr Christine Dufès is a Reader (Associate Professor) in Nanomedicine and Director of the Postgraduate School at the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). She teaches on the Master of Pharmacy and on various MSc postgraduate degrees.
Christine obtained a Doctorate in Pharmacy (with Distinction and congratulations of the Jury, 1997) and a PhD (with a European Label, Distinction and congratulations of the Jury, 2002) from the University of Poitiers (France). After four years as a post-doctoral researcher at the Cancer Research UK Beatson Laboratories in Glasgow, she was appointed as a Lecturer at SIPBS in 2006, obtained fellowship of the Higher Education Academy in 2007, became a Senior Lecturer in 2012 and a Reader in 2019.
Her research focuses on the development of targeted drug- and gene-based nanomedicines for cancer therapy and brain delivery. It resulted in 2 patents, 47 publications in high-impact journals such as Biomaterials and Journal of Controlled Release, 4 book chapters and attracted 3200+ citations (h-index: 21 (Web of Science), 25 (Google scholar)). Christine has attracted over £2M in research funding. All her PhD students (from diverse backgrounds) submitted their theses within the imparted time and are now further developing their careers in either Academia or Industry.
Christine has been awarded the Bourse d’Excellence Lavoisier (2002), the Award of the 9th Annual Symposium of the United Kingdom and Ireland Controlled Release Society (2003), the Biochemical Journal Young Investigator Award (2009) and the Tom Gibson Memorial Award (2012) for her research. She also received the “Best Overall” Strathclyde Teaching Excellence Award (2013) for her teaching and was shortlisted in the category “Best in Faculty of Science” in 2015 and in 2018. She was the only staff member from her department to be nominated for a Strathclyde Teaching Excellence Award by the students in 2020.
She is a Trustee of the British Society of Nanomedicine, Senior Editor of Journal of Interdisciplinary Nanomedicine, Editorial Advisory Board member of Biomaterials Science, Review Editor of Frontiers in Bioengineering and Biotechnology – Nanobiotechnology, and member of the Editorial Boards of 6 journals (Journal of Liposome Research, Journal of Pharmaceutical Sciences, Journal of Nanotechnology: Nanomedicine & Nanobiotechnology, Pharmaceutical Nanotechnology, Pharmaceutics and Scientia Pharmaceutica).
Her research highlights include:
DNA-based nanomedicines (cancer therapy):
- Tumour regression/disappearance after intravenous administration of a novel tumour-targeted dendriplex encoding Tumour Necrosis Factor (TNFα), with complete disappearance of 90% of the tumours and regression of the remaining ones
- Regression/disappearance of prostate tumours after intravenous administration of a novel tumour-targeted polypropylenimine dendrimer combined with either TNFα, TRAIL and IL-12 expression plasmids, with complete disappearance of up to 70% of PC-3 tumours and up to 50% of DU145 tumours. It is the first time that gene therapy was shown to be efficacious for the treatment of prostate cancer in laboratory settings (doctoral work of Dr Majed Al Robaian and Dr Najla Altwaijry).
- Tumour regression/disappearance after intravenous administration of a novel tumour-targeted dendriplex encoding p73, with complete disappearance of 10% of the tested tumours and long-term survival of the animals. It is the first time that a tumour-targeted p73 could lead to tumour suppression after intravenous administration.
DNA-based nanomedicines (brain delivery):
- Increase of gene expression in the brain followingintravenous injection of transferrin-bearing dendriplex (at least twice higher than that of the unmodified dendriplex), while decreasing the non-specific gene expression in the lung. Gene expression was at least 3-fold higher in the brain than in any tested peripheral organs (doctoral work of Dr Sukrut Somani).
- Increase of gene expression in the brain following intravenous injection of lactoferrin-bearing dendriplex (by more than 6.4-fold compared to that of the unmodified dendriplex), while decreasing the non-specific gene expression in the lung and the kidneys. Gene expression was significantly higher in the brain than in any other tested peripheral organs. The administered gene was expressed in the hippocampus, which plays an important role in consolidating information from short-term memory into long-term memory. It is a primary site for Alzheimer's pathology, which makes gene expression in this brain area particularly interesting for future therapeutic developments (doctoral work of Dr Sukrut Somani).
Drug-based nanomedicines (cancer therapy):
- Tumour regression/disappearance after intravenous administration of the vitamin E extract tocotrienol entrapped in novel tumour-targeted vesicles, with complete disappearance of 40% of the melanoma tumours. It is the first time that a tocotrienol formulation can lead to tumour suppression (doctoral work of Dr Ju Yen Fu).
- Tumour regression/disappearance after intravenous administration of the green tea extract epigallocatechin gallate encapsulated in novel tumour-targeted vesicles, with complete disappearance of 40% of the tumours for both tested tumour types. It is the first time that a green tea extract was shown to have an anti-cancer therapeutic effect.
- Synergy between docetaxel and mebendazole (collaborative work with Professor Hing Leung (Principal Investigator), the Beatson Institute for Cancer Research). We demonstrated that mebendazole (an anthelmintic drug that inhibits microtubule assembly) potently synergises docetaxel-mediated cell kill in vitro and in vivo. Liposomes entrapping docetaxel and mebendazole suppressed in vivo prostate tumour growth and extended progression-free survival. Our data supports a new concept of combined mebendazole/docetaxel treatment that warrants further clinical evaluation.
Podcast about recent research results: http://www.youtube.com/embed/JhbIoXsAM7M