Publications

Metabolomic profiling of the immune stimulatory effect of eicosenoids on PMA-differentiated THP-1 cells

Alqarni Abdulmalik M, Dissanayake Tharushi, Nelson David J, Parkinson John A, Dufton Mark J, Ferro Valerie A, Watson David G

Vaccines Vol 7 (2019)

https://doi.org/10.3390/vaccines7040142

Effect of melittin on metabolomic profile and cytokine production in PMA-differentiated THP-1 cells

Alqarni Abdulmalik M, Ferro Valerie A, Parkinson John A, Dufton Mark J, Watson David G

Vaccines Vol 6 (2018)

https://doi.org/10.3390/vaccines6040072

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells

Alonezi Sanad, Tusiimire Jonans, Wallace Jennifer, Dufton Mark J, Parkinson John A, Young Louise C, Clements Carol J, Park Jin-Kyu, Jeon Jong-Woon, Ferro Valerie A, Watson David G

Metabolites Vol 7, pp. 1-18 (2017)

https://doi.org/10.3390/metabo7020014

Metabolomic profiling of the effects of melittin on cisplatin resistant and cisplatin sensitive ovarian cancer cells using mass spectrometry and biolog microarray technology

Alonezi Sanad, Tusiimire Jonans, Wallace Jennifer, Dufton Mark J, Parkinson John A, Young Louise C, Clements Carol J, Park Jin Kyu, Jeon Jong Woon, Ferro Valerie A, Watson David G

Metabolites Vol 6 (2016)

https://doi.org/10.3390/metabo6040035

Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co-stimulated with LPS

Tusiimire Jonans, Wallace Jennifer, Woods Nicola, Dufton Mark J, Parkinson John A, Abbott Grainne, Clements Carol J, Young Louise, Park Jin Kyu, Jeon Jong Woon, Ferro Valerie A, Watson David G

Vaccines Vol 4 (2016)

https://doi.org/10.3390/vaccines4020011

An LCMS method for the assay of melittin in cosmetic formulations containing bee venom

Tusiimire Jonans, Wallace Jennifer, Dufton Mark, Parkinson John, Clements Carol J, Young Louise, Park Jin Kyu, Jeon Jong Woon, Watson David G

Analytical and Bioanalytical Chemistry Vol 407, pp. 3627-3635 (2015)

https://doi.org/10.1007/s00216-015-8578-5

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Research Interests

• Bioinformatics. Software for topological analysis and interpretation, leading to prediction of topomorphic sites in biological macromolecules. Application to discovery of new generation of topomorphic drugs and understanding the process of natural evolution for application to protein engineering. Collaborative partners: Dept of Computer & Information Sciences (Dr John Wilson);   Dept of Pharmacy (Prof Simon Mackay).
• Snake venom chemistry, especially the supportive role of venom enzymes in enhancing the efficacy of the key toxins. Collaborative partner: Dr John Parkinson (Pure & Applied Chemistry). Venom action, as a guide for the development of protein-based drugs and strategies for enhancing the speed and efficacy of drug delivery.
• Biomolecular structures and mechanisms, and their evolutionary history.
• Role of biomolecule chain fold topology in determining directionality of structural and functional evolution.
• Drug action through site specific perturbation of chain fold topologies in proteins and nucleic acids.

Professional Activities

Strathclyde S100 Event

Speaker

26/5/2011

RSC Perkin, Dundee

Invited speaker

1/2008

Scottish Enterprise, Dundee and Glasgow

Invited speaker

1/2008

Pharmaken

Invited speaker

1/2008

More professional activities

Projects

Leveraging Assets in Human Health Towards Novel Agrochemical Leads

Jamieson, Craig (Principal Investigator) Dufton, Mark (Co-investigator) Watson, Allan (Co-investigator)

"Food security is a pressing, global issue and has been defined by the World Health Organisation as being when all people at all times have access to sufficient, safe, nutritious food to maintain a healthy and active life. One of the basic tenets of food security is in production: to ensure sufficient quantities of food are available on a sustainable basis. A significant threat to this important goal is the loss of crop yield due to the impact of pests, which can seriously compromise output. It has been posited that climate change will potentially compound this problem, with milder winters contributing to the survival of a variety of pests, such as aphids, resulting in damage to crops both earlier in the farming year and for a longer period. Allied with the pressures of a burgeoning global population, it is clear that new and effective strategies to ensure high and sustainable crop yield are now imperative to safeguard future food production activities.

Insecticidal agents have been at the vanguard of crop protection strategies for over 50 years. In particular, the advent of the neonicotinoid class of insecticides is widely regarded as a major breakthrough in crop protection science. The unique biological profile of neonicitinoids coupled with low mammalian toxicity has led to the establishment of these as high value products, accounting for around 20% of the global insecticide market, with around US$1.6 billion annual worldwide sales in 2008, escalating to US$2.1 billion by 2011. However, in common with many other extensively deployed agrochemical products, resistance is now being encountered, which poses a significant threat to continuing crop protection efforts using this highly successful class of compound.

The development of new, active, and safe insecticidal agents to replace out-dated and ineffective measures is essential for food security. The proposed research describes a novel approach to achieving this goal, ultimately leading to an unprecedented platform for insecticidal research and contributing to the integrity of the global food supply network."

15-Dec-2014 - 14-Dec-2016

Impact Acceleration Account - University Of Strathclyde 2012 / R120526-213

Dufton, Mark (Principal Investigator)

01-Oct-2012 - 31-Mar-2017

Identifying the causes and predictive potential of protein sequence covariation using SID

Dufton, Mark (Principal Investigator)

01-Oct-2005 - 30-Sep-2008

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