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Professor Alastair Florence

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.

Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.

Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.

Publications

Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries
Agimelen Okpeafoh S., Svoboda Vaclav, Ahmed Bilal, Cardona Amengual Javier, Dziewierz Jerzy, Brown Cameron J., McGlone Thomas, Cleary Alison, Tachtatzis Christos, Michie Craig, Florence Alastair J., Andonovic Ivan, Mulholland Anthony J., Sefcik Jan
Advanced Powder Technology, (2018)
http://dx.doi.org/10.1016/j.apt.2018.09.003
The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry
Cardona Javier, Ferreira Carla, Svoboda Vaclav, Ahmed Bilal, McGinty John, Agimelen Okpeafoh S., Hamilton Andrew, Cleary Alison, Atkinson Robert, Michie Craig, Marshall Stephen, Florence Alastair J., Chen Yi-Chieh, Sefcik Jan, Andonovic Ivan, Tachtatzis Christos
International Conference on Manufacturing Research, (2018)
Successful computationally directed templating of metastable pharmaceutical polymorphs
Case David H., Srirambhatla Vijay K., Guo Rui, Watson Rona E., Price Louise S., Polyzois Hector, Cockcroft Jeremy K., Florence Alastair J., Tocher Derek A., Price Sarah L.
Crystal Growth and Design Vol 18, pp. 5322-5331, (2018)
http://dx.doi.org/10.1021/acs.cgd.8b00765
Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisations
Brown Cameron J., McGlone Thomas, Yerdelen Stephanie, Srirambhatla Vijay, Mabbott Fraser, Gurung Rajesh, Briuglia Maria L., Ahmed Bilal, Polyzois Hector, Mcginty John, Perciballi Francesca, Fysikopoulos Dimitris, Macfhionnghaile Pól, Siddique Humera, Raval Vishal, Harrington Tomás S., Vassileiou Antony D., Robertson Murray, Prasad Elke, Johnston Andrea, Johnston Blair, Nordon Alison, Srai Jagjit S., Halbert Gavin, ter Horst Joop H., Price Chris J., Rielly Chris D., Sefcik Jan, Florence Alastair J.
Molecular Systems Design and Engineering Vol 3, pp. 518-549, (2018)
http://dx.doi.org/10.1039/c7me00096k
Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisation
Brown Cameron J., McGlone Thomas, Yerdelen Stephanie, Srirambhatla Vijay, Mabbott Fraser, Gurung Rajesh, Briuglia Maria L., Ahmed Bilal, Polyzois Hector, McGinty John, Perciballi Francesca, Fysikopoulos Dimitris, Macfhionnghaile Pól, Siddique Humera, Raval Vishal, Harrington Tomás S., Vassileiou Antony, Robertson Murray, Prasad Elke, Johnston Andrea, Johnston Blair, Nordon Alison, Srai Jagjit, Halbert Gavin, Ter Horst Joop H., Price Chris J., Rielly Chris D., Sefcik Jan, Florence Alastair J.
Molecular Systems Design and Engineering Vol 2018, pp. 518-549, (2018)
http://dx.doi.org/10.1039/C7ME00096K
Impact of paracetamol impurities on face properties : investigating the surface of single crystals using TOF-SIMS
Ottoboni Sara, Chrubasik Michael, Mir Bruce Layla, Nguyen Thai Thu Hien, Robertson Murray, Johnston Blair, Oswald Iain D. H., Florence Alastair, Price Chris
Crystal Growth and Design Vol 18, pp. 2750–2758, (2018)
http://dx.doi.org/10.1021/acs.cgd.7b01411

more publications

Professional activities

2nd International Symposium on Continuous Manufacturing of Pharmaceuticals
Organiser
26/9/2016
Advanced Process Modelling Forum
Invited speaker
20/4/2016
10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Chair
4/2016
QbD symposium
Invited speaker
16/3/2016
RSC Formulation Science and Technology Group Conference
Keynote/plenary speaker
15/3/2016
Materials Science & Engineering in Drug Development
Invited speaker
12/11/2015

more professional activities

Projects

NF136
Florence, Alastair (Principal Investigator)
Period 15-Jun-2018 - 31-Oct-2018
NF039
Florence, Alastair (Principal Investigator)
Period 17-Nov-2017 - 30-Mar-2018
NF115
Florence, Alastair (Principal Investigator)
Period 02-Oct-2017 - 30-Mar-2018
NF105
Florence, Alastair (Principal Investigator)
Period 02-Feb-2018 - 23-Feb-2018
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator) Ter Horst, Joop (Co-investigator)
Period 01-Oct-2017 - 30-Sep-2019
CMAC Core project: Filter, Wash, Dry
Florence, Alastair (Principal Investigator)
Period 01-Oct-2017 - 30-Sep-2018

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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