Professor Alastair Florence

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.

Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.

Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.

Publications

Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisolâ„¢ 15LV filaments for Fused Filament Fabrication (FFF) 3D printing
Prasad Elke, Islam Muhammad T, Goodwin Daniel J, Megarry Andrew J, Halbert Gavin W, Florence Alastair J, Robertson John
Additive Manufacturing Vol 29 (2019)
https://doi.org/10.1016/j.addma.2019.06.027
Use of Terahertz-Raman spectroscopy to determine solubility of crystalline API in polymeric matrices during hot melt extrusion
Bordos Ecaterina, Islam Muhammad T, Florence Alastair J, Halbert Gavin W, Robertson John
Molecular Pharmaceutics (2019)
https://doi.org/10.1021/acs.molpharmaceut.9b00703
Unconventional ultra scale-down techniques for active pharmaceutical ingredient filtration and size reduction
Ojo EO, Rayat A, Price CJ, Brown CJ, Hoare M, Johnston A, Florence AJ
50th Annual Conference of the British Association of Crystal Growth, pp. 88 (2019)
https://doi.org/10.6084/m9.figshare.9770135.v1
Oxcarbazepine form III : observation of twisted habit in crystals of an elusive pharmaceutical polymorph
Polyzois H, Guo R, Warzecha M, Price S L , Florence AJ
50th Annual Conference of the British Association of Crystal Growth, pp. 69 (2019)
Developing process understanding for continuous manufacturing of Lamivudine (Epivir®) Stable Form I
Ojo Ebenezer, Hosni Zied, Onyemelukwe Iyke, Ramakers Lennart, Houson Ian, Florence Alastair
50th Annual Conference of the British Association of Crystal Growth (2019)
https://doi.org/10.6084/m9.figshare.9775382.v1
Olanzapine Crystal Symmetry Originates in Preformed Centrosymmetric Solute Dimers
Warzecha Monika, Verma Lakshmanji, Palmer Jeremy, Florence Alastair, Vekilov Peter G
Gordon Research Conference on Crystal Growth and Assembly (2019)

more publications

Professional activities

Gordon Research Conference on Crystal Growth and Assembly
Invited speaker
23/6/2019
Centre for International Manufacturing, Institute for Manufacturing, University of Cambridge
Visiting researcher
21/6/2019
MMIP Annual Conference
Participant
20/6/2019
EPSRC Hub Directors Meeting (Event)
Member
11/6/2019
Continuous Manufacturing Research: Progress & Pitfalls
Speaker
26/3/2019
Made Smarter for the Process Industries Workshop
Participant
8/3/2019

more professional activities

Projects

Doctoral Training Partnership 2018-19 University of Strathclyde | Pereira Diaz, Laura
Florence, Alastair (Principal Investigator) Johnston, Blair (Co-investigator) Pereira Diaz, Laura (Research Co-investigator)
01-Jan-2019 - 01-Jan-2022
measure X-PDF data and use PDF modelling and calculations to gain understanding of amorphous materials _ student placement
Florence, Alastair (Principal Investigator)
02-Jan-2019 - 31-Jan-2020
Pressure-dependent In-Situ Monitoring of Granular Materials
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Markl, Daniel (Co-investigator) McArthur, Stephen (Co-investigator) Nordon, Alison (Co-investigator) Oswald, Iain (Co-investigator)
01-Jan-2019 - 31-Jan-2022
Doctoral Training Partnership 2018-19 University of Strathclyde | Johnston, Jenna
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Jenna (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
CMAC Core project 2: Spherical Agglomeration
Florence, Alastair (Principal Investigator)
01-Jan-2018 - 30-Jan-2020
Takeda 2017/18 Proprietary Project
Florence, Alastair (Principal Investigator)
01-Jan-2018 - 30-Jan-2020

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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