Professor Alastair Florence

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.

Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.

Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.

Publications

Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisolâ„¢ 15LV filaments for Fused Filament Fabrication (FFF) 3D printing
Prasad Elke, Islam Muhammad T, Goodwin Daniel J, Megarry Andrew J, Halbert Gavin W, Florence Alastair J, Robertson John
Additive Manufacturing Vol 29 (2019)
https://doi.org/10.1016/j.addma.2019.06.027
Engineering of acetaminophen particle attributes using a wet milling crystallisation platform
Ahmed Bilal, Brown Cameron J, McGlone Thomas, Bowering Deborah L, Sefcik Jan, Florence Alastair J
International Journal of Pharmaceutics Vol 554, pp. 201-211 (2019)
https://doi.org/10.1016/j.ijpharm.2018.10.073
Polymorph Screening Studies of Oxcarbazepine : Twisted Habit in Crystals of the Elusive Form III
Polyzois Hector, Guo Rui, Warzecha Monika, Price Sarah L , Florence Alastair
Gordon Research Conference on Crystal Growth and Assembly (2019)
Oxcarbazepine Form III : Observation of Twisted Habit in Crystals of an Elusive Pharmaceutical Polymorph
Polyzois Hector, Guo Rui, Warzecha Monika, Price Sarah L , Florence Alastair
50th Annual BACG Conference (2019)
Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries
Agimelen Okpeafoh S, Svoboda Vaclav, Ahmed Bilal, Cardona Javier, Dziewierz Jerzy, Brown Cameron J, McGlone Thomas, Cleary Alison, Tachtatzis Christos, Michie Craig, Florence Alastair J, Andonovic Ivan, Mulholland Anthony J, Sefcik Jan
Advanced Powder Technology Vol 29, pp. 2987-2995 (2018)
https://doi.org/10.1016/j.apt.2018.09.003
Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography
Doerr Frederik JS, Oswald Iain DH, Florence Alastair J
Advanced Powder Technology (2018)
https://doi.org/10.1016/j.apt.2018.09.027

more publications

Professional activities

Gordon Research Conference on Crystal Growth and Assembly
Invited speaker
23/6/2019
Centre for International Manufacturing, Institute for Manufacturing, University of Cambridge
Visiting researcher
21/6/2019
MMIP Annual Conference
Participant
20/6/2019
EPSRC Hub Directors Meeting (Event)
Member
11/6/2019
Continuous Manufacturing Research: Progress & Pitfalls
Speaker
26/3/2019
Made Smarter for the Process Industries Workshop
Participant
8/3/2019

more professional activities

Projects

Pressure-dependent In-Situ Monitoring of Granular Materials
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Markl, Daniel (Co-investigator) McArthur, Stephen (Co-investigator) Nordon, Alison (Co-investigator) Oswald, Iain (Co-investigator)
01-Jan-2019 - 31-Jan-2022
CMAC Core project 2: Spherical Agglomeration
Florence, Alastair (Principal Investigator)
01-Jan-2018 - 30-Jan-2019
Doctoral Training Partnership 2018-19 University of Strathclyde | Johnston, Jenna
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Jenna (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Takeda 2017/18 Proprietary Project
Florence, Alastair (Principal Investigator)
01-Jan-2018 - 30-Jan-2019
ARTICULAR: ARtificial inTelligence for Integrated ICT-enabled pharmaceUticaL mAnufactuRing
Johnston, Blair (Principal Investigator) Florence, Alastair (Co-investigator)
01-Jan-2018 - 30-Jan-2022
CMAC Core project: Antisolvent
Florence, Alastair (Principal Investigator) Sefcik, Jan (Co-investigator)
01-Jan-2017 - 30-Jan-2019

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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