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Prof Alastair Florence

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.

Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.

Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.

Publications

Rapid continuous antisolvent crystallization of multi-component systems
Raza Syed A., Schacht Ulrich, Svoboda Vaclav, Edwards Darren P., Florence Alastair J., Pulham Colin R., Sefcik Jan, Oswald Iain D.H.
Crystal Growth and Design, (2017)
http://dx.doi.org/10.1021/acs.cgd.7b01105
Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs
Turner A., Halbert G., Florence A.
AAPS Annual Meeting and Exposition 2017, (2017)
Mesoscopic solute-rich clusters in olanzapine solutions
Warzecha Monika, Safari Mohammad S., Florence Alastair J., Vekilov Peter G.
Crystal Growth and Design, (2017)
http://dx.doi.org/10.1021/acs.cgd.7b01299
Direct observation of templated two-step nucleation mechanism during olanzapine hydrate formation
Warzecha Monika, Guo Rui, Bhardwaj Rajni M., Reutzel-Edens Susan M., Price Sarah L., Lamprou Dimitrios A., Florence Alastair J.
Crystal Growth and Design, pp. 1-41, (2017)
http://dx.doi.org/10.1021/acs.cgd.7b01060
The solute-rich mesoscopic precursors of crystal nuclei of olanzapine solid forms
Warzecha Monika, Vekilov Peter G. , Florence Alastair
48th BACG Annual Conference, (2017)
Aqueous solubility of organic salts. Investigating trends in a systematic series of 51 crystalline salt forms of methylephedrine
S. de Moraes Lygia, Edwards Darren, Florence Alastair J., Johnston Andrea, Johnston Blair F., Morrison Catriona A., Kennedy Alan R.
Crystal Growth and Design Vol 17, pp. 3277-3286, (2017)
http://dx.doi.org/10.1021/acs.cgd.7b00255

more publications

Professional activities

2nd International Symposium on Continuous Manufacturing of Pharmaceuticals
Organiser
26/9/2016
Advanced Process Modelling Forum
Invited speaker
20/4/2016
10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Chair
4/2016
QbD symposium
Invited speaker
16/3/2016
RSC Formulation Science and Technology Group Conference
Keynote/plenary speaker
15/3/2016
Materials Science & Engineering in Drug Development
Invited speaker
12/11/2015

more professional activities

Projects

Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Devlin, Michael
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Devlin, Michael (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Impact Acceleration Account - University Of Strathclyde 2012 / R120526-222
Florence, Alastair (Principal Investigator)
Period 01-Oct-2012 - 31-Mar-2017
investigate solubility prediction using Random forest analysis
Florence, Alastair (Principal Investigator)
Period 19-Jun-2017 - 31-Aug-2017
Doctoral Training Centre In Continuous Manufacturing And Crystallisation / RS4912
Florence, Alastair (Principal Investigator) Sefcik, Jan (Co-investigator)
Period 01-Jul-2012 - 01-Jul-2012
GSK108
Florence, Alastair (Principal Investigator)
Period 19-Jun-2017 - 31-Dec-2017
Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Mabbott, Fraser Adam
Florence, Alastair (Principal Investigator) Sefcik, Jan (Co-investigator) Mabbott, Fraser Adam (Research Co-investigator)
Period 01-Oct-2012 - 20-Sep-2017

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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