Professor Alastair Florence

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.

Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.

Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.


Machine learning approaches to the prediction of powder flow behaviour of pharmaceutical materials from physical properties
Pereira Diaz Laura, Brown Cameron J, Ojo Ebenezer, Mustoe Chantal, Florence Alastair J
Digital Discovery (2023)
Predicting pharmaceutical powder flow from microscopy images using deep learning
Wilkinson Matthew R, Pereira Diaz Laura, Vassileiou Antony D, Armstrong John A, Brown Cameron J, Castro-Dominguez Bernardo, Florence Alastair J
Digital Discovery (2023)
Tautomerism unveils a self-inhibition mechanism of crystallization
Tang Weiwei, Yang Taimin, Morales-Rivera Cristian A, Geng Xi, Srirambhatla Vijay K, Kang Xiang, Chauhan Vraj P, Hong Sungil, Tu Qing, Florence Alastair J, Mo Huaping, Calderon Hector A, Kisielowski Christian, Hernandez Francisco C Robles, Zou Xiaodong, Mpourmpakis Giannis, Rimer Jeffrey D
Nature Communications Vol 14 (2023)
Machine learning derived correlations for scale-up and technology transfer of primary nucleation kinetics
Yerdelen Stephanie, Yang Yihui, Quon Justin L, Papageorgiou Charles D, Mitchell Chris, Houson Ian, Sefcik Jan, ter Horst Joop H, Florence Alastair J, Brown Cameron J
Crystal Growth and Design Vol 23, pp. 681-693 (2023)
A unified ML framework for solubility prediction across organic solvents
Vassileiou Antony D, Robertson Murray N, Wareham Bruce G, Soundaranathan Mithushan, Ottoboni Sara, Florence Alastair J, Hartwig Thoralf, Johnston Blair F
Digital Discovery Vol 2, pp. 356-367 (2023)
Prediction of mefenamic acid crystal shape by random forest classification
Nakapraves Siya, Warzecha Monika, Mustoe Chantal L, Srirambhatla Vijay, Florence Alastair J
Pharmaceutical Research Vol 39, pp. 3099-3111 (2022)

More publications

Professional activities

PMTC Expert Panel
Sensor Enabled Automation
M-CERSI Workshop
M-CERSI Workshop
Continuous API Manufacturing
Bio-Manufacturing Innovation Summit

More professional activities


Recounting an Ancient Story of Crystallisation: Saffron Rock Candy
Salehian, Mohammad (Principal Investigator) Al Qaraghuli, Mohammed (Co-investigator) Hone, Scott (Co-investigator) Clark, Catriona (Co-investigator) Markl, Daniel (Co-investigator) Florence, Alastair (Co-investigator)
Funding: Cambridge Crystallographic Data Centre (CCDC) Engagement Grant Programme (£1500)
Summary: In this project, we aim to raise awareness of crystallisation science among students of primary and secondary schools through easy-to-follow, self-paced experimental packages. We will demonstrate the crystallisation process in the case of rock candy, along with the underlying science in an easy-to-understand manner. As part of the engagement strategy, crystallisation science's cultural and historical aspects will also be considered. Audiences will learn how crystals form, practice the science behind solubility and super-saturated solutions and understand the impact of crystallisation conditions (such as temperature, pressure, seeding, and concentration) on the final structure and the taste of sugar crystals. The key concepts include crystal growth, seeding crystals, solvent/solute, and solubility.
09-Jan-2023 - 09-Jan-2023
GiBio Gastrointestinal bioreactor to evaluate ingestible medicines and inform formulation and manufacture (EPSRC Strategic equipment)
Batchelor, Hannah (Principal Investigator) Florence, Alastair (Co-investigator) Horan, Linda (Co-investigator) Khadra, Ibrahim (Co-investigator) McArthur, Stephen (Co-investigator)
01-Jan-2022 - 30-Jan-2025
Industrial CASE Account - University of Strathclyde 2022 | Osman, Amal
Johnston, Blair (Principal Investigator) Florence, Alastair (Co-investigator) Osman, Amal (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Dialling up 3D Printing Performance for On Demand Manufacturing (Programme Grant)
Florence, Alastair (Principal Investigator) Johnston, Blair (Co-investigator)
01-Jan-2022 - 30-Jan-2027
DTP 2224 University of Strathclyde | Ross, Lewis
Florence, Alastair (Principal Investigator) Robertson, John (Co-investigator) Ross, Lewis (Research Co-investigator)
01-Jan-2022 - 01-Jan-2025
DTP 2224 University of Strathclyde | Bjarnason, Aaron
Brown, Cameron (Principal Investigator) Florence, Alastair (Co-investigator) Bjarnason, Aaron (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026

More projects


Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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