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Prof Alastair Florence

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.

Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.

Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.

Publications

Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisation
Brown Cameron J., McGlone Thomas, Yerdelen Stephanie, Srirambhatla Vijay, Mabbott Fraser, Gurung Rajesh, Briuglia Maria L., Ahmed Bilal, Polyzois Hector, McGinty John, Perciballi Francesca, Fysikopoulos Dimitris, Macfhionnghaile Pól, Siddique Humera, Raval Vishal, Harrington Tomás S., Vassileiou Antony, Robertson Murray, Prasad Elke, Johnston Andrea, Johnston Blair, Nordon Alison, Srai Jagjit, Halbert Gavin, Ter Horst Joop H., Price Chris J., Rielly Chris D., Sefcik Jan, Florence Alastair J.
Molecular Systems Design & Engineering, (2018)
http://dx.doi.org/10.1039/C7ME00096K
Injection moulding- A novel method of solid oral dosage form manufacturing
Wood Sarahjane, Halbert Gavin, Florence Alastair
Sci Formulation Forum, (2018)
Inkjet printing of oral dosage forms to solubilize BCS Class II drugs
Turner Alice J., Halbert Gavin W., Florence Alastair J.
Sci Formulation Forum, (2018)
Rapid continuous antisolvent crystallization of multi-component systems
Raza Syed A., Schacht Ulrich, Svoboda Vaclav, Edwards Darren P., Florence Alastair J., Pulham Colin R., Sefcik Jan, Oswald Iain D. H.
Crystal Growth and Design Vol 18, pp. 210-218, (2018)
http://dx.doi.org/10.1021/acs.cgd.7b01105
Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs
Turner A., Halbert G., Florence A.
AAPS Annual Meeting and Exposition 2017, (2017)
Mesoscopic solute-rich clusters in olanzapine solutions
Warzecha Monika, Safari Mohammad S., Florence Alastair J., Vekilov Peter G.
Crystal Growth and Design, (2017)
http://dx.doi.org/10.1021/acs.cgd.7b01299

more publications

Professional activities

2nd International Symposium on Continuous Manufacturing of Pharmaceuticals
Organiser
26/9/2016
Advanced Process Modelling Forum
Invited speaker
20/4/2016
10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Chair
4/2016
QbD symposium
Invited speaker
16/3/2016
RSC Formulation Science and Technology Group Conference
Keynote/plenary speaker
15/3/2016
Materials Science & Engineering in Drug Development
Invited speaker
12/11/2015

more professional activities

Projects

NF039
Florence, Alastair (Principal Investigator)
Period 17-Nov-2017 - 30-Mar-2018
CMAC Core project: Impurity Rejection
Florence, Alastair (Principal Investigator)
Period 01-Oct-2017 - 30-Sep-2018
CMAC Core project: Filter, Wash, Dry
Florence, Alastair (Principal Investigator)
Period 01-Oct-2017 - 30-Sep-2018
CMAC Core project: Synthesis to Crystallisation
Florence, Alastair (Principal Investigator)
Period 01-Oct-2017 - 30-Sep-2018
CMAC Core project: Antisolvent
Florence, Alastair (Principal Investigator) Sefcik, Jan (Co-investigator)
Period 01-Oct-2017 - 30-Sep-2018
NF101
Florence, Alastair (Principal Investigator)
Period 08-Jan-2018 - 31-Jan-2018

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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