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Professor Alastair Florence
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Prize And Awards
- Best Poster Award @ CMAC Annual Open Day 2018
- Recipient
- 25/10/2018
- Royal Pharmaceutical Society of Great Britain Conference Science Medal
- Recipient
- 9/2004
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Publications
- Emerging applications and regulatory strategies for advanced medicines manufacturing - towards the development of a platform approach
- Srai Jagjit Singh, Bauer Paul, Badman Clive, Bresciani Massimo, Cooney Charles L, Florence Alastair, Hausner Doug, Konstantinov Konstantin, Lee Sau L, Mascia Salvatore, Nasr Moheb, Trout Bernhardt L
- Journal of Pharmaceutical Sciences Vol 113, pp. 1701-1710 (2024)
- https://doi.org/10.1016/j.xphs.2024.04.016
- Integrated continuous process design for crystallisation, spherical agglomeration, and filtration of lovastatin
- Brown Cameron J, McGinty John, Islam Muhammad T, Rajoub Nazer, Arjmandi-Tash Omid, Ottoboni Sara, Shahid Muhid, Urwin Stephanie J, Lee Ye Seol, Chong Magdalene W S, Papathanasiou Foteini, Prakash Aruna S, Prasad Elke, Spence Bronwyn, Sefcik Jan, Robertson John, Smith Rachel, Litster James D, Price Chris J, Nordon Alison, Adjiman Claire S, Florence Alastair J
- Journal of Pharmaceutical Innovation Vol 19 (2024)
- https://doi.org/10.1007/s12247-024-09815-z
- Comparative study on adaptive Bayesian optimization for batch cooling crystallization for slow and fast kinetic regimes
- Pickles Thomas, Mustoe Chantal, Brown Cameron J, Florence Alastair J
- Crystal Growth and Design Vol 24, pp. 1245-1253 (2024)
- https://doi.org/10.1021/acs.cgd.3c01225
- Developing a model-driven workflow for the digital design of small-scale batch cooling crystallisation with the antiviral lamivudine
- Pickles Thomas, Mustoe Chantal, Boyle Christopher, Cardona Javier, Brown Cameron J, Florence Alastair J
- CrystEngComm Vol 26, pp. 822-834 (2024)
- https://doi.org/10.1039/D3CE00897E
- Tautomerism unveils a self-inhibition mechanism of crystallization
- Tang Weiwei, Yang Taimin, Morales-Rivera Cristian A, Geng Xi, Srirambhatla Vijay K, Kang Xiang, Chauhan Vraj P, Hong Sungil, Tu Qing, Florence Alastair J, Mo Huaping, Calderon Hector A, Kisielowski Christian, Hernandez Francisco C Robles, Zou Xiaodong, Mpourmpakis Giannis, Rimer Jeffrey D
- Nature Communications Vol 14 (2023)
- https://doi.org/10.1038/s41467-023-35924-3
- Expanding the pharmaceutical formulation space in material extrusion 3D printing applications
- Prasad Elke, Robertson John, Florence Alastair J, Halbert Gavin W
- Additive Manufacturing Vol 77 (2023)
- https://doi.org/10.1016/j.addma.2023.103803
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Professional Activities
- Application of calibration free approaches for rapid polymorph discrimination by low frequency Raman spectroscopy
- Contributor
- 25/4/2024
- Organic Process Research and Development (Journal)
- Peer reviewer
- 1/12/2023
- 4th Commercializing Flow Chemistry Summit 2023
- Speaker
- 17/10/2023
- InnovatePharma Healthcare 2023
- Speaker
- 11/9/2023
- CMAC Summer School
- Participant
- 14/6/2023
- Made Smarter Innovation Challenge Forum
- Participant
- 6/6/2023
Projects
- A Regulatory Science Network for the Digital Transformation of Medicines Development and Manufacturing (10113547)
- Markl, Daniel (Principal Investigator) Florence, Alastair (Co-investigator) Johnston, Blair (Co-investigator)
- 01-Jan-2024 - 31-Jan-2024
- Correlating Digital and Experimental Chemical Space to Pharmaceutical Manufacturing Processes
- El-Habbak, Omar (Researcher) Brown, Cameron (Principal Investigator) Florence, Alastair (Principal Investigator)
- This project will deliver a novel, interpretable machine-learning model for predicting powder flow considering physical, chemical, and computed molecule/particle features. The output of this model will facilitate the rapid development of new medicines manufacturing.
- 01-Jan-2023 - 01-Jan-2027
- DTP 2224 University of Strathclyde | MacQueen, Lewis
- Florence, Alastair (Principal Investigator) Robertson, John (Co-investigator) MacQueen, Lewis (Research Co-investigator)
- 01-Jan-2023 - 01-Jan-2027
- DTP 2224 University of Strathclyde | Clark, Connor
- Florence, Alastair (Principal Investigator) Johnston, Blair (Co-investigator) Clark, Connor (Research Co-investigator)
- 01-Jan-2023 - 01-Jan-2027
- Industrial Case Account - University of Strathclyde 2023 | Tierney, Colette
- Florence, Alastair (Principal Investigator) Robertson, John (Co-investigator) Tierney, Colette (Research Co-investigator)
- 01-Jan-2023 - 01-Jan-2026
- Recounting an Ancient Story of Crystallisation: Saffron Rock Candy
- Salehian, Mohammad (Principal Investigator) Al Qaraghuli, Mohammed (Co-investigator) Hone, Scott (Co-investigator) Clark, Catriona (Co-investigator) Markl, Daniel (Co-investigator) Florence, Alastair (Co-investigator)
- Funding: Cambridge Crystallographic Data Centre (CCDC) Engagement Grant Programme (£1500)
Summary: In this project, we aim to raise awareness of crystallisation science among students of primary and secondary schools through easy-to-follow, self-paced experimental packages. We will demonstrate the crystallisation process in the case of rock candy, along with the underlying science in an easy-to-understand manner. As part of the engagement strategy, crystallisation science's cultural and historical aspects will also be considered. Audiences will learn how crystals form, practice the science behind solubility and super-saturated solutions and understand the impact of crystallisation conditions (such as temperature, pressure, seeding, and concentration) on the final structure and the taste of sugar crystals. The key concepts include crystal growth, seeding crystals, solvent/solute, and solubility. - 09-Jan-2023 - 09-Jan-2023
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Contact
Professor
Alastair
Florence
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: alastair.florence@strath.ac.uk
Tel: 548 4877