Personal statement
Director of the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC) and associated 45 PhD Doctoral Training Centre. Leads the new world-class CMAC National Facility within the Technology and Innovation Centre (TIC) at the University of Strathclyde offering access to academic and industrial users to state-of-the art processing, analysis and characterisations facilties and support. Expertise in crystallisation and physical form control and characterisation of pharmaceuticals spanning polymorphism, solvate, co-crystal and salt formation and studies of amorphous systems. Extensive experience in the formation of pharmaceutical particles in continuous processes using a range of technologies as part of the CMAC programme. Interests also in the development and application of new technologies to control and monitor crystallisation and pharmaceutical solids.
Approaches for the characterisation of particles are also widely used and physical analysis of crystalline pharmaceuticals with a focus on the influence of crystallisation processes on structure and critical pharmaceutically relevant attributes that dictates product performance. Exploitation of X-ray powder diffraction techniques for phase identification, structure determination from powder diffraction data and in-situ phase surveys including local order using variable-temperature X-ray powder diffraction are key areas.
Has published over 120 peer reviewed research papers in these areas and currently supervises a large multidisciplinary research group including pharmacists, chemists and chemical engineers.
Professional activities
- PMTC Expert Panel
- Participant
- 26/1/2023
- Sensor Enabled Automation
- Contributor
- 14/9/2022
- M-CERSI Workshop
- Participant
- 13/7/2022
- M-CERSI Workshop
- Speaker
- 13/7/2022
- Continuous API Manufacturing
- Speaker
- 7/7/2022
- Bio-Manufacturing Innovation Summit
- Participant
- 7/7/2022
More professional activities
Projects
- Recounting an Ancient Story of Crystallisation: Saffron Rock Candy
- Salehian, Mohammad (Principal Investigator) Al Qaraghuli, Mohammed (Co-investigator) Hone, Scott (Co-investigator) Clark, Catriona (Co-investigator) Markl, Daniel (Co-investigator) Florence, Alastair (Co-investigator)
- Funding: Cambridge Crystallographic Data Centre (CCDC) Engagement Grant Programme (£1500)
Summary: In this project, we aim to raise awareness of crystallisation science among students of primary and secondary schools through easy-to-follow, self-paced experimental packages. We will demonstrate the crystallisation process in the case of rock candy, along with the underlying science in an easy-to-understand manner. As part of the engagement strategy, crystallisation science's cultural and historical aspects will also be considered. Audiences will learn how crystals form, practice the science behind solubility and super-saturated solutions and understand the impact of crystallisation conditions (such as temperature, pressure, seeding, and concentration) on the final structure and the taste of sugar crystals. The key concepts include crystal growth, seeding crystals, solvent/solute, and solubility. - 09-Jan-2023 - 09-Jan-2023
- GiBio Gastrointestinal bioreactor to evaluate ingestible medicines and inform formulation and manufacture (EPSRC Strategic equipment)
- Batchelor, Hannah (Principal Investigator) Florence, Alastair (Co-investigator) Horan, Linda (Co-investigator) Khadra, Ibrahim (Co-investigator) McArthur, Stephen (Co-investigator)
- 01-Jan-2022 - 30-Jan-2025
- Industrial CASE Account - University of Strathclyde 2022 | Osman, Amal
- Johnston, Blair (Principal Investigator) Florence, Alastair (Co-investigator) Osman, Amal (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
- Dialling up 3D Printing Performance for On Demand Manufacturing (Programme Grant)
- Florence, Alastair (Principal Investigator) Johnston, Blair (Co-investigator)
- 01-Jan-2022 - 30-Jan-2027
- DTP 2224 University of Strathclyde | Ross, Lewis
- Florence, Alastair (Principal Investigator) Robertson, John (Co-investigator) Ross, Lewis (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2025
- DTP 2224 University of Strathclyde | Bjarnason, Aaron
- Brown, Cameron (Principal Investigator) Florence, Alastair (Co-investigator) Bjarnason, Aaron (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
More projects
Address
Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre
Technology Innovation Centre
Location Map
View
University of Strathclyde
in a larger map