Dr Natividad Gomez-Roman

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences


Personal statement

Our work aims to understand the tumour biology of brain and ovarian cancers, which will help us identify novel treatments resulting in improved patient outcomes. We pursue this by developing experimental models of disease that recapitulate the clinical environment, including three-dimensional cell culture systems using scaffolds, organoid and ex-vivo models and in vivo models of disease.

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Evaluating the enhancement of cell kill by radiation therapy through novel wee1 inhibitors with improved brain permeability in the treatment of glioblastoma
Scholefield Emma, Gomez-Roman Natividad
Cancer Research UK - Association for Radiation Research Conference (2023)
Combined inhibition of the Fanconi anaemia (FA) pathway and ATR promotes R-loop generation and profound radiosensitisation in glioblastoma
Rominiyi Ola, Myers Katie, Gomez-Roman Natividad, Jellinek David A, Chalmers Anthony J, Carroll Thomas A, Chen Beining, Al-Tamimi Yahia, Collis Spencer
Brain Tumour Research and Treatment Vol S253 (2022)
O2 : Towards a living biobank of surgically-relevant 3-dimensional glioblastoma stem cell models to evaluate novel therapeutics and interrogate intratumoural heterogeneity
Rominiyi Ola, Vanderlinden A, Myers K, Gomez-Roman Natividad, Dar D, Bagga V, Jellinek D A, Chalmers Anthony, Carroll T A, Al-Tamimi Y, Collis S J
British Journal of Surgery Vol 108 (2021)
Abstract PO-017 : radiotherapy in combination with the brain penetrant ATM inhibitor AZD1390 does not exacerbate radiation toxicity of neural stem cells in vitro or in vivo
Guttierez-Quintana Rodrigo, Walker David J, Jackson Mark R, Gomez-Roman Natividad, Chahal Sandeep, Durant Stephen T, Chalmers Anthony J
Clinical Cancer Research Vol 27 (2021)
Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts
Koessinger Anna L, Koessinger Dominik, Stevenson Katrina, Cloix Catherine, Mitchell Louise, Nixon Colin, Gomez-Roman Natividad, Chalmers Anthony J, Norman Jim C, Tait Stephen W G
Scientific Reports Vol 10 (2020)
Radiation responses of 2D and 3D glioblastoma cells : a novel, 3D-specific radioprotective role of VEGF/Akt signaling through functional activation of NHEJ
Gomez-Roman Natividad, Chong Ming Y, Chahal Sandeep K, Caragher Seamus P, Jackson Mark R, Stevenson Katrina H, Dongre Sidhartha A, Chalmers Anthony J
Molecular Cancer Therapeutics Vol 19, pp. 575-589 (2020)

More publications

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Professional Activities

F1000Research (Journal)
Peer reviewer
Co-chair Radiotherapy drug combinations
RadNet Glasgow Brainstorming Workshop
Scottish Glioblastoma Network - Brain Tumour Scottish Network (External organisation)
SIPBS Research Day 2023
Deciphering the role of cholesterol in the radiation response of glioblastoma

More professional activities


BRAINS Strathclyde Centre for Doctoral Training
MacKenzie, Lewis (Principal Investigator) Childs, Peter (Principal Investigator) Witte, Kimia (Principal Investigator) Jimenez, Melanie (Principal Investigator) Chow, Shiao (Principal Investigator) Fu, Ying (Principal Investigator) Gomez-Roman, Natividad (Principal Investigator) Fazio, Mariana (Principal Investigator) Reid, Andrew Baxter (Principal Investigator)
Centre for Doctoral Training in Bridging Research and Advancements in Neurological Sciences (BRAINS). First cohort of PhD students starting autumn 2023.
Developing Aberdeen's Cancer Research Network
Spiers, Valerie (Principal Investigator) kiltie, anne (Principal Investigator) Gomez-Roman, Natividad (Co-investigator) Boyd, Marie (Co-investigator) Tomlinson, Ian P M (Principal Investigator) Gourley, Charlie (Co-investigator) Machesky, Laura (Co-investigator) Chalmers, Anthony (Principal Investigator) Broche, Lionel (Co-investigator) Stansfield, Ian (Co-investigator)
The aim of this proposal is to encourage new collaborative research and innovation in these fields, through working with colleagues in the CRUK Scotland Centre based in Edinburgh and Glasgow, broadening the range of cancer research being conducted in Scotland.
01-Jan-2022 - 30-Jan-2023
Investigating Novel Wee1 and Chk1 Inhibitors with Improved Brain Permeability for the Treatment of Glioblastoma
Gomez-Roman, Natividad (Principal Investigator)
SULSA-industrial collaboration evaluating novel brain permeable compounds in 3D glioblastoma model systems
01-Jan-2022 - 31-Jan-2023
Understanding the role of cholesterol in the survival and treatment resistance of glioblastoma and its feasibility as a druggable target
Gomez-Roman, Natividad (Principal Investigator) Morgan, John (Post Grad Student)
01-Jan-2021 - 30-Jan-2024
Developing more representative laboratory models of the blood-tumour barrier to improve the drug development pipeline for patients with glioblastoma.
Chalmers, Anthony (Principal Investigator) Carruthers, Ross D (Co-investigator) Birch, Joanna (Co-investigator) Smith, Colin (Co-investigator) Ireson, Chistopher (Co-investigator) Brennan, Paul (Co-investigator) Thompson, Gerry (Co-investigator) Gomez-Roman, Natividad (CoI) Salmeron-Sanchez, Manuel (CoI) Brunton, Val (CoI)
01-Jan-2021 - 31-Jan-2024
Investigating cholesterol protection to radiation treatment in glioblastoma
Gomez-Roman, Natividad (Principal Investigator)
01-Jan-2021 - 31-Jan-2023

More projects

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Dr Natividad Gomez-Roman
Strathclyde Chancellor's Fellow
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: natividad.gomez-roman@strath.ac.uk
Tel: 548 2122