Dr Natividad Gomez-Roman

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Our work aims to understand the tumour biology of brain and ovarian cancers, which will help us identify novel treatments resulting in improved patient outcomes. We pursue this by developing experimental models of disease that recapitulate the clinical environment, including three-dimensional cell culture systems using scaffolds, organoid and ex-vivo models and in vivo models of disease.

Expertise

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Prize And Awards

2023 AWERB 3Rs Prize: Recipient; 4/10/2023
Fellowship of the Higher Education Academy: Recipient; 7/9/2023
CRUK RadNet CRISPR Workshop Travel Bursary: Recipient; 14/6/2022
Strathclyde Chancellor's Fellowship: Recipient; 1/11/2020
Poster Prize, NC3Rs Fellows Meeting: Recipient; 1/5/2019
Aurora Programme for Professional Development in Women: Recipient; 1/9/2018

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Publications

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Publications

ClonoScreen3D – a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma: Jackson Mark R, Richards Amanda R, Ayoola Oladipupo Abdul-Basit, Chahal Sandeep K, Carager Seamus, Chalmers Anthony J, Gomez-Roman Natividad; International Journal of Radiation Oncology - Biology - Physics Vol 120, pp. 162-177 (2024); https://doi.org/10.1016/j.ijrobp.2024.02.046
A joint physics and radiobiology DREAM team vision - towards better response prediction models to advance radiotherapy: Vens C, van Luijk P, Vogelius RI, El Naqa I, Humbert-Vidan L, von Neubeck C, Gomez-Roman N, Bahn E, Brualla L, Böhlen TT, Ecker S, Koch R, Handeland A, Pereira S, Possenti L, Rancati T, Todor D, Vanderstraeten B, Van Heerden M, Ullrich W, Jackson M, Alber M, Marignol L; Radiotherapy and Oncology Vol 196 (2024); https://doi.org/10.1016/j.radonc.2024.110277
ClonoScreen3D : a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma: Jackson Mark R, R Richards Amanda, Ayoola Oladipupo Abdul-Basit, Chahal Sandeep K, Carager Seamus, Chalmers Anthony J, Gomez-Roman Natividad; (2023); https://doi.org/10.1101/2023.10.04.560635
Evaluating the enhancement of cell kill by radiation therapy through novel wee1 inhibitors with improved brain permeability in the treatment of glioblastoma: Scholefield Emma, Gomez-Roman Natividad; Cancer Research UK - Association for Radiation Research Conference (2023)
Deciphering the role of cholesterol in the radiation response of glioblastoma: Gomez-Roman Natividad; Radiotherapy and Oncology Vol 182 (2023); https://doi.org/10.1016/S0167-8140(23)67287-1
Combined inhibition of the Fanconi anaemia (FA) pathway and ATR promotes R-loop generation and profound radiosensitisation in glioblastoma: Rominiyi Ola, Myers Katie, Gomez-Roman Natividad, Jellinek David A, Chalmers Anthony J, Carroll Thomas A, Chen Beining, Al-Tamimi Yahia, Collis Spencer; Brain Tumour Research and Treatment Vol S253 (2022); https://doi.org/10.14791/btrt.2022.10.F-1432

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Research

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Professional Activities

VIVA (PhD) - internal examiner: Examiner; 23/5/2024
European Society for Radiotherapy and Oncology: Participant; 3/5/2024
How does radiation affect cell metabolism?: Speaker; 3/5/2024
Molecular Oncology (Journal): Peer reviewer; 12/12/2023
Expanding Theories call: Advisor; 10/12/2023
MRes Viva - University of Oxford: Examiner; 16/10/2023

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Projects

Characterising cholesterol trafficking in glioblastoma and brain cells, and its contribution to tumour development, progression and treatment resistance: Gomez-Roman, Natividad (Principal Investigator); 01-Sep-2024 - 31-Aug-2027
Development of A Novel Non-Animal Research Method for Glioblastoma Research: Houston, Grace (Researcher) Gomez-Roman, Natividad (Principal Investigator); 22-Jul-2024 - 23-Aug-2024
Development of A Novel Non-Animal Research Method for Glioblastoma Research: Houston, Grace (Academic) Gomez-Roman, Natividad (Principal Investigator); 22-Jul-2024 - 17-Aug-2024
Development of A Novel Non-Animal Research Method for Glioblastoma Research: Gomez-Roman, Natividad (Principal Investigator); 22-Jul-2024 - 30-Aug-2024
Development of A Novel Non-Animal Research Method for Glioblastoma Research: Gomez-Roman, Natividad (Principal Investigator) Hutchison, Amber (Principal Investigator); The development of a non-animal method that allows the development of in vitro glioblastoma tumours would allow for the replacement of current animal models. A non-animal research method would allow for the development of novel therapeutic agents, and investigation into gene functions of glioblastomas without the use of animals.; 15-Jul-2024 - 16-Aug-2024
Exploring Cholesterol Metabolism, Lipid Droplets, and NPC Dysfunction in Cellular Health and Disease: Gomez-Roman, Natividad (Principal Investigator) Hutchison, Amber (Researcher); The project aims to address the connection between cholesterol metabolism, lipid droplets and
NPC dysfunction in glioblastoma cells to uncover a novel therapeutic intervention that exploits lipid metabolism in cancer cells; 10-Jun-2024 - 12-Jul-2024