Dr Natividad Gomez-Roman

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Our work aims to understand the tumour biology of brain and ovarian cancers, which will help us identify novel treatments resulting in improved patient outcomes. We pursue this by developing experimental models of disease that recapitulate the clinical environment, including three-dimensional cell culture systems using scaffolds, organoid and ex-vivo models and in vivo models of disease.


Abstract PO-017 : radiotherapy in combination with the brain penetrant ATM inhibitor AZD1390 does not exacerbate radiation toxicity of neural stem cells in vitro or in vivo
Guttierez-Quintana Rodrigo, Walker David J, Jackson Mark R, Gomez-Roman Natividad, Chahal Sandeep, Durant Stephen T, Chalmers Anthony J
Clinical Cancer Research Vol 27 (2021)
Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts
Koessinger Anna L, Koessinger Dominik, Stevenson Katrina, Cloix Catherine, Mitchell Louise, Nixon Colin, Gomez-Roman Natividad, Chalmers Anthony J, Norman Jim C, Tait Stephen W G
Scientific Reports Vol 10 (2020)
Radiation responses of 2D and 3D glioblastoma cells : a novel, 3D-specific radioprotective role of VEGF/Akt signaling through functional activation of NHEJ
Gomez-Roman Natividad, Chong Ming Y, Chahal Sandeep K, Caragher Seamus P, Jackson Mark R, Stevenson Katrina H, Dongre Sidhartha A, Chalmers Anthony J
Molecular Cancer Therapeutics Vol 19, pp. 575-589 (2020)
Patient-specific 3D-printed glioblastomas
Gomez-Roman Natividad, Chalmers Anthony J
Nature Biomedical Engineering Vol 3, pp. 498-499 (2019)
Glioblastoma's next top model : novel culture systems for brain cancer radiotherapy research
Caragher Seamus, Chalmers Anthony J, Gomez-Roman Natividad
Cancers Vol 11 (2019)
Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells
Carruthers Ross D, Ahmed Shafiq U, Ramachandran Shaliny, Strathdee Karen, Kurian Kathreena M, Hedley Ann, Gomez-Roman Natividad, Kalna Gabriela, Neilson Mathew, Gilmour Lesley, Stevenson Katrina H, Hammond Ester M, Chalmers Anthony J
Cancer Research Vol 78, pp. 5060-5071 (2018)

More publications

Professional activities

ESTRO - Radiobiology Workshop
Modelling glioblastoma responses to drug-radiation combination treatments
Modelling treatment response of drug-radiation combinations in glioblastoma
CRISPR in Radiation Research Workshop
The Journal of Pathology Clinical Research (Journal)
Peer reviewer
Gliomodel (External organisation)

More professional activities


BRAINS Strathclyde Centre for Doctoral Training
MacKenzie, Lewis (Principal Investigator) Childs, Peter (Principal Investigator) Witte, Kimia (Principal Investigator) Jimenez, Melanie (Principal Investigator) Chow, Shiao (Principal Investigator) Fu, Ying (Principal Investigator) Gomez-Roman, Natividad (Principal Investigator) Fazio, Mariana (Principal Investigator) Reid, Andrew Baxter (Principal Investigator)
Centre for Doctoral Training in Bridging Research and Advancements in Neurological Sciences (BRAINS). First cohort of PhD students starting autumn 2023.
Developing Aberdeen's Cancer Research Network
Spiers, Valerie (Principal Investigator) kiltie, anne (Principal Investigator) Gomez-Roman, Natividad (Co-investigator) Boyd, Marie (Co-investigator) Tomlinson, Ian P M (Principal Investigator) Gourley, Charlie (Co-investigator) Machesky, Laura (Co-investigator) Chalmers, Anthony (Principal Investigator) Broche, Lionel (Co-investigator) Stansfield, Ian (Co-investigator)
The aim of this proposal is to encourage new collaborative research and innovation in these fields, through working with colleagues in the CRUK Scotland Centre based in Edinburgh and Glasgow, broadening the range of cancer research being conducted in Scotland.
01-Jan-2022 - 30-Jan-2023
Investigating Novel Wee1 and Chk1 Inhibitors with Improved Brain Permeability for the Treatment of Glioblastoma
Gomez-Roman, Natividad (Principal Investigator)
SULSA-industrial collaboration evaluating novel brain permeable compounds in 3D glioblastoma model systems
01-Jan-2022 - 31-Jan-2023
Understanding the role of cholesterol in the survival and treatment resistance of glioblastoma and its feasibility as a druggable target
Gomez-Roman, Natividad (Principal Investigator) Morgan, John (Post Grad Student)
01-Jan-2021 - 30-Jan-2024
Developing more representative laboratory models of the blood-tumour barrier to improve the drug development pipeline for patients with glioblastoma.
Chalmers, Anthony (Principal Investigator) Carruthers, Ross D (Co-investigator) Birch, Joanna (Co-investigator) Smith, Colin (Co-investigator) Ireson, Chistopher (Co-investigator) Brennan, Paul (Co-investigator) Thompson, Gerry (Co-investigator) Gomez-Roman, Natividad (CoI) Salmeron-Sanchez, Manuel (CoI) Brunton, Val (CoI)
01-Jan-2021 - 31-Jan-2024
Investigating cholesterol protection to radiation treatment in glioblastoma
Gomez-Roman, Natividad (Principal Investigator)
01-Jan-2021 - 31-Jan-2023

More projects


Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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