Dr Natividad Gomez-Roman

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Our work aims to understand the tumour biology of brain and ovarian cancers, which will help us identify novel treatments resulting in improved patient outcomes. We pursue this by developing experimental models of disease that recapitulate the clinical environment, including three-dimensional cell culture systems using scaffolds, organoid and ex-vivo models and in vivo models of disease.

Expertise

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Prize And Awards

2023 AWERB 3Rs Prize: Recipient; 4/10/2023
Fellowship of the Higher Education Academy: Recipient; 7/9/2023
CRUK RadNet CRISPR Workshop Travel Bursary: Recipient; 14/6/2022
Strathclyde Chancellor's Fellowship: Recipient; 1/11/2020
Poster Prize, NC3Rs Fellows Meeting: Recipient; 1/5/2019
Aurora Programme for Professional Development in Women: Recipient; 1/9/2018

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Publications

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Publications

ClonoScreen3D – a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma: Jackson Mark R, R Richards Amanda, Ayoola Oladipupo Abdul-Basit, Chahal Sandeep K, Carager Seamus, Chalmers Anthony J, Gomez-Roman Natividad; International Journal of Radiation Oncology - Biology - Physics (2024); https://doi.org/10.1016/j.ijrobp.2024.02.046
ClonoScreen3D : a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma: Jackson Mark R, R Richards Amanda, Ayoola Oladipupo Abdul-Basit, Chahal Sandeep K, Carager Seamus, Chalmers Anthony J, Gomez-Roman Natividad; (2023); https://doi.org/10.1101/2023.10.04.560635
Evaluating the enhancement of cell kill by radiation therapy through novel wee1 inhibitors with improved brain permeability in the treatment of glioblastoma: Scholefield Emma, Gomez-Roman Natividad; Cancer Research UK - Association for Radiation Research Conference (2023)
Deciphering the role of cholesterol in the radiation response of glioblastoma: Gomez-Roman Natividad; Radiotherapy and Oncology Vol 182 (2023); https://doi.org/10.1016/S0167-8140(23)67287-1
Combined inhibition of the Fanconi anaemia (FA) pathway and ATR promotes R-loop generation and profound radiosensitisation in glioblastoma: Rominiyi Ola, Myers Katie, Gomez-Roman Natividad, Jellinek David A, Chalmers Anthony J, Carroll Thomas A, Chen Beining, Al-Tamimi Yahia, Collis Spencer; Brain Tumour Research and Treatment Vol S253 (2022); https://doi.org/10.14791/btrt.2022.10.F-1432
O2 : Towards a living biobank of surgically-relevant 3-dimensional glioblastoma stem cell models to evaluate novel therapeutics and interrogate intratumoural heterogeneity: Rominiyi Ola, Vanderlinden A, Myers K, Gomez-Roman Natividad, Dar D, Bagga V, Jellinek D A, Chalmers Anthony, Carroll T A, Al-Tamimi Y, Collis S J; British Journal of Surgery Vol 108 (2021); https://doi.org/10.1093/bjs/znab117.002

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Research

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Professional Activities

Molecular Oncology (Journal): Peer reviewer; 12/12/2023
Expanding Theories call: Advisor; 10/12/2023
MRes Viva - University of Oxford: Examiner; 16/10/2023
F1000Research (Journal): Peer reviewer; 11/8/2023
Co-chair Radiotherapy drug combinations: Speaker; 4/6/2023
RadNet Glasgow Brainstorming Workshop: Participant; 2/6/2023

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Projects

Exploring the Reversed Blood-Brain Barrier: Witte, Kimia (Principal Investigator) Gomez-Roman, Natividad (Co-investigator); 01-Jan-2023 - 31-Jan-2024
Developing Aberdeen's Cancer Research Network: Spiers, Valerie (Principal Investigator) Kiltie, Anne (Principal Investigator) Gomez-Roman, Natividad (Co-investigator) Boyd, Marie (Co-investigator) Tomlinson, Ian P M (Principal Investigator) Gourley, Charlie (Co-investigator) Machesky, Laura (Co-investigator) Chalmers, Anthony (Principal Investigator) Broche, Lionel (Co-investigator) Stansfield, Ian (Co-investigator); The aim of this proposal is to encourage new collaborative research and innovation in these fields, through working with colleagues in the CRUK Scotland Centre based in Edinburgh and Glasgow, broadening the range of cancer research being conducted in Scotland.; 01-Jan-2022 - 30-Jan-2023
Investigating Novel Wee1 and Chk1 Inhibitors with Improved Brain Permeability for the Treatment of Glioblastoma: Gomez-Roman, Natividad (Principal Investigator); SULSA-industrial collaboration evaluating novel brain permeable compounds in 3D glioblastoma model systems; 01-Jan-2022 - 31-Jan-2023
Understanding the role of cholesterol in the survival and treatment resistance of glioblastoma and its feasibility as a druggable target: Gomez-Roman, Natividad (Principal Investigator) Morgan, John (Post Grad Student); 01-Jan-2021 - 30-Jan-2024
Developing more representative laboratory models of the blood-tumour barrier to improve the drug development pipeline for patients with glioblastoma.: Chalmers, Anthony (Principal Investigator) Carruthers, Ross D (Co-investigator) Birch, Joanna (Co-investigator) Smith, Colin (Co-investigator) Ireson, Chistopher (Co-investigator) Brennan, Paul (Co-investigator) Thompson, Gerry (Co-investigator) Gomez-Roman, Natividad (CoI) Salmeron-Sanchez, Manuel (CoI) Brunton, Val (CoI); 01-Jan-2021 - 31-Jan-2024
Investigating cholesterol protection to radiation treatment in glioblastoma: Gomez-Roman, Natividad (Principal Investigator); 01-Jan-2021 - 31-Jan-2023