Publications

The effect of mephedrone on human neuroblastoma and astrocytoma cells

Alanazi Ibrahim M, Alzahrani Abdullah R, Alsaad Mohammad A, Moqeem Abdulaziz L, Hamdi Abdulmohsen M, Taher Mohiuddin M, Watson David G, Grant M Helen

Saudi Pharmaceutical Journal Vol 32 (2024)

https://doi.org/10.1016/j.jsps.2024.102011

Cardiac function may be compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants : a pilot study using a novel echocardiography measurement

Jenkinson Mark R J, Meek Dominic R M, Tate Rothwelle, Brady Adrian, MacMillan Sandy, Grant Helen, Currie Susan

The Bone & Joint Journal Vol 106-B, pp. 51-58 (2024)

https://doi.org/10.1302/0301-620X.106B3.BJJ-2023-0814.R1

Cardiac function is compromised in patients with elevated blood cobalt levels secondary to metal on metal hip implants

Meek Dominic, Jenkinson Mark, MacMillan Sandy, Tate Rothwelle, Grant Mary, Currie Susan

International Hip Society conference, pp. 31-31 (2023)

https://doi.org/10.1302/1358-992X.2023.12.031

Metabolomics analysis as a tool to measure cobalt neurotoxicity : an in vitro validation

Alanazi Ibrahim M, Alzahrani Abdullah R, Zughaibi Torki A, Al-Asmari Ahmed I, Tabrez Shams, Henderson Catherine, Watson David, Grant Mary Helen

Metabolites Vol 13 (2023)

https://doi.org/10.3390/metabo13060698

Cardiac function is compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants

Jenkinson Mark, Meek Dominic, MacMillan Sandy, Tate Rothwelle, Grant Mary, Currie Susan

Heart Vol 109, pp. A4.1-A4 (2023)

https://doi.org/10.1136/heartjnl-SCF-2023.11

Effects of acute and chronic cobalt treatment on adult rat cardiomyocyte calcium handling

Olatunji Zainab O, MacMillan Sandy, Cameron-Ruiz Miren, Bosakhar Zainab Y, MacKenzie Graeme, Grant Mary H, Tate Rothwelle, MacQuaide Niall, Currie Susan

Heart Vol 109 (2023)

https://doi.org/10.1136/heartjnl-SCF-2023.18

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Professional Activities

eurotox

Participant

2019

BSI Standards CenELEC Workshop (External organisation)

Advisor

17/6/2017

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Projects

Investigating the translational application of CaMKII as a biomarker for cobalt cardiotoxicity

Currie, Susan (Principal Investigator) Grant, Mary (Co-investigator) Tate, Rothwelle (Co-investigator)

01-Jan-2019 - 31-Jan-2021

Improving control over the mechanical and transport properties of collagen-based scaffolds for Tissue Engineering and Regenerative Medicine

Grant, Mary (Principal Investigator)

01-Jan-2015 - 30-Jan-2019

EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Claasen, Myndert

Zagnoni, Michele (Principal Investigator) Grant, Mary (Co-investigator) Claasen, Myndert (Research Co-investigator)

01-Jan-2014 - 15-Jan-2020

BTG- Nanotoxicology

Grant, Mary (Principal Investigator) Patwardhan, Siddharth (Principal Investigator) Urquhart, Andrew (Principal Investigator)

Although nanoparticles are extensively used in a wide range of commercial applications, the understanding of their toxicity has started to emerge only recently and confusion regarding their safe use is widespread. In this project, we aim to assess the toxicity of newly-invented nanoparticles which have applications in biomedical materials such as drug delivery. Consequences of exposure to the nanoparticles will be assessed (using appropriate ISO standard protocols) by effects on viability, proliferation and cytokine release. One outcome of this project will be known toxicity and drug delivering ability of new nanoparticles.

05-Jan-2011 - 01-Jan-2012

Knowledge Transfer Account / RA4658

Grant, Mary (Principal Investigator)

01-Jan-2011 - 30-Jan-2012

KTA - 3-D hepatocyte model systems for testing the toxicity of new pharmaceuticals

Grant, Mary (Principal Investigator)

The toxicty of novel candidate pharmaceuicals is usually tested in animals. Cultured liver cells (hepatocytes) are being developed for in vitro testing of toxicity in order to reduce and replace the use of animals. Instability of their functions in culture is limiting progress towards this aim. This project investigates the potential of a new culture matrix (Orla 3-D Cell Carrier glass matrix) developed by Orla Protein Technologies to maintain functional hepatocytes in a 3-dimensional configuration.

01-Jan-2011 - 30-Jan-2011

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