Professor Iain Hunter
Research Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Insights into the spectrum of activity and mechanism of action of MGB-BP-3 Hind Charlotte, Clifford Melanie, Woolley Charlotte, Harmer Jane, McGee Leah M C, Tyson-Hirst Izaak, Tait Henry J, Brooke Daniel P, Dancer Stephanie J, Hunter Iain S, Suckling Colin J, Beveridge Rebecca, Parkinson John A, Sutton J Mark, Scott Fraser J ACS Infectious Diseases Vol 8, pp. 2552-2563 (2022) https://doi.org/10.1021/acsinfecdis.2c00445 Phosphoproteome dynamics of streptomyces rimosus during submerged growth and antibiotic production Šarić Ela, Quinn Gerry A, Nalpas Nicolas, Paradžik Tina, Kazazić Saša, Filić Želimira, Šemanjski Maja, Herron Paul, Hunter Iain, Maček Boris, Vujaklija Dušica mSystems Vol 7 (2022) https://doi.org/10.1128/msystems.00199-22 Multitargeted anti-infective drugs : resilience to resistance in the antimicrobial resistance era Suckling Colin J, Hunter Iain S, Scott Fraser J Future Drug Discovery Vol 4 (2022) https://doi.org/10.4155/fdd-2022-0001 Bilateral symmetry of linear streptomycete chromosomes Algora-Gallardo Lis, Schniete Jana K, Mark David R, Hunter Iain S, Herron Paul R Microbial Genomics Vol 7 (2021) https://doi.org/10.1099/mgen.0.000692 ActDES – a curated actinobacterial database for evolutionary studies Schniete Jana K, Selem-Mojica Nelly, Birke Anna S, Cruz-Morales Pablo, Hunter Iain S, Barona-Gómez Francisco, Hoskisson Paul A Microbial Genomics Vol 7 (2021) https://doi.org/10.1099/mgen.0.000498 Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2) Schniete Jana K, Reumerman Richard, Kerr Leena, Tucker Nicholas P, Hunter Iain S, Herron Paul R, Hoskisson Paul A Access Microbiology (2020) https://doi.org/10.1099/acmi.0.000122
Publications
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Acies Bio Limited (External organisation) Member 1/8/2009 SQA (External organisation) Member 1/9/2008 MGB Biopharma (External organisation) Advisor 1/2008
S-MGBs to Treat Invasive and Serious Fungal Diseases (IFDs) Scott, Fraser (Principal Investigator) Hunter, Iain (Co-investigator) Suckling, Colin (Co-investigator) 01-Jan-2023 - 31-Jan-2024 S-MGBs to Treat Invasive and Serious Fungal Diseases (IFDs) Scott, Fraser (Principal Investigator) Hunter, Iain (Co-investigator) Suckling, Colin (Co-investigator) 01-Jan-2022 - 30-Jan-2023 Investigating a novel class of Gram-negative active antibiotic suitable for clinical use Scott, Fraser (Principal Investigator) Hunter, Iain (Co-investigator) Suckling, Colin (Co-investigator) Tucker, Nicholas (Co-investigator) 01-Jan-2020 - 30-Jan-2023 Strathclyde COVID-19 Research Portfolio: Novel testing, digital health support and third sector collaboration for impact on social care Bedford, Tim (Principal Investigator) Corrigan, Damion (Co-investigator) Dunlop, Mark (Co-investigator) Egan, Kieren (Co-investigator) Fleming, Leanne (Co-investigator) Flowers, Paul (Co-investigator) Grealy, Madeleine (Co-investigator) Hoskisson, Paul (Co-investigator) Hunter, Iain (Co-investigator) Janssen, Xanne (Co-investigator) Kirk, Alison (Co-investigator) Knifton, Lee (Co-investigator) Lenhart, Otto (Co-investigator) Maguire, Roma (Co-investigator) Morton, Alec (Co-investigator) Quinn, Neil (Co-investigator) Scott, Fraser (Co-investigator) Suckling, Colin (Co-investigator) Ward, Andrew (Co-investigator) Williams, Lynn (Co-investigator) 01-Jan-2020 - 16-Jan-2021 Re-engineering robustness in to industrial antibiotic producing Streptomyces strains (Super Follow on Fund) Hoskisson, Paul (Principal Investigator) Hunter, Iain (Co-investigator) 01-Jan-2019 - 31-Jan-2022 Enhancing the yield of industrial Actinomycete fermentations Hoskisson, Paul (Principal Investigator) Hunter, Iain (Co-investigator) A new and radical approach to strain construction is needed for the UK to remain competitive in manufacturing off-patent antibiotics. Antibiotic fermentation processes balance nutrients and cell growth rate with the chemical and physical environments. Cellular output is traditionally improved by selecting higher-producing mutants and optimising fermentation media. However, many antibiotics are unstable in the extracellular environment, with well characterised relationships between pH and degradation rate. The pH range for operation of the biological system often conflicts with the optimum for chemical stability of the product. For an established commercial process we propose to utilise recent advances in synthetic biology and genomics to develop a bacterial strain and industrial fermentation process capable of operating at a lower pH, facilitating stability of the desired product. 01-Jan-2016 - 31-Jan-2019
Professional Activities
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Contact
Professor
Iain
Hunter
Research Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: i.s.hunter@strath.ac.uk
Tel: 548 4159