Dr Arnaud Javelle

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Ion Transport in Bacteria

Research in my laboratory is focused on membrane proteins involved in transport of ions across cellular membranes and in signalling processes relating to ion availability. Studies of membrane transporters/channels have had a great impact on our understanding human disease and drug design; indeed ion channels are, at present, the third biggest target classe in drug discovery and about 30% of current clinically marked drugs are targeted against these proteins.
The philosophy of my research, is to use simple and well studied bacterial model organisms, and a multidisciplinary approach to shed more light on two ubiquitous families of ion transporters both of which are conserved from bacteria to man: the ammonium transporter from the Amt/Rh family (TC 1.A.11) and the sulphate permease from the SulP/SLC26A family (TC 2.A.53).

I am a Fellow of the Higher Education Academy.

Publications

The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB
Dias Mirandela Gaëtan, Tamburrino Giulia, Hoskisson Paul A, Zachariae Ulrich, Javelle Arnaud
FASEB Journal Vol 33, pp. 1989-1999 (2019)
https://doi.org/10.1096/fj.201800782R
Merging in-solution X-ray and neutron scattering data allows fine structural analysis of membrane-protein detergent complexes
Dias Mirandela Gaëtan, Tamburrino Giulia, Ivanović Miloš T, Strnad Felix M, Byron Olwyn, Rasmussen Tim, Hoskisson Paul A, Hub Jochen S, Zachariae Ulrich, Gabel Frank, Javelle Arnaud
Journal of Physical Chemistry Letters Vol 9, pp. 3910–3914 (2018)
https://doi.org/10.1021/acs.jpclett.8b01598
The E. coli dicarboxylic acid transporters DauA act as a signal transducer by interacting with the DctA uptake system
Karinou Eleni, Hoskisson Paul A, Strecker Alexander, Unden Gottfried, Javelle Arnaud
Scientific Reports Vol 7 (2017)
https://doi.org/10.1038/s41598-017-16578-w
Prestin and the good vibrations
Birke Anna, Javelle Arnaud
Biochemical Journal Vol 473, pp. 2425-2427 (2016)
https://doi.org/10.1042/BCJ20160015
Conserved structure and domain organization among bacterial Slc26 transporters
Compton-Daw Emma, Page Kimberly, Findlay Heather E, Haertlein Michael, Moulin Martine, Zachariae Ulrich, Norman David G, Gabel Frank, Javelle Arnaud
Biochemical Journal Vol 463, pp. 297-307 (2014)
https://doi.org/10.1042/BJ20130619
Ammonium transport proteins with changes in one of the conserved pore histidines have different performance in ammonia and methylamine conduction
Wang Jinan, Fulford Tim, Shao Qiang, Javelle Arnaud, Yang Huaiyu, Zhu Weiliang, Merrick Mike
PLOS One Vol 8 (2013)
https://doi.org/10.1371/journal.pone.0062745

more publications

Professional activities

“The ammonium transporter from the Amt/Mep/Rh family Mystery solved?”
Speaker
30/4/2019
The ammonium transporter from the Amt/Mep/Rh family: Mystery solved?
Speaker
5/12/2018
Investigating the metamorphic properties of annexin A5 during membrane integration
External Examiner
4/12/2018
The ammonium transporter from the Amt/Mep/Rh family Mystery solved?
Speaker
8/11/2018
The ammonium transporter from the Amt/Rh family; functional interaction with lipids
Speaker
26/10/2018
Structure and Function of the ammonium transporter AmtB from E. coli
Speaker
2/7/2018

more professional activities

Projects

Influence of ammonium transport mechanism of the conserved Mep-Amt-Rh protein family in the fungal filamentation induction
Javelle, Arnaud (Principal Investigator) BOECKSTAENS, Melanie (Researcher)
EMBO Short term Fellowship
The objective is to perform an in vitro assay using purified yeast mep ammonium transporter to undertake quantitative kinetic measurements under a variety of experimental condition. This assay using Solid Surface Membrane Electrophysiology (SSME) consists in measuring transport activity by electrophysiology after reconstitution of the purified transporter into artificial liposomes.
02-Jan-2018 - 17-Jan-2018
Visit to Devro (Gordon Paul, Darren Quinn, Katrina Davidson for PhD studentships via IBioIC/Strathclyde CD
Javelle, Arnaud (Principal Investigator)
Visit to Devro (Gordon Paul, Darren Quinn, Katrina Davidson for PhD studentships via IBioIC/Strathclyde CDT
11-Jan-2018
Elucidating the mechanism of ammonium transport by the ubiquitous family of Amt/Rh protein
Javelle, Arnaud (Principal Investigator) Gabel, Frank (Principal Investigator)
01-Jan-2018 - 30-Jan-2018
Functional characterisation of membrane transporters involved in human physiopathology
Javelle, Arnaud (Principal Investigator)
01-Jan-2017 - 30-Jan-2018
Characterisation of bacterial dicarboxylic acid transporters
Javelle, Arnaud (Principal Investigator) Übelmesser, Nadine (Post Grad Student)
ERASMUS
24-Jan-2016 - 27-Jan-2017
Elucidating the mechanism of ammonium transport by the Amt protein family” collaborative project with neutron beamtime for Small Angle Neutron Scattering analysis
Javelle, Arnaud (Principal Investigator) Gabel, Frank (Research Co-investigator)
01-Jan-2016 - 30-Jan-2016

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Hamnett Wing

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