Dr Arnaud Javelle
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Personal statement
Ion Transport in Bacteria
Research in my laboratory is focused on membrane proteins involved in transport of ions across cellular membranes and in signalling processes relating to ion availability. Studies of membrane transporters/channels have had a great impact on our understanding human disease and drug design; indeed ion channels are, at present, the third biggest target classe in drug discovery and about 30% of current clinically marked drugs are targeted against these proteins.
The philosophy of my research, is to use simple and well studied bacterial model organisms, and a multidisciplinary approach to shed more light on two ubiquitous families of ion transporters both of which are conserved from bacteria to man: the ammonium transporter from the Amt/Rh family (TC 1.A.11) and the sulphate permease from the SulP/SLC26A family (TC 2.A.53).
I am a Fellow of the Higher Education Academy.
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Publications
- Prokaryotic ammonium transporters : what has three decades of research revealed?
- Bizior Adriana, Williamson Gordon, Harris Thomas, Hoskisson Paul A, Javelle Arnaud
- Microbiology Vol 169 (2023)
- https://doi.org/10.1099/mic.0.001360
- Coexistence of ammonium transporter and channel mechanisms in Amt-Mep-Rh Twin-His variants impairs the filamentation signalling capacity of fungal Mep2 transceptors
- Williamson Gordon, Brito Ana Sofia, Bizior Adriana, Tamburrino Giulia, Dias Mirandela Gaetan, Harris Thomas, Hoskisson Paul A, Zachariae Ulrich, Marini Anna Maria, Boeckstaens Melanie, Javelle Arnaud
- mBio Vol 13 (2022)
- https://doi.org/10.1128/mbio.02913-21
- Correction : a two-lane mechanism for selective biological ammonium transport
- Williamson Gordon, Tamburrino Giulia, Bizior Adriana, Boeckstaens Mélanie, Dias Mirandela Gaëtan, Bage Marcus G, Pisliakov Andrei, Ives Callum M, Terras Eilidh, Hoskisson Paul A, Marini Anna-Maria, Zachariae Ulrich, Javelle Arnaud
- eLife Vol 11 (2022)
- https://doi.org/10.7554/elife.77377
- A two-lane mechanism for selective biological ammonium transport
- Williamson Gordon, Tamburrino Guila, Bizior Adriana, Boeckstaens Mélanie, Dias Mirandela Gaëtan, Bage Marcus G, Pisliakov Andrei, Ives Callum M, Terras Eilidh, Hoskisson Paul A, Marini Anna Maria, Zachariae Ulrich, Javelle Arnaud
- eLife Vol 9 (2020)
- https://doi.org/10.7554/eLife.57183
- The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB
- Dias Mirandela Gaëtan, Tamburrino Giulia, Hoskisson Paul A, Zachariae Ulrich, Javelle Arnaud
- FASEB Journal Vol 33, pp. 1989-1999 (2019)
- https://doi.org/10.1096/fj.201800782R
- Merging in-solution X-ray and neutron scattering data allows fine structural analysis of membrane-protein detergent complexes
- Dias Mirandela Gaëtan, Tamburrino Giulia, Ivanović Miloš T, Strnad Felix M, Byron Olwyn, Rasmussen Tim, Hoskisson Paul A, Hub Jochen S, Zachariae Ulrich, Gabel Frank, Javelle Arnaud
- Journal of Physical Chemistry Letters Vol 9, pp. 3910–3914 (2018)
- https://doi.org/10.1021/acs.jpclett.8b01598
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Professional Activities
- “The ammonium transporter from the Amt/Mep/Rh family Mystery solved?”
- Speaker
- 30/4/2019
- The ammonium transporter from the Amt/Mep/Rh family: Mystery solved?
- Speaker
- 5/12/2018
- Investigating the metamorphic properties of annexin A5 during membrane integration
- External Examiner
- 4/12/2018
- The ammonium transporter from the Amt/Mep/Rh family Mystery solved?
- Speaker
- 8/11/2018
- The ammonium transporter from the Amt/Rh family; functional interaction with lipids
- Speaker
- 26/10/2018
- Structure and Function of the ammonium transporter AmtB from E. coli
- Speaker
- 2/7/2018
Projects
- Influence of ammonium transport mechanism of the conserved Mep-Amt-Rh protein family in the fungal filamentation induction
- Javelle, Arnaud (Principal Investigator) BOECKSTAENS, Melanie (Researcher)
- EMBO Short term Fellowship
The objective is to perform an in vitro assay using purified yeast mep ammonium transporter to undertake quantitative kinetic measurements under a variety of experimental condition. This assay using Solid Surface Membrane Electrophysiology (SSME) consists in measuring transport activity by electrophysiology after reconstitution of the purified transporter into artificial liposomes. - 02-Jan-2018 - 17-Jan-2018
- Visit to Devro (Gordon Paul, Darren Quinn, Katrina Davidson for PhD studentships via IBioIC/Strathclyde CD
- Javelle, Arnaud (Principal Investigator)
- Visit to Devro (Gordon Paul, Darren Quinn, Katrina Davidson for PhD studentships via IBioIC/Strathclyde CDT
- 11-Jan-2018
- Elucidating the mechanism of ammonium transport by the ubiquitous family of Amt/Rh protein
- Javelle, Arnaud (Principal Investigator) Gabel, Frank (Principal Investigator)
- 01-Jan-2018 - 30-Jan-2018
- Functional characterisation of membrane transporters involved in human physiopathology
- Javelle, Arnaud (Principal Investigator)
- 01-Jan-2017 - 30-Jan-2018
- Characterisation of bacterial dicarboxylic acid transporters
- Javelle, Arnaud (Principal Investigator) Übelmesser, Nadine (Post Grad Student)
- ERASMUS
- 24-Jan-2016 - 27-Jan-2017
- Elucidating the mechanism of ammonium transport by the Amt protein family” collaborative project with neutron beamtime for Small Angle Neutron Scattering analysis
- Javelle, Arnaud (Principal Investigator) Gabel, Frank (Research Co-investigator)
- 01-Jan-2016 - 30-Jan-2016
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Contact
Dr
Arnaud
Javelle
Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: arnaud.javelle@strath.ac.uk
Tel: 548 3827