Professor Blair Johnston
Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications
- A novel integrated workflow for isolation solvent selection using prediction and modelling
- Ottoboni Sara, Wareham Bruce, Vassileiou Antony, Robertson Murray, Brown Cameron J, Johnston Blair, Price Chris J
- Organic Process Research and Development Vol 25, pp. 1143-1159 (2021)
- https://doi.org/10.1021/acs.oprd.0c00532
- Quantification of swelling characteristics of pharmaceutical particles
- Soundaranathan Mithushan, Vivattanaseth Pattavet, Walsh Erin, Pitt Kendal, Johnston Blair, Markl Daniel
- International Journal of Pharmaceutics Vol 590 (2020)
- https://doi.org/10.1016/j.ijpharm.2020.119903
- Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers
- Warzecha Monika, Verma Lakshmanji, Johnston Blair F, Palmer Jeremy C, Florence Alastair J, Vekilov Peter G
- Nature Chemistry Vol 12, pp. 914-920 (2020)
- https://doi.org/10.1038/s41557-020-0542-0
- Data mining crystallization kinetics
- Brown Cameron, Maldonado Diego A, Vassileiou Antony, Johnston Blair, Florence Alastair
- Current Trends in Chemical Process Technology and Materials Development (2020)
- Data mining crystallization kinetics
- Brown Cameron, Maldonado Diego, Vassileiou Antony, Johnston Blair, Florence Alastair
- (2020)
- Non-leaching, highly biocompatible nanocellulose surfaces that efficiently resist fouling by bacteria in an artificial dermis model
- Hassan Ghada, Forsman Nina, Wan Xing, Keurulainen Leena, Bimbo Luis M, Stehl Susanne, van Charante Frits, Chrubasik Michael, Prakash Aruna S, Johansson Leena-Sisko, Mullen Declan C, Johnston Blair F, Zimmermann Ralf, Werner Carsten, Yli-Kauhaluoma Jari, Coenye Tom, Saris Per E J, Österberg Monika, Moreira Vânia M
- ACS Applied Bio Materials Vol 3, pp. 4095-4108 (2020)
- https://doi.org/10.1021/acsabm.0c00203
Research interests
Dr Blair Johnston is a Reader in Computational Modelling at the Strathclyde Institute of Pharmacy and Biomedical Sciences. He teaches on the Masters of Pharmacy, Pharmaceutical Analysis, Clinical Pharmacy and Chemistry with Drug Discovery degrees.
My group has research interests in five broad areas: drug discovery, molecular structure simulation, machine learning and prediction, data analysis, and web-enabled science and collaboration tools. In the vast majority of our research, we work closely with experimental scientists in the design and execution of collaborative research to realise the full potential of their laboratory data. This combination of experiment and theory often provides unique insight into the systems being studied.
Professional activities
- Novel off-target effects of doxorubicin on cardiovascular gap-junctional proteins
- Contributor
- 5/2/2021
- P011 - Endothelial connexin-43 dysregulation in response to the anthracycline doxorubicin
- Contributor
- 14/12/2020
- P2.5.6 - Novel off-target effects of anti-cancer drugs on cardiovascular gap-junctional proteins
- Contributor
- 12/10/2020
- Data Mining Crystallisation Kinetics
- Contributor
- 19/8/2020
- Cambridge Crystallographic Data Centre (CCDC) European UGM and Science Day
- Participant
- 13/6/2019
- EPSRC Future Manufacturing Research Hubs Showcase Event - CMAC
- Speaker
- 30/4/2019
Projects
- International Collaboration for Digital Design and Manufacture of Amorphous Pharmaceuticals
- Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Robertson, John (Co-investigator)
- 01-Jan-2022 - 31-Jan-2025
- CMMI-EPSRC - Right First Time Manufacture of Pharmaceuticals (RiFTMaP)
- Markl, Daniel (Principal Investigator) Johnston, Blair (Co-investigator)
- 01-Jan-2021 - 31-Jan-2024
- Made Smarter Innovation: Digital Medicines Manufacturing Research Centre (DM2)
- Florence, Alastair (Principal Investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Pierce, Gareth (Co-investigator)
- 01-Jan-2021 - 28-Jan-2025
- Digital Design Accelerator Platform to Connect Active Material Design to Product Performance (Manufacturing Made Smarter)
- Florence, Alastair (Principal Investigator) Johnston, Blair (Co-investigator)
- 01-Jan-2020 - 31-Jan-2022
- Doctoral Training Partnership 2018-19 University of Strathclyde | Pereira-Diaz, Laura
- Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Johnston, Blair (Co-investigator) Pereira-Diaz, Laura (Research Co-investigator)
- 01-Jan-2019 - 01-Jan-2023
- Investigating the biomolecular complexity of drug-induced cardiotoxicity by fingerprinting single cell and cardiac spheroid mass spectral information using Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS)
- Cunningham, Margaret Rose (Principal Investigator) Veerman, Ben (Post Grad Student) Johnston, Blair (Co-investigator) Currie, Susan (Co-investigator)
- The aim of this project is to significantly advance upon ongoing efforts in understanding drug-induced cardiotoxicity not only at the single cell level but in a multicellular model that may better reflect the cellular microenvironment of the heart. Extending studies to assess the metabolite changes in the multicellular environment in response to cancer therapeutics may reveal events integral to toxicity which may lead to new knowledge to develop ways to minimise or prevent cellular toxicity in the cardiac niche.
- 01-Jan-2019 - 28-Jan-2022
Address
Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre