Publications

Testing on continuous production of mefenamic acids - design of experiment through simulation and process optimisation

Wu Kai Eivind, Brown Cameron J, Robertson Murray, Johnston Blair F, Lloyd Rhys, Panoutsos George

European Journal of Pharmaceutical Sciences Vol 210 (2025)

https://doi.org/10.1016/j.ejps.2025.107102

Quality by digital design to accelerate sustainable medicines development

Mustoe Chantal L, Turner Alice J, Urwin Stephanie J, Houson Ian, Feilden Helen, Markl Daniel, Al Qaraghuli Mohammed M, Chong Magdalene WS, Robertson Murray, Nordon Alison, Johnston Blair F, Brown Cameron J, Robertson John, Adjiman Claire, Batchelor Hannah, Benyahia Brahim, Bresciani Massimo, Burcham Christopher L, Cardona Javier, Cottini Ciro, Dunn Andrew S, Fradet David, Halbert Gavin W, Henson Mark, Hidber Pirmin, Langston Marianne, Lee Ye Seol, Li Wei, Mantanus Jérôme, McGinty John, Mehta Bhavik, Naz Tabbasum, Ottoboni Sara, Prasad Elke, Quist Per-Ola, Reynolds Gavin K, Rielly Chris, Rowland Martin, Schlindwein Walkiria, Schroeder Sven LM, Sefcik Jan, Settanni Ettore, Siddique Humera, Smith Kenneth, Smith Rachel, Srai Jagjit Singh, Thorat Alpana A, Vassileiou Antony, Florence Alastair J

International Journal of Pharmaceutics Vol 681 (2025)

https://doi.org/10.1016/j.ijpharm.2025.125625

Optimisation of additively manufactured coiled flow inverters for continuous viral inactivation processes

Barrera Maria Cecilia, Leech Damien, Josifovic Aleksandar, Tolouei Anita, Alford Gareth, Wallace Martin J, Bennett Nicholas, Wildman Ricky, Irvine Derek J, Croft Anna, Özcan Ender, Florence Alastair J, Johnston Blair, Robertson John, Brown Cameron J

Chemical Engineering Research and Design Vol 213, pp. 126-136 (2025)

https://doi.org/10.1016/j.cherd.2024.11.040

Flexible modelling of the dissolution performance of directly compressed tablets

Maclean Natalie, Armstrong John A, Carroll Mark A, Salehian Mohammad, Mann James, Reynolds Gavin, Johnston Blair, Markl Daniel

International Journal of Pharmaceutics Vol 656 (2024)

https://doi.org/10.1016/j.ijpharm.2024.124084

Deep generative model for pharmaceutical process design

Alvarado. D, Johnston B, Brown C

CMAC Open Days 2023, pp. 56 (2023)

Digital process design to define and deliver pharmaceutical particle attributes

Urwin Stephanie J, Chong Magdalene WS, Li Wei, McGinty John, Mehta Bhavik, Ottoboni Sara, Pathan Momina, Prasad Elke, Robertson Murray, McGowan Mark, al-Attili Mais, Gramadnikova Ekaterina, Siddique Mariam, Houson Ian, Feilden Helen, Benyahia Brahim, Brown Cameron J, Halbert Gavin W, Johnston Blair, Nordon Alison, Price Chris J, Reilly Chris D, Sefcik Jan, Florence Alastair J

Chemical Engineering Research and Design Vol 196, pp. 726-749 (2023)

https://doi.org/10.1016/j.cherd.2023.07.003

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Research Interests

Dr Blair Johnston is a Reader in Computational Modelling at the Strathclyde Institute of Pharmacy and Biomedical Sciences. He teaches on the Masters of Pharmacy, Pharmaceutical Analysis, Clinical Pharmacy and Chemistry with Drug Discovery degrees.

My group has research interests in five broad areas: drug discovery, molecular structure simulation, machine learning and prediction, data analysis, and web-enabled science and collaboration tools. In the vast majority of our research, we work closely with experimental scientists in the design and execution of collaborative research to realise the full potential of their laboratory data. This combination of experiment and theory often provides unique insight into the systems being studied.

Professional Activities

Data Mining Crystallisation Kinetics

Contributor

31/3/2021

Novel off-target effects of doxorubicin on cardiovascular gap-junctional proteins

Contributor

5/2/2021

P011 - Endothelial connexin-43 dysregulation in response to the anthracycline doxorubicin

Contributor

14/12/2020

P2.5.6 - Novel off-target effects of anti-cancer drugs on cardiovascular gap-junctional proteins

Contributor

12/10/2020

Data Mining Crystallisation Kinetics

Contributor

19/8/2020

Cambridge Crystallographic Data Centre (CCDC) European UGM and Science Day

Participant

13/6/2019

More professional activities

Projects

DPN-MED: Digital Plug-and-Produce Network for Sustainable Medicines Development and Manufacturing

Fitzpatrick, Stephen (Principal Investigator) Florence, Alastair (Principal Investigator) Florence, Alastair (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator)

01-Jan-2025 - 30-Jan-2025

EPSRC MediForge Hub: An Integrated, Reconfigurable and Cyberphysical Manufacturing Platform for Resilient and Sustainable Medicines Manufacture (Manufacturing Research Hub)

Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Cardona Amengual, Javier (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Robertson, John (Co-investigator) Sefcik, Jan (Co-investigator)

01-Jan-2024 - 30-Jan-2031

PharmaCrystNet: Improving the Predictive Capabilities of Crystallisation Models in

Brown, Cameron (Principal Investigator) Dolean Maini, Victorita (Co-investigator) Johnston, Blair (Co-investigator)

01-Jan-2024 - 28-Jan-2026

SHARPEN: SHARing data to accelerate Pharmaceutical manufacturing Efficiency across trusted Networks

Johnston, Blair (Principal Investigator) Florence, Alastair (Co-investigator) Markl, Daniel (Co-investigator)

01-Jan-2024 - 31-Jan-2026

A Regulatory Science Network for the Digital Transformation of Medicines Development and Manufacturing (10113547)

Markl, Daniel (Principal Investigator) Florence, Alastair (Co-investigator) Johnston, Blair (Co-investigator)

01-Jan-2024 - 31-Jan-2024

DTP 2224 University of Strathclyde | Robertson, Jason

Johnston, Blair (Principal Investigator) Markl, Daniel (Co-investigator) Robertson, Jason (Research Co-investigator)

01-Jan-2023 - 01-Jan-2029

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