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Dr Blair Johnston

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Strathclyde Institute of Pharmacy and Biomedical Sciences

Publications

Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisations
Brown Cameron J., McGlone Thomas, Yerdelen Stephanie, Srirambhatla Vijay, Mabbott Fraser, Gurung Rajesh, Briuglia Maria L., Ahmed Bilal, Polyzois Hector, Mcginty John, Perciballi Francesca, Fysikopoulos Dimitris, Macfhionnghaile Pól, Siddique Humera, Raval Vishal, Harrington Tomás S., Vassileiou Antony D., Robertson Murray, Prasad Elke, Johnston Andrea, Johnston Blair, Nordon Alison, Srai Jagjit S., Halbert Gavin, ter Horst Joop H., Price Chris J., Rielly Chris D., Sefcik Jan, Florence Alastair J.
Molecular Systems Design and Engineering Vol 3, pp. 518-549, (2018)
http://dx.doi.org/10.1039/c7me00096k
Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisation
Brown Cameron J., McGlone Thomas, Yerdelen Stephanie, Srirambhatla Vijay, Mabbott Fraser, Gurung Rajesh, Briuglia Maria L., Ahmed Bilal, Polyzois Hector, McGinty John, Perciballi Francesca, Fysikopoulos Dimitris, Macfhionnghaile Pól, Siddique Humera, Raval Vishal, Harrington Tomás S., Vassileiou Antony, Robertson Murray, Prasad Elke, Johnston Andrea, Johnston Blair, Nordon Alison, Srai Jagjit, Halbert Gavin, Ter Horst Joop H., Price Chris J., Rielly Chris D., Sefcik Jan, Florence Alastair J.
Molecular Systems Design and Engineering Vol 2018, pp. 518-549, (2018)
http://dx.doi.org/10.1039/C7ME00096K
Impact of paracetamol impurities on face properties : investigating the surface of single crystals using TOF-SIMS
Ottoboni Sara, Chrubasik Michael, Mir Bruce Layla, Nguyen Thai Thu Hien, Robertson Murray, Johnston Blair, Oswald Iain D. H., Florence Alastair, Price Chris
Crystal Growth and Design Vol 18, pp. 2750–2758, (2018)
http://dx.doi.org/10.1021/acs.cgd.7b01411
Degradation behavior of silk nanoparticles – enzyme responsiveness
Wongpinyochit Thidarat, Johnston Blair F., Seib F. Philipp
ACS Biomaterials Science & Engineering Vol 4, pp. 942-951, (2018)
http://dx.doi.org/10.1021/acsbiomaterials.7b01021
Regioselective reaction of heterocyclic N-oxides, an acyl chloride and cyclic thioethers
Frei Przemysslaw, Jones D. Heulyn, Kay Steven T., McLellan Jayde A., Johnston Blair F., Kennedy Alan R., Tomkinson Nicholas C. O.
Journal of Organic Chemistry, (2018)
http://dx.doi.org/10.1021/acs.joc.7b02457
Aqueous solubility of organic salts. Investigating trends in a systematic series of 51 crystalline salt forms of methylephedrine
S. de Moraes Lygia, Edwards Darren, Florence Alastair J., Johnston Andrea, Johnston Blair F., Morrison Catriona A., Kennedy Alan R.
Crystal Growth and Design Vol 17, pp. 3277-3286, (2017)
http://dx.doi.org/10.1021/acs.cgd.7b00255

more publications

Research interests

Dr Blair Johnston is a Senior Lecturer in Computational Modelling at the Strathclyde Institute of Pharmacy and Biomedical Sciences. He teaches on the Masters of Pharmacy, Pharmaceutical Analysis, Clinical Pharmacy and Chemistry with Drug Discovery degrees.

My group has research interests in five broad areas: drug discovery, molecular structure simulation, machine learning and prediction, data analysis, and web-enabled science and collaboration tools. In the vast majority of our research, we work closely with experimental scientists in the design and execution of collaborative research to realise the full potential of their laboratory data. This combination of experiment and theory often provides unique insight into the systems being studied.

Professional activities

Accelrys European UGM 09, Barcelona, Spain
Keynote/plenary speaker
2009

more professional activities

Projects

Predicting the Propensity of Solvate and Hydrate Formation in Small Molecule Crystal Structures
Johnston, Blair (Principal Investigator)
Period 01-Jan-2018 - 30-Jun-2021
ARTICULAR: ARtificial inTelligence for Integrated ICT-enabled pharmaceUticaL mAnufactuRing
Johnston, Blair (Principal Investigator) Florence, Alastair (Co-investigator)
Period 01-Jul-2018 - 30-Jun-2022
Tracing the fate of nanomedicines in the tumour microenvironment (MC Career Integration) | Totten, John
Seib, Philipp (Principal Investigator) Johnston, Blair (Co-investigator) Totten, John (Research Co-investigator)
Period 01-Oct-2015 - 01-Apr-2019
Generating and Interrogating Crystallographic Data to Predict Solid-State Properties
Kennedy, Alan (Principal Investigator) Silva De Moraes, Lygia (Post Grad Student) Johnston, Blair (Co-investigator)
Period 11-May-2015 - 01-May-2019
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
"Our Hub research is driven by the societal need to produce medicines and materials for modern living through novel manufacturing processes. The enormous value of the industries manufacturing these high value products is estimated to generate £50 billion p.a. in the UK economy. To ensure international competitiveness for this huge UK industry we must urgently create new approaches for the rapid design of these systems, controlling how molecules self-assemble into small crystals, in order to best formulate and deliver these for patient and customer. We must also develop the engineering tools, process operations and control methods to manufacture these products in a resource-efficient way, while delivering the highest quality materials. Changing the way in which these materials are made, from what is called batch crystallisation (using large volume tanks) to continuous crystallisation (a more dynamic, flowing process), gives many advantages, including smaller facilities, more efficient use of expensive ingredients such as solvents, reducing energy requirements, capital investment, working capital, minimising risk and variation and, crucially, improving control over the quality and performance of the particles making them more suitable for formulation into final products. The vision is to quickly and reliably design a process to manufacture a given material into the ideal particle using an efficient continuous process, and ensure its effective delivery to the consumer. This will bring precision medicines and other highly customisable projects to market more quickly. An exemplar is the hubs exciting innovation partnership with Cancer Research UK. Our research will develop robust design procedures for rapid development of new particulate products and innovative processes, integrate crystallisation and formulation to eliminate processing steps and develop reconfiguration strategies for flexible production. This will accelerate innovation towards redistributed anufacturing, more personalisation of products, and manufacturing closer to the patient/customer. We will develop a modular MicroFactory for integrated particle engineering, coupled with a fully integrated, computer-modelling approach to guide the design of processes and materials at molecule, particle and formulation levels. This will help optimise what we call the patient-centric supply chain and provide customisable products. We will make greater use of targeted experimental design, prediction and advanced computer simulation of new formulated materials, to control and optimise the processes to manufacture them. Our talented team of scientists will use the outstanding capabilities in the award winning £34m CMAC National Facility at Strathclyde and across our 6 leading university spokes (Bath, Cambridge, Imperial, Leeds, Loughborough, Sheffield). This builds on existing foundations independently recognised by global industry as 'exemplary collaboration between industry, academia and government which represents the future of pharmaceutical manufacturing and supply chain framework'. Our vision will be translated from research into industry through partnership and co-investment of £31m. This includes 10 of world's largest pharmaceutical companies (eg AstraZeneca, GSK), chemicals and food companies (Syngenta, Croda, Mars) and 19 key technology companies (Siemens, 15 SMEs) Together, with innovation spokes eg Catapult (CPI) we aim to provide the UK with the most advanced, integrated capabilities to deliver continuous manufacture, leading to better materials, better value, more sustainable and flexible processes and better health and well-being for the people of the UK and worldwide. CMAC will create future competitive advantage for the UK in medicines manufacturing and chemicals sector and is strongly supported by industry / government bodies, positioning the UK as the investment location choice for future investments in research and manufacturing."
Period 01-Jan-2017 - 31-Dec-2023
Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Gurung, Rajesh
Florence, Alastair (Principal Investigator) Johnston, Blair (Co-investigator) Gurung, Rajesh (Research Co-investigator)
Period 01-Oct-2013 - 01-Oct-2017

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology Innovation Centre

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