Dr Ibrahim Khadra

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Dr Ibrahim Khadra is a registered pharmacist at the Palestine Pharmacist Society with a BPharm degree in Pharmacy from Alazhar University Palestine, MSc and PhD in Pharmaceutical analysis from University of Strathclyde, Glasgow. He has extensive experience in Pharmaceutical analysis and Formulation and also he has a strong link to the industry. Ibrahim has extensive experience in the development of oral dosage forms, analytical methods, pharmacokinetics and regulatory affairs within the pharmaceutical industry and academia.  Currently leading a team of researcher on Oral Biopharmaceutical Tool (OrBito) at Strathclyde University, a project funded by the Innovative Medicines Initiative, a public-private partnership between the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The OrBito project aims to enhance our understanding of how orally-administered drugs are taken up from the gastrointestinal tract into the body, and apply this knowledge to create new laboratory tests and computer models that will better predict the performance of these drugs in patients.

Publications

Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
Abuhassan Qamar, Khadra Ibrahim, Pyper Kate, Halbert Gavin W
European Journal of Pharmaceutics and Biopharmaceutics Vol 168, pp. 90-96 (2021)
https://doi.org/10.1016/j.ejpb.2021.08.002
Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations
Maclean Natalie, Walsh Erin, Soundaranathan Mithushan, Khadra Ibrahim, Mann James, Williams Helen, Markl Daniel
International Journal of Pharmaceutics Vol 599 (2021)
https://doi.org/10.1016/j.ijpharm.2021.120221
Tablet disintegration performance : effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics
Markl Daniel, Maclean Natalie, Mann James, Williams Helen, Abbott Alexander, Mead Heather, Khadra Ibrahim
International Journal of Pharmaceutics (2021)
Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19 : a structured summary of a study protocol for a randomised controlled trial
Hanna Catherine R, Blyth Kevin G, Burley Glenn, Carmichael Samantha, Evans Carol, Hinsley Samantha, Khadra Ibrahim, Khoo Saye, Lewsley Liz-Anne, Jones Robert R, Sharma Raman, Taladriz-Sender Andrea, Thomson Emma C, Scott Janet T
Trials Vol 21 (2020)
https://doi.org/10.1186/s13063-020-04891-1
Multidimensional analysis of human intestinal fluid composition
Pyper Kate, Brouwers Joachim, Augustijns Patrick, Khadra I, Dunn C, Wilson CG, Halbert GW
European Journal of Pharmaceutics and Biopharmaceutics Vol 153, pp. 226-240 (2020)
https://doi.org/10.1016/j.ejpb.2020.06.011
Small scale design of experiment investigation of equilibrium solubility in simulated fasted and fed intestinal fluid
McPherson Stephanie, Perrier Jeremy, Dunn Claire, Khadra Ibrahim, Davidson Scott, Ainousah Bayan, Wilson Clive G, Halbert Gavin
European Journal of Pharmaceutics and Biopharmaceutics Vol 150, pp. 14-23 (2020)
https://doi.org/10.1016/j.ejpb.2020.01.016

More publications

Research interests

1-    Oral Drug Delivery/Formulation

 Orodispersible thin films (OTFs) were first established as breath fresheners and have since progressed to the delivery of active pharmaceutical ingredients (APIs). Composed principally of one or more water soluble, film-forming polymers, OTFs dissolve very rapidly in contact with saliva, releasing the active ingredient(s) without the need to chew or drink water. This makes them ideally suited to elderly or paediatric populations, who may have difficulty swallowing other solid oral dosage forms such as tablets or capsules.

 This is a growing area with a lot of industrial interest and lack of regulatory information and quick turn over for generic API; therefore the focus will be on the  following area:

-       Tatse Masking of API

-       The use of sweetener and flavour as a taste mask strategy

-       Dissolution assays and Biowavier

-       Thin film stability following the ICH guidelines

-       The use of different film former polymer for different purposes (IR, SR, and wound care application)

 

2-    Oral Biopharmaceutics

As most drugs are taken orally, as tablets or capsules for example. However, designing these pharmaceutical products in such a way that the active ingredient is absorbed at an appropriate rate and extent by the gut is far from easy. Therefore to be able to enhance the understanding of how orally-administered drugs are taken up from the gastrointestinal tract into the body, and apply this knowledge to create new laboratory tests and computer models that will better predict the performance of these drugs in patients.

This is another area of industrial and regulatory interest for which I will follow and continue the research generated and initiated in the oral biopharmaceutical tools project “Orbito” – we will also collaborate with our current industrial partners e.g. GSK, Pfizer, AZ, Novartis and others, and will be linked to colleague in CMAC (Professor Joop Ter Horst, CRUK (Professor Gavin Halbert) and also with the regulatory authorities in UK, Europe and USA.

The  focus will be on the following:

-       API physicochemical characterization

-      Drug solubility in human gastric and intestinal fluids “fed and fasted state” using the DOE approach

-       Develop small-scale tests for dissolution, nucleation and supersaturation.

-       Develop of predictive tools that the industrial partners can use to predict the behavior of their API.

 

3-    Extrusion, 3D and Chocolate Printing

 The applications of three dimensional (3D) printing in the field of pharmaceutical science and medicine are growing rapidly and the technique generates numerous benefits currently and also very promising potential applications in the near future such as drug discovery and delivery and tissue fabrication. 3D printing technology offers many advantages, for example, it permits customization of products and therefore it can be applied on a number of areas, such as drug delivery or tissue engineering.

The work in this area started and project with a leading Pharamceutical Compnay has been initiated which focus on the extrusion of drug loaded filament and the use of 3D printing technology to print a design for female health care.

Also the use of chocolate as drug delivery system for pediatric application is another growing area, the chocolate printer was developed in house and ready to use. This work is coordinated and led by Professor Clive Wilson and myself.

Professional activities

Orbito Annual Conference
Speaker
11/12/2020
Orbito Annual Conference
Speaker
11/2020
UNGAP annual conference
Speaker
3/2/2020
CPD to Saudi Food and Drug Authority
Consultant
14/10/2019
In-viro and In-silico profiling to assist Drug Development
Participant
2018
AstraZeneca Research Day
Speaker
2017

More professional activities

Projects

Understanding long-term stability of solid pharmaceutical dosage forms by characterisation
Markl, Daniel (Principal Investigator) Khadra, Ibrahim (Co-investigator)
01-Jan-2021 - 30-Jan-2023
Exploring the role of the gut microbiome and its interaction with food components in patients with Crohn’s disease - an integrated systems biology approach
Khadra, Ibrahim (Co-investigator) Rattray, Nicholas (Principal Investigator)
This PhD studentship will look into exploring the role of the gut microbiome and its interaction with food components in patients with Crohn’s disease as an integrated systems biology approach.
01-Jan-2021 - 01-Jan-2024
Biocompatible silk hydrogels as tunable stem cell constructs for the treatment of stroke. (skype)
Carswell, Hilary (Principal Investigator) Seib, Philipp (Co-investigator) Khadra, Ibrahim (Research Co-investigator)
01-Jan-2020 - 30-Jan-2023
Combined use of in-vitro and in-silico models for drug discovery
Khadra, Ibrahim (Principal Investigator)
01-Jan-2020 - 31-Jan-2024
Glasgow Early Treatment Arm FavIpiravir (GETAFIX): A randomized controlled study of favipiravir as an early treatment arm in COVID-19 hospitalized patients (COVID-19)
Burley, Glenn (Principal Investigator) Khadra, Ibrahim (Research Co-investigator)
18-Jan-2020 - 30-Jan-2021
AZ/EPSRC Case Award PhD "2"
Khadra, Ibrahim (Co-investigator) Markl, Daniel (Principal Investigator)
Development of a Multimodal Sensor System for Performance Monitoring of Pharmaceuticals
01-Jan-2020 - 01-Jan-2024

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

Location Map

View University of Strathclyde in a larger map