Dr Ibrahim Khadra

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Strathclyde Institute of Pharmacy and Biomedical Sciences

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Personal statement

Dr Ibrahim Khadra is a registered pharmacist at the Palestine Pharmacist Society with a BPharm degree in Pharmacy from Alazhar University Palestine, MSc and PhD in Pharmaceutical analysis from University of Strathclyde, Glasgow. He has extensive experience in Pharmaceutical analysis and Formulation and also he has a strong link to the industry. Ibrahim has extensive experience in the development of oral dosage forms, analytical methods, pharmacokinetics and regulatory affairs within the pharmaceutical industry and academia.  Currently leading a team of researcher on Oral Biopharmaceutical Tool (OrBito) at Strathclyde University, a project funded by the Innovative Medicines Initiative, a public-private partnership between the European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The OrBito project aims to enhance our understanding of how orally-administered drugs are taken up from the gastrointestinal tract into the body, and apply this knowledge to create new laboratory tests and computer models that will better predict the performance of these drugs in patients.

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Publications

The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing
Obeid Mohammad A, Haifawi Saja, Khadra Ibrahim
International Journal of Pharmaceutics: X Vol 5 (2023)
https://doi.org/10.1016/j.ijpx.2023.100168
Study of in vitro poorly soluble drug solubility into fasted state simulated intestinal fluid reflective of in vivo gastrointestinal variability
McKinnon Zoe, Batchelor Hannah, Khadra Ibrahim, Halbert Gavin
British Journal of Pharmacy Vol 8 (2023)
https://doi.org/10.5920/bjpharm.1380
Characterisation of ciprofloxacin-loaded polymeric fiber mats prepared by meltelectrospinning
Obeid Mohammad A, Akil Lina, A Aljabali Alaa, Khadra Ibrahim
Macromolecular Materials and Engineering (2023)
https://doi.org/10.1002/mame.202300376
Structured solubility behaviour in fed simulated intestinal fluids
Silva Maria Inês, Khadra Ibrahim, Pyper Kate, Halbert Gavin W
European Journal of Pharmaceutics and Biopharmaceutics Vol 193, pp. 58-73 (2023)
https://doi.org/10.1016/j.ejpb.2023.10.017
Excipients impact on fenofibrate equilibrium solubility in fasted and fed simulated intestinal fluids assessed using a design of experiment protocol
Ainousah Bayan E, Khadra Ibrahim, Halbert Gavin W
Pharmaceutics Vol 15 (2023)
https://doi.org/10.3390/pharmaceutics15102484
Fed intestinal solubility limits and distributions applied to the developability classification system
Silva Maria Inês, Khadra Ibrahim, Pyper Kate, Halbert Gavin W
European Journal of Pharmaceutics and Biopharmaceutics Vol 186, pp. 74-84 (2023)
https://doi.org/10.1016/j.ejpb.2023.03.005

More publications

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Research Interests

1-    Oral Drug Delivery/Formulation

 Orodispersible thin films (OTFs) were first established as breath fresheners and have since progressed to the delivery of active pharmaceutical ingredients (APIs). Composed principally of one or more water soluble, film-forming polymers, OTFs dissolve very rapidly in contact with saliva, releasing the active ingredient(s) without the need to chew or drink water. This makes them ideally suited to elderly or paediatric populations, who may have difficulty swallowing other solid oral dosage forms such as tablets or capsules.

 This is a growing area with a lot of industrial interest and lack of regulatory information and quick turn over for generic API; therefore the focus will be on the  following area:

-       Tatse Masking of API

-       The use of sweetener and flavour as a taste mask strategy

-       Dissolution assays and Biowavier

-       Thin film stability following the ICH guidelines

-       The use of different film former polymer for different purposes (IR, SR, and wound care application)

 

2-    Oral Biopharmaceutics

As most drugs are taken orally, as tablets or capsules for example. However, designing these pharmaceutical products in such a way that the active ingredient is absorbed at an appropriate rate and extent by the gut is far from easy. Therefore to be able to enhance the understanding of how orally-administered drugs are taken up from the gastrointestinal tract into the body, and apply this knowledge to create new laboratory tests and computer models that will better predict the performance of these drugs in patients.

This is another area of industrial and regulatory interest for which I will follow and continue the research generated and initiated in the oral biopharmaceutical tools project “Orbito” – we will also collaborate with our current industrial partners e.g. GSK, Pfizer, AZ, Novartis and others, and will be linked to colleague in CMAC (Professor Joop Ter Horst, CRUK (Professor Gavin Halbert) and also with the regulatory authorities in UK, Europe and USA.

The  focus will be on the following:

-       API physicochemical characterization

-      Drug solubility in human gastric and intestinal fluids “fed and fasted state” using the DOE approach

-       Develop small-scale tests for dissolution, nucleation and supersaturation.

-       Develop of predictive tools that the industrial partners can use to predict the behavior of their API.

 

3-    Extrusion, 3D and Chocolate Printing

 The applications of three dimensional (3D) printing in the field of pharmaceutical science and medicine are growing rapidly and the technique generates numerous benefits currently and also very promising potential applications in the near future such as drug discovery and delivery and tissue fabrication. 3D printing technology offers many advantages, for example, it permits customization of products and therefore it can be applied on a number of areas, such as drug delivery or tissue engineering.

The work in this area started and project with a leading Pharamceutical Compnay has been initiated which focus on the extrusion of drug loaded filament and the use of 3D printing technology to print a design for female health care.

Also the use of chocolate as drug delivery system for pediatric application is another growing area, the chocolate printer was developed in house and ready to use. This work is coordinated and led by Professor Clive Wilson and myself.

Professional Activities

University of Strathclyde (Event)
Chair
8/2022
EDAN Annual Conference
Speaker
2/5/2022
UNGAP Meeting
Speaker
1/3/2022
Palestine Syndicate of Pharmacists (External organisation)
Advisor
1/1/2022
University of Strathclyde (Event)
Advisor
1/2022
Strathclyde Institute Of Pharmacy And Biomedical Sciences (Organisational unit)
Member
12/2021

More professional activities

Projects

GiBio Gastrointestinal bioreactor to evaluate ingestible medicines and inform formulation and manufacture (EPSRC Strategic equipment)
Batchelor, Hannah (Principal Investigator) Florence, Alastair (Co-investigator) Horan, Linda (Co-investigator) Khadra, Ibrahim (Co-investigator) McArthur, Stephen (Co-investigator)
01-Jan-2022 - 30-Jan-2025
DTP 2224 University of Strathclyde | Abu-Rajab Tamimi, Rana
Khadra, Ibrahim (Principal Investigator) Batchelor, Hannah (Co-investigator) Abu-Rajab Tamimi, Rana (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Understanding long-term stability of solid pharmaceutical dosage forms by characterisation
Markl, Daniel (Principal Investigator) Khadra, Ibrahim (Co-investigator)
01-Jan-2021 - 31-Jan-2024
Biocompatible silk hydrogels as tunable stem cell constructs for the treatment of stroke. (skype)
Carswell, Hilary (Principal Investigator) Seib, Philipp (Co-investigator) Khadra, Ibrahim (Research Co-investigator)
01-Jan-2020 - 30-Jan-2023
Industrial Case Account - University of Strathclyde 2020 | Jesney, Hannah
Markl, Daniel (Principal Investigator) Khadra, Ibrahim (Co-investigator) Jesney, Hannah (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Combined use of in-vitro and in-silico models for drug discovery
Khadra, Ibrahim (Principal Investigator)
01-Jan-2020 - 31-Jan-2024

More projects

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Contact

Dr Ibrahim Khadra
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: ibrahim.khadra@strath.ac.uk
Tel: 548 2654