Publications

Antimicrobial 3D printed implants for periprosthetic joint infections

Yuste Iván, Luciano Francis C, Rodríguez Carmina, Ramirez Bianca I, Rapti Chrysi, Anaya Bryan J, Lalatsa Aikaterini, Ribed-Sánchez Almudena, Sanz-Ruiz Pablo, González-Burgos Elena, Serrano Dolores R

Drug Delivery and Translational Research (2025)

Novel enabling strategies for oral peptide delivery

Öngoren B, Kara A, Serrano DR, Lalatsa A

International Journal of Pharmaceutics Vol 681 (2025)

https://doi.org/10.1016/j.ijpharm.2025.125888

Integration of 3D-printed micromixers and spray drying for pulmonary delivery of antimicrobial microparticles

Anaya Bryan J, Kara Aytug, Raposo Rafaela, Tirado Diego F, Lalatsa Aikaterini, González-Burgos Elena, Serrano Dolores R

International Journal of Pharmaceutics Vol 674 (2025)

https://doi.org/10.1016/j.ijpharm.2025.125493

Continuous manufacturing of nanomedicines using 3D-printed microfluidic devices

Kara Aytug, Ongoren Baris, Anaya Bryan J, Lalatsa Aikaterini, Serrano Dolores R

Applied Materials Today Vol 43 (2025)

https://doi.org/10.1016/j.apmt.2025.102672

Targeted oral fixed-dose combination of amphotericin B-miltefosine for visceral leishmaniasis

Fernández-García Raquel, Walsh David, O'Connell Peter, Passero Luiz Felipe D, de Jesus Jéssica A, Laurenti Marcia Dalastra, Dea-Ayuela María Auxiliadora, Ballesteros M Paloma, Lalatsa Aikaterini, Bolás-Fernández Francisco, Healy Anne Marie, Serrano Dolores R

Molecular Pharmaceutics Vol 22, pp. 1437–1448 (2025)

https://doi.org/10.1021/acs.molpharmaceut.4c01133

Dicentrine purified from the leaves of Ocotea puberula controls the intracellular spreading of L. (L.) amazonensis and L. (V.) braziliensis amastigotes and has therapeutic activity as a topical treatment in experimental cutaneous leishmaniasis

Adriana Jesus Jéssica, Araujo Flores Gabriela V, da Silva Souza Dalete Christine, Costa Tristão Daniela, Serrano Dolores R, Lalatsa Aikaterina, Laurenti Márcia Dalastra, Ghilardi Lago João Henrique, Gomes Ferraz Humberto, Pereira da Silva Rosana, Domingues Passero Luiz Felipe

Microorganisms Vol 13 (2025)

https://doi.org/10.3390/microorganisms13020309

More publications

Professional Activities

PhD Examination - University College London (UCL School of Pharmacy)

Examiner

20/6/2025

MRC (External organisation)

Advisor

3/6/2025

Advanced Materials (Journal)

Peer reviewer

15/5/2025

PhD Examiner - Universidad Complutense Madrid

Examiner

7/3/2025

National Science Center (External organisation)

Advisor

28/11/2024

Fundamentals of Pharmaceutical Nanoscience 2nd Edition (Hardcover)ISBN:9783031594779, 3031594770Book Editor (Event)

Peer reviewer

24/9/2024

More professional activities

Projects

Understanding biofilm formation on medical device surfaces

Serrano, Dolores R. (Principal Investigator) Lalatsa, Aikaterini (Co-investigator) Ramage, Gordon (Co-investigator)

Implantation of medical devices, such as orthopaedic implants, accounts for a significant proportion of hospital-acquired infections. These infections are notoriously difficult to treat because they are primarily caused by biofilms. There is limited knowledge about biofilm formation on implanted devices, and existing in vitro models can not accurately replicate the physiological microenvironment, leading to a shortage of animal-free models for testing antimicrobial and antibiofilm strategies. No previous attempts to mimic medical device-biofilm interfaces are described in the literature as most of them only model the bone structure or the biofilm microenvironment, but not the complex interface between the two. This project aims to develop an in vitro 3D-printed organ-on-a-chip model that mimics the physiological human bone microenvironment in terms of osseointegration and biofilm growth on the surface of orthopaedic medical devices after implantation. The acetabular component of a hip replacement will be used as a proof of concept model. Novel methods to understand how bacterial and fungal biofilms (S. aureus and C. albicans) are formed on the surface of implanted medical devices will be developed allowing the testing of the efficacy of different antimicrobials. Validation of the methodology using in vivo preclinical PJI models will be carried out. The implementation of these novel 3D in vitro methods in clinical settings could significantly improve the management of prosthetic joint infections (PJIs) guiding the rational selection of antimicrobial drugs.

01-Jan-2025 - 31-Jan-2027

Development of a oligonucleotide nanoparticle

Lalatsa, Aikaterini (Principal Investigator)

14-Jan-2024 - 21-Jan-2024

Stability of Monoclonal Anti-Bodies (MABs) - Capillary Zone Electrophoresis analysis

Lalatsa, Aikaterini (Principal Investigator)

25-Jan-2024 - 19-Jan-2025

Engineered silks for surgical wounds

Lalatsa, Aikaterini (Principal Investigator) Connolly, Patricia (Co-investigator)

02-Jan-2023 - 30-Jan-2027

Manufacture and release of Lucentis Drug Product

Lalatsa, Aikaterini (Principal Investigator)

02-Jan-2023 - 28-Jan-2025

Qualified persons training programme 23-25

Lalatsa, Aikaterini (Principal Investigator) Young, David (Co-investigator)

extension to K230850-101

01-Jan-2023 - 31-Jan-2025

More projects