Publications

A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection

Sá-Pessoa Joana, López-Montesino Sara, Przybyszewska Kornelia, Rodríguez-Escudero Isabel, Marshall Helina, Ova Adelia, Schroeder Gunnar N, Barabas Peter, Molina María, Curtis Tim, Cid Víctor J, Bengoechea José A

Nature Communications Vol 14 (2023)

https://doi.org/10.1038/s41467-023-36629-3

Terrisporobacter hibernicus sp. nov., isolated from bovine faeces in Northern Ireland

Mitchell Molly, Nguyen Scott V, Connor Mairead, Fairley Derek J, Donoghue Orla, Marshall Helina, Koolman Leonard, McMullan Geoff, Schaffer Kirsten E, McGrath John W, Fanning Séamus

International Journal of Systematic and Evolutionary Microbiology Vol 73 (2023)

https://doi.org/10.1099/ijsem.0.005667

A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site

Szylar Gabriella, Wysoczanski Riccardo, Marshall Helina, Marks Daniel JB, José Ricardo, Ehrenstein Michael E, Brown Jeremy S

Scientific Reports Vol 12 (2022)

https://doi.org/10.1038/s41598-022-07914-w

Effects of expression of Streptococcus pneumoniae PspC on the ability of Streptococcus mitis to evade complement-mediated immunity

Marshall Helina, José Ricardo J, Kilian Mogens, Petersen Fernanda C, Brown Jeremy S

Frontiers in Microbiology Vol 12 (2021)

https://doi.org/10.3389/fmicb.2021.773877

Early-career researchers shaping publishing strategy

Marshall Helina, Fernandes Maria

Learned Publishing Vol 34, pp. 675-678 (2021)

https://doi.org/10.1002/leap.1383

Enterobacter species

Skinnader Oisin, Nguyen Scott, Marshall Helina, Meharg Caroline, Fanning Séamus

Encyclopedia of Dairy Sciences Third edition (2021) (2021)

https://doi.org/10.1016/B978-0-08-100596-5.23002-3

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Research Interests

Our research group is focused on elucidating bacterial adaptations for commensalism and immune evasion. Her work delves into the intricate interactions between bacteria and hosts, aiming to understand the evolution of virulence and commensal traits. With a particular interest in immune evasion strategies employed by bacteria, our research spans across diverse model systems, including Gram-negative gut and Gram-positive respiratory infection models. By studying pathogens like Salmonella enterica serovar Uganda and Streptococcus species, we investigate how these bacteria modulate the immune system and establish symbiotic relationships with hosts. This research not only sheds light on fundamental biological mechanisms but also holds promise for informing strategies to combat infections, especially in the context of global challenges such as antimicrobial resistance and the aftermath of the COVID-19 pandemic.

Current University of Strathclyde collaborators:

• Professor Paul Hoskisson
• Dr Ralf Bauer
• Dr Melanie Jimenez

External collaborators include:

• Professor Séamus Fanning (University College Dublin)
• Professor Mogens Kilian (Aarhus University)
• Professor Jeremy Brown (University College London)
• Professor Laurent Bozec (University of Toronto)
• Professor Ian Henderson (University of Queensland, Australia)
• Dr CJ Anderson (University of Edinburgh)
• Professor Hervé Tettelin (University of Maryland)
• Dr Jason Rosch (St Jude's Children's Hospital, Memphis)
• Centers for Disease Control, USA
• Health Protection Agency, UK

Professional Activities

17th European Meeting on the Molecular Biology of the Pneumococcus

Organiser

2025

Elected Member of the RSE Young Academy of Scotland (External organisation)

Advisor

8/2024

Chance or Necessity?: Streptococcus pneumoniae vs. Streptococcus mitis

Speaker

16/4/2024

Streptococcus mitis: Friend, Foe or Janus-faced?

Speaker

20/3/2024

Strathclyde Institute Of Pharmacy And Biomedical Sciences (Organisational unit)

Member

2024

Scottish Universities Life Sciences Alliance (SULSA) (External organisation)

Chair

2024

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Projects

A study of the bacterial ecology of a chocolate production environment and characterisation of Salmonella species, a zoonotic food-borne bacteria of importance to the food industry

Marshall, Helina (Principal Investigator)

PhD studentship completed
Student: Oisin Skinnader
Supervisors: Prof. Séamus Fanning and Dr Helina Marshall

01-Oct-2019 - 31-Jul-2024

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