Professor John McCarron

Strathclyde Institute of Pharmacy and Biomedical Sciences


Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity metabolism
Wilson Calum, Zhang Xun, Lee Matthew D, MacDonald Margaret, Heathcote Helen R, Alorfi Nasser MN, Buckley Charlotte, Dolan Sharron, McCarron John G
Metabolism (2020)
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer
Casciano Jessica C, Perry Caroline, Cohen-Nowak Adam J, Miller Katelyn D, Voorde Johan Vande, Zhang Qifeng, Chalmers Susan, Sandison Mairi E, Lui Qin, Hedley Ann, McBryan Tony, Tang Hsin-Yao, Gorman Nicole, Beer Thomas, Speicher David W, Adams Peter D, Lui Xuefeng, Schlegel Richard, McCarron John G, Wakelam Michael J O, Gottlieb Eyal, Kossenkov Andrew V, Schug Zachary T
British Journal of Cancer Vol 122, pp. 868-884 (2020)
Hydrogen peroxide depolarizes mitochondria and inhibits IP3-evoked Ca2+ release in the endothelium of intact arteries
Zhang Xun, Lee Matthew D, Wilson Calum, McCarron John G
Cell Calcium Vol 84 (2019)
FK506 regulates IP3 evoked Ca2+ release independently of FKBP in endothelial cells
Buckley Charlotte, Wilson Calum, McCarron John G
British Journal of Pharmacology (2019)
Multi-plane remote refocussing epifluorescence microscopy to image dynamic Ca2+ events
Lawton Penelope F, Buckley Charlotte, Saunter Christopher D, Wilson Calum, Corbett Alexander D, Slater Patrick S, McCarron John G, Girkin John M
Biomedical Optics Express Vol 10, pp. 5611-5624 (2019)
Endothelial TRPV4 channels modulate vascular tone by Ca 2+-induced Ca 2+ release at inositol 1,4,5-trisphosphate receptors
Heathcote Helen R, Lee Matthew D, Zhang Xun, Saunter Christopher D, Wilson Calum, McCarron John G
British Journal of Pharmacology Vol 176, pp. 3297-3317 (2019)

More publications

Professional activities

FASEB Smooth Muscle conference.
Keynote/plenary speaker
Swarm Intelligence in endothelial signalling
Invited speaker
EuroPhysiology conference
Keynote/plenary speaker
11th World Congress for Microcirculation
Keynote/plenary speaker
19th Imperial College London International Symposium
Keynote/plenary speaker
International Symposium for Resistance Arteries

More professional activities


Mitochondrial amplification of local calcium entry and vascular contraction in hypertension
McCarron, John (Principal Investigator) Buckley, Charlotte (Co-investigator) Chalmers, Susan (Co-investigator) Wilson, Calum (Co-investigator)
03-Jan-2020 - 02-Jan-2023
Optical Cannula: Development of a tool for studying the inside of tubular organs under physiologically relevant conditions by imaging from within
McCarron, John (Principal Investigator)
01-Jan-2017 - 18-Jan-2021
McCarron, John (Principal Investigator) Wilson, Calum (Co-investigator)
01-Jan-2017 - 27-Jan-2021
Endothelial acetylcholine release explains flow mediated dilation and is impaired in type 2 diabetes
McCarron, John (Principal Investigator) Wilson, Calum (Co-investigator)
09-Jan-2017 - 25-Jan-2020
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Ratnayake, Manuela
Ratnayake, Manuela (Research Co-investigator) McCarron, John (Principal Investigator) Sandison, Mairi (Co-investigator)
01-Jan-2014 - 01-Jan-2018
BTG: Investigating vascular cell fate using micro-patterned cell arrays and extended time-lapse imaging
Sandison, Mairi (Principal Investigator) McCarron, John (Co-investigator) Zagnoni, Michele (Co-investigator)
Cardiovascular disease occurs when blood vessel structure changes through proliferation of cells in the vessel wall. The source of these cells is the vessel itself but precisely which cell(s) proliferate is unclear. Understanding their origins is a prerequisite for informed development of treatment. To investigate this, we will combine micro-patterned cell array technologies with long-term, timelapse imaging to develop new approaches for simultaneously monitoring the fate of large numbers of cells obtained from vascular cell isolations. Array architectures will be created to isolate the various cell types, probe cell-cell interactions and investigate how these interactions affect cellular differentiation and proliferation.
17-Jan-2014 - 14-Jan-2014

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Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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