Prizes and awards
- Hypertension Journal top scientific paper
- Recipient
- 2020
- Research Leave Fellowship
- Recipient
- 2006
- Research Leave Fellowship
- Recipient
- 2000
- American Heart Fellowship, Massachusetts Affiliate
- Recipient
- 1991
Professor John McCarron
Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications
- Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity metabolism
- Wilson Calum, Zhang Xun, Lee Matthew D, MacDonald Margaret, Heathcote Helen R, Alorfi Nasser MN, Buckley Charlotte, Dolan Sharron, McCarron John G
- Metabolism (2020)
- MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer
- Casciano Jessica C, Perry Caroline, Cohen-Nowak Adam J, Miller Katelyn D, Voorde Johan Vande, Zhang Qifeng, Chalmers Susan, Sandison Mairi E, Lui Qin, Hedley Ann, McBryan Tony, Tang Hsin-Yao, Gorman Nicole, Beer Thomas, Speicher David W, Adams Peter D, Lui Xuefeng, Schlegel Richard, McCarron John G, Wakelam Michael J O, Gottlieb Eyal, Kossenkov Andrew V, Schug Zachary T
- British Journal of Cancer Vol 122, pp. 868-884 (2020)
- https://doi.org/10.1038/s41416-019-0711-3
- Hydrogen peroxide depolarizes mitochondria and inhibits IP3-evoked Ca2+ release in the endothelium of intact arteries
- Zhang Xun, Lee Matthew D, Wilson Calum, McCarron John G
- Cell Calcium Vol 84 (2019)
- https://doi.org/10.1016/j.ceca.2019.102108
- FK506 regulates IP3 evoked Ca2+ release independently of FKBP in endothelial cells
- Buckley Charlotte, Wilson Calum, McCarron John G
- British Journal of Pharmacology (2019)
- https://doi.org/10.1111/bph.14905
- Multi-plane remote refocussing epifluorescence microscopy to image dynamic Ca2+ events
- Lawton Penelope F, Buckley Charlotte, Saunter Christopher D, Wilson Calum, Corbett Alexander D, Slater Patrick S, McCarron John G, Girkin John M
- Biomedical Optics Express Vol 10, pp. 5611-5624 (2019)
- https://doi.org/10.1364/BOE.10.005611
- Endothelial TRPV4 channels modulate vascular tone by Ca 2+-induced Ca 2+ release at inositol 1,4,5-trisphosphate receptors
- Heathcote Helen R, Lee Matthew D, Zhang Xun, Saunter Christopher D, Wilson Calum, McCarron John G
- British Journal of Pharmacology Vol 176, pp. 3297-3317 (2019)
- https://doi.org/10.1111/bph.14762
Professional activities
- FASEB Smooth Muscle conference.
- Keynote/plenary speaker
- 2019
- Swarm Intelligence in endothelial signalling
- Invited speaker
- 2018
- EuroPhysiology conference
- Keynote/plenary speaker
- 2018
- 11th World Congress for Microcirculation
- Keynote/plenary speaker
- 2018
- 19th Imperial College London International Symposium
- Keynote/plenary speaker
- 23/11/2017
- International Symposium for Resistance Arteries
- Organiser
- 2017
Projects
- Mitochondrial amplification of local calcium entry and vascular contraction in hypertension
- McCarron, John (Principal Investigator) Buckley, Charlotte (Co-investigator) Chalmers, Susan (Co-investigator) Wilson, Calum (Co-investigator)
- 03-Jan-2020 - 02-Jan-2023
- Optical Cannula: Development of a tool for studying the inside of tubular organs under physiologically relevant conditions by imaging from within
- McCarron, John (Principal Investigator)
- 01-Jan-2017 - 18-Jan-2021
- ENDOTHELIAL Ca2+ SIGNALLING IN HYPERTENSION VISUALIZED FROM INSIDE PRESSURIZED ARTERIES
- McCarron, John (Principal Investigator) Wilson, Calum (Co-investigator)
- 01-Jan-2017 - 27-Jan-2021
- Endothelial acetylcholine release explains flow mediated dilation and is impaired in type 2 diabetes
- McCarron, John (Principal Investigator) Wilson, Calum (Co-investigator)
- 09-Jan-2017 - 25-Jan-2020
- EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Ratnayake, Manuela
- Ratnayake, Manuela (Research Co-investigator) McCarron, John (Principal Investigator) Sandison, Mairi (Co-investigator)
- 01-Jan-2014 - 01-Jan-2018
- BTG: Investigating vascular cell fate using micro-patterned cell arrays and extended time-lapse imaging
- Sandison, Mairi (Principal Investigator) McCarron, John (Co-investigator) Zagnoni, Michele (Co-investigator)
- Cardiovascular disease occurs when blood vessel structure changes through proliferation of cells in the vessel wall. The source of these cells is the vessel itself but precisely which cell(s) proliferate is unclear. Understanding their origins is a prerequisite for informed development of treatment. To investigate this, we will combine micro-patterned cell array technologies with long-term, timelapse imaging to develop new approaches for simultaneously monitoring the fate of large numbers of cells obtained from vascular cell isolations. Array architectures will be created to isolate the various cell types, probe cell-cell interactions and investigate how these interactions affect cellular differentiation and proliferation.
- 17-Jan-2014 - 14-Jan-2014
Address
Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing