Professor John Murphy

Pure and Applied Chemistry

Personal statement

I am an organic chemist and my research group revels in exploring chemical reactivity in synthesis and in biology. We have a particular interest in electron transfer reactions and in radical chemistry, but are generally interested in mechanisms of organic reactions.

Read more about my research group at http://www.johnmurphygroup.com/

I was born in Dublin and educated at Trinity College, Dublin (BA) and the University of Cambridge (PhD). I obtained my DSc in 2002.

After my PhD, I held Fellowships at the University of Alberta and the University of Oxford. I moved to the University of Nottingham as Lecturer, and was promoted to Reader there.

I moved to my current position as Merck-Pauson Professor of Chemistry at the University of Strathclyde in 1995.

I was visiting Professor at a number of institutions:

  • Universite Claude Bernard Lyon 1, 2017
  • Université Pierre et Marie Curie, Paris, 2004
  • NAIST, Japan, 2001
  • l’Université d’Aix Marseille 1996

I also was Visiting Fellow to the Australian National University in 1995 and 2007. I held a Royal Society Leverhulme Senior Research Fellowship in 2001.

I was elected Fellow of the Royal Society of Edinburgh (National Academy of  Scotland) in 2001. 

I was Director of the Glasgow Centre for Physical Organic Chemistry (GCPOC) 2008-2013.

From August 2006 - August 2008, I was Director of WestCHEM, the newly formed integrated Research School in Chemistry for the West of Scotland.

From 2013-2016, I was Head of Department of Pure and Applied Chemistry

Prizes:

2018 Alexander von Humboldt Research Prize (Alexander von Humboldt Foundation)

2016 C W Rees Award for Heterocyclic chemistry (Royal Society of Chemistry)

2012 Bader Award  (Royal Society of Chemistry)

Publications

Synthesis of arylethylamines via C(sp3)–C(sp3) palladium-catalyzed cross-coupling
Lippa Rhys A, Battersby David J, Murphy John A, Barrett Tim N
Journal of Organic Chemistry Vol 86, pp. 3583–3604 (2021)
https://doi.org/10.1021/acs.joc.0c02958
Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core
Lippa Rhys A, Barrett John, Pal Sandeep, Rowedder James E, Murphy John A, Barrett Tim N
European Journal of Medicinal Chemistry Vol 208 (2020)
https://doi.org/10.1016/j.ejmech.2020.112719
Et3SiH + KOtBu provide multiple reactive intermediates that compete in the reactions and rearrangements of benzylnitriles and indolenines
Smith Andrew J, Dimitrova Daniela, Arokianathar Jude N, Clark Kenneth F, Poole Darren L, Leach Stuart G, Murphy John A
Chemical Science Vol 11, pp. 12364-12370 (2020)
https://doi.org/10.1039/D0SC04244G
Visible light-mediated smiles rearrangements and annulations of non-activated aromatics
Lawson Connor A, Dominey Andrew P, Williams Glynn D, Murphy John A
Chemical Communications Vol 56, pp. 11445-11448 (2020)
https://doi.org/10.1039/D0CC04666C
Computational study on the boundary between the concerted and stepwise mechanism of bimolecular SNAr reactions
Rohrbach Simon, Murphy John A, Tuttle Tell
Journal of the American Chemical Society Vol 142, pp. 14871-14876 (2020)
https://doi.org/10.1021/jacs.0c01975
Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner-Wadsworth-Emmons-based approach
Lippa Rhys A, Murphy John A, Barrett Tim N
Beilstein Journal of Organic Chemistry Vol 16, pp. 1617-1626 (2020)
https://doi.org/10.3762/BJOC.16.134

More publications

Research interests

His chemical interests are in mechanistic and synthetic chemistry, in reactive intermediates and in the development of new reactions.

Professional activities

ESOR (European Symposium on Organic Reactivity)
Contributor
3/9/2017
Royal Society International Exchanges Panel 2017-2019 (Event)
Member
2017
Evolution of Organic Electron Donors
Invited speaker
12/2016
Transition metal-free coupling reactions
Invited speaker
25/10/2016
Transition metal-free coupling reactions
Invited speaker
7/4/2016
12th International Symposium on Organic Free Radicals (ISOFR)
Keynote/plenary speaker
2016

More professional activities

Projects

Industrial Case Account - University of Strathclyde 2019 | McMahon, Connor
Murphy, John (Principal Investigator) Tuttle, Tell (Co-investigator) McMahon, Connor (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
Industrial Case Account - University of Strathclyde 2019 / S190404-107
Murphy, John (Principal Investigator)
01-Jan-2019 - 30-Jan-2024
Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Kerr, William (Principal Investigator) Brown, Cameron (Co-investigator) Florence, Alastair (Co-investigator) Jamieson, Craig (Co-investigator) Johnston, Blair (Co-investigator) Murphy, John (Co-investigator) Palmer, David (Co-investigator) Tomkinson, Nick (Co-investigator)
01-Jan-2019 - 31-Jan-2023
Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Murphy, John (Co-investigator) Bell, Jonathan (Researcher)
EP/S035990/1 £5,495, 023 from EPSRC.Prof William J. Kerr is the Strathclyde PI.

Next generation catalysis and synthesis: Chemists seeking to discover new medicines need new reactions that will allow them to make and investigate structures that are currently difficult, or even impossible, to make. A key objective of this proposal will be to develop new reagents, catalysts, and reactions to facilitate the more efficient preparation of drug-like molecules to accelerate drug discovery. Similarly, we will develop new ways of performing some of the most common chemical transformations in the synthesis of medicines whilst avoiding the use of carcinogenic reagents
01-Jan-2019 - 31-Jan-2023
Development of new sustainable molecular transformations with alkali/alkaline earth metal reagents
Murphy, John (Principal Investigator)
01-Jan-2018 - 28-Jan-2020
Industrial CASE Account - University of Strathclyde 2017 | Greaves, Megan
Nelson, David (Principal Investigator) Murphy, John (Co-investigator) Greaves, Megan (Research Co-investigator)
01-Jan-2017 - 01-Jan-2021

More projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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