Dr Brian Patton

Strathclyde Chancellor's Fellow

Physics

Personal statement

My research interests lie in exploiting properties of diamond that allow it to sense electric and magnetic fields. By optically imaging sub-100nm particles of diamond, I hope to use them as sensors for detecting the fields generated by living cells, particularly neurons.

In order to take advantage of the small size of the nanodiamond, I also use superresolution techniques to increase the precision with which we can determine the location of the nanodiamond. As the particles are embedded in living tissue, it will also be necessary to use adaptive optics methods to correct for the optical aberrations introduced by the tissue and which, uncorrected, would degrade the quality of the imaging.

Publications

Nanodiamonds enable adaptive-optics enhanced, super-resolution, two-photon excitation microscopy
Johnstone Graeme E, Cairns Gemma S, Patton Brian R
Royal Society Open Science Vol 6 (2019)
https://doi.org/10.1098/rsos.190589
Three-dimensional STED microscopy of aberrating tissue using dual adaptive optics
Patton Brian R, Burke Daniel, Owald David, Gould Travis J, Bewersdorf Joerg, Booth Martin J
Optics Express Vol 24, pp. 8862-8876 (2016)
https://doi.org/10.1364/OE.24.008862
All-optical method for characterizing individual fluorescent nanodiamonds
Miles Benjamin T, Greenwood Alexander B, Patton Brian R, Gersen Henkjan
ACS Photonics Vol 3, pp. 343-348 (2016)
https://doi.org/10.1021/acsphotonics.5b00732
Adaptive optics for single molecule switching nanoscopy
Burke Daniel, Patton Brian, Huang Fang, Bewersdorf Joerg, Booth Martin J
2015 Conference on Lasers and Electro-Optics, CLEO 2015 Conference on Lasers and Electro-Optics, CLEO 2015, pp. 2267 (2015)
https://doi.org/10.1364/CLEO_SI.2015.STh4K.4
Aberrations and adaptive optics in super-resolution microscopy
Booth Martin, Andrade Débora, Burke Daniel, Patton Brian, Zurauskas Mantas
Microscopy Vol 64, pp. 251-261 (2015)
https://doi.org/10.1093/jmicro/dfv033
Is phase-mask alignment aberrating your STED microscope?
Patton Brian R, Burke Daniel, Vrees Robert, Booth Martin J
Methods and Applications in Fluorescence Vol 3 (2015)
https://doi.org/10.1088/2050-6120/3/2/024002

more publications

Professional activities

Nanodiamonds for adaptive optics enhanced two photon excitation microscopy
Contributor
9/7/2019
Superresolution microscopy and adaptive optics for deep tissue microscopy using nanodiamonds
Contributor
2/7/2019
Biophotonics and Biomedical Microscopy
Organiser
10/10/2018
Future of Optical Techniques in Biology
Speaker
12/9/2018
RMS Frontiers in Bioimaging 2018
Member of programme committee
27/6/2018
Annual meeting for the SHIELD Consortium
Invited speaker
14/6/2018

more professional activities

Projects

Doctoral Training Partnership 2018-19 University of Strathclyde | Pistoni, Sofia
Patton, Brian (Principal Investigator) McConnell, Gail (Co-investigator) Pistoni, Sofia (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
URF Enhancement: Multiscale correlative imaging ? linking the nanoscale to the whole organism
Patton, Brian (Principal Investigator)
01-Jan-2018 - 31-Jan-2021
Direct Wavefront Sensing for Efficient Measurement of Electronic Spin in Nanodiamond
Patton, Brian (Principal Investigator)
15-Jan-2018 - 14-Jan-2019
Low-cost, open-access imaging for identifying and quantifying water quality (GCRF)
Patton, Brian (Principal Investigator)
04-Jan-2017 - 30-Jan-2019
Multiscale neural imaging - from synapse to whole-organism
Patton, Brian (Principal Investigator)
01-Jan-2017 - 31-Jan-2021
Nanodiamond as an optically robust fluorophore for targeted imaging of neural structures
Patton, Brian (Principal Investigator)
This is a studentship awarded under the Diamond Sciences and Technologies Centre for Doctoral Training, headed by the University of Warwick.
01-Jan-2017 - 01-Jan-2021

more projects