Dr Leighton Pritchard
Strathclyde Chancellor's Fellow
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Please visit our group website: https://sipbs-compbiol.github.io/
Our group specialises in computational biology and bioinformatics, particularly for microbial genomics, but also in humans and plants. We have interests in taxonomy and classification of microbes, and the relationships between genome evolution and the different capabilities of organisms. We aim to understand links between genome and phenotype, such as the ability to produce - or resist - antibiotics, to produce enzymes and other products of biotechological value, the responses of human and plant cells to disease and infection, and the ways in which microbial pathogens interact with and control their hosts.
We study these areas using a range of techniques including phylogenetics and phylogenomics, comparative genomics and pangenomics, and mathematical and structural modelling.
You can follow the group (@SCompBiol), or me personally (@widdowquinn) on Twitter.
Publications
- Biological ammonium transporters : evolution and diversification
- Williamson Gordon, Harris Thomas, Bizior Adriana, Hoskisson Paul Alan, Pritchard Leighton, Javelle Arnaud
- FEBS Journal (2024)
- https://doi.org/10.1111/febs.17059
- Biological ammonium transporters from the Amt/Mep/Rh superfamily : mechanism, energetics, and technical limitations
- Williamson Gordon, Bizior Adriana, Harris Thomas, Pritchard Leighton, Hoskisson Paul A, Javelle Arnaud
- Bioscience Reports Vol 44 (2024)
- https://doi.org/10.1042/BSR20211209
- THAPBI PICT - a fast, cautious, and accurate metabarcoding analysis pipeline
- Cock Peter J A, Cooke David E L, Thorpe Peter, Pritchard Leighton
- PeerJ Vol 11 (2023)
- https://doi.org/10.7717/peerj.15648
- cazy_webscraper : local compilation and interrogation of comprehensive CAZyme datasets
- Hobbs Emma E M, Gloster Tracey M, Pritchard Leighton
- Microbial Genomics Vol 9 (2023)
- https://doi.org/10.1099/mgen.0.001086
- cazy_webscraper : local compilation and interrogation of comprehensive CAZyme datasets
- Hobbs Emma E M, Gloster Tracey MN, Pritchard Leighton
- (2022)
- https://doi.org/10.1101/2022.12.02.518825
- Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance
- McLellan Hazel, Harvey Sarah E, Steinbrenner Jens, Armstrong Miles R, He Qin, Clewes Rachel, Pritchard Leighton, Wang Wei, Wang Shumei, Nussbaumer Thomas, Dohai Bushra, Luo Qingquan, Kumari Priyanka, Duan Hui, Roberts Ana, Boevink Petra C, Neumann Christina, Champouret Nicolas, Hein Ingo, Falter-Braun Pascal, Beynon Jim, Denby Katherine, Birch Paul R J
- Proceedings of the National Academy of Sciences of the United States of America Vol 119 (2022)
- https://doi.org/10.1073/pnas.2114064119
Professional Activities
- Family disagreements: what do conflicts between whole-genome, core gene, MLST and 16S classifications tell us about Streptomyces?
- Contributor
- 18/4/2023
- The Royal Statistical Society (External organisation)
- Member
- 20/12/2022
- Association for Computing Machinery (External organisation)
- Member
- 20/12/2022
- Access Microbiology (Journal)
- Peer reviewer
- 12/12/2022
- Untangling the taxonomically complex genus Streptomyces to improve pangenomic analyses
- Contributor
- 22/9/2022
- External Examiner, PhD
- Examiner
- 15/8/2022
Projects
- BBSRC-NSF/BIO: Collaborative Proposal: genomeRxiv: a microbial whole-genome database and diagnostic marker design resource for classification, identification, and data sharing
- Pritchard, Leighton (Principal Investigator)
- 08-Jan-2021 - 28-Jan-2025
- Targeted Innovation in the UK Seed Potato Industry to Improve Productivity and Quality
- Pritchard, Leighton (Principal Investigator)
- 01-Jan-2019 - 31-Jan-2021
Contact
Dr
Leighton
Pritchard
Strathclyde Chancellor's Fellow
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: leighton.pritchard@strath.ac.uk
Tel: 548 4962