Dr Nicholas Rattray

Professor

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites

Publications

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Publications

dia-PASEF enables rapid profiling of the human secretome for deeper insights into cellular dynamics and inflammatory mechanisms: Tayler Chloe L, Bateman Serena, Haslam Charlie, Müller Leonie, Norris Kerena, Rosa-Roseberry Evan, Martens Stan, Yu Jonathan, Dickinson Eleanor, Booty Lee, Beveridge Rebecca, Rattray Nicholas J W, Peltier-Heap Rachel; Molecular & cellular proteomics : MCP Vol 25 (2026); https://doi.org/10.1016/j.mcpro.2026.101597
REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect : Rationale and protocol for a trial of biological effect: Wilson Daisy, Acharjee Animesh, Duggal Niharika A, Hombrebueno Jose R, Jones Simon W, Lewis Jonathan W, de Magalhães João Pedro, Martinez-Serrato Yessica, Mazaheri Ali, McGettrick Helen M, Mondal Sudip, Naylor Amy J, Nixon Aline, Nicholson Thomas, Partridge Judith, Pinkney Thomas, Rattray Nicholas J W, Steves Claire, Tomkova Kristina, Welch Carly, Jackson Thomas, Torrado Pacheco Alejandro; PLoS ONE Vol 21 (2026); https://doi.org/10.1371/journal.pone.0346347
The use of frailty screening measures for predicting long-term survival outcomes in head and neck cancer : a systematic review: Ardani Shina, Shah Faizan, Hurley Rhona, Rattray Nicholas JW, Douglas Catriona; European Archives of Oto-Rhino-Laryngology (2026); https://doi.org/10.1007/s00405-026-10237-5
Later life precarity and longitudinal frailty trajectories in older adults: Rowley-Abel Laurence, van den Driest Lisa, Chen Qingwen, Chen Yulu, Chu Su, Lasky-Su Jessica, Rattray Nicholas JW, Marshall Alan; Ageing and Society Vol 46 (2026); https://doi.org/10.1017/S0144686X26100543
The application of omics technologies in Type II diabetes mellitus research: Al Sultan Abdullah, Rattray Zahra, Rattray Nicholas J W; Current Diabetes Reviews Vol 22 (2026); https://doi.org/10.2174/0115733998362669250424162654
OMICmAge quantifies biological age by integrating multi-omics with electronic medical records: Chen Qingwen, Dwaraka Varun B, Carreras-Gallo Natàlia, Armstrong Jenel F, Sehgal Raghav, Argentieri M Austin, Richmond Anne, Aparicio Andrea, Mendez Kevin, Chen Yulu, Begum Sofina, Kachroo Priyadarshini, Prince Nicole, Guo Tao, Went Hannah, Mendez Tavis, Lin Aaron, Turner Logan, Moqri Mahdi, Chu Su H, Kelly Rachel S, Weiss Scott T, Rattray Nicholas J W, Gladyshev Vadim N, Karlson Elizabeth, Wheelock Craig E, Mathé Ewy A, Dahlin Amber, McGeachie Michael J, Marioni Riccardo E, Higgins-Chen Albert T, Smith Ryan, Lasky-Su Jessica; Nature Aging Vol 6, pp. 722-737 (2026); https://doi.org/10.1038/s43587-026-01073-7

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Research

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Professional Activities

Overview of Metabolomics in Scotland: Speaker; 26/11/2026
Frailty sets in far earlier than you'd expect, but you can reverse it.: Recipient; 9/3/2026
Modeling the ageing metabolome.: Speaker; 13/1/2026
Kaiyun Chen: Host; 12/2025
Genomics meets exposomics: advancing gene by environment science: Participant; 20/10/2025
Cancer Research UK CRUK (External organisation): Advisor; 25/9/2025

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Projects

Synergistic integration of deep learning and mathematical modelling to characterise CAR-T cell dynamics and therapeutic outcomes in the TNBC micro-environment (International Exchange Cost Share NSFC): Wu, Yue (Principal Investigator) Chen, Ke (Co-investigator) Rattray, Nicholas (Co-investigator); 01-Jan-2026 - 31-Jan-2027
ACORN: Assessment of Chronic Opioid Risk using Neurobiology: Rattray, Nicholas (Principal Investigator); 01-Jan-2025 - 31-Jan-2027
DTP 2224 University of Strathclyde | Almawazini, Mohammad: Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator) Almawazini, Mohammad (Research Co-investigator); 01-Jan-2025 - 01-Jan-2028
CAMS Industry Partnership: Rattray, Nicholas (Principal Investigator); 01-Jan-2024 - 31-Jan-2027
Frailty (eFI JARSS NHS Monies): Rattray, Nicholas (Principal Investigator); 01-Jan-2024 - 31-Jan-2028
Dxcover Brain Cancer Analysis: Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator); 01-Jan-2024 - 30-Jan-2025