Dr Nicholas Rattray

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites

Publications

Distinct ecological fitness factors coordinated by a conserved Escherichia coli regulator during systemic bloodstream infection: O’Boyle Nicky, Douce Gillian R, Farrell Gillian, Rattray Nicholas J W, Schembri Mark A, Roe Andrew J, Connolly James P R; Proceedings of the National Academy of Sciences Vol 120 (2023); https://doi.org/10.1073/pnas.2212175120
An optimised monophasic faecal extraction method for LC-MS analysis and its application in gastrointestinal disease: Kelly Patricia E, Jene Ng H, Farrell Gillian, McKirdy Shona, Russell Richard K, Hansen Richard, Rattray Zahra, Gerasimidis Konstantinos, Rattray Nicholas J W; Metabolites Vol 12 (2022); https://doi.org/10.3390/metabo12111110
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer: Cai Yuping, Shen Xinyi, Lu Lingeng, Yan Hong, Huang Huang, Gaule Patricia, Muca Engjel, Theriot Casey M, Rattray Zahra, Rattray Nicholas J W, Lu Jun, Ahuja Nita, Zhang Yawei, Paty Philip B, Khan Sajid A, Johnson Caroline H; Biology of Sex Differences Vol 13 (2022); https://doi.org/10.1186/s13293-022-00473-9
An optimised monophasic faecal extraction method for LC-MS analysis and its application in gastrointestinal disease: Kelly Patricia E, Jene Ng H, Farrell Gillian, McKirdy Shona, Russell Richard K, Hansen Richard, Rattray Zahra, Gerasimidis Konstantinos, Rattray Nicholas JW; (2022); https://doi.org/10.1101/2022.09.19.22280109
Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids: Abdullah Mahmud O, Zeng Run X, Margerum Chelsea L, Papadopoli David, Monnin Cian, Punter Kaylee B, Chu Charles, Al-Rofaidi Mohammad, Al-Tannak Naser F, Berardi Domenica, Rattray Zahra, Rattray Nicholas JW, Abraham Sheela A, Eskelinen Eeva-Liisa, Watson David G, Avizonis Daina, Topisirovic Ivan, Chan Edmond YW; Cell Reports Vol 40, pp. 111198 (2022); https://doi.org/10.1016/j.celrep.2022.111198
Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets: Alnoumas Layla, Van Den Driest Lisa, Apczynski Zoe, Lannigan Alison, Johnson Caroline H, Rattray Nicholas J W, Rattray Zahra; BMC Cancer Vol 22, pp. 874 (2022); https://doi.org/10.1186/s12885-022-09969-4

More publications

Professional activities

Using storytelling to recount the untold narratives of breast cancer: Contributor; 15/12/2022
Breaking Barriers: Speaker; 20/9/2022
Invited Vendor (Shimadzu UK) Talk on Translating biological models of the ageing metabolome in to clinically relevant biomarkers.: Speaker; 14/9/2022
British Mass Spectrometry Society Annual Conference: Participant; 14/9/2022
External Viva examiner: Examiner; 6/9/2022
Recounting the Untold Stories of Breast Cancer: Narratives from the Patient, Clinician and Scientist Perspective: Contributor; 2/8/2022

More professional activities

Projects

DTP 2224 University of Strathclyde | Van Den Driest, Lisa: Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator) Van Den Driest, Lisa (Research Co-investigator); 01-Jan-2022 - 01-Jan-2026
To develop a genome-based data mining approach to stratification in breast cancer Copy: Rattray, Nicholas (Principal Investigator); 13-Jan-2022 - 05-Jan-2022
Recounting the Untold Stories of Breast Cancer: Narratives from the Patient, Clinician and Scientist Perspective: Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Chalmers, Susan (Co-investigator) MCFADDEN, Yvonne (Co-investigator); £5700 awarded to develop a series of storytelling events; 14-Jan-2022 - 13-Jan-2023
A novel dietary therapy to control recurrence of gut inflammation in children with Crohn’s disease in remission: Rattray, Nicholas (Principal Investigator); 01-Jan-2021 - 01-Jan-2025
Lisa van Den Driest- FRAME AWARD: Development of a gene expression bioinformatics pipeline to identify driver mutations of colorectal cancer: Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator); Competitively awarded FRAME summer studentship with stipend (£2,500); 22-Jan-2021 - 29-Jan-2021
Erasmus+: Host for Ahmed Gaafar: Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator); 17-Jan-2021 - 30-Jan-2021

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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