Dr Nicholas Rattray

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Contact

Personal statement

Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites

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Area of Expertise

Lab has broad experience in

  • Development of cellular models of disease and ageing
  • Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis
  • Automation of pre/post processing and informatics
  • Development of imaging mass spectrometry capability.
  • Enabling of a broad range of targeted MS workflow focusing on energy metabolites

 

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Publications

A gap analysis of UK biobank publications reveals SNPs associated with intrinsic subtypes of breast cancer
van den Driest Lisa, Kelly Patricia, Marshall Alan, Johnson Caroline H, Lasky-Su Jessica, Lannigan Alison, Rattray Zahra, Rattray Nicholas JW
Computational and Structural Biotechnology Journal (2024)
https://doi.org/10.1016/j.csbj.2024.05.001
Cytotoxicity and toxicoproteomics analysis of thiazolidinedione exposure in human-derived cardiomyocytes
Al Sultan Abdullah, Rattray Zahra, Rattray Nicholas J W
Journal of Applied Toxicology (2024)
https://doi.org/10.1002/jat.4613
Toxicometabolomics-based cardiotoxicity evaluation of Thiazolidinedione exposure in human-derived cardiomyocytes
Al Sultan Abdullah, Rattray Zahra, Rattray Nicholas J W
Metabolomics Vol 20 (2024)
https://doi.org/10.1007/s11306-024-02097-z
Nanoparticle isolation from biological media for protein corona analysis : the impact of incubation and recovery protocols on nanoparticle properties
Daramy Karim, Punnabhum Panida, Hussain Muattaz, Minelli Caterina, Pei Yiwen, Rattray Nicholas JW, Perrie Yvonne, Rattray Zahra
Journal of Pharmaceutical Sciences (2023)
https://doi.org/10.1016/j.xphs.2023.12.021
Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique
Goelen Jan, Farrell Gillian, McGeehan Jonathan, Titman Christopher M, Rattray Nicholas JW, Johnson Trevor N, Horniblow Richard D, Batchelor Hannah K
European Journal of Pharmaceutics and Biopharmaceutics Vol 191, pp. 68-77 (2023)
https://doi.org/10.1016/j.ejpb.2023.08.011
Urinary paraben concentrations and associations with the periconceptional urinary metabolome : untargeted and targeted metabolomics analyses of participants from the early pregnancy study
Rosen Vollmar Ana K, Rattray Nicholas JW, Cai Yuping, Jain Abhishek, Yan Hong, Deziel Nicole C, Calafat Antonia M, Wilcox Allen J, Jukic Anne Marie Z, Johnson Caroline H
Environmental Health Perspectives Vol 131 (2023)
https://doi.org/10.1289/ehp12125

More publications

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Professional Activities

External PhD Viva Examiner - Uiversity of Manchester
Examiner
10/4/2024
Cancer Research UK (External organisation)
Advisor
14/3/2024
External PhD Viva Examiner - University of Glasgow
Examiner
11/3/2024
Trinity College (External organisation)
Advisor
7/3/2024
Translating biological models of the ageing metabolome into clinically relevant biomarkers
Speaker
6/3/2024
Translating discovery stage frailty biomarkers towards the clinic
Speaker
14/2/2024

More professional activities

Projects

Dementia biomarker detection using resonant Raman spectroscopy at point of need.
Rattray, Nicholas (Principal Investigator)
01-Jan-2024 - 31-Jan-2025
iCAL Strathclyde CDT - Industry Contribution
Rattray, Nicholas (Principal Investigator)
01-Jan-2023 - 30-Jan-2026
Harnessing multiparametric biobank data to develop novel predictive models of frailty
Rattray, Nicholas (Principal Investigator)
04-Jan-2023 - 03-Jan-2025
Translating discovery stage frailty biomarkers towards the clinic (RS Industry Fellowship)
Rattray, Nicholas (Principal Investigator)
01-Jan-2023 - 31-Jan-2026
Innovation in rehabilitation technologies through multimodal blood analysis
Jimenez, Melanie (Principal Investigator) Kerr, Andy (Co-investigator) Rattray, Nicholas (Co-investigator)
27-Jan-2023 - 31-Jan-2025
A pilot study evaluating the correlation between RA disease activity and gut dysbiosis
Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator)
01-Jan-2023 - 31-Jan-2024

More projects

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Contact

Dr Nicholas Rattray
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: nicholas.rattray@strath.ac.uk
Tel: 548 2012