Dr Nicholas Rattray

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Contact

Personal statement

Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites

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Area of Expertise

Lab has broad experience in

  • Development of cellular models of disease and ageing
  • Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis
  • Automation of pre/post processing and informatics
  • Development of imaging mass spectrometry capability.
  • Enabling of a broad range of targeted MS workflow focusing on energy metabolites

 

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Publications

A gap analysis of UK biobank publications reveals SNPs associated with intrinsic subtypes of breast cancer
van den Driest Lisa, Kelly Patricia, Marshall Alan, Johnson Caroline H, Lasky-Su Jessica, Lannigan Alison, Rattray Zahra, Rattray Nicholas JW
Computational and Structural Biotechnology Journal Vol 23, pp. 2200-2210 (2024)
https://doi.org/10.1016/j.csbj.2024.05.001
Charting the metabolic biogeography of the colorectum in cancer : challenging the right sided versus left sided classification
Jain Abhishek, Morris Montana T, Berardi Domenica, Arora Trisha, Domingo-Almenara Xavier, Paty Philip B, Rattray Nicholas J W, Kerekes Daniel, Lu Lingeng, Khan Sajid A, Johnson Caroline H
Molecular Cancer Vol 23 (2024)
https://doi.org/10.1186/s12943-024-02133-5
Spatial lipidomic profiles of atherosclerotic plaques : a mass spectrometry imaging study
Ntshangase Sphamandla, Khan Shazia, Bezuidenhout Louise, Gazárková Taťána, Kaczynski Jakub, Sellers Stephanie, Rattray Nicholas Jw, Newby David E, Hadoke Patrick Wf, Andrew Ruth
Talanta Vol 282 (2024)
https://doi.org/10.1016/j.talanta.2024.126954
Recounting the untold stories of breast cancer patient experiences : lessons learned from a patient-public involvement and engagement (PPIE) storytelling event
Cunningham Margaret R, Rattray Nicholas JW, McFadden Yvonne, Berardi Domenica, Daramy Karim, Kelly Patricia E, Galbraith Allison, Lochiel Isobel, Mills Lorraine, Scott Yvonne, Chalmers Susan, Lannigan Alison, Rattray Zahra
International Journal of Pharmacy Practice Vol 32, pp. 515-523 (2024)
https://doi.org/10.1093/ijpp/riae052
The use of orthogonal analytical approaches to profile lipid nanoparticle physicochemical attributes
Davidson Callum G, Abdulrahman Rand, Punnabhum Panida, Cairns Michael, Rattray Nicholas J W, Capomaccio Robin, Treacher Kevin, Perrie Yvonne, Rattray Zahra
Nano Futures Vol 8 (2024)
https://doi.org/10.1088/2399-1984/ad70e6
Nanoparticle isolation from biological media for protein corona analysis : the impact of incubation and recovery protocols on nanoparticle properties
Daramy Karim, Punnabhum Panida, Hussain Muattaz, Minelli Caterina, Pei Yiwen, Rattray Nicholas JW, Perrie Yvonne, Rattray Zahra
Journal of Pharmaceutical Sciences Vol 113, pp. 2826-2836 (2024)
https://doi.org/10.1016/j.xphs.2023.12.021

More publications

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Professional Activities

Metabolomics Circle 2024
Invited speaker
15/11/2024
Univesity of Bialystok
Visiting lecturer
12/11/2024
Scottish Metabolomics Network Symposium 2024
Chair
21/10/2024
Scottish Metabolomics Network Symposium 2024
Organiser
21/10/2024
Shimadzu Research Labs Annual Meeting
Invited speaker
16/10/2024
BMC Methods (Journal)
Editor
1/10/2024

More professional activities

Projects

Frailty (eFI JARSS NHS Monies)
Rattray, Nicholas (Principal Investigator)
01-Oct-2024 - 31-Mar-2028
Dxcover Brain Cancer Analysis
Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator)
01-Sep-2024 - 30-Sep-2025
Dementia biomarker detection using resonant Raman spectroscopy at point of need.
Rattray, Nicholas (Principal Investigator)
01-Feb-2024 - 31-Jan-2025
iCAL Strathclyde CDT - Industry Contribution
Rattray, Nicholas (Principal Investigator)
01-Oct-2023 - 30-Sep-2026
Harnessing multiparametric biobank data to develop novel predictive models of frailty
Rattray, Nicholas (Principal Investigator)
04-Sep-2023 - 03-Mar-2025
Translating discovery stage frailty biomarkers towards the clinic (RS Industry Fellowship)
Rattray, Nicholas (Principal Investigator)
01-Sep-2023 - 31-Aug-2026

More projects

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Contact

Dr Nicholas Rattray
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: nicholas.rattray@strath.ac.uk
Tel: 548 2012