Dr Nicholas Rattray
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites
Area of Expertise
Lab has broad experience in
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Publications
- A gap analysis of UK biobank publications reveals SNPs associated with intrinsic subtypes of breast cancer
- van den Driest Lisa, Kelly Patricia, Marshall Alan, Johnson Caroline H, Lasky-Su Jessica, Lannigan Alison, Rattray Zahra, Rattray Nicholas JW
- Computational and Structural Biotechnology Journal Vol 23, pp. 2200-2210 (2024)
- https://doi.org/10.1016/j.csbj.2024.05.001
- Charting the metabolic biogeography of the colorectum in cancer : challenging the right sided versus left sided classification
- Jain Abhishek, Morris Montana T, Berardi Domenica, Arora Trisha, Domingo-Almenara Xavier, Paty Philip B, Rattray Nicholas J W, Kerekes Daniel, Lu Lingeng, Khan Sajid A, Johnson Caroline H
- Molecular Cancer Vol 23 (2024)
- https://doi.org/10.1186/s12943-024-02133-5
- Spatial lipidomic profiles of atherosclerotic plaques : a mass spectrometry imaging study
- Ntshangase Sphamandla, Khan Shazia, Bezuidenhout Louise, Gazárková Taťána, Kaczynski Jakub, Sellers Stephanie, Rattray Nicholas Jw, Newby David E, Hadoke Patrick Wf, Andrew Ruth
- Talanta Vol 282 (2024)
- https://doi.org/10.1016/j.talanta.2024.126954
- Recounting the untold stories of breast cancer patient experiences : lessons learned from a patient-public involvement and engagement (PPIE) storytelling event
- Cunningham Margaret R, Rattray Nicholas JW, McFadden Yvonne, Berardi Domenica, Daramy Karim, Kelly Patricia E, Galbraith Allison, Lochiel Isobel, Mills Lorraine, Scott Yvonne, Chalmers Susan, Lannigan Alison, Rattray Zahra
- International Journal of Pharmacy Practice Vol 32, pp. 515-523 (2024)
- https://doi.org/10.1093/ijpp/riae052
- The use of orthogonal analytical approaches to profile lipid nanoparticle physicochemical attributes
- Davidson Callum G, Abdulrahman Rand, Punnabhum Panida, Cairns Michael, Rattray Nicholas J W, Capomaccio Robin, Treacher Kevin, Perrie Yvonne, Rattray Zahra
- Nano Futures Vol 8 (2024)
- https://doi.org/10.1088/2399-1984/ad70e6
- Nanoparticle isolation from biological media for protein corona analysis : the impact of incubation and recovery protocols on nanoparticle properties
- Daramy Karim, Punnabhum Panida, Hussain Muattaz, Minelli Caterina, Pei Yiwen, Rattray Nicholas JW, Perrie Yvonne, Rattray Zahra
- Journal of Pharmaceutical Sciences Vol 113, pp. 2826-2836 (2024)
- https://doi.org/10.1016/j.xphs.2023.12.021
Professional Activities
- Metabolomics Circle 2024
- Invited speaker
- 15/11/2024
- Univesity of Bialystok
- Visiting lecturer
- 12/11/2024
- Scottish Metabolomics Network Symposium 2024
- Chair
- 21/10/2024
- Scottish Metabolomics Network Symposium 2024
- Organiser
- 21/10/2024
- Shimadzu Research Labs Annual Meeting
- Invited speaker
- 16/10/2024
- BMC Methods (Journal)
- Editor
- 1/10/2024
Projects
- Frailty (eFI JARSS NHS Monies)
- Rattray, Nicholas (Principal Investigator)
- 01-Oct-2024 - 31-Mar-2028
- Dxcover Brain Cancer Analysis
- Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator)
- 01-Sep-2024 - 30-Sep-2025
- Dementia biomarker detection using resonant Raman spectroscopy at point of need.
- Rattray, Nicholas (Principal Investigator)
- 01-Feb-2024 - 31-Jan-2025
- iCAL Strathclyde CDT - Industry Contribution
- Rattray, Nicholas (Principal Investigator)
- 01-Oct-2023 - 30-Sep-2026
- Harnessing multiparametric biobank data to develop novel predictive models of frailty
- Rattray, Nicholas (Principal Investigator)
- 04-Sep-2023 - 03-Mar-2025
- Translating discovery stage frailty biomarkers towards the clinic (RS Industry Fellowship)
- Rattray, Nicholas (Principal Investigator)
- 01-Sep-2023 - 31-Aug-2026
Contact
Dr
Nicholas
Rattray
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: nicholas.rattray@strath.ac.uk
Tel: 548 2012