Dr Nicholas Rattray

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

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Personal statement

Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites

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Area of Expertise

Lab has broad experience in

  • Development of cellular models of disease and ageing
  • Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis
  • Automation of pre/post processing and informatics
  • Development of imaging mass spectrometry capability.
  • Enabling of a broad range of targeted MS workflow focusing on energy metabolites

 

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Publications

Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique
Goelen Jan, Farrell Gillian, McGeehan Jonathan, Titman Christopher M, Rattray Nicholas JW, Johnson Trevor N, Horniblow Richard D, Batchelor Hannah K
European Journal of Pharmaceutics and Biopharmaceutics Vol 191, pp. 68-77 (2023)
https://doi.org/10.1016/j.ejpb.2023.08.011
Urinary paraben concentrations and associations with the periconceptional urinary metabolome : untargeted and targeted metabolomics analyses of participants from the early pregnancy study
Rosen Vollmar Ana K, Rattray Nicholas JW, Cai Yuping, Jain Abhishek, Yan Hong, Deziel Nicole C, Calafat Antonia M, Wilcox Allen J, Jukic Anne Marie Z, Johnson Caroline H
Environmental Health Perspectives Vol 131 (2023)
https://doi.org/10.1289/ehp12125
ThTP5.2 Outcome of polypharmacy in frail patients post emergency laparotomy
Ng Hwei Jene, Quasim Tara, Rattray Nicholas, Moug Susan
British Journal of Surgery Vol 110 (2023)
https://doi.org/10.1093/bjs/znad241.285
SP1.5 Mortality rate for frail and sarcopenic patients post emergency laparotomy
Ng Hwei Jene, Quasim Tara, Rattray Nicholas, Moug Susan
British Journal of Surgery Vol 110 (2023)
https://doi.org/10.1093/bjs/znad241.015
Global serum profiling an opportunity for earlier cancer detection
Sala Alexandra, Cameron James M, Brennan Paul M, Crosbie Emma J, Curran Tom, Gray Ewan, Martin-Hirsch Pierre, Palmer David S, Rehman Ihtesham U, Rattray Nicholas J W, Baker Matthew J
Journal of Experimental & Clinical Cancer Research Vol 42 (2023)
https://doi.org/10.1186/s13046-023-02786-y
Investigation of frailty markers including a novel biomarker panel in emergency laparotomy : protocol of a prospective cohort study
Ng Hwei Jene, Quasim Tara, Rattray Nicholas J W, Moug Susan
BMC Surgery Vol 23 (2023)
https://doi.org/10.1186/s12893-023-02093-5

More publications

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Professional Activities

Cardiotoxicity Evaluation of Pioglitazone Exposure in Human Derived Cardiomyocytes Using LC-MS based Metabolomics.
Contributor
23/11/2023
Faculty of Science Breaking Barriers 2023
Contributor
24/10/2023
Cancer Research UK CRUK (External organisation)
Advisor
26/9/2023
Meet the Researcher 2023
Contributor
6/6/2023
Using storytelling to recount the untold narratives of breast cancer ​
Contributor
15/12/2022
Breaking Barriers
Speaker
20/9/2022

More professional activities

Projects

Harnessing multiparametric biobank data to develop novel predictive models of frailty
Rattray, Nicholas (Principal Investigator)
04-Jan-2023 - 03-Jan-2025
Translating discovery stage frailty biomarkers towards the clinic (RS Industry Fellowship)
Rattray, Nicholas (Principal Investigator)
01-Jan-2023 - 31-Jan-2026
Analyses of metabolomics and proteomics in breast cancer using tissue samples and serum of newly diagnosed breast cancer patients to develop better biochemical understanding of all phenotypes of breast cancer but with a specific interest in triple negative subphenotypes.
Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator) Lannigan, Alison (Principal Investigator)
A study examining the biomolecular stratification of breast cancer molecular subtypes
01-Jan-2023 - 30-Jan-2026
Innovation in rehabilitation technologies through multimodal blood analysis
Jimenez, Melanie (Principal Investigator) Kerr, Andy (Co-investigator) Rattray, Nicholas (Co-investigator)
27-Jan-2023 - 26-Jan-2024
A pilot study evaluating the correlation between RA disease activity and gut dysbiosis
Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator)
01-Jan-2023 - 31-Jan-2024
DTP 2224 University of Strathclyde | Van Den Driest, Lisa
Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator) Van Den Driest, Lisa (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026

More projects

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Contact

Dr Nicholas Rattray
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: nicholas.rattray@strath.ac.uk
Tel: 548 2012