Dr Nicholas Rattray
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites
Area of Expertise
Lab has broad experience in
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Publications
- Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique
- Goelen Jan, Farrell Gillian, McGeehan Jonathan, Titman Christopher M, Rattray Nicholas JW, Johnson Trevor N, Horniblow Richard D, Batchelor Hannah K
- European Journal of Pharmaceutics and Biopharmaceutics Vol 191, pp. 68-77 (2023)
- https://doi.org/10.1016/j.ejpb.2023.08.011
- Urinary paraben concentrations and associations with the periconceptional urinary metabolome : untargeted and targeted metabolomics analyses of participants from the early pregnancy study
- Rosen Vollmar Ana K, Rattray Nicholas JW, Cai Yuping, Jain Abhishek, Yan Hong, Deziel Nicole C, Calafat Antonia M, Wilcox Allen J, Jukic Anne Marie Z, Johnson Caroline H
- Environmental Health Perspectives Vol 131 (2023)
- https://doi.org/10.1289/ehp12125
- ThTP5.2 Outcome of polypharmacy in frail patients post emergency laparotomy
- Ng Hwei Jene, Quasim Tara, Rattray Nicholas, Moug Susan
- British Journal of Surgery Vol 110 (2023)
- https://doi.org/10.1093/bjs/znad241.285
- SP1.5 Mortality rate for frail and sarcopenic patients post emergency laparotomy
- Ng Hwei Jene, Quasim Tara, Rattray Nicholas, Moug Susan
- British Journal of Surgery Vol 110 (2023)
- https://doi.org/10.1093/bjs/znad241.015
- Global serum profiling an opportunity for earlier cancer detection
- Sala Alexandra, Cameron James M, Brennan Paul M, Crosbie Emma J, Curran Tom, Gray Ewan, Martin-Hirsch Pierre, Palmer David S, Rehman Ihtesham U, Rattray Nicholas J W, Baker Matthew J
- Journal of Experimental & Clinical Cancer Research Vol 42 (2023)
- https://doi.org/10.1186/s13046-023-02786-y
- Investigation of frailty markers including a novel biomarker panel in emergency laparotomy : protocol of a prospective cohort study
- Ng Hwei Jene, Quasim Tara, Rattray Nicholas J W, Moug Susan
- BMC Surgery Vol 23 (2023)
- https://doi.org/10.1186/s12893-023-02093-5
Professional Activities
- Cardiotoxicity Evaluation of Pioglitazone Exposure in Human Derived Cardiomyocytes Using LC-MS based Metabolomics.
- Contributor
- 23/11/2023
- Faculty of Science Breaking Barriers 2023
- Contributor
- 24/10/2023
- Cancer Research UK CRUK (External organisation)
- Advisor
- 26/9/2023
- Meet the Researcher 2023
- Contributor
- 6/6/2023
- Using storytelling to recount the untold narratives of breast cancer
- Contributor
- 15/12/2022
- Breaking Barriers
- Speaker
- 20/9/2022
Projects
- Harnessing multiparametric biobank data to develop novel predictive models of frailty
- Rattray, Nicholas (Principal Investigator)
- 04-Jan-2023 - 03-Jan-2025
- Translating discovery stage frailty biomarkers towards the clinic (RS Industry Fellowship)
- Rattray, Nicholas (Principal Investigator)
- 01-Jan-2023 - 31-Jan-2026
- Analyses of metabolomics and proteomics in breast cancer using tissue samples and serum of newly diagnosed breast cancer patients to develop better biochemical understanding of all phenotypes of breast cancer but with a specific interest in triple negative subphenotypes.
- Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator) Lannigan, Alison (Principal Investigator)
- A study examining the biomolecular stratification of breast cancer molecular subtypes
- 01-Jan-2023 - 30-Jan-2026
- Innovation in rehabilitation technologies through multimodal blood analysis
- Jimenez, Melanie (Principal Investigator) Kerr, Andy (Co-investigator) Rattray, Nicholas (Co-investigator)
- 27-Jan-2023 - 26-Jan-2024
- A pilot study evaluating the correlation between RA disease activity and gut dysbiosis
- Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator)
- 01-Jan-2023 - 31-Jan-2024
- DTP 2224 University of Strathclyde | Van Den Driest, Lisa
- Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator) Van Den Driest, Lisa (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
Contact
Dr
Nicholas
Rattray
Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: nicholas.rattray@strath.ac.uk
Tel: 548 2012