Dr Zahra Rattray

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Senior Lecturer in Translational Pharmaceutics I am a pharmacist by training with experience of working within the hospital, community and industry sectors. I have contributed to a diverse molecule portfolio spanning pre-clinical to late-stage development during my time at AstraZeneca and in collaboration with Patrys Ltd at the Yale School of Medicine (PAT-DX1). My research team has two overall interests; i) Analytical characterization of parenteral formulation attributes and in vivo performance: A key challenge in the commercial translation of newly-discovered drugs is understanding the key performance indicating characteristics crucial to their biological performance and how they interact with living systems. We are interested in developing new tools to profile these performance characteristics. Areas of research interest in my lab are summarized as follows; Understanding the environmental and physicochemical determinants of solution-phase formulation stability for antibody and suspension formulations. Determining key critical quality attributes in particle design to inform optimal in vivo performance. Analytical evaluation of nanomedicine interaction with biological media, and the mechanism of cellular uptake in two- and three-dimensional cellular models. Applying novel imaging modalities for evaluating drug and nanoparticle biodistribution, and impact on tumor response. The interplay between the tumour microenvironment and nanomedicine in vivo performance with a view to developing biorelevant in vitro tests. ii) DNA repair agents and the nuclear import pathway, and their role in cancer: We are interested in screening the functional and phenotypic role of DNA repair mutations. We also develop new small molecule drugs against various nuclear import transporters known to be elevated in cancer.

Expertise

Has expertise in:

    Expertise

    I am an interdisciplinary pharmaceutical researcher with experience in developing injectable drugs (antibodies, small molecules, and nanomedicines). I have significant expertise in the analytical characterization of critical quality attributes for these products and the design of pre-clinical studies for evaluating biological performance (biopharmaceutics).

    Equipment Capabilities

    My laboratory hosts a Malvern Panalytical NanoSight NS300 and Archimedes Resonant Mass Measurement, which are both used to measure particle size and concentration. If you would be interested in accessing these technologies, please get in touch (zahra.rattray@strath.ac.uk).

     

    I am also Director for the new EPSRC Multiscale Metrology Suite (modular setup including Field Flow Fractionation, Inductively-coupled mass spectrometry, Light Scattering and Raman) for Next-Generation Health Nanotechnologies (EP/V028960/1). For more information or to access this facility, please get in touch.

Prizes and awards

Fellow of the Academy of Pharmaceutical Sciences of Great Britain
Recipient
7/2022
International Pharmaceutical Federation Women in Science and Education Rising Star 2022
Recipient
30/6/2022
European Crucible: Seed Funding Award- Developing new tools for evaluating nanoscale biological interactions
Recipient
6/2021
European Crucible: Scottish Cohort
Recipient
1/5/2021
Fellowship of the Higher Education Academy
Recipient
9/2020
Strathclyde Chancellor's Fellow
Recipient
1/9/2018

More prizes and awards

Publications

Sex differences in colon cancer metabolism reveal a novel subphenotype
Cai Yuping, Rattray Nicholas J W, Zhang Qian, Mironova Varvara, Santos-Neto Alvaro, Hsu Kuo-Shun, Rattray Zahra, Cross Justin R, Zhang Yawei, Paty Philip B, Khan Sajid A, Johnson Caroline H
Scientific Reports Vol 10 (2020)
https://doi.org/10.1038/s41598-020-61851-0
ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody
Rattray Zahra, Deng Gang, Zhang Shenqi, Shirali Anupama, May Christopher K, Chen Xiaoyong, Cuffari Benedette J, Liu Jun, Zou Pan, Rattray Nicholas JW, Johnson Caroline H, Dubljevic Valentina, Campbell James A, Huttner Anita, Baehring Joachim M, Zhou Jiangbing, Hansen James E
JCI Insight Vol 6 (2021)
https://doi.org/10.1172/jci.insight.145875
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Rattray Nicholas JW, Trivedi Drupad K, Xu Yun, Chandola Tarani, Johnson Caroline H, Marshall Alan D, Mekli Krisztina, Rattray Zahra, Tampubolon Gindo, Vanhoutte Bram, White Iain R, Wu Frederick CW, Pendleton Neil, Nazroo James, Goodacre Royston
Nature Communications Vol 10 (2019)
https://doi.org/10.1038/s41467-019-12716-2
Evaluation of temporal aggregation processes using spatial intensity distribution analysis
Rattray Zahra, Zindy Egor, Buzza Karen M, Pluen Alain
Protein Self-Assembly Methods and Protocols (2019) (2019)
https://doi.org/10.1007/978-1-4939-9678-0_11
Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications
Rattray Zahra, Dubljevic Valentina, Rattray Nicholas, Greenwood Deanne L, Johnson Caroline H, Campbell James A, Hansen James E
Biochemical and Biophysical Research Communications Vol 496, pp. 858-864 (2018)
https://doi.org/10.1016/j.bbrc.2018.01.139
A DNA-damaging lupus autoantibody synergizes with PARP inhibitors against DNA repair-deficient tumor cells
Rattray Zahra, Patel Jaymin M, Noble Phillip W, Dubljevic Valentina, Greenwood Deanne L, Campbell James A, Hansen James E
Cancer Research Vol 78, pp. 2773 (2018)
https://doi.org/10.1158/1538-7445.AM2018-2773

More publications

Professional activities

EPSRC Peer Review College (External organisation)
Member
6/7/2021
Royal Society of Edinburgh's Young Academy of Scotland (External organisation)
Chair
4/2021
Recounting the Untold Stories of Breast Cancer: Narratives from the Patient, Clinician and Scientist Perspective
Contributor
2/8/2022
Strathclyde researchers work with patients and NHS Lanarkshire clinician to raise awareness of breast cancer
Recipient
25/7/2022
EPSRC (Event)
Peer reviewer
1/7/2022
UK Young Academy Case Study
Contributor
13/6/2022

More professional activities

Projects

Royal Society of Chemistry: Developing an analytical toolbox for modelling antibody aggregation
Rattray, Zahra (Principal Investigator) Halbert, Gavin (Principal Investigator) Considine, Paul (Researcher)
Summer internship funded by Royal Society of Chemistry- £2600
13-Jan-2022 - 12-Jan-2022
Recounting the Untold Stories of Breast Cancer: Narratives from the Patient, Clinician and Scientist Perspective
Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Chalmers, Susan (Co-investigator) MCFADDEN, Yvonne (Co-investigator)
£5700 awarded to develop a series of storytelling events
14-Jan-2022 - 13-Jan-2023
Multiscale Metrology Suite for Next-generation Healthcare Technologies (EPSRC Strategic Equipment)
Rattray, Zahra (Principal Investigator) Bruns, Nico (Co-investigator) Faulds, Karen (Co-investigator) Graham, Duncan (Co-investigator) Halbert, Gavin (Co-investigator) Hoskins, Clare (Co-investigator) McArthur, Stephen (Co-investigator) Perrie, Yvonne (Co-investigator) Reid, Stuart (Co-investigator) Seib, Philipp (Co-investigator)
01-Jan-2021 - 31-Jan-2024
SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis
Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator)
01-Jan-2021 - 28-Jan-2023
Lisa van Den Dreist- FRAME AWARD: Development of a gene expression bioinformatics pipeline to identify driver mutations of colorectal cancer
Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator)
Competitively awarded FRAME summer studentship with stipend (£2,500)
22-Jan-2021 - 29-Jan-2021
Erasmus+: Host for Ahmed Gaafar
Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator)
17-Jan-2021 - 30-Jan-2021

More projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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