Dr Zahra Rattray

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Chancellor's Fellow and Lecturer

My field of expertise lies in the characterization of biologics and nanomedicine formulation attributes and in vivo performance using traditional and novel analytical approaches. 

Areas of interest are summarized as follows;

  • Understanding environmental and physicochemical determinants of solution-phase formulation stability.
  • Determining key critical quality attributes in particle design to inform optimal in vivo performance.
  • Evaluation of nanomedicine interaction with biological media, and the mechanism of cellular uptake in two- and three-dimensional cellular models.
  • Applying novel imaging modalities for evaluating drug and nanoparticle biodistribution, and impact on tumor response.
  • The interplay between the tumour microenvironment and nanomedicine in vivo performance with a view to developing biorelevant in vitro tests.

I am passionate about improving access to education, achievement and realizing potential for young budding scientists and am open to local STEM and healthcare-related widening participation initiatives.

Publications

Evaluation of temporal aggregation processes using spatial intensity distribution analysis
Rattray Zahra, Zindy Egor, Buzza Karen M, Pluen Alain
Protein Self-Assembly (2019) (2019)
https://doi.org/10.1007/978-1-4939-9678-0_11
A DNA-damaging lupus autoantibody synergizes with PARP inhibitors against DNA repair-deficient tumor cells
Rattray Zahra, Patel Jaymin M, Noble Phillip W, Dubljevic Valentina, Greenwood Deanne L, Campbell James A, Hansen James E
Cancer Research Vol 78, pp. 2773 (2018)
https://doi.org/10.1158/1538-7445.AM2018-2773
Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications
Rattray Zahra, Dubljevic Valentina, Rattray Nicholas, Greenwood Deanne L, Johnson Caroline H, Campbell James A, Hansen James E
Biochemical and Biophysical Research Communications Vol 496, pp. 858-864 (2018)
https://doi.org/10.1016/j.bbrc.2018.01.139
Compositions and methods for inhibition of nuclear-penetrating antibodies
Rattray Zahra, Hansen James
(2018)
Compositions and methods for enhancing nuclear translocation
Rattray Zahra, Hansen James E
(2018)
Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids
Johnson Caroline H, Santidrian Antonio F, LeBoeuf Sarah E, Kurzy Michael E, Rattray Nicholas, Rattray Zahra, Warth Benedikt, Ritland Melissa, Hoang Linh T, Loriot Celine, Higa Jason, Hansen James E, Felding Brunhilde H, Siuzdak Gary
Cancer and Metabolism Vol 5 (2017)
https://doi.org/10.1186/s40170-017-0171-2

more publications

Professional activities

Nanotechnology: a blessing or a curse for developing nations?
Interviewee
1/8/2019
Science @ Strathclyde - SIPBS: Virtual Drug Discovery Workshop
Advisor
11/6/2019
Senior Phase Induction Day @ Strathclyde: SIPBS Virtual Drug Discovery Workshop
Advisor
6/6/2019
Health Week @ Garrowhill Primary School: Diabetes and Asthma Workshops
Advisor
31/5/2019
Day of Science @ Strathclyde - SIPBS: Cat Allergy Simulation and STEM activity stands
Advisor
9/5/2019
Integrative Technologies in Precision Medicine
Contributor
25/3/2019

more professional activities

Projects

Silencing KPNA2: A Druggable Target Against Breast Cancer?
Rattray, Zahra (Principal Investigator)
01-Jan-2019 - 31-Jan-2020

more projects

Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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