Dr Zahra Rattray

Strathclyde Chancellor's Fellow

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Chancellor's research fellow and lecturer in Drug Delivery I am interested in the interplay between drugs (small molecule, peptide, and monoclonal antibodies), and their formulation characteristics with biological systems. Understanding this interplay can lead to designing new drugs for targeting various cancer types and help overcome biological barriers to delivering drugs. I utilize a combination of new analytical technologies and multidisciplinary science to drive this understanding. My lab is also interested in applying new technologies to understanding the biological drivers of cancer and SLE. When I am not doing science, I am passionate about outreach and inspiring future scientists.

Prizes and awards

European Crucible: Seed Funding Award- Developing new tools for evaluating nanoscale biological interactions: Recipient; 6/2021
European Crucible: Scottish Cohort: Recipient; 1/5/2021
Strathclyde Chancellor's Fellow: Recipient; 1/9/2018
Postdoctoral fellowship: Recipient; 1/2014
Widening participation award holder: Recipient; 10/2010
AstraZeneca innovation award winner: Recipient; 8/2008

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Publications

Sex differences in colon cancer metabolism reveal a novel subphenotype: Cai Yuping, Rattray Nicholas J W, Zhang Qian, Mironova Varvara, Santos-Neto Alvaro, Hsu Kuo-Shun, Rattray Zahra, Cross Justin R, Zhang Yawei, Paty Philip B, Khan Sajid A, Johnson Caroline H; Scientific Reports Vol 10 (2020); https://doi.org/10.1038/s41598-020-61851-0
ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody: Rattray Zahra, Deng Gang, Zhang Shenqi, Shirali Anupama, May Christopher K, Chen Xiaoyong, Cuffari Benedette J, Liu Jun, Zou Pan, Rattray Nicholas JW, Johnson Caroline H, Dubljevic Valentina, Campbell James A, Huttner Anita, Baehring Joachim M, Zhou Jiangbing, Hansen James E; JCI Insight (2021); https://doi.org/10.1172/jci.insight.145875
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty: Rattray Nicholas JW, Trivedi Drupad K, Xu Yun, Chandola Tarani, Johnson Caroline H, Marshall Alan D, Mekli Krisztina, Rattray Zahra, Tampubolon Gindo, Vanhoutte Bram, White Iain R, Wu Frederick CW, Pendleton Neil, Nazroo James, Goodacre Royston; Nature Communications Vol 10 (2019); https://doi.org/10.1038/s41467-019-12716-2
Evaluation of temporal aggregation processes using spatial intensity distribution analysis: Rattray Zahra, Zindy Egor, Buzza Karen M, Pluen Alain; Protein Self-Assembly Methods and Protocols (2019) (2019); https://doi.org/10.1007/978-1-4939-9678-0_11
Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications: Rattray Zahra, Dubljevic Valentina, Rattray Nicholas, Greenwood Deanne L, Johnson Caroline H, Campbell James A, Hansen James E; Biochemical and Biophysical Research Communications Vol 496, pp. 858-864 (2018); https://doi.org/10.1016/j.bbrc.2018.01.139
A DNA-damaging lupus autoantibody synergizes with PARP inhibitors against DNA repair-deficient tumor cells: Rattray Zahra, Patel Jaymin M, Noble Phillip W, Dubljevic Valentina, Greenwood Deanne L, Campbell James A, Hansen James E; Cancer Research Vol 78, pp. 2773 (2018); https://doi.org/10.1158/1538-7445.AM2018-2773

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Professional activities

EPSRC Peer Review College (External organisation): Member; 6/7/2021
Royal Society of Edinburgh's Young Academy of Scotland (External organisation): Chair; 4/2021
The development and bioanalytical characterization of novel drug delivery systems: Speaker; 28/7/2021
Yale Cancer Center study reveals new pathway for brain tumor therapy: Recipient; 15/6/2021
Nuffield Research Placements 2021: Host; 6/2021
The early assessment of prototype nanomedicine nano-bio interactions: Speaker; 25/5/2021

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Projects

SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis: Li, David (Principal Investigator) Chamberlain, Luke (Co-investigator) Chen, Yu (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Gould, Gwyn (Co-investigator) Hoskisson, Paul (Co-investigator) McConnell, Gail (Co-investigator) Rattray, Zahra (Co-investigator) Van de Linde, Sebastian (Co-investigator); 01-Jan-2021 - 30-Jan-2022
Lisa van Den Dreist- FRAME AWARD: Development of a gene expression bioinformatics pipeline to identify driver mutations of colorectal cancer: Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator); Competitively awarded FRAME summer studentship with stipend (£2,500); 22-Jan-2021 - 29-Jan-2021
Host for Ahmed Gaafar: Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Principal Investigator); 17-Jan-2021 - 30-Jan-2021
The impact of KPNA2 overexpression on breast cancer cellular phenotype (RSE Reboot): Rattray, Zahra (Principal Investigator) Rattray, Nicholas (Co-investigator); 08-Jan-2021 - 07-Jan-2021
Nanoparticle Tracking Analysis: Rattray, Zahra (Principal Investigator); Malvern Nanoparticle Tracking Analysis for particle size and concentration measurement; 16-Jan-2020
Obesity and Neuroinflammation: The Impact of Adipocyte-derived Extracellular Vesicles on Inflammatory Signalling Pathways of Microglia: Colvin, Chiara (Post Grad Student) Gould, Gwyn (Co-investigator) Rattray, Zahra (Co-investigator) Cunningham, Margaret Rose (Principal Investigator); 01-Jan-2020 - 30-Jan-2021

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Address

Strathclyde Institute of Pharmacy and Biomedical Sciences
Robertson Wing

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