My research focuses on exploiting microsystems engineering approaches (lab-on-a-chip, microfluidics, materials engineering) to create new in vitro models for investigating and controlling cell behaviours. Applications of this work include the development of tools for drug screening and for tissue engineering, with a particular focus on vascular cell biology. My background is highly interdisciplinary, spanning the engineering-life science interface, with expertise in a wide range of cell biology, microfabrication, live-cell imaging and analytical technologies.
I have taught on both the BEng/MEng and MSc courses in Biomedical Engineering and I am currently module coordinator for BE105 (Cell Biology 1).
Current research projects, involving collaboration with a diverse range of academic and clinical collaborators, include:
- investigating the phenotypic changes in vascular cells that underlie cardiovascular disease
- the development of organ-on-a-chip models for chronic gynaecological conditions
- the development of new methods for monitoring mitochondrial dynamics in neuronal preparations.
- Automated tracking of mitochondrial motility using image processing and epifluorescence microscopy
More professional activities
- Adenomyosis-on-a-chip: a microfluidic 3D model of the endometrial-myometrial junction (EMJ)
- Sandison, Mairi (Principal Investigator) Zagnoni, Michele (Co-investigator)
- 06-Jan-2021 - 23-Jan-2021
- EPSRC Centre for Doctoral Training in Prosthetics & Orthotics | Talkowski, Tomas
- Buis, Arjan (Principal Investigator) Sandison, Mairi (Principal Investigator) Buis, Arjan (Co-investigator) Corrigan, Damion (Co-investigator) Talkowski, Tomas (Research Co-investigator)
- 01-Jan-2020 - 01-Jan-2024
- Development of novel, automated analyses for the quantification of cellular and sub-cellular dynamics from fluorescence video-microscopy
- Chalmers, Susan (Principal Investigator) Sandison, Mairi (Co-investigator) Murray, Paul (Co-investigator) Campbell, Andrew John (Co-investigator)
- 01-Jan-2020 - 11-Jan-2021
- STEM Equals- Rational design of novel microfluidics devices for evaluating nanomedicine in vitro biological fate
- Rattray, Zahra (Principal Investigator) Kazakidi, Asimina (Co-investigator) Sandison, Mairi (Co-investigator) Perrie, Yvonne (Co-investigator)
- Nanotechnology in health has emerged as a promising solution to addressing unmet clinical need. While demonstrating significant promise and industrial uptake- pipeline attrition rates for nanomedicines remain high, significantly hampering the bench-to-clinic translation of nanomedicines. This is in part due to a lack of models adequately measuring and predicting biological fate. This project uses computational fluid dynamics (CFD) to aid the rational design of microfluidics devices mimicking human blood vasculature. It is anticipated that using CFD, we will be able to design more physiologically-relevant models of blood flow that can be used in the evaluation of nanomedicine biological fate.
- 01-Jan-2020 - 30-Jan-2021
- Transformative Anatomically accurate Microvascular flow Phantoms for Ultrasound therapy research (TAMP-US)
- Mulvana, Helen Elizabeth (Principal Investigator) Jackson, Joseph (Co-investigator) O'Leary, Richard (Co-investigator) Sandison, Mairi (Co-investigator)
- 01-Jan-2020 - 31-Jan-2021
- Strathclyde Chancellor's Fellow CDT: Transformative Technologies for Nanomedicine Characterization Centre for Doctoral Training
- Rattray, Zahra (Principal Investigator) Edkins, Robert (Principal Investigator) Van de Linde, Sebastian (Principal Investigator) Sandison, Mairi (Principal Investigator) Henrich, Oliver (Principal Investigator)
- 31-Jan-2019 - 30-Jan-2024
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