Dr Mairi Sandison

Strathclyde Chancellor's Fellow

Biomedical Engineering

Personal statement

My research focuses on exploiting microsystems engineering approaches (lab-on-a-chip, microfluidics, materials engineering) to create new in vitro models for investigating and controlling cell behaviours. Applications of this work include the development of tools for drug screening and for tissue engineering, with a particular focus on vascular cell biology. My background is highly interdisciplinary, spanning the engineering-life science interface, with expertise in a wide range of cell biology, microfabrication, live-cell imaging and analytical technologies. 

Publications

Investigating the response of skeletal muscle to prosthesis-related loading conditions : an ex vivo animal model
Graser Marisa, Wark Alastair, Day Sarah, Sandison Mairi, McConnell Gail, Buis Arjan
International Society for Prosthetics and Orthotics 18th World Congress (2021)
Metal oxide-doped elastomeric materials for enhancement of 405-nm light-based antimicrobial surface decontamination
McShea Laura, Kambo Harjot, Maclean Michelle, Sandison Mairi
FIS/ HIS 2020 Conference, pp. 145 (2020)
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer
Casciano Jessica C, Perry Caroline, Cohen-Nowak Adam J, Miller Katelyn D, Voorde Johan Vande, Zhang Qifeng, Chalmers Susan, Sandison Mairi E, Lui Qin, Hedley Ann, McBryan Tony, Tang Hsin-Yao, Gorman Nicole, Beer Thomas, Speicher David W, Adams Peter D, Lui Xuefeng, Schlegel Richard, McCarron John G, Wakelam Michael J O, Gottlieb Eyal, Kossenkov Andrew V, Schug Zachary T
British Journal of Cancer Vol 122, pp. 868-884 (2020)
https://doi.org/10.1038/s41416-019-0711-3
The impact of protein corona formation on nanoparticle characteristics
Rattray Zahra, Sandison Mairi
Royal Society of Chemistry Twitter Poster Conference (2020)
Tracking phenotypic heterogeneity at the single cell level in populations of vascular cells through the development of microwell arrays
Smith E, Zagnoni M, Sandison ME
BioMedEng19, pp. 167 (2019)
An in vitro tissue-based model of vascular remodeling in the descending aorta at intercostal artery branch points
Sandison Mairi
14th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease (2019)

More publications

Teaching

I have taught on both the BEng/MEng and MSc courses in Biomedical Engineering and I am currently module coordinator for BE105 (Cell Biology 1).

Research interests

Current research projects, involving collaboration with a diverse range of academic and clinical collaborators, include:

  • investigating the phenotypic changes in vascular cells that underlie cardiovascular disease
  • the development of organ-on-a-chip models for chronic gynaecological conditions
  • the development of new methods for monitoring mitochondrial dynamics in neuronal preparations.

Professional activities

Automated tracking of mitochondrial motility using image processing and epifluorescence microscopy
Contributor
25/11/2020

More professional activities

Projects

Adenomyosis-on-a-chip: a microfluidic 3D model of the endometrial-myometrial junction (EMJ)
Sandison, Mairi (Principal Investigator) Zagnoni, Michele (Co-investigator)
06-Jan-2021 - 23-Jan-2021
EPSRC Centre for Doctoral Training in Prosthetics & Orthotics | Talkowski, Tomas
Buis, Arjan (Principal Investigator) Sandison, Mairi (Principal Investigator) Buis, Arjan (Co-investigator) Corrigan, Damion (Co-investigator) Talkowski, Tomas (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Development of novel, automated analyses for the quantification of cellular and sub-cellular dynamics from fluorescence video-microscopy
Chalmers, Susan (Principal Investigator) Sandison, Mairi (Co-investigator) Murray, Paul (Co-investigator) Campbell, Andrew John (Co-investigator)
01-Jan-2020 - 11-Jan-2021
STEM Equals- Rational design of novel microfluidics devices for evaluating nanomedicine in vitro biological fate
Rattray, Zahra (Principal Investigator) Kazakidi, Asimina (Co-investigator) Sandison, Mairi (Co-investigator) Perrie, Yvonne (Co-investigator)
Nanotechnology in health has emerged as a promising solution to addressing unmet clinical need. While demonstrating significant promise and industrial uptake- pipeline attrition rates for nanomedicines remain high, significantly hampering the bench-to-clinic translation of nanomedicines. This is in part due to a lack of models adequately measuring and predicting biological fate. This project uses computational fluid dynamics (CFD) to aid the rational design of microfluidics devices mimicking human blood vasculature. It is anticipated that using CFD, we will be able to design more physiologically-relevant models of blood flow that can be used in the evaluation of nanomedicine biological fate.
01-Jan-2020 - 30-Jan-2021
Transformative Anatomically accurate Microvascular flow Phantoms for Ultrasound therapy research (TAMP-US)
Mulvana, Helen Elizabeth (Principal Investigator) Jackson, Joseph (Co-investigator) O'Leary, Richard (Co-investigator) Sandison, Mairi (Co-investigator)
01-Jan-2020 - 31-Jan-2021
Strathclyde Chancellor's Fellow CDT: Transformative Technologies for Nanomedicine Characterization Centre for Doctoral Training
Rattray, Zahra (Principal Investigator) Edkins, Robert (Principal Investigator) Van de Linde, Sebastian (Principal Investigator) Sandison, Mairi (Principal Investigator) Henrich, Oliver (Principal Investigator)
31-Jan-2019 - 30-Jan-2024

More projects

Address

Biomedical Engineering
Wolfson Building

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