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Dr Mairi Sandison

Strathclyde Chancellor'S Fellow

Biomedical Engineering

Personal statement

My research background is highly multidisciplinary, centred around the development of microsystems engineering and biophysical techniques as tools for studying basic biological questions and for biochemical analysis.

 

Current research projects are focussed upon combining lab-on-a-chip approaches and material functionalisation with live-cell imaging to: 

  • investigate the phenotypic changes in vascular cells that underlie cardiovascular disease
  • develop new methods for monitoring mitochondrial dynamics in neuronal preparations
  • develop physiologically relevant, in vitro model systems

 

Publications

The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype : direct demonstration of phenotypic modulation
Sandison Mairi E., Dempster John, McCarron John G.
Journal of Physiology Vol 594, pp. 6189-6209, (2016)
http://dx.doi.org/10.1113/JP272729
Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle
McCarron John G., Chalmers Susan, Wilson Calum, Sandison Mairi E.
Vascular Ion Channels in Physiology and DiseaseVascular Ion Channels in Physiology and Disease, (2016)
http://dx.doi.org/10.1007/978-3-319-29635-7_11
Synthesis of an azido-tagged low affinity ratiometric calcium sensor
Caldwell Stuart T., Cairns Andrew G., Olson Marnie, Chalmers Susan, Sandison Mairi, Mullen William, McCarron John G., Hartley Richard C.
Tetrahedron Vol 71, pp. 9571–9578, (2015)
http://dx.doi.org/10.1016/j.tet.2015.10.052
Heterogeneity in the proliferative capacity of smooth muscle cells (SMCs)
Sandison Mairi, McCarron John
FASEB Journal Vol 29, pp. 418.8, (2015)
Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells
Jiwaji Meesbah, Sandison Mairi E., Reboud Julien, Stevenson Ross, Daly Rónán, Barkess Gráinne, Faulds Karen, Kolch Walter, Graham Duncan, Girolami Mark A., Cooper Jonathan M., Pitt Andrew R.
PLoS One Vol 9, (2014)
http://dx.doi.org/10.1371/journal.pone.0099458
Direct visualisation of smooth muscle cell phenotypic plasticity and migration by long-term imaging
Sandison Mairi, Chalmers Susan, Dempster John, McCarron John
FASEB Journal Vol 28, (2014)

more publications

Projects

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Kim, So Jeong
Chalmers, Susan (Principal Investigator) Sandison, Mairi (Co-investigator) Kim, So Jeong (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2019
How the Physicochemical Properties of the Extracellular Environment Influence Smooth Muscle Phenotypic Plasticity
Sandison, Mairi (Principal Investigator)
Period 01-Mar-2016 - 28-Feb-2018
Microfluidic tissue-based models of smooth muscle phenotypic modulation
Sandison, Mairi (Principal Investigator)
Period 03-May-2016 - 05-Mar-2018
BTG: Investigating vascular cell fate using micro-patterned cell arrays and extended time-lapse imaging
Sandison, Mairi (Principal Investigator) McCarron, John (Co-investigator) Zagnoni, Michele (Co-investigator)
Cardiovascular disease occurs when blood vessel structure changes through proliferation of cells in the vessel wall. The source of these cells is the vessel itself but precisely which cell(s) proliferate is unclear. Understanding their origins is a prerequisite for informed development of treatment. To investigate this, we will combine micro-patterned cell array technologies with long-term, timelapse imaging to develop new approaches for simultaneously monitoring the fate of large numbers of cells obtained from vascular cell isolations. Array architectures will be created to isolate the various cell types, probe cell-cell interactions and investigate how these interactions affect cellular differentiation and proliferation.
Period 17-Mar-2014 - 15-Sep-2014

more projects

Address

Biomedical Engineering
Graham Hills Building

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