Publications

Tuning interfacial concentration enhancement through dispersion interactions to facilitate heterogeneous nucleation: McKechnie David, Mulheran Paul A, Sefcik Jan, Johnston Karen; Journal of Physical Chemistry C (2022); https://doi.org/10.1021/acs.jpcc.2c04410
Continuous crystallisation of organic salt polymorphs: McGinty John, Svoboda Vaclav, Macfhionnghaile Pol, Wheatcroft Helen, Price Chris J, Sefcik Jan; Frontiers in Chemical Engineering Vol 4 (2022); https://doi.org/10.3389/fceng.2022.896329
Phase diagram determination and process development for continuous antisolvent crystallizations: Mack Corin, Hoffmann Johannes, Sefcik Jan, ter Horst Joop H; Crystals Vol 12 (2022); https://doi.org/10.3390/cryst12081102
Molecular dynamics investigation of clustering in aqueous glycine solutions: Sweatman Martin B, Afify Nasser D, Ferreiro-Rangel Carlos A, Jorge Miguel, Sefcik Jan; Journal of Physical Chemistry B Vol 126, pp. 4711-4722 (2022); https://doi.org/10.1021/acs.jpcb.2c01975
Crystal nucleation rates from induction time measurements and microfluidic devices: Powell Daniel M, Sefcik Jan, Zagnoni Michele, ter Horst Joop H; CMAC Annual Open Day 2022, pp. 60-60 (2022)
A structured approach to implementation of measurements : crystallisation in the mefenamic acid MicroFactory: Chong Magdalene, Li Wei, Brown Cameron, McGinty John, Robertson Murray, Johnston Blair, Sefcik Jan, Benyahia Brahim, Rielly Chris, Nordon Alison; CMAC Annual Open Day 2022, pp. 61-61 (2022)

Research interests

Our research expertise is in particle engineering and nanostructured materials, with focus on design of novel particulate products and efficient processes for their manufacturing, across a wide range of applications from nucleation and crystallisation, to protein and peptide self-assembly, to organic gels and nanocomposites.

Our research in pharmaceutical manufacturing aligned with CMAC seeks to enhance access to medicines by increasing quality and reducing costs with the aim improving people’s health and wellbeing.

We develop experimental workflows for product and process development of particulate systems for pharmaceutical applications to obtain better control of critical quality attributes in medicines manufacturing.

We also develop new methods for extracting valuable real time information from process analytical tools such as imaging and scattering/backscattering to enable intelligent decision support for monitoring and control of particulate systems and processes, including fouling detection and accurate quantitative estimates of particle shape and size distributions from in situ measurements.

Professional activities

Evaluation of Deep Learning methods for particle characterisation from in-line imaging and chord length distribution measurements: Contributor; 18/9/2022
Multi-sensor Measurements For Quantitative Particle Size And Concentration: Contributor; 20/2/2020
Integrated Filtration and Washing Modelling to Predict Continuous Isolation Performance.: Contributor; 2020
Multi-sensor in situ measurements of particle size, shape and concentration: Contributor; 2/10/2019
8th World Congress on Particle Technology: Participant; 24/4/2018
Particle Measurement in Process: Contributor; 22/3/2018

More professional activities

Projects

The birth of crystals: new understanding of nucleation by direct measurement: Haw, Mark (Principal Investigator) Lue, Leo (Co-investigator) Sefcik, Jan (Co-investigator); 01-Jan-2020 - 31-Jan-2023
Doctoral Training Partnership 2020-2021 University of Strathclyde | Anker, Samira: Johnston, Karen (Principal Investigator) Sefcik, Jan (Co-investigator) Anker, Samira (Research Co-investigator); 01-Jan-2020 - 01-Jan-2024
Catching nucleation in action using surface enhanced Raman spectroscopy: Johnston, Karen (Principal Investigator) Faulds, Karen (Co-investigator) Sefcik, Jan (Co-investigator); 01-Jan-2020 - 30-Jan-2023
Doctoral Training Partnership 2018-19 University of Strathclyde | Flannigan, James: Haw, Mark (Principal Investigator) Sefcik, Jan (Co-investigator) Flannigan, James (Research Co-investigator); 01-Jan-2019 - 01-Jan-2023
RI@S funded summer project: Johnston, Karen (Principal Investigator) Haw, Mark (Co-investigator) Sefcik, Jan (Co-investigator); RI@S funded summer project for Mohammad Talha Dar; 10-Jan-2019 - 05-Jan-2019
Doctoral Training Partnership 2018-19 University of Strathclyde | Cashmore, Andrew: Sefcik, Jan (Principal Investigator) Haw, Mark (Co-investigator) Cashmore, Andrew (Research Co-investigator); 01-Jan-2018 - 01-Jan-2022

More projects

Address

Chemical and Process Engineering
James Weir Building

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Professor Jan Sefcik

Head Of Department

Chemical and Process Engineering