Prof Jan Sefcik

Chemical and Process Engineering


Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation : exploring opportunities between reactive and antisolvent crystallization concepts
Svoboda Vaclav, MacFhionnghaile Pól, McGinty John, Connor Lauren E., Oswald Iain D. H., Sefcik Jan
Crystal Growth and Design, (2017)
Kinetics of early stages of resorcinol-formaldehyde polymerization investigated by solution phase nuclear magnetic resonance spectroscopy
Gaca Katarzyna Z., Parkinson John A., Sefcik Jan
Polymer Vol 110, pp. 62-73, (2017)
Self-assembly of ultra-small micelles from amphiphilic lipopeptoids
Lau King Hang Aaron, Castelletto Valeria, Kendall Thomas, Sefcik Jan, Hamley Ian W., Reza Mehedi, Ruokolainen Janne
Chemical Communications Vol 53, pp. 2178-2181, (2017)
Modelling of artefacts in estimations of particle size of needle-like particles from laser diffraction measurements
Agimelen Okpeafoh S., Mulholland Anthony J., Sefcik Jan
Chemical Engineering Science Vol 158, pp. 445-452, (2017)
Filtration suppresses laser-induced nucleation of glycine in aqueous solutions
Javid Nadeem, Kendall Thomas, Burns Iain S., Sefcik Jan
Crystal Growth and Design Vol 16, pp. 4196−4202, (2016)
Integration of in situ imaging and chord length distribution measurements for estimation of particle size and shape
Agimelen Okpeafoh S., Jawor-Baczynska Anna, McGinty John, Dziewierz Jerzy, Tachtatzis Christos, Cleary Alison, Haley Ian, Michie Craig, Andonovic Ivan, Sefcik Jan, Mulholland Anthony J.
Chemical Engineering Science Vol 144, pp. 87-100, (2016)

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Research interests

Our research deals with materials and processes at colloidal (nanometer to micrometer) length scales. The focus is on synthesis and processing of particulate, colloidal and biomolecular systems.

Particle formation processes/pharmaceutical engineering

Numerous pharmaceutical particulates are formed through antisolvent driven processes, where two solutions are mixed in order to create a thermodynamic driving force for particle formation due to a limited solubility of one or more solutes in the resulting solvent mixture. Such processes are often mixing controlled and can lead to a wide range of intermediate and/or metastable liquid or solid phases. We study kinetics and mechanisms of these processes in order to design and novel continuous processes for manufacturing of nanostructured particles for various pharmaceutical applications. We also study subsequent downstream processes and their effects on resulting particulate products.

Protein Aggregation

Understanding, controlling and utilizing colloidal interactions of proteins is crucial for their downstream processing, including purification, sterilization and storage. Protein interactions with each other determine whether they stay stable in solution or whether they aggregate. Understanding and tuning of protein interactions is thus necessary for improvement of the lifetime stability of therapeutic proteins as well as for rational development of novel separation and sensing procedures for bioprocessing. In fact, there are numerous issues in biotechnology and biomedical engineering, where protein aggregation phenomena have been identified as key factors controlling our success in producing, sensing, handling, and applying biomaterials and therapeutics as desired. We study protein aggregation in solutions under non-equilibrium conditions. The proteins of interest include enzymes and therapeutic proteins in applications such as heat treatment or bioseparations. The modelling work is focused in detailed scattering and spectroscopic characterisation of aggregating protein systems as well as on development and validation of population balance models describing how the mass distribution, structure and activity of protein aggregates evolve in time.

Professional activities

European Summer School on Crystal Nucleation
Invited speaker
Crystallize COST Action CM1402 Annual Meeting
Keynote/plenary speaker
5th European Conference on Crystal Growth
Invited presentation at GSK, Stevenage, UK
Faraday Discussion 179
Invited speaker
Invited Seminar, University of Surrey, Guildford, UK

more professional activities


GSK 112
Sefcik, Jan (Principal Investigator)
Period 16-Jan-2017 - 31-Jul-2017
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
Period 01-Jan-2017 - 31-Dec-2023
Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC Hub)
Florence, Alastair (Principal Investigator) Halbert, Gavin (Co-investigator) Johnston, Blair (Co-investigator) Nordon, Alison (Co-investigator) Price, Chris John (Co-investigator) Sefcik, Jan (Co-investigator) Ter Horst, Joop (Co-investigator)
Period 01-Jan-2017 - 31-Dec-2023
Enabling manufacturing of Functional Nanomaterials using SynBio
Sefcik, Jan (Principal Investigator)
Period 01-Dec-2016 - 30-Nov-2020
Polymorph control in PVDF thin films for sensor applications and composites
Johnston, Karen (Principal Investigator) Sefcik, Jan (CoI) Mulheran, Paul (CoI) Gleskova, Helena (CoI) Liggat, John (CoI) McKechnie, David (Researcher)
In this project we will develop a computational model to guide the design of polymer thin films for composite and flexible sensor applications.
Period 01-Oct-2016 - 31-Mar-2017

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Chemical and Process Engineering
James Weir Building

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