Publications

Secondary nucleation of α-glycine induced by fluid shear investigated using a Couette flow cell

Cashmore Andrew, Georgoulas Konstantinos, Boyle Christopher, Lee Mei, Haw Mark D, Sefcik Jan

Crystal Growth and Design Vol 24, pp. 4975-4984 (2024)

https://doi.org/10.1021/acs.cgd.4c00130

Integrated continuous process design for crystallisation, spherical agglomeration, and filtration of lovastatin

Brown Cameron J, McGinty John, Islam Muhammad T, Rajoub Nazer, Arjmandi-Tash Omid, Ottoboni Sara, Shahid Muhid, Urwin Stephanie J, Lee Ye Seol, Chong Magdalene W S, Papathanasiou Foteini, Prakash Aruna S, Prasad Elke, Spence Bronwyn, Sefcik Jan, Robertson John, Smith Rachel, Litster James D, Price Chris J, Nordon Alison, Adjiman Claire S, Florence Alastair J

Journal of Pharmaceutical Innovation Vol 19 (2024)

https://doi.org/10.1007/s12247-024-09815-z

Assessment of GAFF and OPLS force fields for urea : crystal and aqueous solution properties

Anker Samira, McKechnie David, Mulheran Paul, Sefcik Jan, Johnston Karen

Crystal Growth and Design Vol 24, pp. 143–158 (2024)

https://doi.org/10.1021/acs.cgd.3c00785

Nucleation and growth kinetics of sodium chloride crystallization from water and deuterium oxide

Flannigan James M, MacIver Daniel, Jolliffe Hikaru, Haw Mark D, Sefcik Jan

Crystals Vol 13 (2023)

https://doi.org/10.3390/cryst13091388

Crystallisation of sodium sulfate

Muhammad Abdullah, Sefcik Jan, Hamilton Andrea, Johnston Karen

ISIC 2023 (2023)

Digital process design to define and deliver pharmaceutical particle attributes

Urwin Stephanie J, Chong Magdalene WS, Li Wei, McGinty John, Mehta Bhavik, Ottoboni Sara, Pathan Momina, Prasad Elke, Robertson Murray, McGowan Mark, al-Attili Mais, Gramadnikova Ekaterina, Siddique Mariam, Houson Ian, Feilden Helen, Benyahia Brahim, Brown Cameron J, Halbert Gavin W, Johnston Blair, Nordon Alison, Price Chris J, Reilly Chris D, Sefcik Jan, Florence Alastair J

Chemical Engineering Research and Design Vol 196, pp. 726-749 (2023)

https://doi.org/10.1016/j.cherd.2023.07.003

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Research Interests

Our research expertise is in particle engineering and nanostructured materials, with focus on design of novel particulate products and efficient processes for their manufacturing, across a wide range of applications from nucleation and crystallisation, to protein and peptide self-assembly, to organic gels and nanocomposites.

Our research in pharmaceutical manufacturing aligned with CMAC seeks to enhance access to medicines by increasing quality and reducing costs with the aim improving people’s health and wellbeing.

We develop experimental workflows for product and process development of particulate systems for pharmaceutical applications to obtain better control of critical quality attributes in medicines manufacturing.

We also develop new methods for extracting valuable real time information from process analytical tools such as imaging and scattering/backscattering to enable intelligent decision support for monitoring and control of particulate systems and processes, including fouling detection and accurate quantitative estimates of particle shape and size distributions from in situ measurements.   

Professional Activities

Evaluation of Methods for Particle Characterisation from In-Situ Sensors

Contributor

6/9/2023

Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements

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17/11/2022

Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements

Contributor

19/9/2022

Evaluation of Deep Learning methods for particle characterisation from in-line imaging and chord length distribution measurements

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18/9/2022

Multi-sensor Measurements For Quantitative Particle Size And Concentration

Contributor

20/2/2020

Integrated Filtration and Washing Modelling to Predict Continuous Isolation Performance.

Contributor

2020

More professional activities

Projects

DTP 2224 University of Strathclyde | Park, Alexander

Edkins, Katharina (Principal Investigator) Sefcik, Jan (Co-investigator) Park, Alexander (Research Co-investigator)

01-Oct-2024 - 01-Apr-2028

Industrial Case Account - University of Strathclyde 2023 | Asif, Khadija

Jorge, Miguel (Principal Investigator) Sefcik, Jan (Co-investigator) Asif, Khadija (Research Co-investigator)

01-Oct-2023 - 01-Oct-2027

Recovery of light hydrocarbons from highly sour natural gas

Inglezakis, Vasileios (Principal Investigator) Sefcik, Jan (Co-investigator)

Development and simulation of cryogenic processes for the recovery of light hydrocarbons from CO2-rich streams from the demethanization of natural gas. The study included SLV equilibria, process simulation and heat integration.

01-Sep-2023 - 31-Dec-2023

Effects of mechanical impact and turbulent flow on secondary nucleation

Sefcik, Jan (Principal Investigator)

01-Oct-2022 - 30-Sep-2026

Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation

Price, Chris John (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Sefcik, Jan (Co-investigator)

11-Jul-2022 - 10-Jul-2025

Production of synthetic aviation fuels from CO2 and H2

Inglezakis, Vasileios (Co-investigator) Sefcik, Jan (Principal Investigator) Li, Jun (Co-investigator)

Development and simulation of processes for the production of synthetic aviation fuels from CO2 and H2. Several processes were simulated based on Fischer-Tropsch synthesis and methanol to olefins to jet synthesis.

26-Oct-2021 - 31-Jan-2022

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