Professor Jan Sefcik

Chemical and Process Engineering

Publications

Scalable continuous production of high quality HKUST-1 via conventional and microwave heating
McKinstry Colin, Cussen Edmund J., Fletcher Ashleigh J., Patwardhan Siddharth V., Sefcik Jan
Chemical Engineering Journal Vol 326, pp. 570-577, (2017)
http://dx.doi.org/10.1016/j.cej.2017.05.169
Enabling digitisation of continuous manufacturing processes : the role of image analysis
Cardona Javier, Ferreira Carla Sofia, McGinty John, Hamilton Andrew, Agimelen Okpeafoh, Cleary Alison, Chen Yi-Chieh, Sefcik Jan, Michie Walter, Atkinson Robert, Andonovic Ivan, Tachtatzis Christos
Network Plus: Industrial Systems in the Digital Age Conference 2017, (2017)
Crystallization diagram for antisolvent crystallization of lactose : using design of experiments to investigate continuous mixing- induced supersaturation
Macfhionnghaile Pól, Svoboda Vaclav, McGinty John, Nordon Alison, Sefcik Jan
Crystal Growth and Design Vol 17, pp. 2611-2621, (2017)
http://dx.doi.org/10.1021/acs.cgd.7b00136
Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation : exploring opportunities between reactive and antisolvent crystallization concepts
Svoboda Vaclav, MacFhionnghaile Pól, McGinty John, Connor Lauren E., Oswald Iain D. H., Sefcik Jan
Crystal Growth and Design Vol 17, pp. 1902-1909, (2017)
http://dx.doi.org/10.1021/acs.cgd.6b01866
Kinetics of early stages of resorcinol-formaldehyde polymerization investigated by solution phase nuclear magnetic resonance spectroscopy
Gaca Katarzyna Z., Parkinson John A., Sefcik Jan
Polymer Vol 110, pp. 62-73, (2017)
http://dx.doi.org/10.1016/j.polymer.2016.12.069
Self-assembly of ultra-small micelles from amphiphilic lipopeptoids
Lau King Hang Aaron, Castelletto Valeria, Kendall Thomas, Sefcik Jan, Hamley Ian W., Reza Mehedi, Ruokolainen Janne
Chemical Communications Vol 53, pp. 2178-2181, (2017)
http://dx.doi.org/10.1039/C6CC09888F

more publications

Research interests

Our research deals with materials and processes at colloidal (nanometer to micrometer) length scales. The focus is on synthesis and processing of particulate, colloidal and biomolecular systems.

Particle formation processes/pharmaceutical engineering

Numerous pharmaceutical particulates are formed through antisolvent driven processes, where two solutions are mixed in order to create a thermodynamic driving force for particle formation due to a limited solubility of one or more solutes in the resulting solvent mixture. Such processes are often mixing controlled and can lead to a wide range of intermediate and/or metastable liquid or solid phases. We study kinetics and mechanisms of these processes in order to design and novel continuous processes for manufacturing of nanostructured particles for various pharmaceutical applications. We also study subsequent downstream processes and their effects on resulting particulate products.

Protein Aggregation

Understanding, controlling and utilizing colloidal interactions of proteins is crucial for their downstream processing, including purification, sterilization and storage. Protein interactions with each other determine whether they stay stable in solution or whether they aggregate. Understanding and tuning of protein interactions is thus necessary for improvement of the lifetime stability of therapeutic proteins as well as for rational development of novel separation and sensing procedures for bioprocessing. In fact, there are numerous issues in biotechnology and biomedical engineering, where protein aggregation phenomena have been identified as key factors controlling our success in producing, sensing, handling, and applying biomaterials and therapeutics as desired. We study protein aggregation in solutions under non-equilibrium conditions. The proteins of interest include enzymes and therapeutic proteins in applications such as heat treatment or bioseparations. The modelling work is focused in detailed scattering and spectroscopic characterisation of aggregating protein systems as well as on development and validation of population balance models describing how the mass distribution, structure and activity of protein aggregates evolve in time.

Professional activities

European Summer School on Crystal Nucleation
Invited speaker
20/6/2016
Crystallize COST Action CM1402 Annual Meeting
Keynote/plenary speaker
6/4/2016
5th European Conference on Crystal Growth
Participant
11/9/2015
Invited presentation at GSK, Stevenage, UK
Contributor
3/9/2015
Faraday Discussion 179
Invited speaker
30/3/2015
Invited Seminar, University of Surrey, Guildford, UK
Invited speaker
22/10/2014

more professional activities

Projects

Doctoral Training Centre In Continuous Manufacturing And Crystallisation / RS4912
Florence, Alastair (Principal Investigator) Sefcik, Jan (Co-investigator)
Period 01-Jul-2012 - 01-Jul-2012
GSK 112
Sefcik, Jan (Principal Investigator)
Period 16-Jan-2017 - 31-Jul-2017
Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Mabbott, Fraser Adam
Florence, Alastair (Principal Investigator) Sefcik, Jan (Co-investigator) Mabbott, Fraser Adam (Research Co-investigator)
Period 01-Oct-2012 - 01-May-2017
Polymorph control in PVDF thin films for sensor applications and composites
Johnston, Karen (Principal Investigator) Sefcik, Jan (CoI) Mulheran, Paul (CoI) Gleskova, Helena (CoI) Liggat, John (CoI) McKechnie, David (Researcher)
In this project we will develop a computational model to guide the design of polymer thin films for composite and flexible sensor applications.
Period 01-Oct-2016 - 31-Mar-2017
investigate the continuous crystallisation of organic salts (secondment of John McGinty)
Sefcik, Jan (Principal Investigator)
Period 12-Sep-2016 - 11-Mar-2017
Phase behaviour of a complex multicomponent system
Johnston, Karen (Principal Investigator) Sefcik, Jan (Co-investigator)
Experiments to determine the phase behaviour of coffee-soya milk mixtures for different concentrations and temperatures. Summer project with BP sponsored stipend.
Period 06-Jun-2016 - 05-Aug-2016

more projects

Address

Chemical and Process Engineering
James Weir Building

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