Publications

Computer-aided solvent selection for the design of integrated synthesis, crystallization, and isolation processes

Muhieddine Mohamad H, Jonuzaj Suela, Watson O, Ottoboni Sara, Šefčı́k Ján, Price Chris J, Viswanath Shekhar Krishna, Armstrong Alan, Galindo Amparo, Jackson George, Adjiman Claire S

Organic Process Research and Development (2026)

https://doi.org/10.1021/acs.oprd.6c00168

Crystallisation screening DataFactory : a cyber-physical system for data-driven QbDD

Prostredny Martin, Boyle Christopher, Johnston Jenna, Jolliffe Hikaru Graeme, Robertson Murray, Salekar Sahil Sandeep, Brown Cameron, Sefcik Jan, Robertson John, Cardona Javier, Florence Alastair

23rd International Symposium on Industrial Crystallization (2026)

Spatially and angularly resolved spectroscopy for in situ estimation of particle size and concentration in particle suspensions

Ferreira Carla, Cardona Javier, Agimelen Okpeafoh, Tachtatzis Christos, Andonovic Ivan, Sefcik Jan, Chen Yi-Chieh

Analytical and Bioanalytical Chemistry Vol 418, pp. 7003-7017 (2026)

https://doi.org/10.1007/s00216-026-06696-8

Fluid shear driven secondary nucleation using α-and γ-glycine seeds confirmed with rigorous control experiments

Nahas Lucas, Lee Mei, Haw Mark D, Sefcik Jan

CrystEngComm Vol 28, pp. 3475-3485 (2026)

https://doi.org/10.1039/d6ce00279j

Interface-induced concentration enhancement in glycine solutions investigated using surface plasmon resonance spectroscopy and molecular dynamics simulations

Mackay Ruairidh, Mohammadpour Mozhdeh, Paulose Nadappuram Binoy, Johnston Karen, Sefcik Jan, Lau King Hang Aaron

The Journal of Physical Chemistry Letters Vol 17, pp. 5535–5540 (2026)

https://doi.org/10.1021/acs.jpclett.5c03688

Particle breakage population balance model validation via deep learning analysis of in-situ imaging

Boyle Christopher, Sefcik Jan, Cardona Javier

10th World Congress on Particle Technology (2026)

More publications

Research Interests

Our research expertise is in particle engineering and nanostructured materials, with focus on design of novel particulate products and efficient processes for their manufacturing, across a wide range of applications from nucleation and crystallisation, to protein and peptide self-assembly, to organic gels and nanocomposites.

Our research in pharmaceutical manufacturing aligned with CMAC seeks to enhance access to medicines by increasing quality and reducing costs with the aim improving people’s health and wellbeing.

We develop experimental workflows for product and process development of particulate systems for pharmaceutical applications to obtain better control of critical quality attributes in medicines manufacturing.

We also develop new methods for extracting valuable real time information from process analytical tools such as imaging and scattering/backscattering to enable intelligent decision support for monitoring and control of particulate systems and processes, including fouling detection and accurate quantitative estimates of particle shape and size distributions from in situ measurements.   

Professional Activities

Monitoring pharmaceutical isolation processes through Spatially Offset Raman Spectroscopy: dilution- and displacement-driven filtration-washing

Contributor

25/8/2026

Strategic Themes: EPSRC Multi-Disciplinary IM3AGES Facility Workshop

Participant

26/2/2025

Evaluation of Methods for Particle Characterisation from In-Situ Sensors

Contributor

6/9/2023

Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements

Contributor

17/11/2022

Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements

Contributor

19/9/2022

Evaluation of Deep Learning methods for particle characterisation from in-line imaging and chord length distribution measurements

Contributor

18/9/2022

More professional activities

Projects

EPSRC MediForge Hub: An Integrated, Reconfigurable and Cyberphysical Manufacturing Platform for Resilient and Sustainable Medicines Manufacture (Manufacturing Research Hub)

Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Cardona Amengual, Javier (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Robertson, John (Co-investigator) Sefcik, Jan (Co-investigator)

01-Jan-2024 - 30-Jan-2031

DTP 2224 University of Strathclyde | Park, Alexander

Edkins, Katharina (Principal Investigator) Sefcik, Jan (Co-investigator) Park, Alexander (Research Co-investigator)

01-Jan-2024 - 01-Jan-2028

Industrial Case Account - University of Strathclyde 2023 | Asif, Khadija

Jorge, Miguel (Principal Investigator) Fletcher, Ashleigh (Co-investigator) Sefcik, Jan (Co-investigator) Asif, Khadija (Research Co-investigator)

01-Jan-2023 - 01-Jan-2027

Recovery of light hydrocarbons from highly sour natural gas

Inglezakis, Vasileios (Principal Investigator) Sefcik, Jan (Co-investigator)

Development and simulation of cryogenic processes for the recovery of light hydrocarbons from CO2-rich streams from the demethanization of natural gas. The study included SLV equilibria, process simulation and heat integration.

01-Jan-2023 - 31-Jan-2023

Effects of mechanical impact and turbulent flow on secondary nucleation

Sefcik, Jan (Principal Investigator)

01-Jan-2022 - 30-Jan-2026

Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation

Sefcik, Jan (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Price, Chris John (Co-investigator)

11-Jan-2022 - 10-Jan-2025

More projects