Publications

Quality by digital design to accelerate sustainable medicines development

Mustoe Chantal L, Turner Alice J, Urwin Stephanie J, Houson Ian, Feilden Helen, Markl Daniel, Al Qaraghuli Mohammed M, Chong Magdalene WS, Robertson Murray, Nordon Alison, Johnston Blair F, Brown Cameron J, Robertson John, Adjiman Claire, Batchelor Hannah, Benyahia Brahim, Bresciani Massimo, Burcham Christopher L, Cardona Javier, Cottini Ciro, Dunn Andrew S, Fradet David, Halbert Gavin W, Henson Mark, Hidber Pirmin, Langston Marianne, Lee Ye Seol, Li Wei, Mantanus Jérôme, McGinty John, Mehta Bhavik, Naz Tabbasum, Ottoboni Sara, Prasad Elke, Quist Per-Ola, Reynolds Gavin K, Rielly Chris, Rowland Martin, Schlindwein Walkiria, Schroeder Sven LM, Sefcik Jan, Settanni Ettore, Siddique Humera, Smith Kenneth, Smith Rachel, Srai Jagjit Singh, Thorat Alpana A, Vassileiou Antony, Florence Alastair J

International Journal of Pharmaceutics Vol 681 (2025)

https://doi.org/10.1016/j.ijpharm.2025.125625

Mixing times of miscible liquid systems in agitated vessels

Miller Russell, Barber Isabella Cardona, Lue Leo, Sefcik Jan, Nazemifard Neda

Processes Vol 13 (2025)

https://doi.org/10.3390/pr13041083

Uncovering the vibrational modes of zwitterion glycine in aqueous solution

Christie Mark, Mohammadpour Mozhdeh, Sefcik Jan, Faulds Karen, Johnston Karen

Vibrational Spectroscopy Vol 137 (2025)

https://doi.org/10.1016/j.vibspec.2025.103783

Secondary nucleation of α-glycine induced by fluid shear investigated using a Couette flow cell

Cashmore Andrew, Georgoulas Konstantinos, Boyle Christopher, Lee Mei, Haw Mark D, Sefcik Jan

Crystal Growth and Design Vol 24, pp. 4975-4984 (2024)

https://doi.org/10.1021/acs.cgd.4c00130

Integrated continuous process design for crystallisation, spherical agglomeration, and filtration of lovastatin

Brown Cameron J, McGinty John, Islam Muhammad T, Rajoub Nazer, Arjmandi-Tash Omid, Ottoboni Sara, Shahid Muhid, Urwin Stephanie J, Lee Ye Seol, Chong Magdalene W S, Papathanasiou Foteini, Prakash Aruna S, Prasad Elke, Spence Bronwyn, Sefcik Jan, Robertson John, Smith Rachel, Litster James D, Price Chris J, Nordon Alison, Adjiman Claire S, Florence Alastair J

Journal of Pharmaceutical Innovation Vol 19 (2024)

https://doi.org/10.1007/s12247-024-09815-z

Assessment of GAFF and OPLS force fields for urea : crystal and aqueous solution properties

Anker Samira, McKechnie David, Mulheran Paul, Sefcik Jan, Johnston Karen

Crystal Growth and Design Vol 24, pp. 143–158 (2024)

https://doi.org/10.1021/acs.cgd.3c00785

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Research Interests

Our research expertise is in particle engineering and nanostructured materials, with focus on design of novel particulate products and efficient processes for their manufacturing, across a wide range of applications from nucleation and crystallisation, to protein and peptide self-assembly, to organic gels and nanocomposites.

Our research in pharmaceutical manufacturing aligned with CMAC seeks to enhance access to medicines by increasing quality and reducing costs with the aim improving people’s health and wellbeing.

We develop experimental workflows for product and process development of particulate systems for pharmaceutical applications to obtain better control of critical quality attributes in medicines manufacturing.

We also develop new methods for extracting valuable real time information from process analytical tools such as imaging and scattering/backscattering to enable intelligent decision support for monitoring and control of particulate systems and processes, including fouling detection and accurate quantitative estimates of particle shape and size distributions from in situ measurements.   

Professional Activities

Strategic Themes: EPSRC Multi-Disciplinary IM3AGES Facility Workshop

Participant

26/2/2024

Evaluation of Methods for Particle Characterisation from In-Situ Sensors

Contributor

6/9/2023

Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements

Contributor

17/11/2022

Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements

Contributor

19/9/2022

Evaluation of Deep Learning methods for particle characterisation from in-line imaging and chord length distribution measurements

Contributor

18/9/2022

Multi-sensor Measurements For Quantitative Particle Size And Concentration

Contributor

20/2/2020

More professional activities

Projects

DTP 2224 University of Strathclyde | Park, Alexander

Edkins, Katharina (Principal Investigator) Sefcik, Jan (Co-investigator) Park, Alexander (Research Co-investigator)

01-Jan-2024 - 01-Jan-2028

EPSRC MediForge Hub: An Integrated, Reconfigurable and Cyberphysical Manufacturing Platform for Resilient and Sustainable Medicines Manufacture (Manufacturing Research Hub)

Florence, Alastair (Principal Investigator) Brown, Cameron (Co-investigator) Cardona Amengual, Javier (Co-investigator) Johnston, Blair (Co-investigator) Markl, Daniel (Co-investigator) Nordon, Alison (Co-investigator) Robertson, John (Co-investigator) Sefcik, Jan (Co-investigator)

01-Jan-2024 - 30-Jan-2031

Industrial Case Account - University of Strathclyde 2023 | Asif, Khadija

Jorge, Miguel (Principal Investigator) Fletcher, Ashleigh (Co-investigator) Sefcik, Jan (Co-investigator) Asif, Khadija (Research Co-investigator)

01-Jan-2023 - 01-Jan-2027

Recovery of light hydrocarbons from highly sour natural gas

Inglezakis, Vasileios (Principal Investigator) Sefcik, Jan (Co-investigator)

Development and simulation of cryogenic processes for the recovery of light hydrocarbons from CO2-rich streams from the demethanization of natural gas. The study included SLV equilibria, process simulation and heat integration.

01-Jan-2023 - 31-Jan-2023

Effects of mechanical impact and turbulent flow on secondary nucleation

Sefcik, Jan (Principal Investigator)

01-Jan-2022 - 30-Jan-2026

Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation

Price, Chris John (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Sefcik, Jan (Co-investigator)

11-Jan-2022 - 10-Jan-2025

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