Professor Jan Sefcik

Head Of Department

Chemical and Process Engineering

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Publications

Assessment of GAFF and OPLS force fields for urea : crystal and aqueous solution properties
Anker Samira, McKechnie David, Mulheran Paul, Sefcik Jan, Johnston Karen
Crystal Growth and Design Vol 24, pp. 143–158 (2024)
https://doi.org/10.1021/acs.cgd.3c00785
Nucleation and growth kinetics of sodium chloride crystallization from water and deuterium oxide
Flannigan James M, MacIver Daniel, Jolliffe Hikaru, Haw Mark D, Sefcik Jan
Crystals Vol 13 (2023)
https://doi.org/10.3390/cryst13091388
Crystallisation of sodium sulfate
Muhammad Abdullah, Sefcik Jan, Hamilton Andrea, Johnston Karen
ISIC 2023 (2023)
Digital process design to define and deliver pharmaceutical particle attributes
Urwin Stephanie J, Chong Magdalene WS, Li Wei, McGinty John, Mehta Bhavik, Ottoboni Sara, Pathan Momina, Prasad Elke, Robertson Murray, McGowan Mark, al-Attili Mais, Gramadnikova Ekaterina, Siddique Mariam, Houson Ian, Feilden Helen, Benyahia Brahim, Brown Cameron J, Halbert Gavin W, Johnston Blair, Nordon Alison, Price Chris J, Reilly Chris D, Sefcik Jan, Florence Alastair J
Chemical Engineering Research and Design Vol 196, pp. 726-749 (2023)
https://doi.org/10.1016/j.cherd.2023.07.003
Rapid assessment of crystal nucleation and growth kinetics : comparison of seeded and unseeded experiments
Cashmore Andrew, Miller Russell, Jolliffe Hikaru, Brown Cameron J, Lee Mei, Haw Mark D, Sefcik Jan
Crystal Growth and Design Vol 23, pp. 4779-4790 (2023)
https://doi.org/10.1021/acs.cgd.2c01406
Modelling solution speciation to predict pH and supersaturation for design of batch and continuous organic salt crystallisation processes
McGinty John, Wheatcroft Helen, Price Chris J, Sefcik Jan
Fluid Phase Equilibria Vol 565 (2023)
https://doi.org/10.1016/j.fluid.2022.113676

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Research Interests

Our research expertise is in particle engineering and nanostructured materials, with focus on design of novel particulate products and efficient processes for their manufacturing, across a wide range of applications from nucleation and crystallisation, to protein and peptide self-assembly, to organic gels and nanocomposites.

Our research in pharmaceutical manufacturing aligned with CMAC seeks to enhance access to medicines by increasing quality and reducing costs with the aim improving people’s health and wellbeing.

We develop experimental workflows for product and process development of particulate systems for pharmaceutical applications to obtain better control of critical quality attributes in medicines manufacturing.

We also develop new methods for extracting valuable real time information from process analytical tools such as imaging and scattering/backscattering to enable intelligent decision support for monitoring and control of particulate systems and processes, including fouling detection and accurate quantitative estimates of particle shape and size distributions from in situ measurements.   

Professional Activities

Evaluation of Methods for Particle Characterisation from In-Situ Sensors
Contributor
6/9/2023
Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements
Contributor
17/11/2022
Evaluation of methods for particle characterisation from in-line imaging and chord length distribution measurements
Contributor
19/9/2022
Evaluation of Deep Learning methods for particle characterisation from in-line imaging and chord length distribution measurements
Contributor
18/9/2022
Multi-sensor Measurements For Quantitative Particle Size And Concentration
Contributor
20/2/2020
Integrated Filtration and Washing Modelling to Predict Continuous Isolation Performance.
Contributor
2020

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Projects

Industrial Case Account - University of Strathclyde 2023 | Asif, Khadija
Jorge, Miguel (Principal Investigator) Sefcik, Jan (Co-investigator) Asif, Khadija (Research Co-investigator)
01-Jan-2023 - 01-Jan-2027
Effects of mechanical impact and turbulent flow on secondary nucleation
Sefcik, Jan (Principal Investigator)
01-Jan-2022 - 30-Jan-2026
Sustainable Pharmaceutical Manufacturing: Computer aided solvent design to minimise solvent use across integrated synthesis, purification & isolation
Price, Chris John (Principal Investigator) Kerr, William (Co-investigator) Li, Jun (Co-investigator) Lindsay, David (Co-investigator) Sefcik, Jan (Co-investigator)
11-Jan-2022 - 10-Jan-2025
The birth of crystals: new understanding of nucleation by direct measurement
Haw, Mark (Principal Investigator) Lue, Leo (Co-investigator) Sefcik, Jan (Co-investigator)
01-Jan-2020 - 31-Jan-2023
Doctoral Training Partnership 2020-2021 University of Strathclyde | Anker, Samira
Johnston, Karen (Principal Investigator) Sefcik, Jan (Co-investigator) Anker, Samira (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Catching nucleation in action using surface enhanced Raman spectroscopy
Johnston, Karen (Principal Investigator) Faulds, Karen (Co-investigator) Sefcik, Jan (Co-investigator)
01-Jan-2020 - 30-Jan-2023

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Contact

Professor Jan Sefcik
Head Of Department
Chemical and Process Engineering

Email: jan.sefcik@strath.ac.uk
Tel: 548 2410