Publications

Chemoselective difluoromethylation of nucleosides

Linden Otto, Axer Alexander, Taladriz-Sender Andrea, Burley Glenn A

Organic Letters Vol 27, pp. 6906-6910 (2025)

https://doi.org/10.1021/acs.orglett.5c02204

Preparation of nucleoside analogues : opportunities for innovation at the interface of synthetic chemistry and biocatalysis

Salihovic Admir, Taladriz-Sender Andrea, Burley Glenn A

Chemical Science Vol 16, pp. 11700-11710 (2025)

https://doi.org/10.1039/D5SC03026A

Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2

Salihovic Admir, Ascham Alex, Rosenqvist Petja S, Taladriz-Sender Andrea, Hoskisson Paul A, Hodgson David R W, Grogan Gideon, Burley Glenn A

Chemical Science Vol 16, pp. 1302-1307 (2024)

https://doi.org/10.1039/D4SC07521H

Reactivity profiling for high yielding Ynamine-tagged oligonucleotide click chemistry bioconjugations

Peschke Frederik, Taladriz-Sender Andrea, Watson Allan JB, Burley Glenn A

Bioconjugate Chemistry Vol 35, pp. 1788-1796 (2024)

https://doi.org/10.1021/acs.bioconjchem.4c00353

Gram-scale enzymatic synthesis of 2′-deoxyribonucleoside analogues using nucleoside transglycosylase-2

Salihovic Admir, Ascham Alex, Taladriz-Sender Andrea, Bryson Samantha, Withers Jamie M, Mckean Iain J W, Hoskisson Paul A, Grogan Gideon, Burley Glenn A

Chemical Science Vol 15, pp. 15399-15407 (2024)

https://doi.org/10.1039/D4SC04938A

Mechanistic basis of the Cu(OAc)2 catalyzed azide-ynamine (3+2)cycloaddition reaction

Bunschoten Roderick P, Peschke Frederik, Taladriz-Sender Andrea, Alexander Emma, Andrews Matthew J, Kennedy Alan R, Fazakerley Neal J, Lloyd Jones Guy C, Watson Allan J B, Burley Glenn A

Journal of the American Chemical Society Vol 146, pp. 13558-13570 (2024)

https://doi.org/10.1021/jacs.4c03348

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Professional Activities

Facility Showcase Event

Participant

20/5/2025

In Cell NMR – Developing Cellular Characterization Tools for Oligonucleotide Therapeutics

Speaker

17/5/2023

Establishing a chemical biological toolbox to understand the mechanisms of splice-switching small molecules

Speaker

29/1/2022

Chemical Biological Strategies to Modulate Gene Expression

Speaker

15/9/2021

Development of Splice-Switching Molecules as Inducers of Apoptosis

Speaker

24/6/2019

Nucleic acid assembly mediated by the fluorous effect

Speaker

6/7/2018

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Projects

GLAS-CYTO: AN INTEGRATED FACILITY FOR THE BIOPHYSICAL ANALYSIS OF CELLULAR INTERACTIONS

Burley, Glenn (Principal Investigator) Chamberlain, Luke (Co-investigator) Chow, Shiao (Co-investigator) Corrigan, Damion (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Faulds, Karen (Co-investigator) Jamieson, Craig (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator) Taladriz Sender, Andrea (Research Co-investigator)

01-Jan-2024 - 31-Jan-2025

NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments

Parkinson, John (Principal Investigator) Burley, Glenn (Co-investigator) Dufès, Christine (Co-investigator) Irving, Craig (Co-investigator) Jamieson, Craig (Co-investigator) Scott, Fraser (Co-investigator) Seib, Philipp (Co-investigator) Taladriz Sender, Andrea (Co-investigator)

01-Jan-2023 - 31-Jan-2024

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