Professor Nicholas Tomkinson

Pure and Applied Chemistry

Personal statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

Publications

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Publications

The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins: Salaun Christine, Tomkinson Nicholas CO, Chamberlain Luke H; Journal of Biological Chemistry Vol 299 (2023); https://doi.org/10.1016/j.jbc.2023.105201
Expanding the range of bioorthogonal tags for multiplex stimulated Raman scattering microscopy: Murphy Neville, Tipping William J, Braddick Henry J, Wilson Liam T, Tomkinson Nicholas CO, Faulds Karen, Graham Duncan, Farràs Pau; Angewandte Chemie International Edition (2023); https://doi.org/10.1002/anie.202311530
Automated LC-MS analysis and data extraction for high-throughput chemistry: Mason Joseph, Wilders Harry, Fallon David J, Thomas Ross P, Bush Jacob T, Tomkinson Nicholas C O, Rianjongdee Francesco; Digital Discovery (2023); https://doi.org/10.1039/d3dd00167a
Covalent targeting of non-cysteine residues in PI4KIIIβ: Cosgrove Brett, Grant Emma K, Bertrand Sophie, Down Kenneth D, Somers Don O, P. Evans John, Tomkinson Nicholas C O, Barker Michael D; RSC Chemical Biology (2023); https://doi.org/10.1039/d3cb00142c
Efficient ligand discovery using sulfur(VI) fluoride reactive fragments: Aatkar Arron, Vuorinen Aini, Longfield Oliver E, Gilbert Katharine, Peltier-Heap Rachel, Wagner Craig D, Zappacosta Francesca, Rittinger  Katrin, Chung Chun-wa, House David, Tomkinson Nicholas C O, Bush Jacob T; ACS Chemical Biology Vol 18, pp. 1926-1937 (2023); https://doi.org/10.1021/acschembio.3c00034
Photoaffinity labelling displacement assay using multiple recombinant protein domains: Fallon David J, Phillipou Alex, Schofield Christopher J, House David, Tomkinson Nicholas C O, Bush Jacob T; Biochemical Journal Vol 480, pp. 1183-1197 (2023); https://doi.org/10.1042/bcj20230129

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Research

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Research Interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

Reactions should proceed at room temperature
Reactions should proceed in the presence of moisture and air
Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.