
Professor Nicholas Tomkinson
Pure and Applied Chemistry
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Publications
- The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
- Salaun Christine, Tomkinson Nicholas CO, Chamberlain Luke H
- Journal of Biological Chemistry Vol 299 (2023)
- https://doi.org/10.1016/j.jbc.2023.105201
- Expanding the range of bioorthogonal tags for multiplex stimulated Raman scattering microscopy
- Murphy Neville, Tipping William J, Braddick Henry J, Wilson Liam T, Tomkinson Nicholas CO, Faulds Karen, Graham Duncan, Farràs Pau
- Angewandte Chemie International Edition (2023)
- https://doi.org/10.1002/anie.202311530
- Automated LC-MS analysis and data extraction for high-throughput chemistry
- Mason Joseph, Wilders Harry, Fallon David J, Thomas Ross P, Bush Jacob T, Tomkinson Nicholas C O, Rianjongdee Francesco
- Digital Discovery (2023)
- https://doi.org/10.1039/d3dd00167a
- Covalent targeting of non-cysteine residues in PI4KIIIβ
- Cosgrove Brett, Grant Emma K, Bertrand Sophie, Down Kenneth D, Somers Don O, P. Evans John, Tomkinson Nicholas C O, Barker Michael D
- RSC Chemical Biology (2023)
- https://doi.org/10.1039/d3cb00142c
- Efficient ligand discovery using sulfur(VI) fluoride reactive fragments
- Aatkar Arron, Vuorinen Aini, Longfield Oliver E, Gilbert Katharine, Peltier-Heap Rachel, Wagner Craig D, Zappacosta Francesca, Rittinger Katrin, Chung Chun-wa, House David, Tomkinson Nicholas C O, Bush Jacob T
- ACS Chemical Biology Vol 18, pp. 1926-1937 (2023)
- https://doi.org/10.1021/acschembio.3c00034
- Photoaffinity labelling displacement assay using multiple recombinant protein domains
- Fallon David J, Phillipou Alex, Schofield Christopher J, House David, Tomkinson Nicholas C O, Bush Jacob T
- Biochemical Journal Vol 480, pp. 1183-1197 (2023)
- https://doi.org/10.1042/bcj20230129
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Research Interests
As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:
- Reactions should proceed at room temperature
- Reactions should proceed in the presence of moisture and air
- Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer
Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.
Professional Activities
- PhD viva - Faye Cruickshank
- External Examiner
- 11/5/2016
- Hiroya Takizawa
- Host
- 22/2/2016
- Carbonyl and Enolate Chemistry
- Participant
- 14/1/2016
- Ono Pharmaceutical Co Ltd (Japan)
- Visiting researcher
- 11/11/2015
- Ono Pharmaceutical Co Ltd (Japan)
- Visiting researcher
- 4/6/2015
- UCB Celltech Ltd (External organisation)
- Member
- 24/3/2015
Projects
- Industrial CASE Account - University of Strathclyde 2022 | Otyakmaz, Ayse Birsen
- Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Otyakmaz, Ayse Birsen (Research Co-investigator)
- 01-Jan-2023 - 01-Jan-2027
- Industrial Case Account - University of Strathclyde 2023 | Anderson, Jack
- Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Anderson, Jack (Research Co-investigator)
- 01-Jan-2023 - 01-Jan-2027
- Industrial CASE Account - University of Strathclyde 2022 | Barr, Fraser
- Tomkinson, Nick (Principal Investigator) Burley, Glenn (Co-investigator) Barr, Fraser (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
- Delivering the impossible – novel fatty acid delivery reagents to enable in vivo research and discovery
- Tomkinson, Nick (Principal Investigator)
- 03-Jan-2022 - 02-Jan-2025
- Industrial CASE Account - University of Strathclyde 2021 | Powell, Daniel
- Tomkinson, Nick (Principal Investigator) Jamieson, Craig (Co-investigator) Powell, Daniel (Research Co-investigator)
- 01-Jan-2022 - 01-Jan-2026
- Targeting The ZDHHC9-Gcp16 Interaction As A Novel Therapeutic Strategy In Cancer And Neurological Disorders
- Chamberlain, Luke (Principal Investigator) Tomkinson, Nick (Co-investigator)
- 01-Jan-2021 - 30-Jan-2025
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Contact
Professor
Nicholas
Tomkinson
Pure and Applied Chemistry
Email: nicholas.tomkinson@strath.ac.uk
Tel: 548 2276