Professor Nicholas Tomkinson

Pure and Applied Chemistry


Personal statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

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The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
Salaun Christine, Tomkinson Nicholas CO, Chamberlain Luke H
Journal of Biological Chemistry Vol 299 (2023)
Expanding the range of bioorthogonal tags for multiplex stimulated Raman scattering microscopy
Murphy Neville, Tipping William J, Braddick Henry J, Wilson Liam T, Tomkinson Nicholas CO, Faulds Karen, Graham Duncan, Farràs Pau
Angewandte Chemie International Edition (2023)
Automated LC-MS analysis and data extraction for high-throughput chemistry
Mason Joseph, Wilders Harry, Fallon David J, Thomas Ross P, Bush Jacob T, Tomkinson Nicholas C O, Rianjongdee Francesco
Digital Discovery (2023)
Covalent targeting of non-cysteine residues in PI4KIIIβ
Cosgrove Brett, Grant Emma K, Bertrand Sophie, Down Kenneth D, Somers Don O, P. Evans John, Tomkinson Nicholas C O, Barker Michael D
RSC Chemical Biology (2023)
Efficient ligand discovery using sulfur(VI) fluoride reactive fragments
Aatkar Arron, Vuorinen Aini, Longfield Oliver E, Gilbert Katharine, Peltier-Heap Rachel, Wagner Craig D, Zappacosta Francesca, Rittinger  Katrin, Chung Chun-wa, House David, Tomkinson Nicholas C O, Bush Jacob T
ACS Chemical Biology Vol 18, pp. 1926-1937 (2023)
Photoaffinity labelling displacement assay using multiple recombinant protein domains
Fallon David J, Phillipou Alex, Schofield Christopher J, House David, Tomkinson Nicholas C O, Bush Jacob T
Biochemical Journal Vol 480, pp. 1183-1197 (2023)

More publications

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Research Interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

  • Reactions should proceed at room temperature
  • Reactions should proceed in the presence of moisture and air
  • Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.

Professional Activities

PhD viva - Faye Cruickshank
External Examiner
Hiroya Takizawa
Carbonyl and Enolate Chemistry
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
UCB Celltech Ltd (External organisation)

More professional activities


Industrial CASE Account - University of Strathclyde 2022 | Otyakmaz, Ayse Birsen
Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Otyakmaz, Ayse Birsen (Research Co-investigator)
01-Jan-2023 - 01-Jan-2027
Industrial Case Account - University of Strathclyde 2023 | Anderson, Jack
Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Anderson, Jack (Research Co-investigator)
01-Jan-2023 - 01-Jan-2027
Industrial CASE Account - University of Strathclyde 2022 | Barr, Fraser
Tomkinson, Nick (Principal Investigator) Burley, Glenn (Co-investigator) Barr, Fraser (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Delivering the impossible – novel fatty acid delivery reagents to enable in vivo research and discovery
Tomkinson, Nick (Principal Investigator)
03-Jan-2022 - 02-Jan-2025
Industrial CASE Account - University of Strathclyde 2021 | Powell, Daniel
Tomkinson, Nick (Principal Investigator) Jamieson, Craig (Co-investigator) Powell, Daniel (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Targeting The ZDHHC9-Gcp16 Interaction As A Novel Therapeutic Strategy In Cancer And Neurological Disorders
Chamberlain, Luke (Principal Investigator) Tomkinson, Nick (Co-investigator)
01-Jan-2021 - 30-Jan-2025

More projects

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Professor Nicholas Tomkinson
Pure and Applied Chemistry

Tel: 548 2276