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Prof Nick Tomkinson

Pure and Applied Chemistry

Personal statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

Publications

A regioselective three component reaction of pyridine N-oxides, acyl chlorides and cyclic ethers
Jones D. Heulyn, Kay Steven T., McLellan Jayde A., Kennedy Alan R., Tomkinson Nicholas C. O.
Organic Letters, (2017)
http://dx.doi.org/10.1021/acs.orglett.7b01481
Small molecules and their roles in effective pre-clinical target validation
Clegg Michael, Tomkinson Nicholas C. O., Prinjah Rab K., Humphreys Philip G.
Future Medicinal Chemistry, (2017)
Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry
Greaves Jennifer, Munro Kevin R., Davidson Stuart C., Riviere Matthieu, Wojno Justyna, Smith Terry K., Tomkinson Nicholas C.O., Chamberlain Luke H.
Proceedings of the National Academy of Sciences Vol 114, (2017)
A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis
Diez Ardanuy Cinta, Greaves Jennifer, Munro Kevin R., Tomkinson Nicholas C.O., Chamberlain Luke H.
Scientific Reports, (2017)
http://dx.doi.org/10.1038/s41598-017-00036-8
Preparation of symmetrical and non-symmetrical fluorene sulfonamide scaffolds
Jones D. Heulyn, Tellam James P., Bresciani Stefano, Wojno-Picon Justyna, Cooper Anthony W. J., Tomkinson Nicholas C. O.
Synlett Vol 28, pp. 577-582, (2016)
http://dx.doi.org/10.1055/s-0036-1588916
Clinical progress and pharmacology of small molecule bromodomain inhibitors
Theodoulou Natalie H, Tomkinson Nicholas CO, Prinjha Rab K , Humphreys Philip G
Current Opinion in Chemical Biology Vol 33, pp. 58-66, (2016)
http://dx.doi.org/10.1016/j.cbpa.2016.05.028

more publications

Research interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

  • Reactions should proceed at room temperature
  • Reactions should proceed in the presence of moisture and air
  • Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.

Professional activities

PhD viva - Faye Cruickshank
External Examiner
11/5/2016
Carbonyl and Enolate Chemistry
Contributor
14/1/2016
DHHC Palmitoylation
Participant
11/11/2015
DHHC Palmitoylation
Participant
4/6/2015
UCB Celltech Ltd (External organisation)
Member
24/3/2015
Chemistry and Pharmaceutical Science Review
External Examiner
3/3/2015

more professional activities

Projects

Industrial Case Account 2016 | Maciuk, Sergej
Tomkinson, Nicholas (Principal Investigator) Jamieson, Craig (Co-investigator) Maciuk, Sergej (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Industrial Case Account 2016 | Cooper, Alasdair Ker
Nelson, David (Principal Investigator) Tomkinson, Nicholas (Co-investigator) Cooper, Alasdair Ker (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Industrial Case Account 2015 | Curle, Jonathan
Tomkinson, Nicholas (Principal Investigator) Nelson, David (Co-investigator) Curle, Jonathan (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Industrial Case Account 2014 | Chung, Raymond
Kerr, William (Principal Investigator) Tomkinson, Nicholas (Co-investigator) Chung, Raymond (Research Co-investigator)
Period 01-Oct-2016 - 01-Apr-2020
Doctoral Training Partnership (DTP - University of Strathclyde) | McLellan, Jayde
Tomkinson, Nicholas (Principal Investigator) Chamberlain, Luke (Co-investigator) McLellan, Jayde (Research Co-investigator)
Period 01-Oct-2015 - 01-Apr-2019
Industrial Case Account 2013 | Owens, Philippa Kate
Kerr, William (Principal Investigator) Tomkinson, Nicholas (Co-investigator) Owens, Philippa Kate (Research Co-investigator)
Period 01-Nov-2013 - 01-May-2017

more projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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