Professor Nicholas Tomkinson

Pure and Applied Chemistry

Personal statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

Publications

A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy
Wilson Liam T, Tipping William J, Jamieson Lauren E, Wetherill Corinna, Henley Zoë, Faulds Karen, Graham Duncan, MacKay Simon P, Tomkinson Nick C O
Analyst Vol 145, pp. 5289-5298 (2020)
https://doi.org/10.1039/D0AN00865F
Application of atypical acetyl-lysine methyl mimetics in the development of selective inhibitors of the bromodomain-containing protein 7 (BRD7)/bromodomain-containing protein 9 (BRD9) bromodomains
Clegg Michael A, Bamborough Paul, Chung Chun-wa, Craggs Peter D, Gordon Laurue, Grandi Paola, Leveridge Melanie, Lindon Matthew, Liwicki Gemma M, Michon Anne-Marie, Molnar Judit, Rioja Inmaculada, Soden Peter E, Theodoulou Natalie H, Werner Thilo, Tomkinson Nicholas C O, Prinjha Rab K, Humphreys Philip G
Journal of Medicinal Chemistry Vol 63, pp. 5816-5840 (2020)
https://doi.org/10.1021/acs.jmedchem.0c00075
The optimization of potent ATAD2 and CECR2 bromodomain inhibitors with an atypical binding mode
Lucas Simon C C, Atkinson Stephen J, Bamborough Paul, Barnett Heather, Chung Chun-wa, Gordon Laurie, Mitchell Darren J, Phillipou Alexander, Prinjah Rab K, Sheppard Robert J, Tomkinson Nicholas C O, Watson Robert J, Demont Emmanuel H
Journal of Medicinal Chemistry Vol 63, pp. 5212-5241 (2020)
https://doi.org/10.1021/acs.jmedchem.0c00021
The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation
Salaun Christine, Greaves Jennifer, Tomkinson Nicholas C O, Chamberlain Luke H
Journal of Biological Chemistry Vol 295, pp. 7501-7515 (2020)
https://doi.org/10.1074/jbc.RA120.012726
A scalable, metal-, azide- and halogen-free method for the preparation of triazoles
Clark Peter R, Williams Glynn D, Hayes Jerome F, Tomkinson Nicholas C O
Angewandte Chemie International Edition Vol 59, pp. 6740-6744 (2020)
https://doi.org/10.1002/anie.201915944
PhotoAffinity bits : a photoaffinity-based fragment screening platform for efficient identification of protein ligands
Grant Emma K, Fallon David J, Hann Michael M, Fantom Ken G M, Quinn Chad, Zappacosta Francesca, Annan Roland S, Cheung Chun-Wa, Bamborough Paul, Dixon David P, Stacey Peter, House David, Patel Vipulkumar K, Tomkinson Nick C O, Bush Jacob T
(2020)
https://doi.org/10.26434/chemrxiv.12053445.v1

more publications

Research interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

  • Reactions should proceed at room temperature
  • Reactions should proceed in the presence of moisture and air
  • Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.

Professional activities

PhD viva - Faye Cruickshank
External Examiner
11/5/2016
Carbonyl and Enolate Chemistry
Participant
14/1/2016
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
11/11/2015
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
4/6/2015
UCB Celltech Ltd (External organisation)
Member
24/3/2015
Chemistry and Pharmaceutical Science Review
External Examiner
3/3/2015

more professional activities

Projects

Industrial Case Account - University of Strathclyde 2019 | McKeown, Aidan
Kerr, William (Principal Investigator) Tomkinson, Nick (Co-investigator) McKeown, Aidan (Research Co-investigator)
01-Jan-2020 - 01-Jan-2024
Industrial Case Account - University of Strathclyde 2019 | Abate, Immacolata
Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Abate, Immacolata (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
Industrial Case Account - University of Strathclyde 2019 | Galindo, Alex
Tomkinson, Nick (Principal Investigator) Chamberlain, Luke (Co-investigator) Galindo, Alex (Research Co-investigator)
01-Jan-2019 - 01-Jan-2023
Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Kerr, William (Principal Investigator) Brown, Cameron (Co-investigator) Florence, Alastair (Co-investigator) Jamieson, Craig (Co-investigator) Johnston, Blair (Co-investigator) Murphy, John (Co-investigator) Palmer, David (Co-investigator) Tomkinson, Nick (Co-investigator)
01-Jan-2019 - 31-Jan-2023
Industrial CASE Account - University of Strathclyde 2018 | Duffy, Jennifer
Jamieson, Craig (Principal Investigator) Tomkinson, Nick (Co-investigator) Duffy, Jennifer (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Industrial Case Account 2016 | Livingstone, Keith
Jamieson, Craig (Principal Investigator) Tomkinson, Nick (Co-investigator) Livingstone, Keith (Research Co-investigator)
01-Jan-2016 - 26-Jan-2020

more projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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