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Professor Nicholas Tomkinson

Pure and Applied Chemistry

Personal statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

Publications

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions
Fort Loic, Batista José Miguel, Thomason Peter A., Spence Heather J., Whitelaw Jamie A., Tweedy Luke, Greaves Jennifer, Martin Kirsty J., Anderson Kurt I., Brown Peter, Lilla Sergio, Neilson Matthew P., Tafelmeyer Petra, Zanivan Sara, Ismail Shehab, Bryant David M., Tomkinson Nicholas C. O., Chamberlain Luke H., Mastick Grant S., Insall Robert H., Machesky Laura M.
Nature Cell Biology Vol 20, pp. 1159-1171, (2018)
http://dx.doi.org/10.1038/s41556-018-0198-9
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation
Pariollaud Marie, Gibbs Julie E., Hopwood Thomas W., Brown Sheila, Begley Nicola, Vonslow Ryan, Poolman Toryn, Guo Baoqiang, Saer Ben, Jones D. Heulyn, Tellam James P., Bresciani Stefano, Tomkinson Nicholas C.O., Wojno-Picon Justyna, Cooper Anthony W.J., Daniels Dion A., Trump Ryan P., Grant Daniel, Zuercher William, Willson Timothy M., MacDonald Andrew S., Bolognese Brian, Podolin Patricia L., Sanchez Yolanda, Loudon Andrew S.I., Ray David W.
Journal of Clinical Investigation Vol 128, pp. 2281-2296, (2018)
http://dx.doi.org/10.1172/JCI93910
Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy
Jamieson Lauren E., Greaves Jennifer, McLellan Jayde A., Munro Kevin R., Tomkinson Nicholas C.O., Chamberlain Luke H., Faulds Karen, Graham Duncan
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy Vol 197, pp. 30-36, (2018)
http://dx.doi.org/10.1016/j.saa.2018.01.064
Regioselective reaction of heterocyclic N-oxides, an acyl chloride and cyclic thioethers
Frei Przemysslaw, Jones D. Heulyn, Kay Steven T., McLellan Jayde A., Johnston Blair F., Kennedy Alan R., Tomkinson Nicholas C. O.
Journal of Organic Chemistry, (2018)
http://dx.doi.org/10.1021/acs.joc.7b02457
A regioselective three component reaction of pyridine N-oxides, acyl chlorides and cyclic ethers
Jones D. Heulyn, Kay Steven T., McLellan Jayde A., Kennedy Alan R., Tomkinson Nicholas C. O.
Organic Letters, (2017)
http://dx.doi.org/10.1021/acs.orglett.7b01481
Small molecules and their roles in effective pre-clinical target validation
Clegg Michael, Tomkinson Nicholas C. O., Prinjah Rab K., Humphreys Philip G.
Future Medicinal Chemistry, (2017)

more publications

Research interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

  • Reactions should proceed at room temperature
  • Reactions should proceed in the presence of moisture and air
  • Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.

Professional activities

PhD viva - Faye Cruickshank
External Examiner
11/5/2016
Carbonyl and Enolate Chemistry
Participant
14/1/2016
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
11/11/2015
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
4/6/2015
UCB Celltech Ltd (External organisation)
Member
24/3/2015
Chemistry and Pharmaceutical Science Review
External Examiner
3/3/2015

more professional activities

Projects

Industrial Case Account 2016 | Maciuk, Sergej
Tomkinson, Nicholas (Principal Investigator) Jamieson, Craig (Co-investigator) Maciuk, Sergej (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Industrial Case Account 2016 | Cooper, Alasdair
Nelson, David (Principal Investigator) Tomkinson, Nicholas (Co-investigator) Cooper, Alasdair (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Industrial Case Account 2015 | Curle, Jonathan
Tomkinson, Nicholas (Principal Investigator) Nelson, David (Co-investigator) Curle, Jonathan (Research Co-investigator)
Period 01-Oct-2016 - 01-Oct-2020
Industrial Case Account 2014 | Chung, Raymond
Kerr, William (Principal Investigator) Tomkinson, Nicholas (Co-investigator) Chung, Raymond (Research Co-investigator)
Period 01-Oct-2016 - 01-Apr-2020
Doctoral Training Partnership (DTP - University of Strathclyde) | McLellan, Jayde
Tomkinson, Nicholas (Principal Investigator) Chamberlain, Luke (Co-investigator) McLellan, Jayde (Research Co-investigator)
Period 01-Oct-2015 - 01-Apr-2019
Industrial Case Account 2013 | Owens, Philippa Kate
Kerr, William (Principal Investigator) Tomkinson, Nicholas (Co-investigator) Owens, Philippa Kate (Research Co-investigator)
Period 01-Nov-2013 - 26-Jan-2018

more projects

Address

Pure and Applied Chemistry
Thomas Graham Building

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