Professor Nicholas Tomkinson

Pure and Applied Chemistry

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Personal statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

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Publications

Label-free screening of drug-induced liver injury using stimulated Raman scattering microscopy and spectral phasor analysis
Tipping William J, Wilson Liam T, Tomkinson Nicholas C O, Faulds Karen, Graham Duncan
Analytical Chemistry (2024)
https://doi.org/10.1021/acs.analchem.4c01285
bbSelect : an open-source tool for performing a 3D pharmacophore-driven diverse selection of R-groups
Rianjongdee Francesco, Palmer David, Pickett Stephen D, Pogány Peter, Tomkinson Nicholas CO, Green Darren VS
Journal of Chemical Information and Modeling (2024)
https://doi.org/10.1021/acs.jcim.4c00453
A mechanistic investigation of the N-hydroxyphthalimide catalyzed benzylic oxidation mediated by sodium chlorite
Grunshaw Thomas, Wood Susanna H, Sproules Stephen, Parrott Andrew, Nordon Alison, Shapland Peter D P, Wheelhouse Katherine M P, Tomkinson Nicholas C O
Journal of Organic Chemistry Vol 89, pp. 7933-7945 (2024)
https://doi.org/10.1021/acs.joc.4c00583
Expanding the range of bioorthogonal tags for multiplex stimulated Raman scattering microscopy
Murphy Neville, Tipping William J, Braddick Henry J, Wilson Liam T, Tomkinson Nicholas CO, Faulds Karen, Graham Duncan, Farràs Pau
Angewandte Chemie International Edition Vol 62 (2023)
https://doi.org/10.1002/anie.202311530
The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
Salaun Christine, Tomkinson Nicholas CO, Chamberlain Luke H
Journal of Biological Chemistry Vol 299 (2023)
https://doi.org/10.1016/j.jbc.2023.105201
Automated LC-MS analysis and data extraction for high-throughput chemistry
Mason Joseph, Wilders Harry, Fallon David J, Thomas Ross P, Bush Jacob T, Tomkinson Nicholas C O, Rianjongdee Francesco
Digital Discovery Vol 2, pp. 1894-1899 (2023)
https://doi.org/10.1039/d3dd00167a

More publications

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Research Interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

  • Reactions should proceed at room temperature
  • Reactions should proceed in the presence of moisture and air
  • Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.

Professional Activities

PhD viva - Faye Cruickshank
External Examiner
11/5/2016
Hiroya Takizawa
Host
22/2/2016
Carbonyl and Enolate Chemistry
Participant
14/1/2016
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
11/11/2015
Ono Pharmaceutical Co Ltd (Japan)
Visiting researcher
4/6/2015
UCB Celltech Ltd (External organisation)
Member
24/3/2015

More professional activities

Projects

A Prosperity Partnership for the Design of Next-Generation Antibody Drug Bioconjugates (Next-Gen ADC)
Burley, Glenn (Principal Investigator) Jamieson, Craig (Co-investigator) Kerr, William (Co-investigator) Nordon, Alison (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator)
15-Jan-2023 - 14-Jan-2028
Industrial Case Account - University of Strathclyde 2023 | Anderson, Jack
Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Anderson, Jack (Research Co-investigator)
01-Jan-2023 - 01-Jan-2027
Industrial CASE Account - University of Strathclyde 2022 | Otyakmaz, Ayse Birsen
Burley, Glenn (Principal Investigator) Tomkinson, Nick (Co-investigator) Otyakmaz, Ayse Birsen (Research Co-investigator)
01-Jan-2023 - 01-Jan-2027
Industrial CASE Account - University of Strathclyde 2022 | Barr, Fraser
Tomkinson, Nick (Principal Investigator) Burley, Glenn (Co-investigator) Barr, Fraser (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Delivering the impossible – novel fatty acid delivery reagents to enable in vivo research and discovery
Tomkinson, Nick (Principal Investigator)
03-Jan-2022 - 02-Jan-2025
Industrial CASE Account - University of Strathclyde 2021 | Powell, Daniel
Tomkinson, Nick (Principal Investigator) Jamieson, Craig (Co-investigator) Powell, Daniel (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026

More projects

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Contact

Professor Nicholas Tomkinson
Pure and Applied Chemistry

Email: nicholas.tomkinson@strath.ac.uk
Tel: 548 2276