Dr Michele Zagnoni

Senior Lecturer

Electronic and Electrical Engineering

Personal statement

Michele Zagnoni's research is based on the development of new microsystems for basic biology investigation, diagnosis and treatment of disease using microfluidic and lab-on-a-chip technologies. More information on: www.zagnonilab.com

Expertise

Has expertise in:

    Microfabrication of polymeric structures

    Theoretical and experimental expertise in fluid dynamics at the microscale

    On chip cell culture

    Organ on a chip

    Bioimaging

    Miniaturised bioassay

Prizes and awards

Member of Departmental Safety Committee
Recipient
5/2011

more prizes and awards

Qualifications

08/2013             Member of the EPSRC Peer Review College

06/2013             Affiliate Membership to the Royal Society of Chemistry

10/2012:            SCQF Certificate for Biosafety Practitioner Level 1

10/2012:            PostGraduate Certificate in Advanced Academic Studies

04/2006:            Ph.D. degree in Electronic Engineering and Computer Science

11/2002:            Italian state certification for the practice of engineering as a profession (Chartered Engineer)

10/2002:                Dr. Eng. degree (5 year degree) in Electronic Engineering (Bioengineering qualification)

Publications

Surface enhanced Raman scattering (SERS) based microfluidics for single cell analysis
Willner Marjorie R, McMillan Kay, Graham Duncan, Vikesland Peter J, Zagnoni Michele
Analytical Chemistry (2018)
https://doi.org/10.1021/acs.analchem.8b02636
Drug screening of biopsy-derived multicellular spheroids using microfluidic technology
Mulholland Theresa E, McAllister Milly, Patek Samantha, Flint David, Underwood Mark, Sim Alexander, Edwards Joanne, Zagnoni Michele
Cancer Research Vol 78 (2018)
https://doi.org/10.1158/1538-7445.AM2018-5024
Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons
Ritchie Louise, Tate Rothwelle, Chamberlain Luke H, Robertson Graham, Zagnoni Michele, Sposito Teresa, Wray Selina, Wright John A, Bryant Clare E, Gay Nicholas J, Bushell Trevor J
Neuropharmacology Vol 135, pp. 1-10 (2018)
https://doi.org/10.1016/j.neuropharm.2018.02.025
Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient
Mulholland Theresa, McAllister Milly, Patek Samantha, Flint David, Underwood Mark, Sim Alexander, Edwards Joanne, Zagnoni Michele
Scientific Reports Vol 8 (2018)
https://doi.org/10.1038/s41598-018-33055-0
Investigating mechanisms of protein transport and assembly at the node of Ranvier
Grunewald E, Malavasi E, Ghosh A, Zagnoni M, Sherman D, Brophy P
Glia Vol 65 (2017)
https://doi.org/10.1002/glia.23157
Optofluidic Surface Enhanced Raman Spectroscopy (SERS) interrogation for targeted detection of individual cells
Willner Marjorie, Graham Duncan, Zagnoni Michele, Vikesland Peter
253rd American Chemical Society National Meeting & Exposition (2017)

more publications

Teaching

Teaching Staff for the course EE312 - Instrumentation and Microcontrollers (3rd year) at the University of Strathclyde.

Support Staff for the course EE105 - Electronic Techniques and Design (1st year) at the University of Strathclyde.

Teaching Staff for Small Group Tutorials (SGT) at the University of Strathclyde.

Research interests

We use microfluidics for the development of screening and diagnostic systems for healthcare applications, including fundamental biological research, drug screening and personalized medicine therapy, for the creation of organ-on-a-chip in vitro models and for synthetic biology applications.

Professional activities

Microfluidic screening for 3D oncology
Speaker
21/2/2019
EACR (External organisation)
Advisor
2018
Cell Model System Summer School
Participant
7/6/2018
Chiara Da San Martino
Host
5/2018
PhD External Examiner
Examiner
4/2018
A microfluidic solution to precision oncology
Speaker
5/12/2018

more professional activities

Projects

A microfluidic approach to investigating vascular cell fate at the single-cell level
Zagnoni, Michele (Principal Investigator) Sandison, Mairi (Co-investigator)
01-Jan-2018 - 30-Jan-2022
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Megarity, Daniel
Zagnoni, Michele (Principal Investigator) Bushell, Trevor (Co-investigator) Megarity, Daniel (Research Co-investigator)
01-Jan-2017 - 01-Jan-2021
How are repairing brain cells successfully recruited to multiple sclerosis lesions?
Zagnoni, Michele (Principal Investigator)
01-Jan-2017 - 29-Jan-2020
Droplet-based Microfluidic Platform for Intracellular Ion Channel Drug Discovery
Zagnoni, Michele (Principal Investigator)
Ion channels are proteins that are involved in the regulation of almost every cellular mechanism and they constitute the second largest class of pharmacological drug targets. A family of these channels are located in the inner compartments of a cell (i.e. they are intracellular) and they are typically excluded from industrial large-throughput automated screening (e.g. automated patch clamp technology) that probe ion channels only in the outer cell membrane. As such, implications arise that affect the hit discovery rate of new drugs for such proteins. This proposal aims to produce and test a new microsystem technology for drug screening of human intracellular ion channels. The system will comprise a medium-throughput microfluidic prototype relying entirely on synthetic cell membranes harbouring intracellular ion channels. Whilst developing this new technology, this study will investigate two proteins that are involved in cancer and neurodegeneration, namely CLIC1 (used for validation) and CLIC4, which currently has no known pharmacological identified drug. Drug screening will be done in collaboration with industrial partners AstraZeneca and Smartox.
01-Jan-2016 - 30-Jan-2019
Industrial Case Account 2016 | Robertson, Jack
Burley, Glenn (Principal Investigator) Zagnoni, Michele (Co-investigator) Robertson, Jack (Research Co-investigator)
01-Jan-2016 - 01-Jan-2020
Three-dimensional modelling of endothelial cell dysfunction in cerebral small vessel disease
Zagnoni, Michele (Principal Investigator)
01-Jan-2016 - 28-Jan-2017

more projects

Address

Electronic and Electrical Engineering
Technology Innovation Centre

Location Map

View University of Strathclyde in a larger map