Dr Michele Zagnoni

Reader

Electronic and Electrical Engineering

Personal statement

Michele Zagnoni's research is based on the development of new microsystems for basic biology investigation, diagnosis and treatment of disease using microfluidic and lab-on-a-chip technologies. More information on: www.zagnonilab.com

Expertise

Has expertise in:

    Microfabrication of polymeric structures

    Theoretical and experimental expertise in fluid dynamics at the microscale

    On chip cell culture

    Organ on a chip

    Bioimaging

    Miniaturised bioassay

Prizes and awards

Member of Departmental Safety Committee
Recipient
5/2011

More prizes and awards

Qualifications

08/2013             Member of the EPSRC Peer Review College

06/2013             Affiliate Membership to the Royal Society of Chemistry

10/2012:            SCQF Certificate for Biosafety Practitioner Level 1

10/2012:            PostGraduate Certificate in Advanced Academic Studies

04/2006:            Ph.D. degree in Electronic Engineering and Computer Science

11/2002:            Italian state certification for the practice of engineering as a profession (Chartered Engineer)

10/2002:                Dr. Eng. degree (5 year degree) in Electronic Engineering (Bioengineering qualification)

Publications

Microfluidic technologies for immunotherapy studies on solid tumours
Paterson K, Zanivan S, Glasspool R, Coffelt S B, Zagnoni M
Lab on a Chip (2021)
https://doi.org/10.1039/D0LC01305F
Detection of estrogen receptor alpha and assessment of fulvestrant activity in MCF-7 tumour spheroids using microfluidics and SERS
Kapara Anastasia, Findlay Paterson Karla A, Brunton Valerie G, Graham Duncan, Zagnoni Michele, Faulds Karen
Analytical Chemistry Vol 93, pp. 5862-5871 (2021)
https://doi.org/10.1021/acs.analchem.1c00188
Advances in microfluidic in vitro systems for neurological disease modeling
Holloway Paul M, Willaime-Morawek Sandrine, Siow Richard, Barber Melissa, Owens Róisín M, Sharma Anup D, Rowan Wendy, Hill Eric, Zagnoni Michele
Journal of Neuroscience Research Vol 99, pp. 1276-1307 (2021)
https://doi.org/10.1002/jnr.24794
Microdroplet operations in polymeric microtubes
Zhang Yu, Wang Ziyun, New Declan, Zagnoni Michele
Analytical Chemistry Vol 93, pp. 2411-2418 (2021)
https://doi.org/10.1021/acs.analchem.0c04360
Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures
Katsikoudi Antigoni, Ficulle Elena, Cavallini Annalisa, Sharman Gary, Guyot Amelie, Zagnoni Michele, Eastwood Brian J, Hutton Michael, Bose Suchira
Journal of Biological Chemistry Vol 295, pp. 13079-13093 (2020)
https://doi.org/10.1074/jbc.RA120.013325
Seeing around corners : cells solve mazes and respond at a distance using attractant breakdown
Tweedy Luke, Thomason Peter A, Paschke Peggy I, Martin Kirsty, Machesky Laura M, Zagnoni Michele, Insall Robert H
Science Vol 369 (2020)
https://doi.org/10.1126/science.aay9792

More publications

Teaching

Teaching Staff for the course EE312 - Instrumentation and Microcontrollers (3rd year) at the University of Strathclyde.

Support Staff for the course EE105 - Electronic Techniques and Design (1st year) at the University of Strathclyde.

Teaching Staff for Small Group Tutorials (SGT) at the University of Strathclyde.

Research interests

We use microfluidics for the development of screening and diagnostic systems for healthcare applications, including fundamental biological research, drug screening and personalized medicine therapy, for the creation of organ-on-a-chip in vitro models and for synthetic biology applications.

Professional activities

PhD external examiner - Heriot Watt
Examiner
11/2019
PhD external examiner - UCL
Examiner
7/2019
Microfluidic screening for 3D oncology
Speaker
21/2/2019
A microfluidic solution to precision oncology
Speaker
5/12/2018
A microfluidic solution to maximise screening of cancer patient-derived spheroids
Speaker
8/11/2018
OncoScreen: a microfluidic platform for animal-free 3D oncology
Speaker
26/10/2018

More professional activities

Projects

Adenomyosis-on-a-chip: a microfluidic 3D model of the endometrial-myometrial junction (EMJ)
Sandison, Mairi (Principal Investigator) Zagnoni, Michele (Co-investigator)
06-Jan-2021 - 23-Jan-2021
Studying drug delivery in micro and nano flows
Zagnoni, Michele (Principal Investigator)
03-Jan-2019 - 02-Jan-2021
A microfluidic approach to investigating vascular cell fate at the single-cell level
Zagnoni, Michele (Principal Investigator) Sandison, Mairi (Co-investigator)
01-Jan-2018 - 30-Jan-2022
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Megarity, Daniel
Zagnoni, Michele (Principal Investigator) Bushell, Trevor (Co-investigator) Megarity, Daniel (Research Co-investigator)
01-Jan-2017 - 01-Jan-2022
How are repairing brain cells successfully recruited to multiple sclerosis lesions?
Zagnoni, Michele (Principal Investigator)
01-Jan-2017 - 29-Jan-2020
Droplet-based Microfluidic Platform for Intracellular Ion Channel Drug Discovery
Zagnoni, Michele (Principal Investigator)
Ion channels are proteins that are involved in the regulation of almost every cellular mechanism and they constitute the second largest class of pharmacological drug targets. A family of these channels are located in the inner compartments of a cell (i.e. they are intracellular) and they are typically excluded from industrial large-throughput automated screening (e.g. automated patch clamp technology) that probe ion channels only in the outer cell membrane. As such, implications arise that affect the hit discovery rate of new drugs for such proteins. This proposal aims to produce and test a new microsystem technology for drug screening of human intracellular ion channels. The system will comprise a medium-throughput microfluidic prototype relying entirely on synthetic cell membranes harbouring intracellular ion channels. Whilst developing this new technology, this study will investigate two proteins that are involved in cancer and neurodegeneration, namely CLIC1 (used for validation) and CLIC4, which currently has no known pharmacological identified drug. Drug screening will be done in collaboration with industrial partners AstraZeneca and Smartox.
01-Jan-2016 - 30-Jan-2019

More projects

Address

Electronic and Electrical Engineering
Royal College Building

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