Dr Michele Zagnoni

Reader

Electronic and Electrical Engineering

Personal statement

Michele Zagnoni's research is based on the development of new microsystems for basic biology investigation, diagnosis and treatment of disease using microfluidic and lab-on-a-chip technologies. More information on: www.zagnonilab.com

Expertise

Has expertise in:

    Microfabrication of polymeric structures

    Theoretical and experimental expertise in fluid dynamics at the microscale

    On chip cell culture

    Organ on a chip

    Bioimaging

    Miniaturised bioassay

Prizes and awards

Member of Departmental Safety Committee
Recipient
5/2011

More prizes and awards

Qualifications

08/2013             Member of the EPSRC Peer Review College

06/2013             Affiliate Membership to the Royal Society of Chemistry

10/2012:            SCQF Certificate for Biosafety Practitioner Level 1

10/2012:            PostGraduate Certificate in Advanced Academic Studies

04/2006:            Ph.D. degree in Electronic Engineering and Computer Science

11/2002:            Italian state certification for the practice of engineering as a profession (Chartered Engineer)

10/2002:                Dr. Eng. degree (5 year degree) in Electronic Engineering (Bioengineering qualification)

Publications

Assessment of CAR-T cell-mediated cytotoxicity in 3D microfluidic cancer co-culture models for combination therapy
Paterson K, Paterson S, Mulholland T, Coffelt S B, Zagnoni M
IEEE Open Journal of Engineering in Medicine and Biology (2022)
https://doi.org/10.1109/OJEMB.2022.3178302
A modular microfluidic platform to enable complex and customisable in vitro models for neuroscience
Megarity D, Vroman R, Kriek M, Downey P, Bushell T J, Zagnoni M
Lab on a Chip Vol 22, pp. 1989-2000 (2022)
https://doi.org/10.1039/D2LC00115B
PYCR1-dependent proline synthesis in cancer associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix
Kay Emily J, Paterson Karla, Riero-Domingo Carla, Sumpton David, Daebritz Henry, Tardito Saverio, Boldrini Claudia, Hernandez-Fernaud Juan R, Athineos Dimitris, Dhayade Sandeep, Stepanova Ekaterina, Gjerga Enio, Neilson Lisa J, Lilla Sergio, Hedley Ann, Koulouras Grigorios, McGregor Grace, Jamieson Craig, Johnson Radia Marie, Park Morag, Kirschner Kristina, Miller Crispin, Kamphorst Jurre J, Loayza-Puch Fabricio, Saez-Rodriguez Julio, Mazzone Massimiliano, Blyth Karen, Zagnoni Michele, Zanivan Sara
Nature Metabolism (2022)
Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons
Malavasi Elise, Ghosh A, Booth Daniel, Zagnoni Michele, Sherman Diane, Brophy Peter J
eLife Vol 10 (2021)
https://doi.org/10.7554/eLife.68089
Microfluidic technologies for immunotherapy studies on solid tumours
Paterson K, Zanivan S, Glasspool R, Coffelt S B, Zagnoni M
Lab on a Chip Vol 21, pp. 2306-2329 (2021)
https://doi.org/10.1039/D0LC01305F
Detection of estrogen receptor alpha and assessment of fulvestrant activity in MCF-7 tumour spheroids using microfluidics and SERS
Kapara Anastasia, Findlay Paterson Karla A, Brunton Valerie G, Graham Duncan, Zagnoni Michele, Faulds Karen
Analytical Chemistry Vol 93, pp. 5862-5871 (2021)
https://doi.org/10.1021/acs.analchem.1c00188

More publications

Teaching

Teaching Staff for the course EE312 - Instrumentation and Microcontrollers (3rd year) at the University of Strathclyde.

Support Staff for the course EE105 - Electronic Techniques and Design (1st year) at the University of Strathclyde.

Teaching Staff for Small Group Tutorials (SGT) at the University of Strathclyde.

Research interests

We use microfluidics for the development of screening and diagnostic systems for healthcare applications, including fundamental biological research, drug screening and personalized medicine therapy, for the creation of organ-on-a-chip in vitro models and for synthetic biology applications.

Professional activities

Adenomyosis-on-a-chip: a 3D endometrial-myometrial microfluidic model
Contributor
17/11/2021
PhD external examiner - Heriot Watt
Examiner
11/2019
PhD external examiner - UCL
Examiner
7/2019
Microfluidic screening for 3D oncology
Speaker
21/2/2019
A microfluidic solution to precision oncology
Speaker
5/12/2018
A microfluidic solution to maximise screening of cancer patient-derived spheroids
Speaker
8/11/2018

More professional activities

Projects

Developing an assay to measure neuron-to-neuron spread of α-synuclein pathology on a microfluidics platform
Zagnoni, Michele (Principal Investigator)
01-Jan-2021 - 30-Jan-2022
Adenomyosis-on-a-chip: a microfluidic 3D model of the endometrial-myometrial junction (EMJ)
Sandison, Mairi (Principal Investigator) Zagnoni, Michele (Co-investigator) Busch, Caroline (Researcher)
06-Jan-2021 - 23-Jan-2021
Studying drug delivery in micro and nano flows
Zagnoni, Michele (Principal Investigator)
03-Jan-2019 - 02-Jan-2021
Provision of microfluidic well plates - phase2
Zagnoni, Michele (Principal Investigator)
07-Jan-2019 - 31-Jan-2019
A microfluidic approach to investigating vascular cell fate at the single-cell level
Zagnoni, Michele (Principal Investigator) Sandison, Mairi (Co-investigator)
01-Jan-2018 - 30-Jan-2022
Production of microfluidic devices
Zagnoni, Michele (Principal Investigator)
23-Jan-2018 - 03-Jan-2018

More projects

Address

Electronic and Electrical Engineering
Royal College Building

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