110. Ruthenium-Catalyzed Ester Reductions Applied to Pharmaceutical Intermediates. Youssef Shaalan, Lee Boulton, and Craig Jamieson. Org. Process Res. Dev., 2020, 24, 2745-2751.
109. Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. Simon C. C. Lucas, Stephen J. Atkinson, Paul Bamborough, Heather Barnett, Chun-wa Chung, Laurie Gordon, Darren J. Mitchell, Alexander Phillipou, Rab K. Prinjha, Robert J. Sheppard, Nicholas C. O. Tomkinson, Robert J. Watson, and Emmanuel H. Demont. J. Med. Chem., 2020, 63, 5212-5241.
108. . Alkene Syn- and Anti-oxyamination with Malonoyl Peroxides. Jonathan M. Curle, Marina C. Perieteanu, Phillip G. Humprhreys, Alan R. Kennedy, Nicholas C. O. Tomkinson. Org. Lett., 2020, 22, 1659-1664.
107. Et3SiH + KOtBu Provide Multiple Reactive Intermediates that Compete in the Reactions and Rearrangements of Benzylnitriles and Indolenines. Andrew J. Smith, Daniela Dimitrova, Jude N. Arokianathar, Kenneth F. Clark, Darren L. Poole, Stuart G. Leach, and John A. Murphy. Chem. Sci., 2020, 11, 12364-12370..
106. Visible Light-mediated Smiles Rearrangements and Annulations of Non-activated Aromatics. Connor A. Lawson, Andrew P. Dominey, Glynn D. Williams, and John A. Murphy, Chem. Commun., 2020, 56, 11445-11448.
105. Computational Study on the Boundary Between the Concerted and Stepwise Mechanism of Bimolecular SNAr Reactions. Simon Rohrbach, John A. Murphy, and Tell Tuttle. J. Am. Chem. Soc., 2020, 142, 14871-14876.
104. UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow. Luke Green, Keith Livingstone, Sophie Bertrand, Simon Peace, and Craig Jamieson. Chem. Eur. J., 2020, 26, 14866-14870.
103. Transition Metal-free Coupling of 1,3-Dipoles and Boronic Acids as a Sustainable Approach to C-C Bond Formation. Keith Livingstone, Sophie Bertrand, Alan R. Kennedy, and Craig Jamieson. Chem. Eur. J., 2020, 26, 10591-10597.
102. One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles. Keith Livingstone, Sophie Bertrand, and Craig Jamieson. J. Org. Chem., 2020, 85, 7413-7423.
101. An Azide and Acetylene Free Synthesis of 1-Substituted 1,2,3-Triazoles. Sarah J. M. Patterson, Peter R. Clark, Glynn D. Williams, and Nicholas C. O. Tomkinson. Tet. Lett., 2020, 61, article number 152483.
100. Discovery of the First Potent and Selective αvβ5 Integrin Inhibitor Based on an Amide-Containing Core. Rhys Lippa, John Barrett, Sandeep Pal, James E. Rowedder, John A. Murphy, and Tim N. Barrett. Eur. J. Med. Chem., 2020, 208, article number 112719.
99. Stereoselective Remote Functionalization via Palladium-Catalyzed Redox-Relay Heck Methodologies. Holly Bonfield, Damien Valette, David M. Lindsay, and Marc Reid, Chem. Eur. J., 2020, 27, 158-174.
98. PhotoAffinity Bits: A photoaffinity‐based fragment screening platform for efficient identification of protein ligands. Emma. K. Grant, David J. Fallon, Michael M. Hann, Ken G. M. Fantom, Chad Quinn, Francesca Zappacosta, Roland S. Annan, Chun-wa Chung, Paul Bamborough, David P. Dixon, Peter Stacey, David House, Vipulkumar K. Patel, Nicholas C. O. Tomkinson, and Jacob Bush, Angew. Chem. Int. Ed., 2020, 59, 21096-21105.
97. Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype. Christopher R. Wellaway, Paul Bamborough, Sharon G. Bernard, Chun-wa Chung, Peter D. Craggs, Leanne Cutler, Emmanuel H. Demont, John P. Evans, Laurie Gordon, Bhumika Karamshi, Antonia J. Lewis, Matthew J. Lindon, Darren J. Mitchell, Inmaculada Rioja, Peter E. Soden, Simon Taylor, Robert J. Watson, Rob Willis, James M. Woolven, Beata S. Wyspiańska, William J. Kerr, and Rab K. Prinjha, J. Med. Chem., 2020, 63, 9020-9044.
96. Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner–Wadsworth–Emmons-based approach. Rhys A. Lippa, John A. Murphy, and Tim N. Barrett, Belstein J. Org. Chem., 2020, 16, 1617-1626.
95. A Mechanistic and Cautionary Case Study on the Use of Alternating Potential in Electrochemical Reactions. Alfie Wills, Darren L. Poole, Catherine M. Alder, and Marc Reid, ChemElectroChem, 2020, 7, 2771-2776.
94. Application of Atypical Acetyl-Lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Michael Clegg, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie J. Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Gemma Michele Liwicki, Anne-Marie Michon, Judit Molnar, Inmaculada Rioja, Peter Soden, Natalie Theodoulou, Thilo Werner, Nicholas C. O. Tomkinson, Rab K. Prinjha, and Philip G Humphreys, J. Med. Chem., 2020, 63, 5816-5840.
93. New Reductive Rearrangement of N-Arylindoles Triggered by the Grubbs-Stoltz Reagent Et3SiH/KOtBu. Andrew J. Smith, Daniela Dimitrova, Jude N. Arokainathar, Krystian Kolodziejczak, Allan Young, Mark Allison, Darren L. Poole, Stuart G. Leach, John A. Parkinson, Tell Tuttle, and John A. Murphy, Chem. Sci., 2020, 11, 3719-3726.
92. Hi-JAK-ing The Ubiquitin System: The Design and Physicochemical Optimisation of JAK PROTACs. Rishi R. Shah, Joanna M. Redmond, Andrei Mihut, Malini Menon, John P. Evans, John A. Murphy, Michelle A. Bartholomew, and Diane M. Coe, Bioorg. Med. Chem., 2020, article number 115326.
91. A Scalable, Metal-, Azide- and Halogen-Free Method for the Preparation of Triazoles. Peter R. Clark, Glynn D. Williams, Jerome F. Hayes, and Nicholas C. O. Tomkinson, Angew. Chem. Int. Ed., 2020, 59, 6740-6744.
90. Hydrogen Atom Transfer-mediated Domino Cyclisation Reaction to Access (Spiro)Quinazolinones. Oliver J. Turner, David J. Hirst, and John A. Murphy, Chem. Eur. J., 2020, 26, 3026-3029.
89. Exploring Ligand Stability in Protein Crystal Structures using Binding Pose Metadynamics. Lucia Fusani, David S. Palmer, Don O. Somers, and Ian D. Wall, J. Chem. Inf. Model., 2020, 60, 1528-1539.
88. The Right Light – De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry. Holly E. Bonfield, Kayleigh Mercer, Alba Diaz-Rodriguez, Gemma C. Cook, Blandine S. J. McKay, Pawel Slade, George M. Taylor, Wei Xiang Ooi, Jason D. Williams, Jack P. M. Roberts, John A. Murphy, Luca Schmermund, Wolfgang Kroutil, Tamara Mielke, Jared Cartwright, Gideon Grogan, and Lee J. Edwards, ChemPhotoChem, 2020, 4, 45-51.