a female researcher injects a sample from a device into a small container

Strathclyde-GSKOur Publications

Over 120 primary peer-reviewed research papers have been published to date, with many in high impact journals, including Angew. Chem., Int. Ed.; J. Am. Chem. Soc.; Chem. Sci.; ACS Chem. Biol.; ACS Catal.; and J. Med. Chem.  Additionally, 26 patents have been filed based on research carried out as part of our collaborative projects.

Across the programme, research projects are carefully selected to advance innovation and understanding in areas of science that are relevant to the pharmaceutical industry in general or GSK in particular.

Collaborative Research Papers

126. Oxygenated Cyclopentenones via the Pauson-Khand Reaction of Silyl Enol Ether Substrates. Paul Shaw, Storm J. Hassell-Hart, Gayle E. Douglas, Andrew G. Malcolm, Alan R. Kennedy, Gemma V. White, Laura C. Paterson, and William J. Kerr, Org. Lett., 2022 24, 2750-2755. 

125. A Chemo- and Regioselective Tandem [3 + 2] Heteroannulation Strategy for Carbazole Synthesis: Combining Two Mechanistically Distinct Bond-Forming Processes.  Emma Campbell, Andrea Taladriz-Sender, Olivia l. Paisley, Alan R. Kennedy, Jacob T. Bush, and Glenn A. Burley, J. Org. Chem., 2022 87, 4603-4616. 

124. Nitrogen-Centered Radicals in Functionalization of sp2 Systems: Generation, Reactivity, and Applications in Synthesis. Cassie Pratley, Sabine Fenner, and John A. Murphy, Chem. Rev., 2022, 122, 8181–8260.

123. Replacement of Less-Preferred Dipolar Aprotic and Ethereal Solvents in Synthetic Organic Chemistry with More Sustainable Alternatives. Andrew Jordan, Callum G. J. Hall, Lee R. Thorp, and Helen F. Sneddon, Chem. Rev., 2022, 122, 6749-6794.. 

122. Electrochemical Synthesis of Isoxazolines: Method and Mechanism. Samuel D. L. Holman, Alfie G. Wills, Neal. J. Fazakerley, Darren L. Poole, Diane M. Coe, Leonard Berlouis, and Marc Reid, Chem. Eur. J., 2022, Accepted Article, DOI: 10.1002/chem.2021203728.

121. Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. Philip G. Humphreys, Stephen J. Atkinson, Paul Bamborough, Rino A. Bit, Chun-wa Chung, Peter D. Craggs, Leanne Cutler, Rob Davis, Alan Ferrie, GangLi Gong, Laurie J. Gordon, Matthew Gray, Lee A. Harrison, Thomas G. Hayhow, Andrea Haynes, Nick Henley, David J. Hirst, Ian D. Holyer, Matthew J. Lindon, Cerys Lovatt, David Lugo, Scott McCleary, Judit Molnar, Qendresa Osmani, Chris Patten, Alex Preston, Inmaculada Rioja, Jonathan T. Seal, Nicholas Smithers, Fenglai Sun, Dalin Tang, Simon Taylor, Natalie H. Theodoulou, Clare Thomas, Robert J. Watson, Christopher R. Wellaway, Linrong Zhu, Nicholas C. O. Tomkinson, and Rab K. Prinjha. J. Med. Chem., 2022,  2262–2287.

120. Recent Advances in Visible Light-activated Radical Coupling Reactions Triggered by (i) ruthenium, (ii) iridium and (iii) organic photoredox agents. Jonathan D. Bell and John A. Murphy, Chem. Soc. Rev., 2021, 50, 9540-9685.

119. Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites. Jack Robertson, Marzuq A. Ungogo, Mustafa M. Aldfer, Leandro Lemgruber, Fergus S. McWhinnie, Bela E. Bode, Katherine L. Jones, Allan J. B. Watson, Harry P. de Koning, and Glenn A. Burley, ChemMedChem, 2021, 16, 3396-3401.

118. Bridge Functionalisation of Bicyclo[1.1.1]pentane Derivatives. Joseph M. Anderson, Nicholas D. Measom, John A. Murphy and Darren L. Poole. Angew. Chem. Int. Ed., 2021, 60, 24754-24769.

117. Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors. Michael A. Clegg, Natalie H. Theodoulou, Paul Bamborough, Chun-wa Chung, Peter D. Craggs, Emmanuel H. Demont, Laurie J. Gordon, Gemma M. Liwicki, Alex Phillipou, Nicholas C. O. Tomkinson, Rab K. Prinjha, and Philip G. Humphreys. ACS Med. Chem. Lett., 202112, 1308-1317.

116. A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications. Peter Stacey, Hannah Lithgow, Xiao Lewell, Agnieszka Konopacka, Stephen Besley, Georgina Green, Ryan Whatling, Robert Law, Sascha Röth, Gopal P. Sapkota, Ian E. D. Smith, Glenn A. Burley, John Harling, Andrew B. Benowitz, Markus A. Queisser, and Marcel Muelbaier. SLAS DISCOVERY: Advancing the Science of Drug Discovery, 2021, 6, 885-895.

115. Toward Physics-based Solubility Computation for Pharmaceuticals to Rival Informatics, Daniel J. Fowles, David S. Palmer, Rui Guo, Sarah L. Price, John B. O. Mitchell, J. Chem. Theory Comput. 2021, 17, 3700-3709.

114. Trialkylammonium Salt Degradation: Implications for Methylation and Cross-coupling. Jack B. Washington, Michele Assante, Chunhui Yan, David R McKinney, Vanessa Juba, Andrew Leach, Sharon E Baillie, and Marc Reid. Chem. Sci., 2021, 12, 6949-6963.

113. Synthesis of Arylethylamines via C(sp3)-C(sp3) Palladium-Catalysed Cross-Coupling.  Rhys A. Lippa, David J. Battersby, John A. Murphy, and Tim N. Barrett.  J. Org. Chem., 2021, Article ASAP.  DOI: 10.1021/acs.joc.0c02958.

112. A Sustainable and Scalable Multicomponent Continuous Flow Process to Access Fused Imidazohetrocycle Pharmacophores.  Blake J. Baker, William J. Kerr, David M. Lindsay, Vipulkumar K. Patel, and Darren L. Poole.  Green Chem., 2021, 23, 280-287.

111. Investigating the Effects of the Core Nitrogen Atom Configuration on the Thermodynamic Solubility of 6,5-Bicyclic Heterocycles.  Brett Cosgrove, Kenneth Down, Sophie Bertrand, Nicholas C. O. Tomkinson, and Michael D. Barker.  Bioorg. Med. Chem. Lett., 2021, 33, Article No. 127752.  DOI: 10.1016/j.bmcl.2020.127752.

110. Ruthenium-Catalyzed Ester Reductions Applied to Pharmaceutical Intermediates.  Youssef Shaalan, Lee Boulton, and Craig Jamieson.  Org. Process Res. Dev., 2020, 24, 2745-2751.

109. Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.  Simon C. C. Lucas, Stephen J. Atkinson, Paul Bamborough, Heather Barnett, Chun-wa Chung, Laurie Gordon, Darren J. Mitchell, Alexander Phillipou, Rab K. Prinjha, Robert J. Sheppard, Nicholas C. O. Tomkinson, Robert J. Watson, and Emmanuel H. Demont.  J. Med. Chem., 2020, 63, 5212-5241.

108. . Alkene Syn- and Anti-oxyamination with Malonoyl Peroxides.  Jonathan M. Curle, Marina C. Perieteanu, Phillip G. Humprhreys, Alan R. Kennedy, Nicholas C. O. Tomkinson.  Org. Lett., 2020, 22, 1659-1664.

107. Et3SiH + KOtBu Provide Multiple Reactive Intermediates that Compete in the Reactions and Rearrangements of Benzylnitriles and Indolenines.  Andrew J. Smith, Daniela Dimitrova, Jude N. Arokianathar, Kenneth F. Clark, Darren L. Poole, Stuart G. Leach, and John A. Murphy.  Chem. Sci., 2020, 11, 12364-12370..

106. Visible Light-mediated Smiles Rearrangements and Annulations of Non-activated Aromatics.  Connor A. Lawson, Andrew P. Dominey, Glynn D. Williams, and John A. Murphy, Chem. Commun., 2020, 56, 11445-11448.

105. Computational Study on the Boundary Between the Concerted and Stepwise Mechanism of Bimolecular SNAr Reactions. Simon Rohrbach, John A. Murphy, and Tell Tuttle.  J. Am. Chem. Soc., 2020, 142, 14871-14876.

104. UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow. Luke Green, Keith Livingstone, Sophie Bertrand, Simon Peace, and Craig Jamieson.  Chem. Eur. J., 2020, 26, 14866-14870.

103. Transition Metal-free Coupling of 1,3-Dipoles and Boronic Acids as a Sustainable Approach to C-C Bond Formation. Keith Livingstone, Sophie Bertrand, Alan R. Kennedy, and Craig Jamieson. Chem. Eur. J., 2020, 26, 10591-10597.

102. One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles. Keith Livingstone, Sophie Bertrand, and Craig Jamieson. J. Org. Chem., 2020, 85, 7413-7423.

101. An Azide and Acetylene Free Synthesis of 1-Substituted 1,2,3-Triazoles.  Sarah J. M. Patterson, Peter R. Clark, Glynn D. Williams, and Nicholas C. O. Tomkinson.  Tet. Lett., 2020, In Press.  DOI: 10.1016/j.tetlet.2020.152483.

100. Discovery of the First Potent and Selective αvβ5 Integrin Inhibitor Based on an Amide-Containing Core. Rhys Lippa, John Barrett, Sandeep Pal, James E. Rowedder, John A. Murphy, and Tim N. Barrett. Eur. J. Med. Chem., 2020, 208, article number 112719.  DOI: 10.1016/j.emech.2020.112719.

99. Stereoselective Remote Functionalization via Palladium-Catalyzed Redox-Relay Heck Methodologies. Holly Bonfield, Damien Valette, David M. Lindsay, and Marc Reid, Chem. Eur. J., 2020, Accepted Article.  DOI: 10.1002/chem.202002849.

98. PhotoAffinity Bits: A photoaffinity‐based fragment screening platform for efficient identification of protein ligands.  Emma. K. Grant, David J. Fallon, Michael M. Hann, Ken G. M. Fantom, Chad Quinn, Francesca Zappacosta, Roland S. Annan, Chun-wa Chung, Paul Bamborough, David P. Dixon, Peter Stacey, David House, Vipulkumar K. Patel, Nicholas C. O. Tomkinson, and Jacob Bush, Angew. Chem. Int. Ed., 2020, Accepted Article.  DOI:10.1002/anie.202008361.

97. Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype. Christopher R. Wellaway, Paul Bamborough, Sharon G. Bernard, Chun-wa Chung, Peter D. Craggs, Leanne Cutler, Emmanuel H. Demont, John P. Evans, Laurie Gordon, Bhumika Karamshi, Antonia J. Lewis, Matthew J. Lindon, Darren J. Mitchell, Inmaculada Rioja, Peter E. Soden, Simon Taylor, Robert J. Watson, Rob Willis, James M. Woolven, Beata S. Wyspiańska, William J. Kerr, and Rab K. Prinjha, J. Med. Chem., 2020, Accepted Manuscript.  DOI: 10.1021/asc.jmedchem.0c00566.

96. Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner–Wadsworth–Emmons-based approach. Rhys A. Lippa, John A. Murphy, and Tim N. Barrett, Belstein J. Org. Chem., 2020, 16, 1617-1626.

95. A Mechanistic and Cautionary Case Study on the Use of Alternating Potential in Electrochemical Reactions. Alfie Wills, Darren L. Poole, Catherine M. Alder, and Marc Reid, ChemElectroChem, 2020, Accepted Manuscript.  DOI: 10.1002/celc.202000648.

94. Application of Atypical Acetyl-Lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Michael Clegg, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie J. Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Gemma Michele Liwicki, Anne-Marie Michon, Judit Molnar, Inmaculada Rioja, Peter Soden, Natalie Theodoulou, Thilo Werner, Nicholas C. O. Tomkinson, Rab K. Prinjha, and Philip G Humphreys, J. Med. Chem., 2020, Accepted Manuscript.  DOI: 10.1021/acs.jmedchem.0c00075.

93. New Reductive Rearrangement of N-Arylindoles Triggered by the Grubbs-Stoltz Reagent Et3SiH/KOtBu.  Andrew J. Smith, Daniela Dimitrova, Jude N. Arokainathar, Krystian Kolodziejczak, Allan Young, Mark Allison, Darren L. Poole, Stuart G. Leach, John A. Parkinson, Tell Tuttle, and John A. Murphy, Chem. Sci., 2020, 11, 3719-3726.

92. Hi-JAK-ing The Ubiquitin System: The Design and Physicochemical Optimisation of JAK PROTACs.  Rishi R. Shah, Joanna M. Redmond, Andrei Mihut, Malini Menon, John P. Evans, John A. Murphy, Michelle A. Bartholomew, and Diane M. Coe, Bioorg. Med. Chem., 2020, accepted article.  DOI:  10.1016/j.bmc.2020.115326.

91. A Scalable, Metal-, Azide- and Halogen-Free Method for the Preparation of Triazoles.  Peter R. Clark, Glynn D. Williams, Jerome F. Hayes, and Nicholas C. O. Tomkinson, Angew. Chem. Int. Ed., 2020, 59, 6740-6744.

90. Hydrogen Atom Transfer-mediated Domino Cyclisation Reaction to Access (Spiro)Quinazolinones. Oliver J. Turner, David J. Hirst, and John A. Murphy, Chem. Eur. J., 2020, 26, 3026-3029.

89. Exploring Ligand Stability in Protein Crystal Structures using Binding Pose Metadynamics. Lucia Fusani, David S. Palmer, Don O. Somers, and Ian D. Wall, J. Chem. Inf. Model., 2020, 60, 1528-1539.

88. The Right Light – De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry.  Holly E. Bonfield, Kayleigh Mercer, Alba Diaz-Rodriguez, Gemma C. Cook, Blandine S. J. McKay, Pawel Slade, George M. Taylor, Wei Xiang Ooi, Jason D. Williams, Jack P. M. Roberts, John A. Murphy, Luca Schmermund, Wolfgang Kroutil, Tamara Mielke, Jared Cartwright, Gideon Grogan, and Lee J. Edwards, ChemPhotoChem, 2020, 4, 45-51.

87. Metal-free C–C Bond Formation via Coupling of Nitrile Imines and Boronic Acids. Keith Livingstone, Sophie Bertrand, Jenna Mowat, and Craig Jamieson.  Chem. Sci., 2019, 10, 10412-10416. 

86. S-Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C-Alkylation.  Iain J. W. McKean, Joanna C. Sadler, Anibal Cuetos, Amina Frese, Luke D. Humphreys, Gideon Grogan, Paul A. Hoskisson, and Glenn A. Burley. Angew. Chem. Int. Ed., 2019, 58, 17583-17588.

85. A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family.  Emma K. Grant, David J. Fallon, Christian Eberl, Ken G. M. Fantom, Francesca Zappacosta, Cassie Messenger, Nicholas C. O. Tomkinson, and Jacob Bush, Angew. Chem. Int. Ed., 2019, 58, 17322-17327.

84. Copper-catalysed C–H functionalisation gives access to 2-aminobenzimidazoles. Peter R. Clark, Glynn D. Williams, and Nicholas C. O. Tomkinson. Org. Biomol. Chem., 2019, 17, 7943-7955.

83. Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor - (3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by a Stereoselective Methylation.  Tim N. Barrett, Jonathan A. Taylor, Daniel Barker, Panayiotis A. Procopiou, James D.F. Thompson, John Barrett, Joelle Le, Sean M. Lynn, Peter Pogany, Cassie Pratley, John M. Pritchard, James A. Roper, James E. Rowedder, Robert J. Slack, Giovanni Vitulli, Simon J. F. Macdonald, and William J. Kerr, J. Med. Chem., 2019, 62, 7543-7556. 

82. Concerted Nucleophilic Aromatic Substitution Reactions.  Simon Rohrbach, Andrew J. Smith, Jia H. Pang, Darren L. Poole, Tell Tuttle, Shunsuke Chiba, and John A. Murphy, Angew. Chem. Int. Ed., 2019, 48, 16368-16388.

81. PROTAC-mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding.  Christopher P. Tinworth, Hannah Lithgow, Lars Dittus, Zuni I. Bassi, Sophie E. Hughes, Marcel Muelbaier, Han Dai, Ian E. D. Smith, William J. Kerr, Glenn A. Burley, Marcus Bantscheff, and John D. Harling, ACS Chem. Biol., 2019, 14, 342-347.

80. A Cascade Suzuki-Miyaura/Diels-Alder Protocol: Exploring the Bifunctional Utility of Vinyl Bpin.  David L. Cain, Callum McLaughin, John J. Molloy, Cameron Carpenter-Warren, Niall A. Anderson, and Allan J. B. Watson, Synlett, 2019, 30, 787-791.

79. The Electrophilic Fluorination of Enol Esters Using SelectFluor: A Polar Two-Electron Process.  Susanna H. Wood, Stephen Etridge, Alan R. Kennedy, Jonathan M. Percy, and David J. Nelson, Chem. Eur. J., 2019, 25, 5574-5585.

78. N-Alkyl-a-amino Acids in Nature and their Biocatalytic Preparation.  Julia F. Hyslop, Sarah L. Lovelock, Allan J. B. Watson, Peter W. Sutton, and Gheorghe-Doru Roiban, Journal of Biotechnology, 2019, 293, 56-65.

77. Advancements in the Development of non-BET Bromodomain Chemical Probes. Michael A. Clegg, Nicholas C. O. Tomkinson, Rab K. Prinjha, and P. Humpreys, ChemMedChem, 2019, 14, 362-385.

76. Biocatalytic Synthesis of Chiral N-Functionalized Amino Acids, Julia F. Hyslop, Sarah L. Lovelock, Peter W. Sutton, Kristin K. Brown, Allan J. B. Watson, and Gheorghe-Doru Roiban, Angew. Chem. Int. Ed., 2018, 57, 13821–13824.

75. Hydrogen Atom Transfer-mediated Cyclisations of Nitriles. John A. Murphy, Oliver Turner, David Hirst, and Eric Talbot, Chem. Eur. J., 2018, 24, 28658-18662.

74. Dual Roles for Potassium Hydride in Haloarene Reduction: CSNAr and Single Electron Transfer Reduction via Organic Electron Donors Formed in Benzene.  Joshua P. Barham, Samuel E. Dalton, Mark Allison, Ciuseppe Nocera, Allan Young, Matthew P. John, Thomas McGuire, Sebastien Campos, Tell Tuttle, and John A. Murphy, J. Am. Chem. Soc., 2018140, 11510-11518.

73. Mechanistic Insight Enables Practical, Scalable, Room Temperature, Chan-Lam N-arylation of N-aryl Sulfonamides.  Julien C. Vantourout, Ling Li, Enrique Bendito-Moll, Sonia Chabbra, Kenneth Arrington, Bela E. Bode, Albert Isidro-Llobet, John A. Kowalski, Mark G. Nilson, Katherine M. P. Wheelhouse, John L. Woodward, Shiping Xie, David C. Leitch, and Allan J. B. Watson, ACS Catal.2018, 8, 9560-9566. 

72. Contra-Thermodynamic, Photocatalytic E → Z Isomerization of Styrenyl Boron Species: Vectors to Facilitate Exploration of 2D Chemical Space. John J. Molloy, Jan B. Metternich, Constantin G. Daniliuc, Allan J. B. Watson, and Ryan Gilmour, Angew. Chem. Int. Ed.201857, 3168-3172.

71. A Practical and General Amidation method from Isocyanates Enabled by Flow Technology . Jason D. Williams, William J. Kerr, Stuart G. Leach, and David M. Lindsay, Angew. Chem. Int. Ed.201857, 12126-12130.

70. Alkene Oxyamination using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines. Carla Alamillo-Ferrer, Jonathan M. Curle, Stuart C. Davidson, Simon C. C. Lucas, Stephen J. Atkinson, Matthew Campbell, Alan R. Kennedy, and Nicholas C. O. Tomkinson, J. Org. Chem201883, 6728–6740.

69. A Detailed Study of Irradiation Requirements Towards an Efficient Photochemical Wohl‐Ziegler Procedure in Flow. Holly E. Bonfield, Jason D. Williams, Wei Xiang Ooi, Stuart G. Leach, William J. Kerr, Lee J. Edwards, ChemPhotoChem2018, 2, 938-944.

68. Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.  Robert P. Law, Stephen J. Atkinson, Paul Bamborough, Chun-wa Chung, Emmanuel H. Demont, Laurie J. Gordon, Matthew Lindon, Rab K. Prinjha, Allan J. B. Watson, and David J. Hirst, J. Med. Chem., 201861, 4317-4334.

67. Oxidative β-Sulfonylation of Cyclic Amines. Robert J. Griffiths, Wei C. Kong, Stephen A. Richards, Glenn A. Burley, Michael C. Willis, and Eric P. Talbot, Chem. Sci.2018, 9, 2295-2300.

66. Optimal water networks in protein cavities with GAsol and 3D-RISM. Lucia Fusani, Ian Wall, David Palmer, and Alvaro Cortes, Bioinformatics201834, 1947–1948.

65. Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition.  Samuel E. Dalton, Lars Dittus, Daniel A. Thomas, Máire A. Convery, Joao Nunes, Jacob T. Bush, John P. Evans, Thilo Werner, Marcus Bantscheff, John A. Murphy, and Sebastien Campos, J. Am. Chem. Soc.2018140, 932-939. 

64. Electron-Transfer and Hydride-Transfer Pathways in the Stoltz–Grubbs Reducing System (KOtBu/Et3SiH). Andrew J. Smith, Allan Young, Simon Rohrback, Erin F. O'Connor, Mark Allison, HongShuang Want, Darren L. Poole, Tell Tuttle, and John A. Murphy, Angew. Chem. Int. Ed., 2017, 56, 12747-13751.

63. A Computational Study of Anionic Alkoxide–Allene and Amide–Allene Cyclizations. Florimond Cumine, Allan Young, Hans-Ulrich Reissig, Tell Tuttle, and John A. Murphy,  Eur. J. Org. Chem.2017, 6867–6871.

62. New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study. Marie-Pierre Dreanic, Colin M. Edge, and Tell Tuttle, ACS Omega20172, 5737-5747.

61. Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware. Thomas A. Clohessy, Alastair Roberts, Eric S. Manas, Vipulkumar K. Patel, Niall A. Anderson, and Allan J. B. Watson, Org. Lett.201719, 6368-6371. 

60. Site-selective Deuteration of N-heterocycles via Iridium-catalyzed Hydrogen Isotope Exchange.  William J. Kerr, David M. Lindsay, Philippa K. Owens, Marc Reid, Tell Tuttle, and Sebastien Campos, ACS Catal.20177, 7182-7186. 

59. Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides.  Helena S. Buchanan, Steven M. Pauff, Tilemachos D. Kosmidis, Andrea Taladriz-Sender, Olivia I. Rutherford, Marine Z. C. Hatit, Sabine Fenner, Allan J. B. Watson, and Glenn A. Burley, Org. Lett.201719, 3759-3762. 

58. Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists.  Afjal H. Miah, Aurelie C. Champigny, Rebecca H. Graves, Simon T. Hodgson, Jonathan M. Percy, and Panayiotis A. Procopiou, Bioorg. Med. Chem.2017, 25, 5327-5340.

57. One-Pot, Three-Step Synthesis of Cyclopropylboronic Acid Pinacol Esters from Synthetically Tractable Propargylic Silyl Ethers. Jonathan A. Spencer, Craig Jamieson, and Eric P. A. Talbot, Org. Lett.2017, 19, 3891-3894.

56. Small molecules and their role in effective pre-clinical target validation. Michael Clegg, Nicholas C. O. Tomkinson, Rab K. Prinjah, and Philip G. Humphreys, Future Med. Chem.2017, 9, 1579-1582.

55. Aqueous Solubility of Organic Salts. Investigating Trends in a Systematic Series of 51 Crystalline Salt Forms of Methylephedrine. Lygia S. de Moraes, Darren Edwards, Alastair J. Florence, Andrea Johnston, Blair F. Johnston, Catriona A. Morrison, and Alan R. Kennedy, Cryst. Growth Des.201717 (6), pp 3277–3286.

54. A study of kidetopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling. Florimond Cumine, Shengze Zhou, Tell Tuttle, and John A. Murphy, Org. Biomol. Chem., 2017, 15, 3324-3336.

53. A Tandem Enzymatic sp2-C-Methylation Process: Coupling In Situ S-Adenosyl-L-Methionine Formation with Methyl Transfer. Joanna C. Sadler, Luke D. Humpreys, Radka Snajdrova, and Glenn A. Burley, ChemBioChem2017, 18, 992-995.

52. Spectroscopic studies of the Chan-Lam amination: A mechanism-inspired solution to boronic ester reactivity. Julien C. Vantourout, Haralampos N. Miras, Albert Isidro-Llobet, Stephen Sproules, and Allan J. B. Watson, J. Am. Chem. Soc.2017,  139,  4769–4779.

51. Iron-Catalyzed Isopropylation of Electron-Deficient Aryl and Heteroaeryl Chlorides. James N. Sanderson, Andrew P. Dominey and Jonathan M. Percy, Adv. Synth. Catal. 2017359, 1007-1017.

50. Synthesis of Oxindoles and Benzofuranones via Oxidation of 2-Heterocyclic BMIDAs. C. P. Seath, J. W. B. Fyfe, J. J. Molloy and A. J. B. Watson, Synthesis201749, 891-898.

49. Chemoselective oxidation of aryl organoboron systems enabled by boronic acid-selective phase transfer. John J. Molloy, Thomas A. Clohessy, Craig Irving, Niall A. Anderson, Guy C. Lloyd-Jones and Allan J. B. Watson, Chem. Sci.20178, 1551-1559.

48. Chemoselective Suzuki-Myaura Cross-Coupling via Kinetic Transmetallation. James W. B. Fyfe, Neal J. Fazakerley and Allan J. B. Watson, Angew. Chem. Int. Ed.201756, 1249-1253.

47. Transition-metal-free amine oxidation: a chemoselective strategy for the late-stage formation of lactams. Robert J. Griffiths, Glenn A. Burley and Eric P. A. Talbot, Org. Lett.201719, 870-873.

46. Standardless, automated determination of chlorine-35 by 35Cl Nuclear Magnetic Resonance. Simon A. Watson, Andrew J. Edwards and John A. Parkinson, Analytical Letters201750, 161-172.

45. Structural and Functional Basis of C-Methylation of Coumarin Scaffolds by NovO. Joanna C. Sadler, Chun-Wa Chung, Julie E. Mosley, Glenn A. Burley and Luke D. Humphreys, ACS Chem. Biol., 201712, 374-379.

44. Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor. Nicholas D. Measom, Kenneth D. Down, David J. Hirst, Craig Jamieson, Eric S. Manas, Vipulkumar K. Patel and Don O. Somers, ACS Med. Chem. Lett., 20178, 43-48.

43. Discovery of a Potent, Cell Penetrant and Selective p300/CBP-Associated Factor (PCAF)/General Control Non-Derepressible 5 (GCN5) Bromodomain Chemical Probe.  Philip G. Humphreys,  Paul Bamborough,  Chun-Wa Chung,  Peter D. Craggs,  Laurie J. Gordon,  Paola Grandi,  Thomas G. Hayhow,  Jameed Hussain,  Katherine L. Jones,  Matthew Lindon,  Anne-Marie Michon,  Jessica F. Renaux,  Colin J. Suckling,  David F. Tough and  Rab K. Prinjha, J. Med. Chem., 2017, 60, 695–709.

42. Contra-thermodynamic Hydrogen Atom Abstraction in the Selective C-H Functionalization of Trialkylamine N-CH3 Groups. Joshua P. Barham, Matthew P. John, and John A. Murphy, J. Am. Chem. Soc., 2016, 138, 15482-15487.

41. Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study. William J. Kerr, Richard J. Mudd, Philippa K. Owens, Marc Reid, Jack A. Brown and Sebastien Campos, J. Labelled Compd. Radiopharm.201659, 601-603.

40. Evolution of a novel orally bioavailable series of PI3K δ inhibitors from an inhaled lead for the treatment of respiratory disease. Augustin Amour, Nick Barton, Anthony W. J. Cooper, Graham Inglis, Craig Jamieson, Christopher N. Luscombe, David Perez, Simon Peace, Paul Rowland, Chris Tame, Sorif Uddin, Giovanni Vitulli, and Natalie Wellaway.  J. Med. Chem.201659. 7239-7251.

39. Modular Construction of Fluoroarenes from a New Difluorinated Building Block by Cross-Coupling/Electrocyclisation/Dehydrofluorination Reactions. Jonathan M. Percy, Helena Emerson, James W. B. Fyfe, Alan R. Kennedy, Sergej Maciuk, David Orr, Lucie Rathouska, Joanna M. Redmond and Peter G. WilsonChemistry – A European Journal 201622, 12166-12175.

38. Alkene dioxygenation with malonoyl peroxides: Synthesis of g-lactones, isobenzofuranones and tetrahydrofurans. Carla Alamillo-Ferrer, Marianna Karabourniotis-Sotti, Alan R. Kennedy, Matthew Campbell and Nicholas C. O. Tomkinson, Org. Lett., 201618, 3102–3105.

37. A computational triage approach to the synthesis of novel difluorocyclopentenes and fluorinated cycloheptadienes using thermal rearrangements. David Orr, Jonathan M. Percy and Zoe A. Harrison, Chem. Sci.20167, 6369-6380.

36. Clinical Progress and Pharmacology of Small Molecule Bromodomain Inhibitors. Natalie H. Theodoulou, Nicholas C. O. Tomkinson, Rab K. Prinjha, and Philip G. Humphreys, Current Opinion in Chemical Biology201633, 58-66.

35. KOtBu: a Privileged Reagent for Electron Transfer Reactions? Joshua P. Barham, Graeme Coulthard, Katie J. Emery, Eswararao Doni, Florimond Cumine, Giuseppe Nocera, Matthew P John, Leonard E. A. Berlouis, Thomas M. McGuire, Tell Tuttle, and John A. Murphy, J. Am. Chem. Soc.2016 138 , 7402–7410.

34. GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain. Paul Bamborough, Heather A. Barnett, Isabelle Becher, Mark J. Bird, Chun-Wa Chung, Peter D. Craggs, Emmanuel H. Demont, Hawa Diallo, David J. Fallon, Laurie J. Gordon, Paola Grandi, Clare I. Hobbs, Edward Hooper-Greenhill, Emma J. Jones, Robert P. Law, Armelle Le Gall, David Lugo, Anne-Marie Michon, Darren J. Mitchell, Rab K. Prinjha, Robert J. Sheppard, Allan J. B. Watson, and Robert J. Watson, ACS Med. Chem. Lett.2016 7 , 552–557.

33. C – H Arylation of Heterocyclic N Oxides Through In-Situ Diazotisation Of Anilines Without Added Promoters: A Green And Selective Coupling Process. Aymeric  P. Colleville, Richard A. J. Horan, Sandrine Olazabal, and Nicholas C. O. Tomkinson, Org. Process Res. Dev.201620, 1283–1296.

32. Chan-Evans-Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem. Julien C Vantourout, Robert P. Law, Albert Isidro-Llobet, Stephen J. Atkinson, and Allan J. B. Watson, J. Org. Chem., 201681, 3942-3950.

31. Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine. Marine Z. C. Hatit, Joanna C. Sadler, Liam A. McLean, Benjamin C. Whitehurst, Ciaran P. Seath, Luke D. Humphreys, Robert J. Young, Allan J. B. Watson, and Glenn A. Burley, Org. Lett.201618, 1694-1697.

30. Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J. A. Borthwick, N. Ancellin, S. M. Bertrand, R. P. Bingham, P. S. Carter, C.-W. Chung, I. Churcher, N. Dodic, C. N. Fournier, P. L. Francis, A. Hobbs, C. Jamieson, S. D. Pickett, S. E. Smith, D. O. Somers, C. Spitzfaden, C. J. Suckling, and R. J. Young, J. Med. Chem., 201659, 2452-2467.

29. Double deprotonation of pyridinols generates potent organic electron donor initiators for haloarene-arene coupling. Joshua P. Barham, Graeme Coulthard, Ryan G. Kane, Nathan Delgado, Matthew P. John, and John A. Murphy, Angew. Chem. Int. Ed.201655, 4492-4496.  

28. 2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. L. Shukla, L. A. Ajram, M. Begg, B. Evans, R. H. Graves, S. T. Hodgson, S. M. Lynn, A. H. Miah, J. M. Percy, P. A. Procopiou, S. A. Richards, and R. J. Slack, Eur. J. Med. Chem.2016115, 14-25.

27. Iridium(I) NHC/phosphine catalysts for mild and chemoselective hydrogenation processes. William J. Kerr, Richard J. Mudd, and Jack A. Brown, Chemistry – A European Journal201622, 4738–4742.

26. Predicting the reducing power of organic super electron donors. Greg M. Anderson, Iain Cameron, John A. Murphy and Tell Tuttle, RSC Adv.20166, 11335-11343.

25. Progress in the Development of non-BET Bromodomain Chemical Probes. Natalie H. Theodoulou, Nicholas C. O. Tomkinson, Rab K. Prinjha and Philip G. Humphreys, ChemMedChem201611, 477–487.

24. Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2. Robert J. Slack, Maryam Hafeji, Rebecca Rogers, Steve B. Ludbrook, John F. Marshall, David J. Flint, Susan Pyne, and Jane C. Denyer, Pharmacology2016, 97, 114–125.

23. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. Natalie H. Theodoulou, Paul Bamborough, Andrew J. Bannister, Isabelle Becher, Rino A. Bit, Ka H. Che, Chun-wa Chung, Antje Dittmann, Gerard Drewes, David H. Drewry, Laurie Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Anne-Marie. Michon, Judit Molnar, Samuel C. Robson, Nicholas C. O. Tomkinson, Tony Kouzarides, Rab K. Prinjha and Philip G. Humphreys, J. Med. Chem., 201559, 1425-1439.

22. Alkene anti-Dihydroxylation with Malonoyl Peroxides. Carla Alamillo-Ferrer, Stuart J. Davidson, Michael J. Rawling, Natalie H. Theodoulou, Matthew Campbell, Phillip G. Humphreys, Alan R. Kennedy, and Nicholas C. O. Tomkinson, Org. Lett., 2015, 17, 5132-5135.

21. Strategies towards chemoselective suzuki-miyaura cross-coupling. James W. B Fyfe and Allan J. B. Watson, Synlett201526, 1139-1144.

20. A modular synthesis of functionalised phenols enabled by controlled boron speciation. John J Molloy, Robert P. Law, James W. B. Fyfe, Ciaran P. Seath, David J. Hirst, and Allan J. B. Watson, Org. Biomol. Chem.201513, 3093-3102.

19. Speciation control during Suzuki-Miyaura cross-coupling of haloaryl and haloalkenyl MIDA boronic esters. James W. B. Fyfe, E. Valverde, Ciaran P. Seath, Alan R. Kennedy, Joanna M. Redmond, Niall A. Anderson, and Allan J. B. Watson,Chemistry – A European Journal201521, 8951-8964.

18. One-Pot Homologation of Boronic Acids: A Platform for Diversity-Oriented Synthesis. Calum W. Muir, Julien C. Vantourout, Albert Isidro-Llobet, Simon J. F. MacDonald, and Allan J. B. Watson, Org. Lett., 201517, 6030-6033.

17. The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits. Sophie M. Bertrand, Nicolas Ancellin, Benjamin Beaufils, Ryan P. Bingham, Jennifer A. Borthwick, Anne-Benedicte. Boullay, Eric Boursier, Paul S. Carter, Chun-wa. Chung, Ian Churcher, Nerina Dodic, Marie-Helene. Fouchet, Charlene Fournier, Peter L. Francis, Laura A. Gummer, Kenny Herry, Andrew Hobbs, Clare I. Hobbs, Paul Homes, Craig Jamieson, Edwige Nicodeme, Stephen D. Pickett, Iain H. Reid, Graham L. Simpson, Lisa A. Sloan, Sarah E. Smith, Donald O’N. Somers, Claus Spitzfaden, Colin J. Suckling, Klara Valko, Yoshiaki Washio, and Robert J. Young, J. Med. Chem.201558, 7140-7163.

16. A modular synthesis of functionalised phenols enabled by controlled boron speciation. John J. Molloy, Robert P. Law, James W. B. Fyfe, Ciaran P. Seath, David J. Hirst and Allan J. B. Watson, Org. Biomol. Chem.201513, 3093-3102.

15. One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates. Joshua P. Barham, Matthew P. John, John A. Murphy, Beilstein J. Org. Chem., 201410, 2981–2988.

14. Chemoselective boronic ester synthesis via controlled speciation. James W. B Fyfe, Ciaran P Seath, and Allan J. B Watson, Angew. Chem. Int. Ed.2014, 53, 12077-12080.

13. Identifying the Roles of Amino Acids, Alcohols and 1,2-Diamines as Mediators in Coupling of Haloarenes to Arenes. Shengze Zhou, Eswararao Doni, Greg M. Anderson, Ryan G. Kane, Scott W. MacDougall, Victoria M. Ironmonger, Tell Tuttle and John A. Murphy, J. Am. Chem. Soc.2014136, 17818–17826. 

12. Iridium(I)-Catalyzed Regioselective C-H Activation and Hydrogen Isotope Exchange of Non-aromatic Unsaturated Functionality. W. J. Kerr, R. J. Mudd, L. C. Paterson, and J. A. Brown, Chem. Eur. J.201420, 14604-14607.

11. Evaluating the Thermal Vinylcyclopropane Rearrangement (VCPR) as a Practical Method for the Synthesis of Difluorinated Cyclopentenes: Experimental and Computational Studies of Rearrangement Stereospecificity. David Orr, Jonathan M. Percy, Tell Tuttle, Alan R. Kennedy and Zoë A. Harrison, Chem. Eur. J.201420, 14305–14316.

10. Regiospecific Synthesis of  2-Aryl 1,2,3-Triazoles from 2,5-Disubstituted Tetrazoles via Photochemically Generated Nitrile Imine Intermediates. S. Stewart, R. Harris, and C. Jamieson, Synlett201425, 2480-2484.

9. Aryldiazonium Tetrafluoroborate Salts as Green and Efficient Coupling Partners for the Suzuki–Miyaura Reaction: From Optimisation to Mole Scale. A. P. Colleville, R. A. J. Horan, and N. C. O. Tomkinson, Org. Process Res. Dev.201418, 1128–1136.

8. Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists. A. H. Miah, H. Abas, M. Begg, B. J. Marsh, D. E. O’Flynn, A. J. Ford, J. M. Percy, P. A. Procopiou, S. A. Richards, and S.-A. Rumley, Bioorg. Med. Chem.201422, 4298-4311.

7. Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-Chemokine Receptor 4 (CCR4) antagonists. A. H. Miah, R. C. B. Copley, D. O'Flynn, J. M. Percy, and P. A. Procopiou, Org. Biomol. Chem., 201412, 1779-1792.

6. Organic super-electron-donors: initiators in transition metal-free haloarene–arene coupling. S. Zhou, G. M. Anderson, B. Mondal, E. Doni, V. Ironmonger, M. Kranz, T. Tuttle, and J. A. Murphy, Chem. Sci., 20145 , 476-482.

5. Mechanistic insights into the malonoyl peroxide syn-dihydroxylation of alkenes. M. J. Rawling, J. H. Rowley, M. Campbell, A. R. Kennedy, J. A. Parkinson, and N. C. O. Tomkinson, Chem. Sci., 20145, 1777-1785.

4. Discovery of Novel Irreversible Inhibitors of Interleukin (IL)-2-inducible Tyrosine Kinase (Itk) by Targeting Cysteine 442 in the ATP Pocket. J. D. Harling, A. M. Deakin, S. Campos, R. Grimley, L. Chaudry, C. Nye, O. Polyakova, C. M. Besant, N. Barton, D. Somers, J. Barrett, R. H. Graves, L. Hanns, W. J. Kerr, and R. Solari, J. Biol. Chem., 2013, 288, 28195-28206.

3. Single-Step Microwave-Mediated Synthesis of Oxazoles and Thiazoles from 3-Oxetanone: A Synthetic and Computational Study. D. Orr, A. Tolfrey, J. M. Percy, J. Frieman, Z. A. Harrison, M. Campbell-Crawford, and V. K. Patel, Chem. Eur. J., 201319, 9655-9662.

2. Alkene Dihydroxylation with Malonoyl Peroxides: Catalysis Using Fluorinated Alcohols. Sylvain Picon, Michael Rawling, Matthew Campbell and Nicholas C. O. Tomkinson, Org. Lett.201214, 6250-6253.

1. Asymmetric Rhodium-Catalysed Addition of Arylboronic Acids to Acyclic Unsaturated Esters Containing a Basic γ-Amino Group. N. A. Anderson, B. J. Fallon, E. Valverde, S. J. F. MacDonald, J. M. Pritchard, C. J. Suckling, and A. J. B. Watson, Synlett201223, 2817-2821.

>120 research papers have been published in high impact, peer-reviewed journals.