Professor Helen Grant
Emeritus Professor
Biomedical Engineering
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Metabolomics analysis as a tool to measure cobalt neurotoxicity : an in vitro validation Alanazi Ibrahim M, Alzahrani Abdullah R, Zughaibi Torki A, Al-Asmari Ahmed I, Tabrez Shams, Henderson Catherine, Watson David, Grant Mary Helen Metabolites Vol 13 (2023) https://doi.org/10.3390/metabo13060698 Effects of acute and chronic cobalt treatment on adult rat cardiomyocyte calcium handling Olatunji Zainab O, MacMillan Sandy, Cameron-Ruiz Miren, Bosakhar Zainab Y, MacKenzie Graeme, Grant Mary H, Tate Rothwelle, MacQuaide Niall, Currie Susan Heart Vol 109 (2023) https://doi.org/10.1136/heartjnl-SCF-2023.18 Cardiac function is compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants Jenkinson Mark, Meek Dominic, MacMillan Sandy, Tate Rothwelle, Grant Mary, Currie Susan Heart Vol 109 (2023) https://doi.org/10.1136/heartjnl-SCF-2023.11 Concentration- and time-dependent effects of cobalt in rat and human ventricular cardiac fibroblasts MacMillan S, Olatunji Z O, Bosakhar Z Y, MacKenzie G, Grant M H, Tate R, Macquaide N, Currie S Acta Physiologica Vol 236, pp. 614 (2022) https://doi.org/10.1111/apha.13876 Cobalt-mediated contractile dysfunction in adult hearts and consequent effects on cardiomyocyte calcium transients MacMillan S, Olatunji Z O, Bosakhar Z Y, MacKenzie G, Grant M H, Tate R, Macquaide N, Currie S Acta Physiologica Vol 236, pp. 922 (2022) https://doi.org/10.1111/apha.13877 Global longitudinal strain is compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants Jenkinson M RJ, Meek RMD, MacMillan S, Tate R, Grant MH, Currie S Europhysiology 2022 (2022)
Publications
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eurotox Participant 2019 BSI Standards CenELEC Workshop (External organisation) Advisor 17/6/2017
Investigating the translational application of CaMKII as a biomarker for cobalt cardiotoxicity Currie, Susan (Principal Investigator) Grant, Mary (Co-investigator) Tate, Rothwelle (Co-investigator) 01-Jan-2019 - 31-Jan-2021 Improving control over the mechanical and transport properties of collagen-based scaffolds for Tissue Engineering and Regenerative Medicine Grant, Mary (Principal Investigator) 01-Jan-2015 - 30-Jan-2019 EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Claasen, Myndert Zagnoni, Michele (Principal Investigator) Grant, Mary (Co-investigator) Claasen, Myndert (Research Co-investigator) 01-Jan-2014 - 15-Jan-2020 Epsrc Doctoral Training Grant | Davidson, Scott Cebula, Izabela (Principal Investigator) Grant, Mary (Co-investigator) Davidson, Scott (Research Co-investigator) 01-Jan-2012 - 17-Jan-2016 Medical Devices Doctoral Training Centre Renewal | Macneill, Olivia Grant, Mary (Principal Investigator) Black, Richard Anthony (Co-investigator) Macneill, Olivia (Research Co-investigator) 01-Jan-2012 - 15-Jan-2017 BTG- Nanotoxicology Grant, Mary (Principal Investigator) Patwardhan, Siddharth (Principal Investigator) Urquhart, Andrew (Principal Investigator) Although nanoparticles are extensively used in a wide range of commercial applications, the understanding of their toxicity has started to emerge only recently and confusion regarding their safe use is widespread. In this project, we aim to assess the toxicity of newly-invented nanoparticles which have applications in biomedical materials such as drug delivery. Consequences of exposure to the nanoparticles will be assessed (using appropriate ISO standard protocols) by effects on viability, proliferation and cytokine release. One outcome of this project will be known toxicity and drug delivering ability of new nanoparticles. 05-Jan-2011 - 01-Jan-2012
Professional Activities
Projects
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Contact
Professor
Helen
Grant
Emeritus Professor
Biomedical Engineering
Email: m.h.grant@strath.ac.uk
Tel: Unlisted