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Prof Keith Mathieson

Director

Institute of Photonics

Personal statement

My research group develops optoelectronic devices to interface with neural systems in an effort to understand aspects of neural processing. We collaborate closely with leading neuroscientists and develop high-end technology using advanced semiconductor processing techniques.

Optogenetics: This technique allows neurons to be optically controlled (both activated and suppressed) and has become part of the toolkit allowing neuroscientists to further understanding of the brain. We develop novel photonic devices that allow spatio-temporal control over neural circuits by integrating micron-scale light sources (μLEDs) on to minimally invasive neural probes. These probes can optically excite neurons with laminar specificity and integrated microelectrodes can record the subsequent neural activity.

We work closely with neuroscientist, Dr Shuzo Sakata, who tests these probes in vivo. The work is summarised in the following publication: http://www.nature.com/articles/srep28381

The combination of high-density electrophysiological recordings with genetic manipulation techniques has the potential to make important discoveries in the field of neuroscience.

Microelectrode Arrays: We have developed high-density microelectrode arrays for the recording of extracellular signals from retinal tissue. This state-of-the-art system is being used to study retinal processing and encoding of dynamic visual images at Stanford University (Chichilnisky Lab) and retinal development in the mouse at the University of California Santa Cruz (Sher Lab).

An example research output from this project is detailed in the  Nature publication (doi:10.1038/nature09424) where the system was used to study colour processing in the retina. It required close collaboration between technology groups at the University of Strathclyde, the University of California Santa Cruz (Litke & Sher), AGH University, Krakow (Dabrowski & Hottowy) and neuroscientists at Stanford (Chichilnisky).

Retinal Prosthesis: We collaborate closely with the group of Prof. Daniel Palanker (Stanford) on the development of an optoelectronic retinal prosthesis to restore sight to patients with degenerative retinal diseases. Here we fabricate an implantable silicon chip that captures the visual scene through near infrared image projection, which also remotely powers the wireless device. A research driver for this project is the development of a device that can restore detailed vision to patients through a minmally invasive implant. For more information see the following publications: Nature Photonics  (doi:10.1038/nphoton.2012.104) and Nature Medicine (doi: doi:10.1038/nm.3851).

 

Publications

Large scale matching of function to the genetic identity of retinal ganglion cells
Pisano Filippo, Zampaglione Erin, McAlinden Niall, Roebber Jennifer, Dawson Martin D., Mathieson Keith, Sher Alexander
Scientific Reports Vol 7, (2017)
http://dx.doi.org/10.1038/s41598-017-15741-7
Spatio-temporal characteristics of retinal response to network-mediated photovoltaic stimulation
Ho Elton, Smith Richard, Goetz Georges A, Lei Xin, Galambos Ludwig, Kamins Theodore I, Harris James, Mathieson Keith, Palanker Daniel, Sher Alexander
Journal of Neurophysiology, pp. 1-29, (2017)
http://dx.doi.org/10.1152/jn.00872.2016
Structured illumination for communications and bioscience using GaN micro-LED arrays interfaced to CMOS
McKendry Jonathan, Xie Enyuan, Herrnsdorf Johannes, McAlinden Niall, Gu Erdan, Watson Ian, Strain Michael, Mathieson Keith, Dawson Martin
Emerging Technologies in Communications, Microsystems, Optoelectronics and Sensors, (2017)
Depth-specific optogenetic control in vivo with a scalable, high density µLED neural probe
Scharf Robert, Tsunematsu Tomomi, McAlinden Niall, Dawson Martin D., Sakata Shuzo, Mathieson Keith
Scientific Reports Vol 6, (2016)
http://dx.doi.org/10.1038/srep28381
SiC protective coating for photovoltaic retinal prosthesis
Lei Xin, Kane Sheryl, Cogan Stuart, Lorach Henri, Galambos Ludwig, Huie Philip, Mathieson Keith, Kamins Theodore, Harris James, Palanker Daniel
Journal of Neural Engineering Vol 13, (2016)
http://dx.doi.org/10.1088/1741-2560/13/4/046016
Photovoltaic pixels for neural stimulation : circuit models and performance
Boinagrov David, Lei Xin, Goetz Georges, Kamins Theodore I., Mathieson Keith, Galambos Ludwig, Harris James S., Palanker Daniel
IEEE Transactions on Biomedical Circuits and Systems Vol 10, pp. 85-97, (2016)
http://dx.doi.org/10.1109/TBCAS.2014.2376528

more publications

Professional activities

External examiner for "Nanokick"
External Examiner
12/1/2017
University of Utah Bioengineering Seminar
Invited speaker
16/11/2016
CUNY - Strathclyde Strategic Links Workshop
Invited speaker
21/6/2016
Optogen 2015
Keynote/plenary speaker
15/12/2015
Innovative Technologies in Biomedicine
Keynote/plenary speaker
13/10/2015
Future Light Technology and Human Health
Invited speaker
22/9/2015

more professional activities

Projects

Fraunhofer UK Research Limited: Studentship Agreement | BOUDET, Antoine
Mathieson, Keith (Principal Investigator) Dawson, Martin (Co-investigator) BOUDET, Antoine (Research Co-investigator)
Period 01-Oct-2014 - 01-Apr-2018
Fraunhofer UK Research Limited: Studentship Agreement | Pisano, Filippo
Mathieson, Keith (Principal Investigator) Riis, Erling (Co-investigator) Pisano, Filippo (Research Co-investigator)
Period 01-Jan-2013 - 10-Feb-2017
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Winstanley, Ruaridh Francis
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Winstanley, Ruaridh Francis (Research Co-investigator)
Period 01-Oct-2015 - 01-Oct-2019
An EPSRC Life Sciences Interface Doctoral Training Centre for Medical Devices | Jeorrett, Abigail Helen
Mathieson, Keith (Principal Investigator) Jeorrett, Abigail Helen (Research Co-investigator)
Period 01-Oct-2010 - 07-Oct-2015
High-Density Microelectrode Array Fabrication
Mathieson, Keith (Principal Investigator)
Period 01-Jul-2016 - 31-Jan-2017
Medical Devices Doctoral Training Centre Renewal | Varkonyi, Gabor
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Varkonyi, Gabor (Research Co-investigator)
Period 01-Oct-2013 - 01-Oct-2017

more projects

Address

Institute of Photonics
Technology Innovation Centre

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