Professor Keith Mathieson

Institute of Photonics

Publications

Photovoltaic retinal prosthesis with high pixel density
Mathieson Keith, Loudin James, Goetz Georges, Huie Philip, Wang Lele, Kamins Theodore I, Galambos Ludwig, Smith Richard, Harris James S, Sher Alexander, Palanker Daniel
Nature Photonics Vol 6, pp. 391-397 (2012)
https://doi.org/10.1038/nphoton.2012.104
Depth-specific optogenetic control in vivo with a scalable, high density µLED neural probe
Scharf Robert, Tsunematsu Tomomi, McAlinden Niall, Dawson Martin D, Sakata Shuzo, Mathieson Keith
Scientific Reports Vol 6 (2016)
https://doi.org/10.1038/srep28381
Photovoltaic restoration of sight with high visual acuity
Lorach Henri, Goetz Georges, Smith Richard, Lei Xin, Mandel Yossi, Kamins Theodore, Mathieson Keith, Huie Philip, Harris James, Sher Alexander, Palanker Daniel
Nature Medicine Vol 21, pp. 476–482 (2015)
https://doi.org/10.1038/nm.3851
Photovoltaic implant simulator reveals resolution limits in subretinal prosthesis
Chen Zhijie Charles, Wang Bing-Yi, Kochnev Goldstein Anna, Butt Emma, Mathieson Keith, Palanker Daniel
Journal of Neural Engineering (2022)
https://doi.org/10.1088/1741-2552/ac8ed8
Micro-LEDs for biomedical applications
McKendry Jonathan, Gu Erdan, McAlinden Niall, Laurand Nicolas, Mathieson Keith, Dawson Martin D
Micro LEDs (2021) (2021)
https://doi.org/10.1016/bs.semsem.2020.12.004
Vertical-junction photodiodes for smaller pixels in retinal prostheses
Huang Tiffany W, Kamins Theodore, Chen Zhijie Charles, Wang Bing-Yi, Bhuckory Mohajeet, Galambos Ludwig, Ho Elton, Ling Tong, Afshar Sean, Shin Andrew, Zuckerman Valentina, Harris James S, Mathieson Keith, Palanker Daniel
Journal of Neural Engineering Vol 18 (2021)
https://doi.org/10.1088/1741-2552/abe6b8

More publications

Research interests

My research group develops optoelectronic devices to interface with neural systems in an effort to understand aspects of neural processing. We collaborate closely with leading neuroscientists and develop high-end technology using advanced semiconductor processing techniques.

Optogenetics: This technique allows neurons to be optically controlled (both activated and suppressed) and has become part of the toolkit allowing neuroscientists to further understanding of the brain. We develop novel photonic devices that allow spatio-temporal control over neural circuits by integrating micron-scale light sources (μLEDs) on to minimally invasive neural probes. These probes can optically excite neurons with laminar specificity and integrated microelectrodes can record the subsequent neural activity.

We work closely with neuroscientist, Dr Shuzo Sakata, who tests these probes in vivo. The work is summarised in the following publication: http://www.nature.com/articles/srep28381

The combination of high-density electrophysiological recordings with genetic manipulation techniques has the potential to make important discoveries in the field of neuroscience.

Retinal Prosthesis: We collaborate closely with the group of Prof. Daniel Palanker (Stanford) on the development of an optoelectronic retinal prosthesis to restore sight to patients with degenerative retinal diseases. Here we fabricate an implantable silicon chip that captures the visual scene through near infrared image projection, which also remotely powers the wireless device. A research driver for this project is the development of a device that can restore detailed vision to patients through a minmally invasive implant. For more information see the following publications: Nature Photonics  (doi:10.1038/nphoton.2012.104) and Nature Medicine (doi: doi:10.1038/nm.3851).

 Microelectrode Arrays: We have developed high-density microelectrode arrays for the recording of extracellular signals from retinal tissue. This state-of-the-art system is being used to study retinal processing and encoding of dynamic visual images at Stanford University (Chichilnisky Lab) and retinal development in the mouse at the University of California Santa Cruz (Sher Lab).

An example research output from this project is detailed in the  Nature publication (doi:10.1038/nature09424) where the system was used to study colour processing in the retina. It required close collaboration between technology groups at the University of Strathclyde, the University of California Santa Cruz (Litke & Sher), AGH University, Krakow (Dabrowski & Hottowy) and neuroscientists at Stanford (Chichilnisky).

 

Professional activities

External examiner for "Nanokick"
External Examiner
12/1/2017
University of Utah Bioengineering Seminar
Invited speaker
16/11/2016
CUNY - Strathclyde Strategic Links Workshop
Invited speaker
21/6/2016
Optogen 2015
Keynote/plenary speaker
15/12/2015
Innovative Technologies in Biomedicine
Keynote/plenary speaker
13/10/2015
Future Light Technology and Human Health
Invited speaker
22/9/2015

More professional activities

Projects

Towards optogenetic cortical implants for hearing impaired HEARLIGHT (H2020 FET OPEN)
Mathieson, Keith (Principal Investigator)
01-Jan-2021 - 31-Jan-2025
Deep brain technologies to understand the cellular origin of diseases DEEPER
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Wozny, Christian (Co-investigator) McAlinden, Niall (Research Co-investigator)
01-Jan-2021 - 30-Jan-2025
RAEng Chair in Emerging Technologies: Neural Interfaces for the Understanding and Treatment of Neurodegenerative Conditions
Mathieson, Keith (Principal Investigator)
RAEng Chair in Emerging Technologies: Neural Interfaces for the Understanding and Treatment of Neurodegenerative Conditions
01-Jan-2019 - 31-Jan-2029
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | McGleish, Olivia Mae
Mathieson, Keith (Principal Investigator) McAlinden, Niall (Co-investigator) McGleish, Olivia Mae (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Neural Interferacing using visible light communication
Mathieson, Keith (Principal Investigator)
01-Jan-2017 - 31-Jan-2020
µLED-based optogenetic auditory midbrain implant
Sakata, Shuzo (Principal Investigator) Mathieson, Keith (Co-investigator)
01-Jan-2016 - 30-Jan-2019

More projects

Address

Institute of Photonics
Technology Innovation Centre

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