Professor Keith Mathieson

Institute of Photonics

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Personal statement

My research is focussed on the development of devices to interface with neural systems. These are microfabriated, optoelectronic, implantable devices to record and activate neual activity within the brain. I hold a 10-year award from the Royal Academy of Engineering as part of their Chair in Emerging Technologies scheme, with a focus on neurotechnology.​

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Publications

Photovoltaic retinal prosthesis with high pixel density
Mathieson Keith, Loudin James, Goetz Georges, Huie Philip, Wang Lele, Kamins Theodore I, Galambos Ludwig, Smith Richard, Harris James S, Sher Alexander, Palanker Daniel
Nature Photonics Vol 6, pp. 391-397 (2012)
https://doi.org/10.1038/nphoton.2012.104
Depth-specific optogenetic control in vivo with a scalable, high density µLED neural probe
Scharf Robert, Tsunematsu Tomomi, McAlinden Niall, Dawson Martin D, Sakata Shuzo, Mathieson Keith
Scientific Reports Vol 6 (2016)
https://doi.org/10.1038/srep28381
Photovoltaic restoration of sight with high visual acuity
Lorach Henri, Goetz Georges, Smith Richard, Lei Xin, Mandel Yossi, Kamins Theodore, Mathieson Keith, Huie Philip, Harris James, Sher Alexander, Palanker Daniel
Nature Medicine Vol 21, pp. 476–482 (2015)
https://doi.org/10.1038/nm.3851
Three-dimensional electro-neural interfaces electroplated on subretinal prostheses
Butt Emma, Wang Bing-Yi, Shin Andrew, Chen Zhijie Charles, Bhuckory Mohajeet, Shah Sarthak, Galambos Ludwig, Kamins Theodore, Palanker Daniel, Mathieson Keith
Journal of Neural Engineering (2024)
https://doi.org/10.1088/1741-2552/ad2a37
Cellular migration into a subretinal honeycomb-shaped prosthesis for high-resolution prosthetic vision
Bhuckory Mohajeet B, Wang Bing-Yi, Chen Zhijie Charles, Shin Andrew, Huang Tiffany, Galambos Ludwig, Vounotrypidis Efstathios, Mathieson Keith, Kamins Theodore, Palanker Daniel
Proceedings of the National Academy of Sciences Vol 120 (2023)
https://doi.org/10.1073/pnas.2307380120
Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats
Wang Bing-Yi, Chen Zhijie Charles, Bhuckory Mohajeet, Huang Tiffany, Shin Andrew, Zuckerman Valentina, Ho Elton, Rosenfeld Ethan, Galambos Ludwig, Kamins Theodore, Mathieson Keith, Palanker Daniel
Nature Communications Vol 13 (2022)
https://doi.org/10.1038/s41467-022-34353-y

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Research Interests

The Neurophotonics research team develops optoelectronic devices to interface with neural systems in an effort to understand aspects of neural processing. We collaborate closely with leading neuroscientists and develop high-end technology using advanced semiconductor processing techniques.​

Current research focuses on the following:​

  • ​Technologies for optogenetic control of neural circuits to further our understanding of brain function (see the EU-funded DEEPER consortium) and ​
  • Optoelectronic devices that function as prosthetic devices to restore lost function – for example, our work on retinal prosthetics with Stanford University and our involvement in the EU-funded HearLight project.​

The research is underpinned by a 10-year, £2.8M award from the Royal Academy of Engineering through their Chair in Emerging Technologies scheme.​

We have a close collaboration with Dr Shuzo Sakata’s neuroscience team, where together we have formed an emerging neurotechnology effort at Strathclyde, that brings together physicists, engineers and neuroscientists to develop new technologies aimed at furthering our understanding of the brain.​

Professional Activities

External examiner for "Nanokick"
External Examiner
12/1/2017
University of Utah Bioengineering Seminar
Invited speaker
16/11/2016
CUNY - Strathclyde Strategic Links Workshop
Invited speaker
21/6/2016
Optogen 2015
Keynote/plenary speaker
15/12/2015
Innovative Technologies in Biomedicine
Keynote/plenary speaker
13/10/2015
Future Light Technology and Human Health
Invited speaker
22/9/2015

More professional activities

Projects

Lasers and photonics of the future: self-assembled optically active resonators (Research Leadership) | McCormick, Emma
Laurand, Nicolas (Principal Investigator) Mathieson, Keith (Co-investigator) McCormick, Emma (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Deep brain technologies to understand the cellular origin of diseases DEEPER | Abbot, James
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Abbot, James (Research Co-investigator)
01-Jan-2022 - 01-Jan-2026
Towards optogenetic cortical implants for hearing impaired HEARLIGHT (H2020 FET OPEN)
Mathieson, Keith (Principal Investigator)
01-Jan-2021 - 31-Jan-2025
Deep brain technologies to understand the cellular origin of diseases DEEPER
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Wozny, Christian (Co-investigator) McAlinden, Niall (Research Co-investigator)
01-Jan-2021 - 30-Jan-2025
RAEng Chair in Emerging Technologies: Neural Interfaces for the Understanding and Treatment of Neurodegenerative Conditions
Mathieson, Keith (Principal Investigator)
RAEng Chair in Emerging Technologies: Neural Interfaces for the Understanding and Treatment of Neurodegenerative Conditions
01-Jan-2019 - 31-Jan-2029
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | McGleish, Olivia Mae
Mathieson, Keith (Principal Investigator) McAlinden, Niall (Co-investigator) McGleish, Olivia Mae (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022

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Contact

Professor Keith Mathieson
Institute of Photonics

Email: keith.mathieson@strath.ac.uk
Tel: 548 4901

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