Professor Keith Mathieson

Director

Institute of Photonics

Publications

Characteristics of prosthetic vision in rats with subretinal flat and pillar electrode arrays
Ho Elton, Lei Xin, Flores Thomas Anthony, Lorach Henri, Huang Tiffany W, Galambos Ludwig, Kamins Theodore, Harris James S, Mathieson Keith, Palanker Daniel
Journal of Neural Engineering (2019)
https://doi.org/10.1088/1741-2552/ab34b3
Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis
Flores Thomas, Huang Tiffany, Bhuckory Mohajeet, Ho Elton, Chen Zhijie, Dalal Roopa, Galambos Ludwig, Kamins Theodore, Mathieson Keith, Palanker Daniel
Scientific Reports Vol 9 (2019)
https://doi.org/10.1038/s41598-019-47082-y
Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons
Flores Thomas, Lei Xin, Huang Tiffany, Lorach Henri, Dalal Roopa, Galambos Ludwig, Kamins Theodore, Mathieson Keith, Palanker Daniel
Journal of Neural Engineering Vol 15 (2018)
https://doi.org/10.1088/1741-2552/aaac39
A compact integrated device for spatially selective optogenetic neural stimulation based on the Utah Optrode Array
Scharf Robert, Reiche Christopher F, McAlinden Niall, Cheng Yunzhou, Xie Enyuan, Sharma Rohit, Tathireddy Prashant, Rieth Loren, Mathieson Keith, Blair Steve
Optogenetics and Optical Manipulation 2018 Optogenetics and Optical Manipulation 2018 (2018)
https://doi.org/10.1117/12.2299296
Large scale matching of function to the genetic identity of retinal ganglion cells
Pisano Filippo, Zampaglione Erin, McAlinden Niall, Roebber Jennifer, Dawson Martin D, Mathieson Keith, Sher Alexander
Scientific Reports Vol 7 (2017)
https://doi.org/10.1038/s41598-017-15741-7
Spatio-temporal characteristics of retinal response to network-mediated photovoltaic stimulation
Ho Elton, Smith Richard, Goetz Georges A, Lei Xin, Galambos Ludwig, Kamins Theodore I, Harris James, Mathieson Keith, Palanker Daniel, Sher Alexander
Journal of Neurophysiology, pp. 1-29 (2017)
https://doi.org/10.1152/jn.00872.2016

more publications

Research interests

My research group develops optoelectronic devices to interface with neural systems in an effort to understand aspects of neural processing. We collaborate closely with leading neuroscientists and develop high-end technology using advanced semiconductor processing techniques.

Optogenetics: This technique allows neurons to be optically controlled (both activated and suppressed) and has become part of the toolkit allowing neuroscientists to further understanding of the brain. We develop novel photonic devices that allow spatio-temporal control over neural circuits by integrating micron-scale light sources (μLEDs) on to minimally invasive neural probes. These probes can optically excite neurons with laminar specificity and integrated microelectrodes can record the subsequent neural activity.

We work closely with neuroscientist, Dr Shuzo Sakata, who tests these probes in vivo. The work is summarised in the following publication: http://www.nature.com/articles/srep28381

The combination of high-density electrophysiological recordings with genetic manipulation techniques has the potential to make important discoveries in the field of neuroscience.

Retinal Prosthesis: We collaborate closely with the group of Prof. Daniel Palanker (Stanford) on the development of an optoelectronic retinal prosthesis to restore sight to patients with degenerative retinal diseases. Here we fabricate an implantable silicon chip that captures the visual scene through near infrared image projection, which also remotely powers the wireless device. A research driver for this project is the development of a device that can restore detailed vision to patients through a minmally invasive implant. For more information see the following publications: Nature Photonics  (doi:10.1038/nphoton.2012.104) and Nature Medicine (doi: doi:10.1038/nm.3851).

 Microelectrode Arrays: We have developed high-density microelectrode arrays for the recording of extracellular signals from retinal tissue. This state-of-the-art system is being used to study retinal processing and encoding of dynamic visual images at Stanford University (Chichilnisky Lab) and retinal development in the mouse at the University of California Santa Cruz (Sher Lab).

An example research output from this project is detailed in the  Nature publication (doi:10.1038/nature09424) where the system was used to study colour processing in the retina. It required close collaboration between technology groups at the University of Strathclyde, the University of California Santa Cruz (Litke & Sher), AGH University, Krakow (Dabrowski & Hottowy) and neuroscientists at Stanford (Chichilnisky).

 

Professional activities

External examiner for "Nanokick"
External Examiner
12/1/2017
University of Utah Bioengineering Seminar
Invited speaker
16/11/2016
CUNY - Strathclyde Strategic Links Workshop
Invited speaker
21/6/2016
Optogen 2015
Keynote/plenary speaker
15/12/2015
Innovative Technologies in Biomedicine
Keynote/plenary speaker
13/10/2015
Future Light Technology and Human Health
Invited speaker
22/9/2015

more professional activities

Projects

RAEng Chair in Emerging Technologies: Neural Interfaces for the Understanding and Treatment of Neurodegenerative Conditions
Mathieson, Keith (Principal Investigator)
01-Jan-2019 - 31-Jan-2029
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | McGleish, Olivia Mae
Mathieson, Keith (Principal Investigator) McAlinden, Niall (Co-investigator) McGleish, Olivia Mae (Research Co-investigator)
01-Jan-2018 - 01-Jan-2022
Neural Interferacing using visible light communication
Mathieson, Keith (Principal Investigator)
01-Jan-2017 - 31-Jan-2020
µLED-based optogenetic auditory midbrain implant
Sakata, Shuzo (Principal Investigator) Mathieson, Keith (Co-investigator)
01-Jan-2016 - 30-Jan-2019
High-Density Microelectrode Array Fabrication
Mathieson, Keith (Principal Investigator)
01-Jan-2016 - 31-Jan-2017
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Winstanley, Ruaridh Francis
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Winstanley, Ruaridh Francis (Research Co-investigator)
01-Jan-2015 - 01-Jan-2019

more projects

Address

Institute of Photonics
Technology Innovation Centre

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