Dr Keith Mathieson

Director

Institute of Photonics

Personal statement

My research group develops devices to interface with neural systems in an effort to understand aspects of neural processing. We collaborate closely with leading neuroscientists and develop high-end technology using advanced semiconductor processing techniques.

Optogenetics: I am currently expanding my research to produce devices that can record from hundreds of neurons in vivo and aim to capitalise upon the advances in genetic techniques, such as optogenetics. The novel aspects of this development will be nanofabricating high-density electrode arrays and integrating them with micron-sized light sources (microLED arrays). This will be done in close collaboration with colleagues at the Institute of Photonics (Prof. M. Dawson's group) and at Strathclyde's Institute of Pharmacy and Biomedical Science (S. Sakata's group).

The combination of high-density electrophysiological recordings with genetic manipulation techniques has the potential to make important discoveries in the field of neuroscience.

Microelectrode Arrays: One such project is in the development of high-density microelectrode arrays for the recording of extracellular signals from retinal tissue. This system is the state-of-the-art and is being used to study retinal processing and encoding of dynamic visual images at the Salk Institute in San Diego and retinal development in the mouse at the University of California Santa Cruz. This  research has resulted in a recent Nature publication (doi:10.1038/nature09424) where the system was used to study colour processing in the retina. It required close collaboration between my group and groups at the University of California Santa Cruz (Litke & Sher), the Salk Institute (Chichilnisky) and AGH University, Krakow (Dabrowski & Hottowy).

Within my group we have also developed novel tools for studying neuronal activity in brain slices. This “bed-of-nails” type electrode array is able to penetrate brain tissue and record extracellular single-unit activity at high resolution (60 microns) and is being extended to cover ~2mm2 of tissue. D. Gunning is funded through a Royal Academy of Engineering Fellowship to pursue this research.

Retinal Prosthesis: I am also involved in the development of prosthesis systems to restore sight to patients with degenerative retinal diseases. I collaborate with Prof. D. Palanker (Stanford University) on the microfabrication of the Stanford Retinal Prosthesis device (doi:10.1038/nphoton.2012.104).

 

Publications

Structured illumination for communications and bioscience using GaN micro-LED arrays interfaced to CMOS
McKendry Jonathan, Xie Enyuan, Herrnsdorf Johannes, McAlinden Niall, Gu Erdan, Watson Ian, Strain Michael, Mathieson Keith, Dawson Martin
Emerging Technologies in Communications, Microsystems, Optoelectronics and Sensors, (2017)
Depth-specific optogenetic control in vivo with a scalable, high density µLED neural probe
Scharf Robert, Tsunematsu Tomomi, McAlinden Niall, Dawson Martin D., Sakata Shuzo, Mathieson Keith
Scientific Reports Vol 6, (2016)
http://dx.doi.org/10.1038/srep28381
SiC protective coating for photovoltaic retinal prosthesis
Lei Xin, Kane Sheryl, Cogan Stuart, Lorach Henri, Galambos Ludwig, Huie Philip, Mathieson Keith, Kamins Theodore, Harris James, Palanker Daniel
Journal of Neural Engineering Vol 13, (2016)
http://dx.doi.org/10.1088/1741-2560/13/4/046016
Photovoltaic pixels for neural stimulation : circuit models and performance
Boinagrov David, Lei Xin, Goetz Georges, Kamins Theodore I., Mathieson Keith, Galambos Ludwig, Harris James S., Palanker Daniel
IEEE Transactions on Biomedical Circuits and Systems Vol 10, pp. 85-97, (2016)
http://dx.doi.org/10.1109/TBCAS.2014.2376528
Corrigendum to "Performance of photovoltaic arrays in-vivo and characteristics of prosthetic vision in animals with retinal degeneration" [Vision Res. 111(Part B) (2015) 142-148]
Lorach Henri, Goetz Georges, Mandel Yossi, Lei Xin, Galambos Ludwig, Kamins Theodore I., Mathieson Keith, Huie Philip, Dalal Roopa, Harris James S., Palanker Daniel
Vision Research Vol 117, pp. 137, (2015)
http://dx.doi.org/10.1016/j.visres.2015.06.005
Interactions of prosthetic and natural vision in animals with local retinal degeneration
Lorach Henri, Lei Xin, Galambos Ludwig, Kamins Theodore, Mathieson Keith, Dalal Roopa, Huie Philip, Harris James, Palanker Daniel
Investigative Ophthalmology and Visual Science Vol 56, pp. 7444-7450, (2015)
http://dx.doi.org/10.1167/iovs.15-17521

more publications

Professional activities

External examiner for "Nanokick"
External Examiner
12/1/2017
University of Utah Bioengineering Seminar
Invited speaker
16/11/2016
CUNY - Strathclyde Strategic Links Workshop
Invited speaker
21/6/2016
Optogen 2015
Keynote/plenary speaker
15/12/2015
Innovative Technologies in Biomedicine
Keynote/plenary speaker
13/10/2015
Future Light Technology and Human Health
Invited speaker
22/9/2015

more professional activities

Projects

Fraunhofer UK Research Limited: Studentship Agreement | BOUDET, Antoine
Mathieson, Keith (Principal Investigator) Dawson, Martin (Co-investigator) BOUDET, Antoine (Research Co-investigator)
Period 01-Oct-2014 - 01-Apr-2018
Fraunhofer UK Research Limited: Studentship Agreement | Pisano, Filippo
Mathieson, Keith (Principal Investigator) Riis, Erling (Co-investigator) Pisano, Filippo (Research Co-investigator)
Period 01-Jan-2013 - 10-Feb-2017
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Winstanley, Ruaridh Francis
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Winstanley, Ruaridh Francis (Research Co-investigator)
Period 01-Oct-2015 - 01-Oct-2019
An EPSRC Life Sciences Interface Doctoral Training Centre for Medical Devices | Jeorrett, Abigail Helen
Mathieson, Keith (Principal Investigator) Jeorrett, Abigail Helen (Research Co-investigator)
Period 01-Oct-2010 - 07-Oct-2015
High-Density Microelectrode Array Fabrication
Mathieson, Keith (Principal Investigator)
Period 01-Jul-2016 - 31-Jan-2017
Medical Devices Doctoral Training Centre Renewal | Varkonyi, Gabor
Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Varkonyi, Gabor (Research Co-investigator)
Period 01-Oct-2013 - 01-Oct-2017

more projects

Address

Institute of Photonics
Technology Innovation Centre

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