Professor Nicholas Tomkinson

Pure and Applied Chemistry

Personal statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

Publications

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Publications

Emerging applications of stimulated Raman scattering microscopy for medicinal chemistry and drug discovery: Braddick Henry J, Tipping William J, Grant Emma K, Tomkinson Nicholas C O, Faulds Karen, Graham Duncan; Chemical Society Reviews (2025); https://doi.org/10.1039/d5cs00748h
Expedited SARS‐CoV‐2 main protease inhibitor discovery through modular 'direct‐to‐biology' screening: Wilders Harry, Biggs George, Rowe Sam M, Cawood Emma E, Riziotis Ioannis G, Rendina Alan R, Grant Emma K, Pettinger Jonathan, Fallon David J, Skehel Mark, House David, Tomkinson Nicholas C O, Bush Jacob T; Angewandte Chemie Vol 137 (2025); https://doi.org/10.1002/ange.202418314
Label-free screening of drug-induced liver injury using stimulated Raman scattering microscopy and spectral phasor analysis: Tipping William J, Wilson Liam T, Tomkinson Nicholas C O, Faulds Karen, Graham Duncan; Analytical Chemistry Vol 96, pp. 10639-10647 (2024); https://doi.org/10.1021/acs.analchem.4c01285
bbSelect : an open-source tool for performing a 3D pharmacophore-driven diverse selection of R-groups: Rianjongdee Francesco, Palmer David, Pickett Stephen D, Pogány Peter, Tomkinson Nicholas CO, Green Darren VS; Journal of Chemical Information and Modeling Vol 64, pp. 4687-4699 (2024); https://doi.org/10.1021/acs.jcim.4c00453
A mechanistic investigation of the N-hydroxyphthalimide catalyzed benzylic oxidation mediated by sodium chlorite: Grunshaw Thomas, Wood Susanna H, Sproules Stephen, Parrott Andrew, Nordon Alison, Shapland Peter D P, Wheelhouse Katherine M P, Tomkinson Nicholas C O; Journal of Organic Chemistry Vol 89, pp. 7933-7945 (2024); https://doi.org/10.1021/acs.joc.4c00583
Expanding the range of bioorthogonal tags for multiplex stimulated Raman scattering microscopy: Murphy Neville, Tipping William J, Braddick Henry J, Wilson Liam T, Tomkinson Nicholas CO, Faulds Karen, Graham Duncan, Farràs Pau; Angewandte Chemie International Edition Vol 62 (2023); https://doi.org/10.1002/anie.202311530

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Research

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Research Interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

Reactions should proceed at room temperature
Reactions should proceed in the presence of moisture and air
Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.

Professional Activities

Strategic Themes - Bioimaging Workshop: Participant; 17/9/2024
PhD viva - Faye Cruickshank: External Examiner; 11/5/2016
Hiroya Takizawa: Host; 22/2/2016
Carbonyl and Enolate Chemistry: Participant; 14/1/2016
Ono Pharmaceutical Co Ltd (Japan): Visiting researcher; 11/11/2015
Ono Pharmaceutical Co Ltd (Japan): Visiting researcher; 4/6/2015

More professional activities

Projects

UKRI2005: DA EPSRC IDLA - University of Strathclyde 2025 / S251622-105: Barham, Joshua (Co-investigator) Tomkinson, Nick (Co-investigator); 01-Jan-2025 - 30-Jan-2030
An integrated analysis of S-acylation dynamics and its importance in cell physiology (APP4861): Chamberlain, Luke (Principal Investigator) Beveridge, Rebecca (Co-investigator) Tomkinson, Nick (Co-investigator); 01-Jan-2025 - 30-Jan-2030
A Prosperity Partnership for the Design, Synthesis, and Evaluation of Next Generation Molecules Beyond Lipinski Space: Jamieson, Craig (Principal Investigator) Beveridge, Rebecca (Co-investigator) Burley, Glenn (Co-investigator) Kerr, William (Co-investigator) Lindsay, David (Co-investigator) Palmer, David (Co-investigator) Tomkinson, Nick (Co-investigator); 01-Jan-2025 - 31-Jan-2030
Non-invasive single cell metabolic studies in adipocytes CT23-6: Gould, Gwyn (Principal Investigator) Faulds, Karen (Co-investigator) Tomkinson, Nick (Co-investigator); 01-Jan-2024 - 30-Jan-2027
Industrial Case Account - University of Strathclyde 2023 | Woodley-Thomas, Charles: Tomkinson, Nick (Principal Investigator) Chamberlain, Luke (Co-investigator) Woodley-Thomas, Charles (Research Co-investigator); 01-Jan-2024 - 01-Jan-2028
Industrial CASE Account - University of Strathclyde 2024 | Whyte, Ryan: Tomkinson, Nick (Principal Investigator) Faulds, Karen (Co-investigator) Whyte, Ryan (Research Co-investigator); 01-Jan-2024 - 01-Jan-2028