Postgraduate research opportunities How does antibody-drug conjugate internalisation differ from the parent antibody?
ApplyKey facts
- Opens: Wednesday 3 December 2025
- Number of places: 1
- Duration: 36 to 48 months
Overview
This project studies how internalisation routes for trafficking antibody-drug conjugates may differ from the parent antibody structure. Findings from this work can be used as a predictor of safety and efficacy.Eligibility
An upper second-class UK Honours degree or overseas equivalent in Pharmaceutical sciences, Chemistry/Chemical sciences or Materials Science is required. If English is not your first language, you must have an IELTS score of at least 6.5 with no component below 5.5
Project Details
Antibody-drug conjugates have emerged as a novel therapeutic modality of interest in oncology and autoimmune disease. Despite their success in achieving targeting, there remain challenges in understanding the basis of their on-target and off-target toxicity. Our current understanding of their internalisation kinetics and routes of cellular entry remains limited. This project will use imaging-based approaches and proteomics to map the trafficking of antibody and antibody-drug conjugate pairs in cell lines of different tissue origins to uncover novel insights into toxicity and efficacy.
Funding details
While there is no funding in place for opportunities marked "unfunded", there are lots of different options to help you fund postgraduate research. Visit funding your postgraduate research for links to government grants, research councils funding and more, that could be available.
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Number of places: 1
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SIPBS (Pharmacy)
Programme: SIPBS (Pharmacy)
SIPBS (Pharmacy)
Programme: SIPBS (Pharmacy)