The Facility currently offers 3 Advanced Techniques in Mass Spectrometry
A Training Course can be requested for MALDI-ToF to understand sample preparations and to run the instrument by researchers at the University of Strathclyde.
Exactive Orbi-Trap (HRMS)
The Thermo-Fisher Scientific Exactive Plus Orbi-Trap Mass Spectrometer with Vanquish UPLC is for analysis of novel compounds ready for research publication and detection of molecules in biological mixtures at pmol concentration scales. This instrument is able to measure masses at 4 decimal point accuracy, so is able to differientiate isotopes ratios in molecules: useful for isotope labeling.
Thermo-Fisher Exactive Plus Mass Spectrometer
Thermo-Fisher Vanquish UPLC
Ionisation:ESI or APCI upon request
Mass Analyser:Orbi-Trap Mass Analyser
MALDI-ToF
MALDI-ToF is a Mass Spectrometry technique for the analysis of molecules of high molecular mass above 2,000 Da such as peptide, proteins and antibodies. This method is a go to for samples struggling with ionisation via convention techniques such as electronspray ionisation as well as molecules that cannot dissolve in peek tubing compatible solvents.
Shimadzu Axima Performance MALDI-ToF
Ionisation: Matrix Assisted Laser Desorption ionisation with a class 3B Laser at 337nm
Mass Analyser: Time of Flight detecting masses up to 500kDa
ICP-Mass Spectrometer
The Agilent ICP-Mass Spectrometer is for the detection of elemental composition at ppb concentration scales primarily for metals. This is currently heavily used for the analysis of metal contaminates in environmental samples.
Agilent 7700 Series ICP-Mass Spectrometer
Agilent ASX-500 Series ICP-MS Autosampler
Ionisation: Inductively Coupled Plasma
Carrier Gas: Argon