Dr Trevor Bushell


Strathclyde Institute of Pharmacy and Biomedical Sciences


Personal statement

I obtained my BSc (Hons) in Pharmacology from the University of Glasgow (1992) and my PhD in Neuroscience from the University of Bristol (1996) before undertaking postdoctoral research at the University of Chicago and Imperial College London. I took up my position here at Strathclyde in 2002.

My research interest lies primarily in the field of neuroscience and focuses on the modulation of neuronal excitability and synaptic transmission in both physiological and pathophysiological conditions. This currently takes several directions including the following: 

  1. Identifying novel roles for protease-activated receptor 2 (PAR-2) in the central nervous system (CNS).
  2. Examining how peripheral inflammation affect CNS function and animal behaviour (with Dr Hui-Rong Jiang)
  3. Determining the role of Toll-like receptor 3 (TLR3) in the CNS development. 
  4. Investigating the role of mitogen-activated protein kinase phosphatase-2 (MKP2) in the CNS.
  5. Developing novel microfluidic devices for neuroscience research (with Dr Michele Zagnoni).

A variety of preparations are utilised in our research including mammalian expression systems, cultured neurones, organotypic slice cultures and acute brain slices. Techniques used include cell death assays, electrophysiology, immunocytochemistry, overexpression of fluorescently tagged proteins of interest, molecular biological techniques including site-directed mutagenesis and real time RT-PCR and in collaboration with  Professor Judy Pratt we utilise a variety of tests to understand rodent behaviour. 

I am involved in teaching both the MPharm and BMS cohorts in numerous classes ranging from 1st to 4th year.  In addition I am lead of the Neuroscience and Mental Health research group.

I am currently the Strathclyde local group representative for the British Neuroscience Association.  I am also a full member of the Society for Neuroscience and a Fellow of the Higher Education Academy.

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Mesoscale standing wave imaging
Foylan Shannan, Schniete Jana Katharina, Kölln Lisa Sophie, Dempster John, Hansen Carsten Gram, Shaw Michael, Bushell Trevor John, McConnell Gail
Journal of Microscopy, pp. 1-9 (2023)
A simple image processing pipeline to sharpen topology maps in multi-wavelength interference microscopy
Tinning Peter W, Schniete Jana K, Scrimgeour Ross, Kölln Lisa S, Rooney Liam M, Bushell Trevor J, McConnell Gail
Optics Letters Vol 48, pp. 1092-1095 (2023)
Developing a modular microfluidic platform for use in neuroscience
Zagnoni Michele, Megarity Daniel, Bushell Trevor
BioMedEng22 (2022)
A modular microfluidic platform to enable complex and customisable in vitro models for neuroscience
Megarity D, Vroman R, Kriek M, Downey P, Bushell T J, Zagnoni M
Lab on a Chip Vol 22, pp. 1989-2000 (2022)
Anti-CD52 antibody treatment in murine experimental autoimmune encephalomyelitis induces dynamic and differential modulation of innate immune cells in peripheral immune and central nervous systems
Barbour Mark, Wood Rachel, Harte Tanith, Bushell Trevor J, Jiang Hui-Rong
Immunology Vol 165, pp. 312-327 (2022)
Use of sedative-hypnotic medications and risk of dementia : a systematic review and meta-analysis
AlDawsari Asma, Bushell Trevor J, Abutheraa Nouf, Sakata Shuzo, Al Hussain Sarah, Kurdi Amanj
British Journal of Clinical Pharmacology Vol 88, pp. 1567-1589 (2022)

More publications

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Professional Activities

Obtaining 3D information from a single 2D image of more than 16,000 live cells using Standing Wave Mesoscopy
Careers talk At St Thomas Acquinas School, Glasgow
Senior Phase Induction Day @ Strathclyde: SIPBS Virtual Drug Discovery Workshop
BNA Festival of Neuroscience 2019
Member of programme committee
Federation of European Neuroscience Societies (External organisation)
Federation of European Neuroscience Societies (External organisation)

More professional activities


Are blood cytokine levels a marker for depression-like behaviour in a mouse model of Alzheimer’s disease (Nicole Edwards)
Bushell, Trevor (Principal Investigator)
01-Jan-2024 - 31-Jan-2024
Establishing cerebral organoids as a human model of stroke
Carswell, Hilary (Principal Investigator) Bushell, Trevor (Co-investigator) McMullen, Calum (Co-investigator) Seib, Philipp (Co-investigator)
04-Jan-2023 - 03-Jan-2025
Depression-like behaviour in a mouse model of Alzheimer’s disease: a reverse translational study.
Bushell, Trevor (Principal Investigator) Sakata, Shuzo (Co-investigator)
01-Jan-2022 - 30-Jan-2025
Does immunomodulation promote resilience to Alzheimer’s pathology?
Bushell, Trevor (Principal Investigator) Sakata, Shuzo (Co-investigator)
01-Jan-2022 - 28-Jan-2023
Understanding the role of cholesterol in the radiation resistance of glioblastoma and its feasibility as a druggable target to improve treatment prognosis (CRUK Radnet)
Gomez-Roman, Natividad (Principal Investigator) Bushell, Trevor (Co-investigator) Graham, Duncan (Co-investigator)
24-Jan-2021 - 30-Jan-2022
Is the novel small molecule PAR2 activator, AC-264163, neuroprotective in a mouse model of Alzheimer's Disease?
Bushell, Trevor (Principal Investigator)
01-Jan-2020 - 31-Jan-2021

More projects

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Dr Trevor Bushell
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: trevor.bushell@strath.ac.uk
Tel: 548 2856