The overuse of antibiotics and their cumulative release into the environment and various waste streams, accidental or otherwise, have given rise to antimicrobial resistance (AMR).

Peptoids are structural isomers of natural peptides that can generate novel functionalities from a greatly expanded set of 200+ synthetic amino acids and resist degradation by enzymes naturally occurring in the body. They are conveniently synthesized via the same solid phase chemical approach as for preparing peptides by coupling one amino acid after another using standardized protocols into specific sequences.

The Lau group recently showed that the antimicrobial activities of peptoids can be enhanced by simple chain-end modifications. This project will expand this theme to tailor the balance between antimicrobial activity and mammalian toxicity. Secondly, molecular self-assembly and other processes will be investigated to temporarily sequester the peptoids’ antimicrobial activity until the peptoids are activated by an externally applied stimulus, e.g., light or sound.  

The project is part of our new interdisciplinary Leverhulme Doctoral School in Nature-Inspired Acoustics (NIA), and the student could further collaborate with researchers from both chemistry and other departments, including Electronic and Electrical Engineering, Biomedical Engineering, and Architecture. 

Only applicants who qualify for UK or Scottish Home Fees will be considered (see Funding Details). However, eligible candidates from all backgrounds, income levels, identities, and experiences are encouraged to apply.

Applicants with either a bachelor’s or Masters degree may apply. Applicants will ordinarily apply for a 4-year PhD scholarship. Talented applicants with less preparation could qualify for a 5-year Master’s + PhD scholarship (see Eligibility).

Apply as soon as possible—applications will be evaluated on a rolling basis starting Jan 31, 2026. After this date, email to inquire about the availability of the opportunity.